PMPA (NMDA antagonist)
Chemical Name: 4-(Phosphonomethyl)-2-piperazinecarboxylic acid
Biological ActivityCompetitive NMDA receptor antagonist. Displays Ki values of 0.84, 2.74, 3.53 and 4.16 μM at GluN2A, GluN2B, GluN2C and GluN2D subunit-containing receptors respectively. Selective over AMPA receptors.
Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
The effect of competitive antagonist chain length on NMDA receptor subunit selectivity.
Feng et al.
Cortically evoked excitatory synaptic transmission in the cat red nucleus is antagonised by D-AP5 but not by D-AP7.
Harris and Davies
Brain Res., 1992;594:176
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PMPA was in use as an NMDA receptor antagonist affecting glutamate site, to study (possible) competition of dopamine for this site. Application of PMPA and dopamine mixtures in different ratios resulted in a decrease of single-channel NMDA receptor openings recorded from outside-out neuron membrane patches. No problem with dissolution in water up to 10 mM concentration.