Enhances GABAergic activity. Long-acting barbiturate; slow-acting barbiturate
(Cat. No. 4579) also available.
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Phenobarbital but not diazepam reduces AMPA/kainate receptor mediated currents and exerts opposite actions on initial seizures in the neonatal rat hippocampus.
Nardou et al.
Calcium current block by (-)-pentobarbital, phenobarbital, and CHEB but not (+)-pentobarbital in acutely isolated hippocampal CA1 neurons: comparison with effects on GABA-activated Cl- current.
ffrench-Mullen et al.