Recombinant Human BDNF Protein

100% sequence homology with Mouse, Rat, Canine, Equine and all other mammalian proteins examined. Earn double rewards for reviews

Carrier Free

Catalog # Availability Size / Price Qty
248-BDB-050/CF
248-BDB-010/CF
248-BDB-250/CF
248-BDB-01M/CF

With Carrier

Catalog # Availability Size / Price Qty
248-BDB-050
248-BDB-010
248-BDB-005
248-BDB-250
248-BDB-01M
Recombinant Human BDNF Protein Bioactivity
2 Images
Product Details
Citations (170)
FAQs
Reviews (1)

Recombinant Human BDNF Protein Summary

Product Specifications

Purity
>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Level
<0.10 EU per 1 μg of the protein by the LAL method.
Activity
Measured in a cell proliferation assay using BaF mouse pro-B cells transfected with TrkB. The ED50 for this effect is 0.2-2 ng/mL. Measured by its binding ability in a functional ELISA. When Recombinant Human TrkB Fc Chimera (Catalog # 688-TK) is coated at 1 μg/mL, Recombinant Human BDNF binds with an apparent Kd <1 nM.
Source
Spodoptera frugiperda, Sf 21 (baculovirus)-derived BDNF protein
His129-Arg247
Accession # P23560
100% sequence homology with Mouse, Rat, Canine, Equine and all other mammalian proteins examined.
Accession #
N-terminal Sequence
Analysis
His129
Predicted Molecular Mass
13.5 kDa
SDS-PAGE
13-14 kDa, reducing conditions

Product Datasheets

248-BDB (with carrier)

248-BDB/CF (carrier free)

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

248-BDB

Formulation Lyophilized from a 0.2 μm filtered solution in Sodium Citrate and NaCl with BSA as a carrier protein.
Reconstitution Reconstitute 5 µg vials at 100 µg/mL in water. Reconstitute 10 µg or larger vials at 250 µg/mL in water.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

248-BDB/CF

Formulation Lyophilized from a 0.2 μm filtered solution in Sodium Citrate and NaCl.
Reconstitution Reconstitute at 250 μg/mL in water.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, ≤ -20 °C under sterile conditions after reconstitution.

Data Images

Bioactivity Recombinant Human BDNF Protein Bioactivity View Larger

Recombinant Human BDNF (Catalog # 248-BDB) stimulates cell proliferation in the BaF mouse pro-B cell line transfected with TrkB. The ED50 for this effect is 0.2-2 ng/mL.

SDS-PAGE Recombinant Human BDNF Protein SDS-PAGE View Larger

2 μg/lane of Recombinant Human BDNF was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) conditions and visualized by Coomassie® Blue staining, showing bands at 13-14 kDa and 11-12 kDa, respectively.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: BDNF

Brain-derived neurotrophic factor (BDNF) is a member of the NGF family of neurotrophic factors (also named neurotrophins) that are required for the differentiation and survival of specific neuronal subpopulations in both the central as well as the peripheral nervous system. The neurotrophin family is comprised of at least four proteins including NGF, BDNF, NT-3, and NT-4/5. These secreted cytokines are synthesized as prepropeptides that are proteolytically processed to generate the mature proteins (1, 2). All neurotrophins have six conserved cysteine residues that are involved in the formation of three disulfide bonds and all share approximately 55% sequence identity at the amino acid level. Similarly to NGF, bioactive BDNF is predicted to be a non-covalently linked homodimer. BDNF cDNA encodes a 247 amino acid residue precursor protein with a signal peptide and a proprotein that are cleaved to yield the 119 amino acid residue mature BDNF. The amino acid sequence of mature BDNF is identical in all mammals examined. High levels of expression of BDNF have been detected in the hippocampus, cerebellum, fetal eye and placenta. In addition, low levels of BDNF expression are also found in the pituitary gland, spinal cord, heart, lung and skeletal muscle. BDNF binds with high affinity and specifically activates the TrkB tyrosine kinase receptor (3). The BDNF signaling pathway utilizes both AKT and ERK pathways to exert its pleiotrophic effects in the central nervous system. BDNF is widely used in cell culture to support neuronal cell differentiation and survival. It also promotes differentiation of pluripotent stem cells into neural progenitor cells.

