Potent and selective 5-HT1D
receptor agonist that displays > 600-fold selectivity over 5-HT1A
receptors and no activity at 5-HT1B
receptors. Reduces dural plasma extravasation evoked by trigeminal ganglion stimulation.
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All Tocris products are intended for laboratory research use only.
Isochroman-6-carboxamides as highly selective 5-HT1D agonists: potential new treatment for migraine without cardiovascular side effects.
Ennis et al.
5-Hydroxytryptamine1B receptor-mediated contraction of rabbit saphenous vein and basilar artery: role of vascular endothelium.
Bhattacharya et al.
Effects of PNU-109,291, a selective 5-HT1D receptor agonist, on electrically induced dural plasma extravasation and capsaicin-evoked c-fos immunoreactivity within trigeminal nucleus caudalis.
Cutrer et al.
The citations listed below are publications that use Tocris products. Selected citations for PNU 109291 include:
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