Catalog Number: 2273
Alternate Names: PMPC
Chemical Name: 4-(Phosphonomethyl)-2-piperazinecarboxylic acid
Biological Activity
Competitive NMDA receptor antagonist. Displays Ki values of 0.84, 2.74, 3.53 and 4.16 μM at NR2A, NR2B, NR2C and NR2D subunit-containing receptors respectively. Selective over AMPA receptors.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water
  • Storage:
    Store at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The effect of competitive antagonist chain length on NMDA receptor subunit selectivity.
    Feng et al.
    Neuropharmacology, 2005;48:354
  2. Cortically evoked excitatory synaptic transmission in the cat red nucleus is antagonised by D-AP5 but not by D-AP7.
    Harris and Davies
    Brain Res., 1992;594:176
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