References
  1. Eide, F.F. et al. (1993) Exp. Neurol. 121:200.
  2. Snider, W.D. (1994) Cell 77:627.
  3. Barbacid, M. (1994) J. Neurobiol. 25:1386.
Long Name
Brain-derived Neurotrophic Factor
Entrez Gene IDs
627 (Human); 12064 (Mouse); 24225 (Rat)
Alternate Names
Abrineurin; ANON2; BDNF; brain-derived neurotrophic factor; BULN2; MGC34632; Neurotrophin

Citations for Recombinant Human BDNF Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

170 Citations: Showing 1 - 10
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  1. Global transcriptome profile of the developmental principles of in vitro iPSC-to-motor neuron differentiation
    Authors: E Solomon, K Davis-Ande, B Hovde, S Micheva-Vi, JF Harris, S Twary, R Iyer
    BMC molecular and cell biology, 2021;22(1):13.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  2. Brain-Derived Neurotrophic Factor Expression and Signaling in Different Perivascular Adipose Tissue Depots of Patients With Coronary Artery Disease
    Authors: S Zierold, K Buschmann, S Gachkar, ML Bochenek, D Velmeden, L Hobohm, CF Vahl, K Schäfer
    Journal of the American Heart Association, 2021;10(6):e018322.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  3. Transcriptional networks identify synaptotagmin-like 3 as a regulator of cortical neuronal migration during early neurodevelopment
    Authors: X Dong, L Yang, K Liu, X Ji, C Tang, W Li, L Ma, Y Mei, T Peng, B Feng, Z Wu, Q Tang, Y Gao, K Yan, W Zhou, M Xiong
    Cell Reports, 2021;34(9):108802.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  4. Engineered glycomaterial implants orchestrate large-scale functional repair of brain tissue chronically after severe traumatic brain injury
    Authors: CV Latchouman, MI Betancur, GA Simchick, MK Sun, R Forghani, CE Lenear, A Ahmed, R Mohankumar, N Balaji, HD Mason, SA Archer-Har, P Azadi, PV Holmes, Q Zhao, RV Bellamkond, L Karumbaiah
    Science Advances, 2021;7(10):.
    Species: Rat
    Sample Types: In Vivo
    Applications: Bioassay
  5. Extracellular nanovesicles for packaging of CRISPR-Cas9 protein and sgRNA to induce therapeutic exon skipping
    Authors: P Gee, MSY Lung, Y Okuzaki, N Sasakawa, T Iguchi, Y Makita, H Hozumi, Y Miura, LF Yang, M Iwasaki, XH Wang, MA Waller, N Shirai, YO Abe, Y Fujita, K Watanabe, A Kagita, KA Iwabuchi, M Yasuda, H Xu, T Noda, J Komano, H Sakurai, N Inukai, A Hotta
    Nat Commun, 2020;11(1):1334.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  6. BDNF promotes activation of astrocytes and microglia contributing to neuroinflammation and mechanical allodynia in cyclophosphamide-induced cystitis
    Authors: H Ding, J Chen, M Su, Z Lin, H Zhan, F Yang, W Li, J Xie, Y Huang, X Liu, B Liu, X Zhou
    J Neuroinflammation, 2020;17(1):19.
    Species: Rat
    Sample Types: In Vivo
    Applications: In Vivo
  7. Neuron-glia interaction through Serotonin-BDNF-NGFR axis enables regenerative neurogenesis in Alzheimer's model of adult zebrafish brain
    Authors: P Bhattarai, MI Cosacak, V Mashkaryan, S Demir, SD Popova, N Govindaraj, K Brandt, Y Zhang, W Chang, K Ampatzis, C Kizil
    PLoS Biol., 2020;18(1):e3000585.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  8. Transcriptional Programming of Human Mechanosensory Neuron Subtypes from Pluripotent Stem Cells
    Authors: AR Nickolls, MM Lee, DF Espinoza, M Szczot, RM Lam, Q Wang, J Beers, J Zou, MQ Nguyen, HJ Solinski, AA AlJanahi, KR Johnson, ME Ward, AT Chesler, CG Bönnemann
    Cell Rep, 2020;30(3):932-946.e7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Differentiation
  9. Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCs
