Negative allosteric modulator of 5-HT3
values are 0.36 and 0.73 μ
M in HEK293 cells transfected with human 5-HT3A
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Discovery of a novel allosteric modulator of 5-HT3 receptors: inhibition and potentiation of Cys-loop receptor signaling through a conserved transmembrane intersubunit site.
Trattnig et al.