PARP [Poly(ADP-ribose) Polymerase], also known as ADPRT and PPOL, is a 118-kDa enzyme that uses NAD as a substrate to catalyze the covalent transfer of ADP-ribose to a variety of nuclear protein acceptors. ADP ribosyltransferase is required for cellular repair, and PARP expression is induced by single-strand breaks in DNA. PARP is proteolytically cleaved by Caspase-3 into two fragments of 89- and 24-kDa in one of the hallmark events of apoptosis.
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Poly(ADP-ribose) Polymer/pADPr
R&D Systems | Catalog # 4336-100-01
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Key Product Details
Features
PAR Polymer was first synthesized using poly(ADP-ribose) polymerase (PARP) in the presence of NAD+, cleaved from PARP, and subsequently purified. The PAR Polymer is recognized by Trevigen's anti-PAR monoclonal and polyclonal antibodies.
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Formulation, Preparation, and Storage
Shipping
The product is shipped with ice packs or equivalent. Upon receipt, store it immediately at the temperature recommended on the product label.
Storage
Store the unopened product at -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Background: PAR/pADPr
Long Name
Poly [ADP-ribose] Polymer
Alternate Names
PAR
Additional PAR/pADPr Products
Product Documents for Poly(ADP-ribose) Polymer/pADPr
Certificate of Analysis
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Note: Certificate of Analysis not available for kit components.
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Citations for Poly(ADP-ribose) Polymer/pADPr
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Q: What is the concentration of this polymer in units of mass/volume?
A: The concentration of poly(ADP-ribose) Polymer/pADPr is determined by measuring light absorbance at 258 nm using the molar extinction coefficient of PAR. This measurement yields concentration in units of μM. The chain length of this polymer ranges between 2 and 300 ADP-ribose units. Because we are unable to evaluate the variation in polymer length and polymer branching, we are unable to calculate a concentration based on mass. As such, this product is bottled and sold by the concentration in molarity.