PMPA (NMDA antagonist)

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2273/10
2273/50
PMPA (NMDA antagonist) | CAS No. 113919-36-1 | NMDA Receptor Antagonists
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Description: Competitive NMDA antagonist
Alternative Names: PMPC

Chemical Name: 4-(Phosphonomethyl)-2-piperazinecarboxylic acid

Product Details
Reviews (1)

Biological Activity

Competitive NMDA receptor antagonist. Displays Ki values of 0.84, 2.74, 3.53 and 4.16 μM at GluN2A, GluN2B, GluN2C and GluN2D subunit-containing receptors respectively. Selective over AMPA receptors.

Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.

Technical Data

M.Wt:
224.15
Formula:
C6H13N2O5P
Solubility:
Soluble to 100 mM in water
Storage:
Store at +4°C
CAS No:
113919-36-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Antagonism at NMDA receptor
By Sergiy Sylantyev on 11/29/2020
Application: Species: Human

PMPA was in use as an NMDA receptor antagonist affecting glutamate site, to study (possible) competition of dopamine for this site. Application of PMPA and dopamine mixtures in different ratios resulted in a decrease of single-channel NMDA receptor openings recorded from outside-out neuron membrane patches. No problem with dissolution in water up to 10 mM concentration.


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