(-)-Quinpirole hydrochloride

  ( 26 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:1061
Chemical Name:(4aR-trans)-4,4a,5,6,7,8,8a,9-Octahydro-5-propyl-1H-pyrazolo[3,4-g]quinoline hydrochloride
Product Details
Citations (26)
Supplemental Products
Reviews
Biological Activity
Selective dopamine D2 receptor agonist (Ki values are 4.8, ~24, ~30 and 1900 nM at D2, D3, D4 and D1 receptors respectively).
Technical Data
  • M.Wt:
    255.79
  • Formula:
    C13H21N3.HCl
  • Solubility:
    Soluble to 100 mM in water and to 25 mM in DMSO
  • Purity:
    >98
  • Storage:
    Desiccate at -20°C
  • CAS No:
    85798-08-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of Eli Lilly and Company
Product Datasheets
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for (-)-Quinpirole hydrochloride include:

26 Citations: Showing 1 - 10
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  1. Role of dopamine D2 receptor in stress-induced myelin loss.
    Authors: Choi
    Sci Rep  2017;7(1):11654
  2. Subtype-specific effects of dopaminergic D2 receptor activation on synaptic trains in layer V pyramidal neurons in the mouse prefrontal cortex.
    Authors: Leyrer-Jackson
    Physiol Rep  2017;5(22):e13499
  3. Mechanisms underlying the endogenous dopaminergic inhibition of spinal locomotor circuit function in Xenopus tadpoles.
    Authors: Picton Et al.
    Scientific Reports  2016;6:35749
  4. Dopaminergic neurons differentiating from LRRK2 G2019S induced pluripotent stem cells show early neuritic branching defects.
    Authors: Borgs Et al.
    Scientific Reports  2016;6:33377
  5. Dopamine D1 receptor activation regulates the expression of the estrogen synthesis gene aromatase B in radial glial cells.
    Authors: Xing Et al.
    Neuropsychopharmacology  2015;9:310
  6. Endogenous 17β-estradiol is required for activity-dependent long-term potentiation in the striatum: interaction with the dopaminergic system.
    Authors: Tozzi Et al.
    Front Cell Neurosci  2015;9:192
  7. A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in dopamine D2 and D3 receptor agonist-induced autophagy activation.
    Authors: Wang Et al.
    Proc Natl Acad Sci U S A  2015;11:2057
  8. Muscarinic regulation of dopamine and glutamate transmission in the nucleus accumbens.
    Authors: Shin Et al.
    Nat Neurosci  2015;112:8124
  9. PFOS induces behavioral alterations, including spontaneous hyperactivity that is corrected by dexamfetamine in zebrafish larvae.
    Authors: Spulber Et al.
    PLoS One  2014;9:e94227
  10. Hyperactivity induced by the dopamine D2/D3 receptor agonist quinpirole is attenuated by inhibitors of endocannabinoid degradation in mice.
    Authors: Luque-Rojas Et al.
    Int J Neuropsychopharmacol  2013;16:661
  11. Dopamine D2 receptor activation leads to an up-regulation of glial cell line-derived neurotrophic factor via Gβγ-Erk1/2-dependent induction of Zif268.
    Authors: Ahmadiantehrani and Ron
    J Neurochem  2013;
  12. Differential regulation of MeCP2 phosphorylation in the CNS by dopamine and serotonin.
    Authors: Hutchinson Et al.
    Eur J Neurosci  2012;37:321
  13. A novel mechanism of cocaine to enhance dopamine d2-like receptor mediated neurochemical and behavioral effects. An in vivo and in vitro study.
    Authors: Ferraro Et al.
    J Neurosci  2012;37:1856
  14. Dopaminergic modulation of ganglion-cell photoreceptors in rat.
    Authors: Hook Et al.
    Autophagy  2012;35:507
  15. Loss of Mecp2 in substantia nigra dopamine neurons compromises the nigrostriatal pathway.
    Authors: Gantz Et al.
    J Neurosci  2011;31:12629
  16. Wnt5a-dopamine D2 receptor interactions regulate dopamine neuron development via extracellular signal-regulated kinase (ERK) activation.
    Authors: Yoon Et al.
    Neuropsychopharmacology  2011;286:15641
  17. Dopaminergic regulation of sleep and cataplexy in a murine model of narcolepsy.
    Authors: Burgess Et al.
    Sleep  2010;33:1295
  18. Dopamine-dependent tuning of striatal inhibitory synaptogenesis.
    Authors: Goffin Et al.
    Neuron  2010;30:2935
  19. Role of aberrant striatal dopamine D1 receptor/cAMP/protein kinase A/DARPP32 signaling in the paradoxical calming effect of amphetamine.
    Authors: Napolitano Et al.
    J Neurosci  2010;30:11043
  20. Competitive regulation of synaptic Ca2+ influx by D2 dopamine and A2A adenosine receptors.
    Authors: Higley and Sabatini
    Nat Neurosci  2010;13:958
  21. MeCP2 in the nucleus accumbens contributes to neural and behavioral responses to psychostimulants.
    Authors: Deng Et al.
    J Biol Chem  2010;13:1128
  22. Dopamine neuron glutamate cotransmission: frequency-dependent modulation in the mesoventromedial projection.
    Authors: Chuhma Et al.
    Neuroscience  2009;164:1068
  23. Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior.
    Authors: González-Maeso Et al.
    PLoS One  2007;53:439
  24. Regulation of dopamine transporter function and cell surface expression by D3 dopamine receptors.
    Authors: Zapata Et al.
    J Biol Chem  2007;282:35842
  25. Impaired dopamine release and synaptic plasticity in the striatum of PINK1-deficient mice.
    Authors: Kitada Et al.
    Proc Natl Acad Sci U S A  2007;104:11441
  26. Haloperidol, but not clozapine, produces dramatic catalepsy in delta9-THC-treated rats: possible clinical implications.
    Authors: Marchese Et al.
    Br J Pharmacol  2003;140:520
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Average Rating: 5 (Based on 1 review)

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Species Mouse

Other Experimental Details

Other Experimental Details Goes into water well. We usually make up a 1 mM stock for many experiments.

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