Cell-permeable peptide inhibitor of Pim-1 kinase, derived from p27Kip1
. Inhibits Pim-1 phosphorylation of p27Kip1
and Bad; induces cell cycle arrest (at G1
) and apoptosis in DU145 prostate cancer cells. Also inhibits Pim-1-dependent growth of DU145 cells in vitro
and in vivo
. Displays no effect on the growth of normal prostate epithelial RPWE-1 cells at concentrations of 10 and 20 μ
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Cell-permeable carboxyl-terminal p27Kip1 peptide exhibits anti-tumor activity by inhibiting Pim-1 kinase.
Morishita et al.