PKHD1 Antibody [DyLight 550]

Novus Biologicals | Catalog # BC110-60480R

Novus Biologicals
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Key Product Details

Species Reactivity

Human, Mouse

Applications

Peptide ELISA, Immunocytochemistry/ Immunofluorescence

Label

DyLight 550 (Excitation = 562 nm, Emission = 576 nm)

Antibody Source

Polyclonal Rabbit IgG
View all PKHD1 Primary Antibodies »

Product Specifications

Immunogen

A synthetic peptide derived from the human PKHD1 protein (within residues 3800-3900). [UniProt# Q8TCZ9]

Reactivity Notes

Immunogen sequence has 86% identity to mouse.

Localization

Membrane; single-pass type I membrane.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Description

This conjugate is made on demand and is not held in inventory. Each order represents a unique lot. All conjugates are generated using validated conjugation protocols and meet strict degree of labeling (F/P) specifications; additional information is available upon request. The antibody concentration is provided on the individual product label.

For specialized conjugation needs, like large quantities, specific concentrations, and defined F/P ratios, bulk and custom antibody conjugation services are available.

Applications for PKHD1 Antibody [DyLight 550]

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Peptide ELISA

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
This PKHD1 antibody is useful for peptide ELISA.

Recommended applications are based on validated applications from the unconjugated base product BC110-60480. This conjugated antibody is not kept in inventory and is made to order using validated conjugation protocols.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: PKHD1

PKHD1 is a type I membrane protein that undergoes regulated proteolysis. Many proteolytic cleavages occur on the ectodomain whereas at least one cleavage occurs on the cytoplasmic portion of PKHD1. The later generates a C-terminal intracellular fragment that localizes to the nucleus. This proteolysis requires activation of protein kinase C (PKC) and release of intracellular calcium. PKHD1 is expressed in the cilia of the bile duct epithelium and leads to abnormalities in the rubric of the ductal plate malformation. The intracellular C-terminus of PKHD1 interacts with calcium modulating cyclophilin ligand (CAML), a protein implicated in calcium signaling. PKHD1 may participate in the mediation of intracellular calcium in the distal nephron in a manner similar to PKD1 and PKD2. Mutations in the PKHD1 gene result in autosomal recessive polycystic kidney disease (ARPKD), a severe form of polycystic kidney disease characterized by enlarged kidneys and congenital hepatic fibrosis.

Alternate Names

polycystic kidney and hepatic disease 1 (autosomal recessive)

Gene Symbol

PKHD1

Additional PKHD1 Products

Product Documents for PKHD1 Antibody [DyLight 550]

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for PKHD1 Antibody [DyLight 550]

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

FAQs

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