Catalog Number: 4592
Biological Activity
Cell-permeable peptide inhibitor of Pim-1 kinase, derived from p27Kip1. Inhibits Pim-1 phosphorylation of p27Kip1 and Bad; induces cell cycle arrest (at G1) and apoptosis in DU145 prostate cancer cells. Also inhibits Pim-1-dependent growth of DU145 cells in vitro and in vivo. Displays no effect on the growth of normal prostate epithelial RPWE-1 cells at concentrations of 10 and 20 μM.
Technical Data
  • M.Wt:
    2820.33
  • Formula:
    C111H211N59O26S
  • Sequence:
    GGGRRRRRRRRGCKKPGLRRRQT
  • Solubility:
    Soluble to 2 mg/ml in 20% acetonitrile / water
  • Storage:
    Store at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Cell-permeable carboxyl-terminal p27Kip1 peptide exhibits anti-tumor activity by inhibiting Pim-1 kinase.
    Morishita et al.
    J.Biol.Chem., 2011;286:2681

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