Potent inhibitor of MMP-3 expression (IC50
= 60 nM); down-regulates induction of MMP-3 in both stressed dopaminergic cells and activated microglia. Also suppresses proinflammatory responses and inhibits NO production in activated microglia. Attenuates motor deficits, prevents neurodegeneration and suppresses microglial activation in a Parkinson's disease mouse model. Brain penetrant.
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A novel compound PTIQ protects the nigral dopaminergic neurones in an animal model of Parkinsons disease induced by MPTP.
Son et al.
Syntheses of tetrahydroisoquinoline derivatives that inhibit NO production in activated BV-2 microglial cells.
Seo et al.