PM 102

Catalog # Availability Size / Price Qty
4034/1
PM 102
1 Image
Description: Antagonist of heparin (Cat. No. 2812)
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Biological Activity

Peptide that reverses the anticoagulant effect of heparin (Cat. No. 2812). Potently binds heparin (Kd = 36 nM in vitro).

Technical Data

M.Wt:
5830
Formula:
C235H425N111O64
Sequence:
AEARARRAAARAARRAKK(AEARARRAAARAARRA)PX(AEARARRAAARAARRA)EN

(Modifications: Ala-1 = N-terminal Ac, Ala-19 = ε-Ac, X-36 = Dpr, Ala-37 = β-Ac, Glu-53 = C-terminal Amide)

Solubility:
Soluble to 5 mg/ml in water
Storage:
Store at -20°C
CAS No:
1234564-95-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold under license

Background References

  1. Reversal of heparin-induced increases in aPTT in the rat by PM102, a novel he. antagonist.
    Cushing et al.
    Eur.J.Pharmacol., 2010;635:165
  2. Development of he. antagonists with focused biological activity.
    Shenoy et al.
    Curr.Pharmaceut.Des., 1999;5:965
  3. Novel concatameric heparin-binding peptides reverse he. and low-molecular-weight he. anticoagulant activities in patient plasma in vitro and in rats in vivo.
    Schick et al.
    Blood, 2004;103:4

Product Datasheets

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Reconstitution Calculator

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