PU 02
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Description: Negative allosteric modulator of 5-HT3
Chemical Name: 6-[(1-Naphthalenylmethyl)thio]-9H-purine
Purity: ≥97%
Biological Activity
Negative allosteric modulator of 5-HT3 receptors (IC50 values are 0.36 and 0.73 μM in HEK293 cells transfected with human 5-HT3A and 5-HT3AB receptors respectively).Technical Data
M.Wt:
292.36
Formula:
C16H12N4S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥97%
Storage:
Store at +4°C
CAS No:
313984-77-9
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Discovery of a novel allosteric modulator of 5-HT3 receptors: inhibition and potentiation of Cys-loop receptor signaling through a conserved transmembrane intersubunit site.
Trattnig et al.
J.Biol.Chem., 2012;287:25241
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