    Authors: EE Burke, JG Chenoweth, JH Shin, L Collado-To, SK Kim, N Micali, Y Wang, C Colantuoni, RE Straub, DJ Hoeppner, HY Chen, A Sellers, K Shibbani, GR Hamersky, M Diaz Busta, BN Phan, WS Ulrich, C Valencia, A Jaishankar, AJ Price, A Rajpurohit, SA Semick, RW Bürli, JC Barrow, DJ Hiler, SC Page, K Martinowic, TM Hyde, JE Kleinman, KF Berman, JA Apud, AJ Cross, NJ Brandon, DR Weinberger, BJ Maher, RDG McKay, AE Jaffe
    Nat Commun, 2020;11(1):462.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  10. FICD activity and AMPylation remodelling modulate human neurogenesis
    Authors: P Kielkowski, IY Buchsbaum, VC Kirsch, NC Bach, M Drukker, S Cappello, SA Sieber
    Nat Commun, 2020;11(1):517.
    Species: Human
    Sample Types: Whole Cells
    Applications: Differentiation
  11. Variation of Human Neural Stem Cells Generating Organizer States In�Vitro before Committing to Cortical Excitatory or Inhibitory Neuronal Fates
    Authors: N Micali, SK Kim, M Diaz-Busta, G Stein-O'Br, S Seo, JH Shin, BG Rash, S Ma, Y Wang, NA Olivares, JI Arellano, KR Maynard, EJ Fertig, AJ Cross, RW Bürli, NJ Brandon, DR Weinberger, JG Chenoweth, DJ Hoeppner, N Sestan, P Rakic, C Colantuoni, RD McKay
    Cell Rep, 2020;31(5):107599.
    Species: Mouse
    Sample Types:
    Applications: Cell Culture
  12. Capsosiphon fulvescens Glycoproteins Enhance Probiotics-Induced Cognitive Improvement in Aged Rats
    Authors: JH Oh, TJ Nam, YH Choi
    Nutrients, 2020;12(3):.
    Species: Rat
    Sample Types:
    Applications: In Vivo
  13. Fingolimod Modulates Dendritic Architecture in a BDNF-Dependent Manner
    Authors: A Patnaik, E Spiombi, A Frasca, N Landsberge, M Zagrebelsk, M Korte
    Int J Mol Sci, 2020;21(9):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  14. Maturational Changes in Mouse Cutaneous Touch and Piezo2-Mediated Mechanotransduction
    Authors: N Michel, P Narayanan, O Shomroni, M Schmidt
    Cell Rep, 2020;32(3):107912.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  15. Neurons from human mesenchymal stem cells display both spontaneous and stimuli responsive activity
    Authors: N Karaka?, S Bay, N Türkel, N Öztunç, M Öncül, H Bilgen, K Shah, F ?ahin, G Öztürk
    PLoS ONE, 2020;15(5):e0228510.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  16. Viral Delivery of GDNF Promotes Functional Integration of Human Stem Cell Grafts in Parkinson's Disease
    Authors: CW Gantner, IR de Luzy, JA Kauhausen, N Moriarty, JC Niclis, CR Bye, V Penna, CPJ Hunt, CM Ermine, CW Pouton, D Kirik, LH Thompson, CL Parish
    Cell Stem Cell, 2020;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  17. 4-Phenylbutyrate ameliorates apoptotic neural cell death in Down syndrome by reducing protein aggregates
    Authors: K Hirata, T Nambara, K Kawatani, N Nawa, H Yoshimatsu, H Kusakabe, K Banno, K Nishimura, M Ohtaka, M Nakanishi, H Taniguchi, H Arahori, K Wada, K Ozono, Y Kitabatake
    Sci Rep, 2020;10(1):14047.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  18. Pathogenic POGZ mutation causes impaired cortical development and reversible autism-like phenotypes
    Authors: K Matsumura, K Seiriki, S Okada, M Nagase, S Ayabe, I Yamada, T Furuse, H Shibuya, Y Yasuda, H Yamamori, M Fujimoto, K Nagayasu, K Yamamoto, K Kitagawa, H Miura, N Gotoda-Nis, H Igarashi, M Hayashida, M Baba, M Kondo, S Hasebe, K Ueshima, A Kasai, Y Ago, A Hayata-Tak, N Shintani, T Iguchi, M Sato, S Yamaguchi, M Tamura, S Wakana, A Yoshiki, AM Watabe, H Okano, K Takuma, R Hashimoto, H Hashimoto, T Nakazawa
    Nat Commun, 2020;11(1):859.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  19. Defects in mRNA Translation in LRRK2-Mutant hiPSC-Derived Dopaminergic Neurons Lead to Dysregulated Calcium Homeostasis
