(-)-Quinpirole hydrochloride

Catalog # Availability Size / Price Qty
1061/10
1061/50
(-)-Quinpirole hydrochloride | CAS No. 85798-08-9 | Non-selective Dopamine Receptor Agonists
1 Image
Description: Selective D2-like agonist

Chemical Name: (4aR-trans)-4,4a,5,6,7,8,8a,9-Octahydro-5-propyl-1H-pyrazolo[3,4-g]quinoline hydrochloride

Purity: ≥98%

Product Details
Citations (39)
Supplemental Products
Reviews (2)

Biological Activity

Selective dopamine D2 receptor agonist (Ki values are 4.8, ~24, ~30 and 1900 nM at D2, D3, D4 and D1 receptors respectively).

Technical Data

M.Wt:
255.79
Formula:
C13H21N3.HCl
Solubility:
Soluble to 100 mM in water and to 25 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at -20°C
CAS No:
85798-08-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of Eli Lilly and Company

Background References

  1. Modulation of [3H]quinpirole binding in brain by monoamine oxidase inhibitors: evidence for a potential novel binding site.
    Levant et al.
    J.Pharmacol.Exp.Ther., 1996;278:145
  2. DA receptor pharmacology.
    Seeman and Van Tol
    Trends Pharmacol.Sci., 1994;15:264
  3. Effects of quinpirole on central DA systems in sensitized and non-sensitized rats.
    Sullivan et al.
    Neuroscience, 1998;83:781

Product Datasheets

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Citations for (-)-Quinpirole hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for (-)-Quinpirole hydrochloride include:

