Catalog Number: 5102
Chemical Name: 5-(1H-Pyrrolo[2,3-b]pyridin-3-ylmethyl)-N-[[4-(trifluoromethyl)phenyl]methyl]-2-pyridinamine dihydrochloride
Biological Activity
Potent dual KIT/Fms inhibitor (IC50 values are 16 and 28 nM respectively). Inhibits BCR-FMS cell proliferation and osteoclast differentiation in vitro (IC50 values are 92 and 170 nM respectively). Attenuates LPS-induced TNFα and IL-6 release, mast cell activation and macrophage kidney proliferation in vivo.
Technical Data
  • M.Wt:
    455.3
  • Formula:
    C21H17F3N4.2HCl
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >97%
  • Storage:
    Store at -20°C
  • CAS No:
    1779796-38-1
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor.
    Zhang et al.
    Proc.Natl.Acad.Sci.U.S.A., 2013;110:5689

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