Chemical Name: (4aR-trans)-4,4a,5,6,7,8,8a,9-Octahydro-5-propyl-1H-pyrazolo[3,4-g]quinoline hydrochloride
Biological ActivitySelective dopamine D2 receptor agonist (Ki values are 4.8, ~24, ~30 and 1900 nM at D2, D3, D4 and D1 receptors respectively).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Modulation of [3H]quinpirole binding in brain by monoamine oxidase inhibitors: evidence for a potential novel binding site.
Levant et al.
DA receptor pharmacology.
Seeman and Van Tol
Trends Pharmacol.Sci., 1994;15:264
Effects of quinpirole on central DA systems in sensitized and non-sensitized rats.
Sullivan et al.
Citations for (-)-Quinpirole hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for (-)-Quinpirole hydrochloride include:
39 Citations: Showing 1 - 10
A novel luminescence-based-β-arrestin recruitment assay for unmodified receptors.
Authors: Pedersen Et al.
J Biol Chem 2021;
Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner.
Authors: Dorst Et al.
Nat Commun 2020;11:5113
A Differential Hypofunctionality of Gαi Proteins Occurs in Adolescent Idiopathic Scoliosis and Correlates with the Risk of Disease Progression.
Authors: Akoume Et al.
Sci Rep 2019;9:10074
Differential contributions of striatal dopamine D1 and D2 receptors to component processes of value-based decision making.
Authors: Verharen Et al.
Glutamatergic and dopaminergic modulation of cortico-striatal circuits probed by dynamic calcium imaging of networks reconstructed in microfluidic chips.
Authors: Lassus Et al.
Sci Rep 2018;8:17461
DA Receptor Subtypes Mediate Opposing Effects on Form Deprivation Myopia in Pigmented Guinea Pigs.
Invest Ophthalmol Vis Sci 2018;59(11):4441
Selective blockade of spinal D2DR by levo-corydalmine attenuates MOR tolerance via suppressing PI3K/Akt-MAPK signaling in a MOR-dependent manner.
Authors: Dai Et al.
Exp Mol Med 2018;50:148
Melanotan II causes hypothermia in mice by activation of mast cells and stimulation of histamine 1 receptors.
Authors: Jain Et al.
Am J Physiol Endocrinol Metab 2018;315:E357
Cocaine Inhibition of Synaptic Transmission in the Ventral Pallidum Is Pathway-Specific and Mediated by Serotonin.
Authors: Matsui and Alvarez
Cell Rep 2018;23(13):3852
The locus coeruleus drives disinhibition in the midline thalamus via a dopaminergic mechanism.
Authors: Beas Et al.
Nat Neurosci 2018;21:963
Role of DA D2 receptor in stress-induced myelin loss.
Sci Rep 2017;7(1):11654
Subtype-specific effects of DArgic D2 receptor activation on synaptic trains in layer V pyramidal neurons in the mouse prefrontal cortex.
Physiol Rep 2017;5(22):e13499
Inhibiting clathrin-mediated endocytosis of the leucine-rich G protein-coupled receptor-5 diminishes cell fitness.
Authors: Snyder Et al.
J Biol Chem 2017;292:7208
Activation of DRD5 inhibits tumor growth by autophagic cell death.
Authors: Leng Et al.
Mechanisms underlying the endogenous DArgic inhibition of spinal locomotor circuit function in Xenopus tadpoles.
Authors: Picton Et al.
Scientific Reports 2016;6:35749
DArgic neurons differentiating from LRRK2 G2019S induced pluripotent stem cells show early neuritic branching defects.
Authors: Borgs Et al.
Scientific Reports 2016;6:33377
DA D1 receptor activation regulates the expression of the estrogen synthesis gene aromatase B in radial glial cells.
Authors: Xing Et al.
Endogenous 17β-OE is required for activity-dependent long-term potentiation in the striatum: interaction with the DArgic system.
Authors: Tozzi Et al.
Front Cell Neurosci 2015;9:192
A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in DA D2 and D3 receptor agonist-induced autophagy activation.
Authors: Wang Et al.
Proc Natl Acad Sci U S A 2015;11:2057
Muscarinic regulation of DA and glutamate transmission in the nucleus accumbens.
Authors: Shin Et al.
Nat Neurosci 2015;112:8124
PFOS induces behavioral alterations, including spontaneous hyperactivity that is corrected by dexamfetamine in zebrafish larvae.
Authors: Spulber Et al.
PLoS One 2014;9:e94227
Hyperactivity induced by the DA D2/D3 receptor agonist quinpirole is attenuated by inhibitors of endocannabinoid degradation in mice.
Authors: Luque-Rojas Et al.
Int J Neuropsychopharmacol 2013;16:661
DA D2 receptor activation leads to an up-regulation of glial cell line-derived neurotrophic factor via Gβγ-Erk1/2-dependent induction of Zif268.
Authors: Ahmadiantehrani and Ron
J Neurochem 2013;
Differential regulation of MeCP2 phosphorylation in the CNS by DA and serotonin.
Authors: Hutchinson Et al.
Eur J Neurosci 2012;37:321
A novel mechanism of cocaine to enhance DA d2-like receptor mediated neurochemical and behavioral effects. An in vivo and in vitro study.
Authors: Ferraro Et al.
J Neurosci 2012;37:1856
DArgic modulation of ganglion-cell photoreceptors in rat.
Authors: Hook Et al.
Loss of Mecp2 in substantia nigra DA neurons compromises the nigrostriatal pathway.
Authors: Gantz Et al.
J Neurosci 2011;31:12629
Wnt5a-DA D2 receptor interactions regulate DA neuron development via extracellular signal-regulated kinase (ERK) activation.
Authors: Yoon Et al.
DArgic regulation of sleep and cataplexy in a murine model of narcolepsy.
Authors: Burgess Et al.
DA-dependent tuning of striatal inhibitory synaptogenesis.
Authors: Goffin Et al.
Role of aberrant striatal DA D1 receptor/cAMP/protein kinase A/DARPP32 signaling in the paradoxical calming effect of amphetamine.
Authors: Napolitano Et al.
J Neurosci 2010;30:11043
Competitive regulation of synaptic Ca2+ influx by D2 DA and A2A adenosine receptors.
Authors: Higley and Sabatini
Nat Neurosci 2010;13:958
MeCP2 in the nucleus accumbens contributes to neural and behavioral responses to psychostimulants.
Authors: Deng Et al.
J Biol Chem 2010;13:1128
DA neuron glutamate cotransmission: frequency-dependent modulation in the mesoventromedial projection.
Authors: Chuhma Et al.
Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior.
Authors: González-Maeso Et al.
PLoS One 2007;53:439
Regulation of DA transporter function and cell surface expression by D3 DA receptors.
Authors: Zapata Et al.
J Biol Chem 2007;282:35842
Impaired DA release and synaptic plasticity in the striatum of PINK1-deficient mice.
Authors: Kitada Et al.
Proc Natl Acad Sci U S A 2007;104:11441
Endocannabinoids mediate presynaptic inhibition of glutamatergic transmission in rat ventral tegmental area DA neurons through activation of CB1 receptors.
Authors: Melis Et al.
J Neurosci 2004;24:53
Haloperidol, but not clozapine, produces dramatic catalepsy in delta9-THC-treated rats: possible clinical implications.
Authors: Marchese Et al.
Br J Pharmacol 2003;140:520
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Voltammetry experiments were used to measure evoked dopamine release. Quinpirole (30nM) reduces dopamine release considerably (near IC50 in dorsal striatum), which was reversed by sulpiride (600nM). Drug works every time!