    Authors: JW Kim, X Yin, A Jhaldiyal, MR Khan, I Martin, Z Xie, T Perez-Rose, M Kumar, L Abalde-Atr, J Xu, L Chen, SM Eacker, DJ Surmeier, NT Ingolia, TM Dawson, VL Dawson
    Cell Stem Cell, 2020;27(4):633-645.e7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  20. Induced Pluripotent Stem Cells to Understand Mucopolysaccharidosis. I: Demonstration of a Migration Defect in Neural Precursors
    Authors: S Lito, A Sidibe, S Ilmjarv, P Burda, M Baumgartne, B Wehrle-Hal, KH Krause, A Marteyn
    Cells, 2020;9(12):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  21. Non-canonical Targets of HIF1a Impair Oligodendrocyte Progenitor Cell Function
    Authors: KC Allan, LR Hu, MA Scavuzzo, AR Morton, AS Gevorgyan, EF Cohn, BLL Clayton, IR Bederman, S Hung, CF Bartels, M Madhavan, PJ Tesar
    Cell Stem Cell, 2020;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  22. RNA dependent suppression of C9orf72 ALS/FTD associated neurodegeneration by Matrin-3
    Authors: N Ramesh, EL Daley, AM Gleixner, JR Mann, S Kour, D Mawrie, EN Anderson, J Kofler, CJ Donnelly, E Kiskinis, UB Pandey
    Acta Neuropathol Commun, 2020;8(1):177.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  23. Modulation of Human Adipose Stem Cells' Neurotrophic Capacity Using a Variety of Growth Factors for Neural Tissue Engineering Applications: Axonal Growth, Transcriptional, and Phosphoproteomic Analyses In Vitro
    Authors: KM Prautsch, A Schmidt, V Paradiso, DJ Schaefer, R Guzman, DF Kalbermatt, S Madduri
    Cells, 2020;9(9):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  24. Rapid generation of regionally specified CNS neurons by sequential patterning and conversion of human induced pluripotent stem cells
    Authors: M Chen, M Maimaitili, M Habekost, KP Gill, N Mermet-Jor, S Nabavi, F Febbraro, M Denham
    Stem Cell Res, 2020;48(0):101945.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  25. Novel method to produce a layered 3D scaffold for human pluripotent stem cell-derived neuronal cells
    Authors: L Honkamäki, T Joki, NA Grigoryev, K Levon, L Ylä-Outine, S Narkilahti
    Journal of neuroscience methods, 2020;350(0):109043.
    Species: Human
    Sample Types: Bioassay
  26. Reduced expression of somatostatin in GABAergic interneurons derived from induced pluripotent stem cells of patients with parkin mutations
    Authors: C Iwasawa, N Kuzumaki, Y Suda, R Kagawa, Y Oka, N Hattori, H Okano, M Narita
    Mol Brain, 2019;12(1):5.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  27. The Parkinson's disease-linked Leucine-rich repeat kinase 2 (LRRK2) is required for insulin-stimulated translocation of GLUT4
    Authors: N Funk, M Munz, T Ott, K Brockmann, A Wenninger-, R Kühn, D Vogt-Weise, F Giesert, W Wurst, T Gasser, S Biskup
    Sci Rep, 2019;9(1):4515.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  28. Microelectrode Array With Transparent ALD TiN Electrodes
    Authors: T Ryynänen, A Pelkonen, K Grigoras, OME Ylivaara, T Hyvärinen, J Ahopelto, M Prunnila, S Narkilahti, J Lekkala
    Front Neurosci, 2019;13(0):226.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  29. ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair
    Authors: JR Klim, LA Williams, F Limone, I Guerra San, BN Davis-Duse, DA Mordes, A Burberry, MJ Steinbaugh, KK Gamage, R Kirchner, R Moccia, SH Cassel, K Chen, BJ Wainger, CJ Woolf, K Eggan
    Nat. Neurosci., 2019;22(2):167-179.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  30. Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration
    Authors: Z Melamed, J López-Erau, MW Baughn, O Zhang, K Drenner, Y Sun, F Freyermuth, MA McMahon, MS Beccari, JW Artates, T Ohkubo, M Rodriguez, N Lin, D Wu, CF Bennett, F Rigo, S Da Cruz, J Ravits, C Lagier-Tou, DW Cleveland
