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PYZD 4409

Catalog #: 4994 Datasheet / COA / SDS

Discontinued Product

4994 has been discontinued.
View all Ubiquitin-activating Enzyme (E1) Inhibitors products.
PYZD 4409 | CAS No. 423148-78-1 | Ubiquitin-activating Enzyme (E1) Inhibitors
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Description: Ubiquitin-activating enzyme (E1) inhibitor

Chemical Name: 1-(3-Chloro-4-fluorophenyl)-4-[(5-nitro-2-furanyl)methylene]-3,5-pyrazolidinedione

Purity: ≥98%

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Biological Activity

PYZD 4409 is an ubiquitin-activating enzyme (E1) inhibitor. Blocks degradation of p53 and cyclin D3. Inhibits NF-κB activation and induces cell death associated with ER stress. Displays antitumor effects in a mouse model of leukemia.

Technical Data

M.Wt:
351.67
Formula:
C14H7ClFN3O5
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
423148-78-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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