Recombinant Cynomolgus/Rhesus Macaque B7-1/CD80 Protein, CF Summary
|Cynomolgus Monkey B7-1/CD80 |
Accession # XP_005548122
|Formulation||Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.|
|Reconstitution||Reconstitute at 250 μg/mL in water.|
|Shipping||The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.|
|Stability & Storage:||
2 μg/lane of Recombinant Cynomolgus Monkey B7‑1/CD80 was resolved with SDS-PAGE underreducing (R) and non-reducing (NR) conditions and visualized by Coomassie® Bluestaining, showing bands at 53-79 kDa and 105-160 kDa, respectively.
B7-1/CD80 and B7-2/CD86, together with their receptors CD28 and CTLA-4, constitute one of the dominant co-stimulatory pathways that regulate T- and B-cell responses (1). Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20-100-fold higher affinity than CD28 and is involved in the down-regulation of the immune response (2-5). B7-1 is expressed on activated B cells, activated T cells, and macrophages. B7-2 is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells, and germinal center B cells (2). Mature cynomolgus monkey B7-1 consists of a 213 amino acid (aa) extracellular domain (ECD) with two immunoglobulin-like domains, a 22 aa transmembrane domain, and a 20 aa cytoplasmic domain. Within the ECD, cynomolgus monkey B7-1 shares 97% and 51% aa sequence identity with human and mouse B7-1, respectively. The B7/CD28/CTLA4 pathway has the ability to both positively and negatively regulate immune responses. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas (6).
- Ville, S. et al. (2015) Front. Immunol. 6:411.
- Azuma, M. et al. (1993) Nature 366:76.
- Freeman, G.J. et al. (1993) Science 262:909.
- Chen, C. et al. (1994) J. Immunol. 152:4929.
- Freeman, G.J. et al. (1993) J. Exp. Med. 178:2185.
- Mir, M.A., et al. (2008) Expert Opin. Ther. Targets 12:969.
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