    Nat. Neurosci., 2019;22(2):180-190.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  31. Long Non-coding RNAs Associated With Neurodegeneration-Linked Genes Are Reduced in Parkinson's Disease Patients
    Authors: M Elkouris, G Kouroupi, A Vourvoukel, N Papagianna, V Kaltezioti, R Matsas, L Stefanis, M Xilouri, PK Politis
    Front Cell Neurosci, 2019;13(0):58.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  32. Gadd45b mediates depressive-like role through DNA demethylation
    Authors: B Labonté, YH Jeong, E Parise, O Issler, M Fatma, O Engmann, KA Cho, R Neve, EJ Nestler, JW Koo
    Sci Rep, 2019;9(1):4615.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  33. Unbiased Profiling of Isogenic Huntington Disease hPSC-Derived CNS and Peripheral Cells Reveals Strong Cell-Type Specificity of CAG Length Effects
    Authors: J Ooi, SR Langley, X Xu, KH Utami, B Sim, Y Huang, NP Harmston, YL Tay, A Ziaei, R Zeng, D Low, F Aminkeng, RM Sobota, F Ginhoux, E Petretto, MA Pouladi
    Cell Rep, 2019;26(9):2494-2508.e7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  34. Vasoactive intestinal peptide controls the suprachiasmatic circadian clock network via ERK1/2 and DUSP4 signalling
    Authors: R Hamnett, P Crosby, JE Chesham, MH Hastings
    Nat Commun, 2019;10(1):542.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  35. Glycosaminoglycans from Alzheimer's disease hippocampus have altered capacities to bind and regulate growth factors activities and to bind tau
    Authors: MB Huynh, MO Ouidja, S Chantepie, G Carpentier, A Maïza, G Zhang, J Vilares, R Raisman-Vo, D Papy-Garci
    PLoS ONE, 2019;14(1):e0209573.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  36. MAP4K4 Activation Mediates Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis
    Authors: C Wu, ME Watts, LL Rubin
    Cell Rep, 2019;26(5):1143-1156.e5.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  37. Polybenzyl Glutamate Biocompatible Scaffold Promotes the Efficiency of Retinal Differentiation toward Retinal Ganglion Cell Lineage from Human-Induced Pluripotent Stem Cells
    Authors: TC Chen, PY She, DF Chen, JH Lu, CH Yang, DS Huang, PY Chen, CY Lu, KS Cho, HF Chen, WF Su
    Int J Mol Sci, 2019;20(1):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  38. Ciliary gene RPGRIP1L is required for hypothalamic arcuate neuron development
    Authors: L Wang, AJ De Solis, Y Goffer, KE Birkenbach, SE Engle, R Tanis, JM Levenson, X Li, R Rausch, M Purohit, JY Lee, J Tan, MC De Rosa, CA Doege, HL Aaron, GJ Martins, JC Brüning, D Egli, R Costa, N Berbari, RL Leibel, G Stratigopo
    JCI Insight, 2019;4(3):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  39. MHC matching fails to prevent long-term rejection of iPSC-derived neurons in non-human primates
    Authors: R Aron Badin, A Bugi, S Williams, M Vadori, M Michael, C Jan, A Nassi, S Lecourtois, A Blancher, E Cozzi, P Hantraye, AL Perrier
    Nat Commun, 2019;10(1):4357.
    Species: Primate (Macaca fascicularis)
    Sample Types: Whole Cells
    Applications: Cell Culture
  40. Relevance of Neurotrophin Receptors CD271 and TrkC for Prognosis, Migration, and Proliferation in Head and Neck Squamous Cell Carcinoma
    Authors: Y Foerster, T Stöver, J Wagenblast, M Diensthube, S Balster, J Gabrielpil, H Petzold, C Geissler
    Cells, 2019;8(10):.
  41. Primary Neurons and Differentiated NSC-34 Cells Are More Susceptible to Arginine-Rich ALS Dipeptide Repeat Protein-Associated Toxicity than Non-Differentiated NSC-34 and CHO Cells
    Authors: AL Gill, MZ Wang, B Levine, A Premasiri, FG Vieira
