Catalog Number: 1121
Chemical Name: (R)-N-(2-Hydroxy-1-methylethyl)-5Z,8Z,11Z,14Z-eicosatetraenamide
Biological Activity
Stable anandamide analog that is a selective agonist for the CB1 receptor (Ki values are 20 and 815 nM for CB1 and CB2 receptors respectively). Also displays agonist activity at vanilloid receptors. Also available in water-soluble emulsion (Cat. No. 1782).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble in ethanol (supplied pre-dissolved in anhydrous ethanol, 5mg/ml)
  • Purity:
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Other Product-Specific Information:
Background References
  1. (R)-Methanandamide: a chiral novel anandamide possessing higher potency and metabolic stability.
    Abadji et al.
    J.Med.Chem., 1994;37:1889
  2. A detailed characterization of the effects of four cannabinoid agonists on operant lever pressing.
    Carriero et al.
    Psychopharmacology (Berl.), 1998;137:147
  3. Head group analogs of arachidonylethanolamide, the endogenous cannabinoid ligand.
    Khanolkar et al.
    J.Med.Chem., 1996;39:4515
  4. Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide.
    Zygmunt et al.
    Nature, 1999;400:452
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