Pseudosubstrate peptide inhibitor of protein kinase C (IC50
= 0.18 μ
M). Attenuates vascular hyperproliferation and hypertrophy induced by high glucose. Inhibits DNA and protein synthesis in vascular smooth muscle cells (VSMCs) in a dose-dependent manner. Inactive control available ([Glu27]-PKC (19-36)
, Cat. No. 4059).
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Other Product-Specific Information:
Possible involvement of phospholipase D and protein kinase C in vascular growth induced by elevated glucose concentration
Yasunari et al.
The citations listed below are publications that use Tocris products. Selected citations for PKC (19-36) include:
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