    Int J Mol Sci, 2019;20(24):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  42. Mitigating Antagonism between Transcription and Proliferation Allows Near-Deterministic Cellular Reprogramming
    Authors: KN Babos, KE Galloway, K Kisler, M Zitting, Y Li, Y Shi, B Quintino, RH Chow, BV Zlokovic, JK Ichida
    Cell Stem Cell, 2019;25(4):486-500.e9.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  43. Cellular alterations identified in pluripotent stem cell-derived midbrain spheroids generated from a female patient with progressive external ophthalmoplegia and parkinsonism who carries a novel variation (p.Q811R) in the POLG1 gene
    Authors: M Chumarina, K Russ, C Azevedo, A Heuer, M Pihl, A Collin, EÅ Frostner, E Elmer, P Hyttel, G Cappellett, M Zini, S Goldwurm, L Roybon
    Acta Neuropathol Commun, 2019;7(1):208.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  44. The Axonal Membrane Protein PRG2 Inhibits PTEN and Directs Growth to Branches
    Authors: A Brosig, J Fuchs, F Ipek, C Kroon, S Schrötter, M Vadhvani, A Polyzou, J Ledderose, M van Diepen, HG Holzhütter, T Trimbuch, N Gimber, J Schmoranze, I Lieberam, C Rosenmund, C Spahn, P Scheerer, M Szczepek, G Leondariti, BJ Eickholt
    Cell Rep, 2019;29(7):2028-2040.e8.
    Species: Mouse
    Sample Types: Whole Cell
    Applications: Cell Culture
  45. Homogenous generation of dopaminergic neurons from multiple hiPSC lines by transient expression of transcription factors
    Authors: S Mahajani, A Raina, C Fokken, S Kügler, M Bähr
    Cell Death Dis, 2019;10(12):898.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  46. Functional characterization of human pluripotent stem cell-derived cortical networks differentiated on laminin-521 substrate: comparison to rat cortical cultures
    Authors: T Hyvärinen, A Hyysalo, FE Kapucu, L Aarnos, A Vinogradov, SJ Eglen, L Ylä-Outine, S Narkilahti
    Sci Rep, 2019;9(1):17125.
    Species: Human
    Sample Types: Whole Cells
    Applications: Differentiation
  47. Immature mDA neurons ameliorate motor deficits in a 6-OHDA Parkinson's disease mouse model and are functional after cryopreservation
    Authors: D Leitner, M Ramamoorth, M Dejosez, TP Zwaka
    Stem Cell Res, 2019;41(0):101617.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  48. Alpha7 nicotinic acetylcholine receptors and neural network synaptic transmission in human induced pluripotent stem cell-derived neurons
    Authors: HM Larsen, SK Hansen, JD Mikkelsen, P Hyttel, TC Stummann
    Stem Cell Res, 2019;41(0):101642.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  49. Dorsal-ventral patterned neural cyst from human pluripotent stem cells in a neurogenic niche
    Authors: Y Zheng, X Xue, AM Resto-Iriz, Z Li, Y Shao, Y Zheng, G Zhao, J Fu
    Sci Adv, 2019;5(12):eaax5933.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  50. Roles of Collagen XXV and Its Putative Receptors PTPsigma/delta in Intramuscular Motor Innervation and Congenital Cranial Dysinnervation Disorder
    Authors: H Munezane, H Oizumi, T Wakabayash, S Nishio, T Hirasawa, T Sato, A Harada, T Yoshida, T Eguchi, Y Yamanashi, T Hashimoto, T Iwatsubo
    Cell Rep, 2019;29(13):4362-4376.e6.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  51. V2a interneuron differentiation from mouse and human pluripotent stem cells
    Authors: JC Butts, N Iyer, N White, R Thompson, S Sakiyama-E, TC McDevitt
    Nat Protoc, 2019;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  52. iPSC-derived functional human neuromuscular junctions model the pathophysiology of neuromuscular diseases
    Authors: CY Lin, M Yoshida, LT Li, A Ikenaka, S Oshima, K Nakagawa, H Sakurai, E Matsui, T Nakahata, MK Saito
