Catalog Number: 1061
Chemical Name: (4aR-trans)-4,4a,5,6,7,8,8a,9-Octahydro-5-propyl-1H-pyrazolo[3,4-g]quinoline hydrochloride
Biological Activity
Selective dopamine D2 receptor agonist (Ki values are 4.8, ~24, ~30 and 1900 nM at D2, D3, D4 and D1 receptors respectively).
Technical Data
  • M.Wt:
    255.79
  • Formula:
    C13H21N3.HCl
  • Solubility:
    Soluble to 100 mM in water and to 25 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Desiccate at -20°C
  • CAS No:
    85798-08-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of Eli Lilly and Company
Background References
  1. Modulation of [3H]quinpirole binding in brain by monoamine oxidase inhibitors: evidence for a potential novel binding site.
    Levant et al.
    J.Pharmacol.Exp.Ther., 1996;278:145
  2. Dopamine receptor pharmacology.
    Seeman and Van Tol
    Trends Pharmacol.Sci., 1994;15:264
  3. Effects of quinpirole on central dopamine systems in sensitized and non-sensitized rats.
    Sullivan et al.
    Neuroscience, 1998;83:781
Citations:

The citations listed below are publications that use Tocris products. Selected citations for (-)-Quinpirole hydrochloride include:

21 Citations: Showing 1 - 10
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  1. Mechanisms underlying the endogenous dopaminergic inhibition of spinal locomotor circuit function in Xenopus tadpoles.
    Authors: Picton Et al.
    Scientific Reports 2016;6:35749
  2. Dopaminergic neurons differentiating from LRRK2 G2019S induced pluripotent stem cells show early neuritic branching defects.
    Authors: Borgs Et al.
    Scientific Reports 2016;6:33377
  3. Dopamine D1 receptor activation regulates the expression of the estrogen synthesis gene aromatase B in radial glial cells.
    Authors: Xing Et al.
    Neuropsychopharmacology 2015;9:310
  4. Endogenous 17β-estradiol is required for activity-dependent long-term potentiation in the striatum: interaction with the dopaminergic system.
    Authors: Tozzi Et al.
    Front Cell Neurosci 2015;9:192
  5. A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in dopamine D2 and D3 receptor agonist-induced autophagy activation.
    Authors: Wang Et al.
    Proc Natl Acad Sci U S A 2015;11:2057
  6. Muscarinic regulation of dopamine and glutamate transmission in the nucleus accumbens.
    Authors: Shin Et al.
    Nat Neurosci 2015;112:8124
  7. Dopamine D2 receptor activation leads to an up-regulation of glial cell line-derived neurotrophic factor via Gβγ-Erk1/2-dependent induction of Zif268.
    Authors: Ahmadiantehrani and Ron
    J Neurochem 2013;
  8. Differential regulation of MeCP2 phosphorylation in the CNS by dopamine and serotonin.
    Authors: Hutchinson Et al.
    Eur J Neurosci 2012;37:321
  9. A novel mechanism of cocaine to enhance dopamine d2-like receptor mediated neurochemical and behavioral effects. An in vivo and in vitro study.
    Authors: Ferraro Et al.
    J Neurosci 2012;37:1856
  10. Dopaminergic modulation of ganglion-cell photoreceptors in rat.
    Authors: Hook Et al.
    Autophagy 2012;35:507
  11. Loss of Mecp2 in substantia nigra dopamine neurons compromises the nigrostriatal pathway.
    Authors: Gantz Et al.
    J Neurosci 2011;31:12629
  12. Wnt5a-dopamine D2 receptor interactions regulate dopamine neuron development via extracellular signal-regulated kinase (ERK) activation.
    Authors: Yoon Et al.
    Neuropsychopharmacology 2011;286:15641
  13. Dopaminergic regulation of sleep and cataplexy in a murine model of narcolepsy.
    Authors: Burgess Et al.
    Sleep 2010;33:1295
  14. Dopamine-dependent tuning of striatal inhibitory synaptogenesis.
    Authors: Goffin Et al.
    Neuron 2010;30:2935
  15. Competitive regulation of synaptic Ca2+ influx by D2 dopamine and A2A adenosine receptors.
    Authors: Higley and Sabatini
    Nat Neurosci 2010;13:958
  16. MeCP2 in the nucleus accumbens contributes to neural and behavioral responses to psychostimulants.
    Authors: Deng Et al.
    J Biol Chem 2010;13:1128
  17. Dopamine neuron glutamate cotransmission: frequency-dependent modulation in the mesoventromedial projection.
    Authors: Chuhma Et al.
    Neuroscience 2009;164:1068
  18. Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior.
    Authors: González-Maeso Et al.
    PLoS One 2007;53:439
  19. Regulation of dopamine transporter function and cell surface expression by D3 dopamine receptors.
    Authors: Zapata Et al.
    J Biol Chem 2007;282:35842
  20. Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice.
    Authors: Kitada Et al.
    Proc Natl Acad Sci U S A 2007;104:11441
  21. Haloperidol, but not clozapine, produces dramatic catalepsy in delta9-THC-treated rats: possible clinical implications.
    Authors: Marchese Et al.
    Br J Pharmacol 2003;140:520
Expand to show all 21 Citations

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