Recombinant Human ASGR2/ASGPR2 Fc Chimera Protein, CF

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Recombinant Human ASGR2/ASGPR2 Fc Chimera Protein Binding Activity
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Recombinant Human ASGR2/ASGPR2 Fc Chimera Protein, CF Summary

Product Specifications

>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Level
<0.10 EU per 1 μg of the protein by the LAL method.
Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human ASGR2 Fc Chimer binds human plasma von Willebrand Factor with an ED50 of 0.15-0.9 μg/mL.
Chinese Hamster Ovary cell line, CHO-derived human ASGR2 protein
MDHuman IgG1
Accession # NP_001172
Accession #
N-terminal Sequence
Structure / Form
Disulfide-linked homodimer
Predicted Molecular Mass
53 kDa
60-74 kDa, reducing conditions

Product Datasheets

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Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.


Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution Reconstitute at 500 μg/mL in PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage:
  • 12 months from date of receipt, ≤ -20 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, ≤ -20 °C under sterile conditions after reconstitution.

Scientific Data

Binding Activity Recombinant Human ASGR2/ASGPR2 Fc Chimera Protein Binding Activity View Larger

Immobilized Recombinant Human ASGR2 Fc Chimera binds human plasma von Willebrand Factor with an ED50 of 0.15-0.9 μg/mL.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Background: ASGR2

Asialoglycoprotein receptor 2 (ASGR-2), also known as C-type lectin domain family 4 member H2 (CLEC4H2) and hepatic lectin H2 (HL-2), is an approximately 48 kDa member of the C-type lectin receptor family (1, 2). ASGR-2 is a single-pass type II transmembrane protein that plays a role in the endocytosis of desialylated glycoproteins and hepatic thrombopoietin production (3). ASGR-2 is closely related to ASGR-1 which is about 2 kDa smaller and is encoded by distinct but closely linked genes. Variations in ASGR-2 structure due to alternative splicing have been reported (4-6). Mature ASGR-2 consists of a 5 amino acid (aa) cytoplasmic domain, a 21 aa transmembrane segment and a 232 aa extracellular domain (ECD). Within the ECD, human ASGR-2 shares 66% and 62% aa sequence identity with mouse and rat ASGR-2, respectively. Both ASGR-2 and ASGR-1 compose the asialoglycoprotein receptor (ASGPR) which mediates removal of potentially hazardous glycoconjugates from blood in health and disease (7). ASGPR, also known as the Ashwell receptor, can modulate von Willebrand factor (vWF) and platelet homeostasis in part through clearance of platelets that are first desialylated during sepsis caused by pathogens including S. pneumoniae. The ASGR-1 chain of the Ashwell receptor can also participate in plasma vWF clearance independently of sialylation and sepsis, ASGR-2 colocalization with plasma vWF was increased in ASGR-1 deficient mice (8). In addition, ASGR-2 expression was shown to be associated with malignant phenotypes in gastric cancer and may represent a specific biomarker for recurrence of some gastric cancers (9).

  1. Spiess, M. and H.F. Lodish. (1985) Proc Natl Acad Sci U.S.A. 19: 6465.
  2. Grewal, P.K. (2010) Methods Enzymol. 479:223.
  3. Grozovsky, R. et al. (2015) Nat Med. 1:47.
  4. Drickamer, K. et al. (1984) J. Biol. Chem. 259:770.
  5. Halberg, D.F. et al. (1987) J. Biol. Chem. 262:9828.
  6. Paietta, E. et al. (1992) J. Biol. Chem. 267:11078.
  7. Harris R.L. et al. (2012) Mol Biol Int. 2012:283974.
  8. Grewal, P. et al. (2008) Nature Medicine. 14:6.
  9. Tanaka H. et al. (2018) Mol Cancer Res. doi: 10.1158/1541. MCR-17-0467. [Epub ahead of print].
Long Name
Asialoglycoprotein Receptor 2
Entrez Gene IDs
433 (Human); 11890 (Mouse); 29403 (Rat)
Alternate Names
ASGPR 2; ASGP-R 2; ASGPR2; ASGP-R2; ASGR2; asialoglycoprotein receptor 2; CLEC4H2; CLEC4H2FLJ60040; C-type lectin domain family 4 member H2; HBxAg-binding protein; HBXBP; Hepatic lectin H2; HL-2


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