    JCI Insight, 2019;4(18):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  53. Isolation of LMX1a ventral midbrain progenitors improves the safety and predictability of human pluripotent stem cell-derived neural transplants in Parkinsonian Disease
    Authors: IR de Luzy, JC Niclis, CW Gantner, JA Kauhausen, CPJ Hunt, C Ermine, CW Pouton, LH Thompson, CL Parish
    J. Neurosci., 2019;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  54. Loss of SATB1 Induces p21-Dependent Cellular Senescence in Post-mitotic Dopaminergic Neurons
    Authors: M Riessland, B Kolisnyk, TW Kim, J Cheng, J Ni, JA Pearson, EJ Park, K Dam, D Acehan, LS Ramos-Espi, W Wang, J Zhang, JW Shim, G Ciceri, L Brichta, L Studer, P Greengard
    Cell Stem Cell, 2019;25(4):514-530.e8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  55. Probing the mechanism of inhibition of amyloid-?(1-42)-induced neurotoxicity by the chaperonin GroEL
    Authors: MA Wälti, J Steiner, F Meng, HS Chung, JM Louis, R Ghirlando, V Tugarinov, A Nath, GM Clore
    Proc. Natl. Acad. Sci. U.S.A., 2018;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  56. RPE phagocytic function declines in age-related macular degeneration and is rescued by human umbilical tissue derived cells
    Authors: G Inana, C Murat, W An, X Yao, IR Harris, J Cao
    J Transl Med, 2018;16(1):63.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  57. Inhibiting p38 MAPK alpha rescues axonal retrograde transport defects in a mouse model of ALS
    Authors: KL Gibbs, B Kalmar, ER Rhymes, AD Fellows, M Ahmed, P Whiting, CH Davies, L Greensmith, G Schiavo
    Cell Death Dis, 2018;9(6):596.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  58. hPSC Modeling Reveals that Fate Selection of Cortical Deep Projection Neurons Occurs in the Subplate
    Authors: MZ Ozair, C Kirst, BL van den Be, A Ruzo, T Rito, AH Brivanlou
    Cell Stem Cell, 2018;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  59. Divergent Prelimbic Cortical Pathways Interact with BDNF to Regulate Cocaine Seeking
    Authors: G Giannotti, SM Barry, BM Siemsen, J Peters, JF McGinty
    J. Neurosci., 2018;0(0):.
    Species: Rat
    Sample Types: In Vivo
    Applications: In Vivo
  60. Proteolytically released Lasso/teneurin-2 induces axonal attraction by interacting with latrophilin-1 on axonal growth cones
    Authors: NV Vysokov, JP Silva, VG Lelianova, J Suckling, J Cassidy, JK Blackburn, N Yankova, MB Djamgoz, SV Kozlov, AG Tonevitsky, YA Ushkaryov
    Elife, 2018;7(0):.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  61. In Silico Labeling: Predicting Fluorescent Labels in Unlabeled Images
    Authors: EM Christians, SJ Yang, DM Ando, A Javaherian, G Skibinski, S Lipnick, E Mount, A O'Neil, K Shah, AK Lee, P Goyal, W Fedus, R Poplin, A Esteva, M Berndl, LL Rubin, P Nelson, S Finkbeiner
    Cell, 2018;173(3):792-803.e19.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  62. Intracerebral Delivery of Brain-Derived Neurotrophic Factor Using HyStem�-C Hydrogel Implants Improves Functional Recovery and Reduces Neuroinflammation in a Rat Model of Ischemic Stroke
    Authors: K Ravina, DI Briggs, S Kislal, Z Warraich, T Nguyen, RK Lam, TI Zarembinsk, M Shamloo
    Int J Mol Sci, 2018;19(12):.
    Species: Rat
    Sample Types: In Vivo
    Applications: In Vivo
  63. A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model
    Authors: N Tsuburaya, K Homma, T Higuchi, A Balia, H Yamakoshi, N Shibata, S Nakamura, H Nakagawa, SI Ikeda, N Umezawa, N Kato, S Yokoshima, M Shibuya, M Shimonishi, H Kojima, T Okabe, T Nagano, I Naguro, K Imamura, H Inoue, T Fujisawa, H Ichijo
    Nat Commun, 2018;9(1):2668.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  64. Cerebellar BDNF promotes exploration and seeking for novelty
