Catalog Number: 1061
Chemical Name: (4aR-trans)-4,4a,5,6,7,8,8a,9-Octahydro-5-propyl-1H-pyrazolo[3,4-g]quinoline hydrochloride
Biological Activity
Selective dopamine D2 receptor agonist (Ki values are 4.8, ~24, ~30 and 1900 nM at D2, D3, D4 and D1 receptors respectively).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water and to 25 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of Eli Lilly and Company
Background References
  1. Modulation of [3H]quinpirole binding in brain by monoamine oxidase inhibitors: evidence for a potential novel binding site.
    Levant et al.
    J.Pharmacol.Exp.Ther., 1996;278:145
  2. Dopamine receptor pharmacology.
    Seeman and Van Tol
    Trends Pharmacol.Sci., 1994;15:264
  3. Effects of quinpirole on central dopamine systems in sensitized and non-sensitized rats.
    Sullivan et al.
    Neuroscience, 1998;83:781

The citations listed below are publications that use Tocris products. Selected citations for (-)-Quinpirole hydrochloride include:

Showing Results 1 - 10 of 20

  1. Dopaminergic neurons differentiating from LRRK2 G2019S induced pluripotent stem cells show early neuritic branching defects
    Authors: Borgs Et al.
    Scientific Reports
  2. Dopamine D1 receptor activation regulates the expression of the estrogen synthesis gene aromatase B in radial glial cells.
    Authors: Xing Et al.
  3. Endogenous 17β-estradiol is required for activity-dependent long-term potentiation in the striatum: interaction with the dopaminergic system.
    Authors: Tozzi Et al.
    Front Cell Neurosci
  4. A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in dopamine D2 and D3 receptor agonist-induced autophagy activation.
    Authors: Wang Et al.
    Proc Natl Acad Sci U S A
  5. Muscarinic regulation of dopamine and glutamate transmission in the nucleus accumbens.
    Authors: Shin Et al.
    Nat Neurosci
  6. Dopamine D2 receptor activation leads to an up-regulation of glial cell line-derived neurotrophic factor via Gβγ-Erk1/2-dependent induction of Zif268.
    Authors: Ahmadiantehrani and Ron
    J Neurochem
  7. Differential regulation of MeCP2 phosphorylation in the CNS by dopamine and serotonin.
    Authors: Hutchinson Et al.
    Eur J Neurosci
  8. A novel mechanism of cocaine to enhance dopamine d2-like receptor mediated neurochemical and behavioral effects. An in vivo and in vitro study.
    Authors: Ferraro Et al.
    J Neurosci
  9. Dopaminergic modulation of ganglion-cell photoreceptors in rat.
    Authors: Hook Et al.
  10. Loss of Mecp2 in substantia nigra dopamine neurons compromises the nigrostriatal pathway.
    Authors: Gantz Et al.
    J Neurosci
  11. Wnt5a-dopamine D2 receptor interactions regulate dopamine neuron development via extracellular signal-regulated kinase (ERK) activation.
    Authors: Yoon Et al.
  12. Dopaminergic regulation of sleep and cataplexy in a murine model of narcolepsy.
    Authors: Burgess Et al.
  13. Dopamine-dependent tuning of striatal inhibitory synaptogenesis.
    Authors: Goffin Et al.
  14. Competitive regulation of synaptic Ca2+ influx by D2 dopamine and A2A adenosine receptors.
    Authors: Higley and Sabatini
    Nat Neurosci
  15. MeCP2 in the nucleus accumbens contributes to neural and behavioral responses to psychostimulants.
    Authors: Deng Et al.
    J Biol Chem
  16. Dopamine neuron glutamate cotransmission: frequency-dependent modulation in the mesoventromedial projection.
    Authors: Chuhma Et al.
  17. Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior.
    Authors: González-Maeso Et al.
    PLoS One
  18. Regulation of dopamine transporter function and cell surface expression by D3 dopamine receptors.
    Authors: Zapata Et al.
    J Biol Chem
  19. Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice.
    Authors: Kitada Et al.
    Proc Natl Acad Sci U S A
  20. Haloperidol, but not clozapine, produces dramatic catalepsy in delta9-THC-treated rats: possible clinical implications.
    Authors: Marchese Et al.
    Br J Pharmacol
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