Potent dual KIT/Fms inhibitor (IC50
values are 16 and 28 nM respectively). Inhibits BCR-FMS cell proliferation and osteoclast differentiation in vitro
values are 92 and 170 nM respectively). Attenuates LPS-induced TNFα
and IL-6 release, mast cell activation and macrophage kidney proliferation in vivo
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All Tocris products are intended for laboratory research use only.
Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor.
Zhang et al.