Catalog Number: 2274
Alternate Names: LY 257883
Chemical Name: (2R*,4S*)-4-(3-Phosphonopropyl)-2-piperidinecarboxylic acid
Biological Activity
Competitive NMDA receptor antagonist that displays moderate selectivity for NR2A-containing receptors (Ki values are 0.13, 0.47, 1.10 and 3.86 μM for NR2A, NR2B, NR2C and NR2D subunits respectively).
Technical Data
  • M.Wt:
    251.22
  • Formula:
    C9H18NO5P
  • Solubility:
    Soluble to 100 mM in water
  • Storage:
    Desiccate at RT
  • CAS No:
    113190-92-4
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. The effect of competitive antagonist chain length on NMDA receptor subunit selectivity.
    Feng et al.
    Neuropharmacology, 2005;48:354
  2. Effect of extracellular pH on the potency of N-methyl-D-aspartic acid receptor competitive antagonists.
    Benveniste and Mayer
    Mol.Pharmacol., 1992;42:679
  3. Identification of subunit- and antagonist-specific amino acid residues in the N-methyl-D-aspartate receptor glutamate-binding pocket.
    Kinarsky et al.
    J.Pharmacol.Exp.Ther., 2005;313:1066
Citations:

The citations listed below are publications that use Tocris products. Selected citations for PPPA include:

1 Citations: Showing 1 - 1

  1. The distinct role of NR2B subunit in the enhancement of visual plasticity in adulthood.
    Authors: Liu Et al.
    Mol Brain 2015;8:49

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