PMPA (NMDA antagonist)
Chemical Name: 4-(Phosphonomethyl)-2-piperazinecarboxylic acid
Biological ActivityCompetitive NMDA receptor antagonist. Displays Ki values of 0.84, 2.74, 3.53 and 4.16 μM at GluN2A, GluN2B, GluN2C and GluN2D subunit-containing receptors respectively. Selective over AMPA receptors.
Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
The effect of competitive antagonist chain length on NMDA receptor subunit selectivity.
Feng et al.
Cortically evoked excitatory synaptic transmission in the cat red nucleus is antagonised by D-AP5 but not by D-AP7.
Harris and Davies
Brain Res., 1992;594:176
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