PPPA
Chemical Name: (2R*,4S*)-4-(3-Phosphonopropyl)-2-piperidinecarboxylic acid
Biological Activity
Competitive NMDA receptor antagonist that displays moderate selectivity for NR2A-containing receptors (Ki values are 0.13, 0.47, 1.10 and 3.86 μM for GluN2A, GluN2B, GluN2C and GluN2D subunits respectively).Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Effect of extracellular pH on the potency of N-MthD.-aspartic acid receptor competitive antagonists.
Benveniste and Mayer
Mol.Pharmacol., 1992;42:679 -
The effect of competitive antagonist chain length on NMDA receptor subunit selectivity.
Feng et al.
Neuropharmacology, 2005;48:354 -
Identification of subunit- and antagonist-specific amino acid residues in the N-MthD.-aspartate receptor glutamate-binding pocket.
Kinarsky et al.
J.Pharmacol.Exp.Ther., 2005;313:1066
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Citation for PPPA
The citations listed below are publications that use Tocris products. Selected citations for PPPA include:
1 Citation: Showing 1 - 1
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The distinct role of NR2B subunit in the enhancement of visual plasticity in adulthood.
Authors: Liu Et al.
Mol Brain 2015;8:49
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