39 Citations: Showing 1 - 10

  1. A novel luminescence-based-β-arrestin recruitment assay for unmodified receptors.
    Authors: Pedersen Et al.
    J Biol Chem  2021;
  2. Polysynaptic inhibition between striatal cholinergic interneurons shapes their network activity patterns in a dopamine-dependent manner.
    Authors: Dorst Et al.
    Nat Commun  2020;11:5113
  3. A Differential Hypofunctionality of Gαi Proteins Occurs in Adolescent Idiopathic Scoliosis and Correlates with the Risk of Disease Progression.
    Authors: Akoume Et al.
    Sci Rep  2019;9:10074
  4. Differential contributions of striatal dopamine D1 and D2 receptors to component processes of value-based decision making.
    Authors: Verharen Et al.
    Neurophsychopharmacology  2019;44:2195
  5. Glutamatergic and dopaminergic modulation of cortico-striatal circuits probed by dynamic calcium imaging of networks reconstructed in microfluidic chips.
    Authors: Lassus Et al.
    Sci Rep  2018;8:17461
  6. DA Receptor Subtypes Mediate Opposing Effects on Form Deprivation Myopia in Pigmented Guinea Pigs.
    Authors: Zhang
    Invest Ophthalmol Vis Sci  2018;59(11):4441
  7. Selective blockade of spinal D2DR by levo-corydalmine attenuates MOR tolerance via suppressing PI3K/Akt-MAPK signaling in a MOR-dependent manner.
    Authors: Dai Et al.
    Exp Mol Med  2018;50:148
  8. Melanotan II causes hypothermia in mice by activation of mast cells and stimulation of histamine 1 receptors.
    Authors: Jain Et al.
    Am J Physiol Endocrinol Metab  2018;315:E357
  9. Cocaine Inhibition of Synaptic Transmission in the Ventral Pallidum Is Pathway-Specific and Mediated by Serotonin.
    Authors: Matsui and Alvarez
    Cell Rep  2018;23(13):3852
  10. The locus coeruleus drives disinhibition in the midline thalamus via a dopaminergic mechanism.
    Authors: Beas Et al.
    Nat Neurosci  2018;21:963
  11. Role of DA D2 receptor in stress-induced myelin loss.
    Authors: Choi
    Sci Rep  2017;7(1):11654
  12. Subtype-specific effects of DArgic D2 receptor activation on synaptic trains in layer V pyramidal neurons in the mouse prefrontal cortex.
    Authors: Leyrer-Jackson
    Physiol Rep  2017;5(22):e13499
  13. Inhibiting clathrin-mediated endocytosis of the leucine-rich G protein-coupled receptor-5 diminishes cell fitness.
    Authors: Snyder Et al.
    J Biol Chem  2017;292:7208
  14. Activation of DRD5 inhibits tumor growth by autophagic cell death.
    Authors: Leng Et al.
    Autophagy  2017;13:1404
  15. Mechanisms underlying the endogenous DArgic inhibition of spinal locomotor circuit function in Xenopus tadpoles.
    Authors: Picton Et al.
    Scientific Reports  2016;6:35749
  16. DArgic neurons differentiating from LRRK2 G2019S induced pluripotent stem cells show early neuritic branching defects.
    Authors: Borgs Et al.
    Scientific Reports  2016;6:33377
  17. DA D1 receptor activation regulates the expression of the estrogen synthesis gene aromatase B in radial glial cells.
    Authors: Xing Et al.
    Neuropsychopharmacology  2015;9:310
  18. Endogenous 17β-OE is required for activity-dependent long-term potentiation in the striatum: interaction with the DArgic system.
    Authors: Tozzi Et al.
    Front Cell Neurosci  2015;9:192
  19. A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in DA D2 and D3 receptor agonist-induced autophagy activation.
    Authors: Wang Et al.
    Proc Natl Acad Sci U S A  2015;11:2057
  20. Muscarinic regulation of DA and glutamate transmission in the nucleus accumbens.
    Authors: Shin Et al.
    Nat Neurosci  2015;112:8124
  21. PFOS induces behavioral alterations, including spontaneous hyperactivity that is corrected by dexamfetamine in zebrafish larvae.
    Authors: Spulber Et al.
    PLoS One  2014;9:e94227
  22. Hyperactivity induced by the DA D2/D3 receptor agonist quinpirole is attenuated by inhibitors of endocannabinoid degradation in mice.
    Authors: Luque-Rojas Et al.
    Int J Neuropsychopharmacol  2013;16:661
  23. DA D2 receptor activation leads to an up-regulation of glial cell line-derived neurotrophic factor via Gβγ-Erk1/2-dependent induction of Zif268.
    Authors: Ahmadiantehrani and Ron
    J Neurochem  2013;
  24. Differential regulation of MeCP2 phosphorylation in the CNS by DA and serotonin.
    Authors: Hutchinson Et al.
    Eur J Neurosci  2012;37:321
  25. A novel mechanism of cocaine to enhance DA d2-like receptor mediated neurochemical and behavioral effects. An in vivo and in vitro study.
    Authors: Ferraro Et al.
    J Neurosci  2012;37:1856
  26. DArgic modulation of ganglion-cell photoreceptors in rat.
    Authors: Hook Et al.
    Autophagy  2012;35:507
  27. Loss of Mecp2 in substantia nigra DA neurons compromises the nigrostriatal pathway.
    Authors: Gantz Et al.
    J Neurosci  2011;31:12629
  28. Wnt5a-DA D2 receptor interactions regulate DA neuron development via extracellular signal-regulated kinase (ERK) activation.
    Authors: Yoon Et al.
    Neuropsychopharmacology  2011;286:15641
  29. DArgic regulation of sleep and cataplexy in a murine model of narcolepsy.
    Authors: Burgess Et al.
    Sleep  2010;33:1295
  30. DA-dependent tuning of striatal inhibitory synaptogenesis.
    Authors: Goffin Et al.
    Neuron  2010;30:2935
  31. Role of aberrant striatal DA D1 receptor/cAMP/protein kinase A/DARPP32 signaling in the paradoxical calming effect of amphetamine.
    Authors: Napolitano Et al.
    J Neurosci  2010;30:11043
  32. Competitive regulation of synaptic Ca2+ influx by D2 DA and A2A adenosine receptors.
    Authors: Higley and Sabatini
    Nat Neurosci  2010;13:958
  33. MeCP2 in the nucleus accumbens contributes to neural and behavioral responses to psychostimulants.
    Authors: Deng Et al.
    J Biol Chem  2010;13:1128
  34. DA neuron glutamate cotransmission: frequency-dependent modulation in the mesoventromedial projection.
    Authors: Chuhma Et al.
    Neuroscience  2009;164:1068
  35. Hallucinogens recruit specific cortical 5-HT(2A) receptor-mediated signaling pathways to affect behavior.
    Authors: González-Maeso Et al.
    PLoS One  2007;53:439
  36. Regulation of DA transporter function and cell surface expression by D3 DA receptors.
    Authors: Zapata Et al.
    J Biol Chem  2007;282:35842
  37. Impaired DA release and synaptic plasticity in the striatum of PINK1-deficient mice.
    Authors: Kitada Et al.
    Proc Natl Acad Sci U S A  2007;104:11441
  38. Endocannabinoids mediate presynaptic inhibition of glutamatergic transmission in rat ventral tegmental area DA neurons through activation of CB1 receptors.
    Authors: Melis Et al.
    J Neurosci  2004;24:53
  39. Haloperidol, but not clozapine, produces dramatic catalepsy in delta9-THC-treated rats: possible clinical implications.
    Authors: Marchese Et al.
    Br J Pharmacol  2003;140:520

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Inhibition of Synaptic Transmission in the VP
By Anonymous on 02/02/2020
Application: Species: Mouse

quinpirole(1 μΜ)

PMID: 29949769

Quinpirole reduces evoked dopamine release
By Anonymous on 03/28/2018
Application: Species: Mouse

Voltammetry experiments were used to measure evoked dopamine release. Quinpirole (30nM) reduces dopamine release considerably (near IC50 in dorsal striatum), which was reversed by sulpiride (600nM). Drug works every time!


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