Chemical Name: (9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid methyl ester
Biological ActivityPristimerin is a potent and reversible inhibitor of monoacylglycerol lipase (MGL) (IC50 = 93 nM). Also suppresses NF-κB activation via inhibition of proteasome chymotrypsin-like activity and IKKαβ. Displays antitumor, anti-inflammatory and antimicrobial activities.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Reactive oxygen species-dependent activation of Bax and Poly(ADP)-ribose) polymerase-1 is requried for mitochondrial cell death induced by triterpenoid Pristimerin in human cervical cancer cells.
Byun et al.
Identification of a potent natural triterpenoid inhibitor of proteosome chymotrypsin-like activity and NF-κB with antimyeloma activity in vitro and in vivo.
Tiedemann et al.
Discovery of potent and reversible monoacylglycerol lipase inhibitors.
King et al.
Citation for Pristimerin
The citations listed below are publications that use Tocris products. Selected citations for Pristimerin include:
1 Citation: Showing 1 - 1
Pristimerin as a Novel Hepatoprotective Agent Against Experimental Autoimmune Hepatitis.
Authors: El-Agamy Et al.
Front Pharmacol 2018;9:292
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