[Phe1Ψ(CH2-NH)Gly2]Nociceptin(1-13)NH2
Tocris Bioscience | Catalog # 1092
Key Product Details
Description
Product Description
[Phe1Ψ(CH2-NH)Gly2]Nociceptin(1-13)NH2 is a potent agonist of the nociceptin (ORL1) receptor, demonstrated both in vitro and in vivo. Selective, competitive antagonism at the nociceptin receptor has also been reported (pA2 = 7.02 and 6.75 in the guinea pig ileum and mouse vas deferens respectively).
Product Specifications
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The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Solubility
| Solubility | Soluble to 0.7mg/ml in water |
Calculators
Background References
References are publications that support the biological activity of the product. See our Citations tab to view 16 publications citing the usage of this product.
- Xu [Phe1ω(CH2-NH)Gly2-nociceptin-(1-13)NH2, a proposed antagonist of the nociceptin receptor, is a potent and stable agonist in the rat spinal cord. Neurosci.Lett. 1998 PMID: 9682833
- Guerrini A new selective antagonist of the nociceptin receptor. Br.J.Pharmacol. 1998 PMID: 9489602
- Okawa Comparison of the effects of [Phe1ω(CH2-NH)Gly2-nociceptin-(1-13)NH2 in rat brain, rat vas deferens and CHO cells expressing recombinant human nociceptin receptors. Br.J.Pharmacol. 1999 PMID: 10369464
- Guerrini Address and message sequences for the nociceptin receptor: a structure-activity study of nociceptin (1-13)-peptide amide. J.Med.Chem. 1997 PMID: 9191955
Product Documents
Certificate of Analysis
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Product Specific Notices
For research use only
Related Research Areas
Citations for [Phe1Ψ(CH2-NH)Gly2]Nociceptin(1-13)NH2
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