Catalog Number: 1092
Biological Activity
Potent agonist of the nociceptin (ORL1) receptor, demonstrated both in vitro and in vivo. Selective, competitive antagonism at the nociceptin receptor has also been reported (pA2 = 7.02 and 6.75 in the guinea pig ileum and mouse vas deferens respectively).
Technical Data
  • M.Wt:
    1367.6
  • Formula:
    C61H102N22O14
  • Sequence:
    FGGFTGARKSARK

    (Modifications: Phe-1 - Gly-2 peptide bond replace with Psi-(CH2-NH), Lys-13 = C-terminal amide)

  • Solubility:
    Soluble to 0.70 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    213130-17-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Address and message sequences for the nociceptin receptor: a structure-activity study of nociceptin (1-13)-peptide amide.
    Guerrini et al.
    J.Med.Chem., 1997;40:1789
  2. A new selective antagonist of the nociceptin receptor.
    Guerrini et al.
    Br.J.Pharmacol., 1998;123:163
  3. [Phe1ω(CH2-NH)Gly2-nociceptin-(1-13)NH2, a proposed antagonist of the nociceptin receptor, is a potent and stable agonist in the rat spinal cord.
    Xu et al.
    Neurosci.Lett., 1998;249:127
  4. Comparison of the effects of [Phe1ω(CH2-NH)Gly2-nociceptin-(1-13)NH2 in rat brain, rat vas deferens and CHO cells expressing recombinant human nociceptin receptors.
    Okawa et al.
    Br.J.Pharmacol., 1999;127:123
Citations:

The citations listed below are publications that use Tocris products. Selected citations for [Phe1Ψ(CH2-NH)Gly2]Nociceptin(1-13)NH2 include:

1 Citations: Showing 1 - 1

  1. Nociceptin inhibits cough in the guinea-pig by activation of ORL(1) receptors.
    Authors: McLeod Et al.
    J Biol Chem 2001;132:1175

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