Detection of Potassium Channel Kv2.2 by Western Blot Western blot of rat brain homogenate. As shown in the autoradiograph, the antibody is specific for the ~125 kDa Voltage Gated Potassium Channel, Kv2.2 subunit. The labeling is blocked by preadsorption with the immunizing peptide.
Preparation and Storage
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
For long-term storage, ≤ -20° C is recommended. Product is stable at ≤ -20° C for at least 1 year.
Background: Potassium Channel Kv2.2
The rat potassium channel Kv2.2 subunit is a 95 - 125 kDa, six transmembrane glycoprotein that belongs to the B subfamily of the potassium channel family. It generates a voltage-dependent channel selective for potassium that helps determine the electrical property of smooth muscle cells, various epithelial cell types and neurons. The symbol K stands for potassium, v for the molecule’s ligand (i.e. voltage), 2 for the family type that is determined by similarity to fruit fly genes, and 2 for the gene number within the family. There are two genes within the Kv2 family (Kv2.1 and Kv2.2) that, although co-expressed, preferentially generate homotetramers rather than heterotetramers. Kv2 family members are associated with action potential repolarization. Kv2.2 is particularly noted for setting the resting membrane potential. Low Kv2.2 activity results in hypersensitive neurons.
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Malin, S.A. and J.M. Nerbonne (2002) J. Neurosci. 22:10094.
Blaine, J.T. and A.B. Ribera (1998) J. Neurosci. 18:9585.
Hwang, P.M. et al. (1992) Neuron 8:473.
O’Grady, S.M. and S.Y. Lee (2005) Int. J. Biochem. Cell Biol. 37:1578.
Entrez Gene IDs:
9312 (Human); 98741 (Mouse); 117105 (Rat)
delayed rectifier potassium channel protein; KCNB2; KV2.2; Potassium Channel Kv2.2; potassium voltage-gated channel subfamily B member 2; potassium voltage-gated channel, Shab-related subfamily, member 2; voltage-gated potassium channel subunit Kv2.2
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