Ubiquitin-activating enzyme (E1) inhibitor. Blocks degradation of p53 and cyclin D3. Inhibits NF-κ
B activation and induces cell death associated with ER stress. Displays antitumor effects in a mouse model of leukemia.
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The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma.
Xu et al.