Catalog Number: 2556
Chemical Name: (S)-3,4-Dihydro-1-[2-[4-(4-methoxyphenyl)-1-piperazinyl]ethyl]-N-methyl-1H-2-benzopyran-6-carboxamide
Biological Activity
Potent and selective 5-HT1D receptor agonist that displays > 600-fold selectivity over 5-HT1A and 5-HT2A receptors and no activity at 5-HT1B, 5-HT1E, 5-HT2B, 5-HT2C, 5-HT6 and 5-HT7 receptors. Reduces dural plasma extravasation evoked by trigeminal ganglion stimulation.
Technical Data
  • M.Wt:
    409.52
  • Formula:
    C24H31N3O3
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Store at +4°C
  • CAS No:
    187665-60-7
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Isochroman-6-carboxamides as highly selective 5-HT1D agonists: potential new treatment for migraine without cardiovascular side effects.
    Ennis et al.
    J.Med.Chem., 1998;41:2180
  2. 5-Hydroxytryptamine1B receptor-mediated contraction of rabbit saphenous vein and basilar artery: role of vascular endothelium.
    Bhattacharya et al.
    J.Pharmacol.Exp.Ther., 2004;309:825
  3. Effects of PNU-109,291, a selective 5-HT1D receptor agonist, on electrically induced dural plasma extravasation and capsaicin-evoked c-fos immunoreactivity within trigeminal nucleus caudalis.
    Cutrer et al.
    Neuropharmacology, 1999;38:1043
Citations:

The citations listed below are publications that use Tocris products. Selected citations for PNU 109291 include:

1 Citations: Showing 1 - 1

  1. 5-HT is a potent relaxant in rat superior mesenteric veins.
    Authors: Watts Et al.
    J Mol Neurosci 2015;3:e00103

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