Catalog Number: 3139
Alternate Names: Vapreotide
Biological Activity
Cyclic octapeptide somatostatin analog (Ki values are 0.7, 5.4, 30.9, 45 and > 1000 nM for sst5, sst2, sst3, sst4 and sst1 receptors respectively). More metabolically stable than somatostatin (Cat. No. 1157). Inhibits growth hormone release in vivo.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: Phe-1 = D-Phe, Trp-4 = D-Trp, Trp-8 = C-terminal amide, Disulfide bridge between 2 - 7)

  • Solubility:
    Soluble to 0.20 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Effects of highly potent octapeptide analogs of somatostatin on growth hormone, insulin and glucagon release.
    Karashima et al.
    Life Sci., 1987;41:1011
  2. Subtype selectivity of peptide analogs for all five coned human somatostatin receptors (hsstr 1-5).
    Patel and Srikant
    Endocrinology, 1994;135:2814
  3. sst2 Somatostatin receptor inhibits cell proliferation through Ras- Rap1-, and B-raf-dependent ERK2 activation.
    Lahlou et al.
    J.Biol.Chem., 2003;278:39356
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