PLX 647 dihydrochloride

Catalog # Availability Size / Price Qty
5102/10
5102/50
PLX 647 dihydrochloride | CAS No. 1779796-38-1 | Additional RTK Inhibitors
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Description: Potent dual Fms/KIT inhibitor

Chemical Name: 5-(1H-Pyrrolo[2,3-b]pyridin-3-ylmethyl)-N-[[4-(trifluoromethyl)phenyl]methyl]-2-pyridinamine dihydrochloride

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Biological Activity

Potent dual KIT/Fms inhibitor (IC50 values are 16 and 28 nM respectively). Inhibits BCR-FMS cell proliferation and osteoclast differentiation in vitro (IC50 values are 92 and 170 nM respectively). Attenuates LPS-induced TNFα and IL-6 release, mast cell activation and macrophage kidney proliferation in vivo.

Technical Data

Formula:
C21H17F3N4.2HCl
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Storage:
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
CAS No:
1779796-38-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor.
    Zhang et al.
    Proc.Natl.Acad.Sci.U.S.A., 2013;110:5689

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