Biological ActivityPrion peptide fragment that shares many physiochemical features with PrPSc. Exhibits neurotoxicity caused by amplification of PrPC-associated signaling responses and induces NF-κB-mediated apoptosis in the mouse neuroblastoma cell line N2a. Forms β-sheet-rich, insoluble, protease-resistant fibrils and is used as a model to study prion diseases in vitro.
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Neurotoxicity of a prion protein fragment.
Forloni et al.
Overstimulation of PrPC signaling pathways by prion peptide 106-126 causes oxidative injury of bioaminergic neuronal cells.
Pietri et al.
p75NTR activation of NF-κB is involved in PrP106-126-induced apoptosis in mouse neuroblastoma cells.
Bai et al.
Citation for Prion Protein 106-126 (human)
The citations listed below are publications that use Tocris products. Selected citations for Prion Protein 106-126 (human) include:
1 Citation: Showing 1 - 1
Binding with nucleic acids or glycosaminoglycans converts soluble protein oligomers to amyloid.
Authors: Domizio Et al.
J Biol Chem 2012;287:736
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