Catalog Number: 3491
Biological Activity
Prion peptide fragment that shares many physiochemical features with PrPSc. Exhibits neurotoxicity caused by amplification of PrPC-associated signaling responses and induces NF-κB-mediated apoptosis in the mouse neuroblastoma cell line N2a. Forms β-sheet-rich, insoluble, protease-resistant fibrils and is used as a model to study prion diseases in vitro.
Technical Data
  • M.Wt:
    1912.26
  • Formula:
    C80H138N26O24S2
  • Sequence:
    KTNMKHMAGAAAAGAVVGGLG
  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    148439-49-0
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Neurotoxicity of a prion protein fragment.
    Forloni et al.
    Nature, 1993;362:543
  2. Overstimulation of PrPC signaling pathways by prion peptide 106-126 causes oxidative injury of bioaminergic neuronal cells.
    Pietri et al.
    J.Biol.Chem., 2006;281:28470
  3. p75NTR activation of NF-κB is involved in PrP106-126-induced apoptosis in mouse neuroblastoma cells.
    Bai et al.
    Neurosci.Res., 2008;62:9
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Prion Protein 106-126 (human) include:

1 Citations: Showing 1 - 1

  1. Binding with nucleic acids or glycosaminoglycans converts soluble protein oligomers to amyloid.
    Authors: Domizio Et al.
    J Biol Chem 2012;287:736

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