Potent and reversible inhibitor of monoacylglycerol lipase (MGL) (IC50
= 93 nM). Also suppresses NF-κ
B activation via inhibition of proteasome chymotrypsin-like activity and IKKαβ
. Displays antitumor, anti-inflammatory and antimicrobial activities.
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All Tocris products are intended for laboratory research use only.
Reactive oxygen species-dependent activation of Bax and Poly(ADP)-ribose) polymerase-1 is requried for mitochondrial cell death induced by triterpenoid Pristimerin in human cervical cancer cells.
Byun et al.
Identification of a potent natural triterpenoid inhibitor of proteosome chymotrypsin-like activity and NF-κB with antimyeloma activity in vitro and in vivo.
Tiedemann et al.
Discovery of potent and reversible monoacylglycerol lipase inhibitors.
King et al.