Biological ActivityPeptide that reverses the anticoagulant effect of heparin (Cat. No. 2812). Potently binds heparin (Kd = 36 nM in vitro).
(Modifications: Ala-1 = N-terminal Ac, Ala-19 = ε-Ac, X-36 = Dpr, Ala-37 = β-Ac, Glu-53 = C-terminal Amide)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Reversal of heparin-induced increases in aPTT in the rat by PM102, a novel he. antagonist.
Cushing et al.
Development of he. antagonists with focused biological activity.
Shenoy et al.
Novel concatameric heparin-binding peptides reverse he. and low-molecular-weight he. anticoagulant activities in patient plasma in vitro and in rats in vivo.
Schick et al.
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Tocris Small Molecules
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