    Authors: D Laricchiut, D Andolina, F Angelucci, F Gelfo, E Berretta, S Puglisi-Al, L Petrosini
    Int. J. Neuropsychopharmacol., 2018;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  65. The striatal kinase DCLK3 produces neuroprotection against mutant huntingtin
    Authors: L Galvan, L Francelle, MC Gaillard, L de Longpre, MA Carrillo-d, G Liot, K Cambon, L Stimmer, S Luccantoni, J Flament, J Valette, M de Chaldée, G Auregan, M Guillermie, C Joséphine, F Petit, C Jan, M Jarrige, N Dufour, G Bonvento, S Humbert, F Saudou, P Hantraye, K Merienne, AP Bemelmans, AL Perrier, N Déglon, E Brouillet
    Brain, 2018;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  66. Chromosomal instability during neurogenesis in Huntington's disease
    Authors: A Ruzo, GF Croft, JJ Metzger, S Galgoczi, LJ Gerber, C Pellegrini, H Wang, M Fenner, S Tse, A Marks, C Nchako, AH Brivanlou
    Development, 2018;145(2):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Differentiation
  67. SORCS1 and SORCS3 control energy balance and orexigenic peptide production
    Authors: A Subkhangul, AR Malik, G Hermey, O Popp, G Dittmar, T Rathjen, MN Poy, A Stumpf, PS Beed, D Schmitz, T Breiderhof, TE Willnow
    EMBO Rep., 2018;19(4):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  68. Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent
    Authors: K Fujimori, M Ishikawa, A Otomo, N Atsuta, R Nakamura, T Akiyama, S Hadano, M Aoki, H Saya, G Sobue, H Okano
    Nat. Med., 2018;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  69. The ubiquitin ligase UBR5 suppresses proteostasis collapse in pluripotent stem cells from Huntington's disease patients
    Authors: S Koyuncu, I Saez, HJ Lee, R Gutierrez-, W Pokrzywa, A Fatima, T Hoppe, D Vilchez
    Nat Commun, 2018;9(1):2886.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  70. Subcellular localisation modulates ubiquitylation and degradation of Ascl1
    Authors: S Gillotin, JD Davies, A Philpott
    Sci Rep, 2018;8(1):4625.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  71. Efficient Generation of CA3 Neurons from Human Pluripotent Stem Cells Enables Modeling of Hippocampal Connectivity In�Vitro
    Authors: A Sarkar, A Mei, ACM Paquola, S Stern, C Bardy, JR Klug, S Kim, N Neshat, HJ Kim, M Ku, MN Shokhirev, DH Adamowicz, MC Marchetto, R Jappelli, JA Erwin, K Padmanabha, M Shtrahman, X Jin, FH Gage
    Cell Stem Cell, 2018;22(5):684-697.e9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  72. Dissecting the Functional Consequences of De Novo DNA Methylation Dynamics in Human Motor Neuron Differentiation and Physiology
    Authors: MJ Ziller, JA Ortega, KA Quinlan, DP Santos, H Gu, EJ Martin, C Galonska, R Pop, S Maidl, A Di Pardo, M Huang, HY Meltzer, A Gnirke, CJ Heckman, A Meissner, E Kiskinis
    Cell Stem Cell, 2018;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  73. Efficient derivation of sympathetic neurons from human pluripotent stem cells with a defined condition
    Authors: K Kirino, T Nakahata, T Taguchi, MK Saito
    Sci Rep, 2018;8(1):12865.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  74. DNA topoisomerase II? stimulates neurite outgrowth in neural differentiated human mesenchymal stem cells through regulation of Rho-GTPases (RhoA/Rock2 pathway) and Nurr1 expression
    Authors: M Zaim, S Isik
    Stem Cell Res Ther, 2018;9(1):114.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  75. Alpha6-Containing Nicotinic Acetylcholine Receptors Mediate Nicotine-Induced Structural Plasticity in Mouse and Human iPSC-Derived Dopaminergic Neurons
    Authors: G Collo, L Cavalleri, M Zoli, U Maskos, E Ratti, E Merlo Pich
    Front Pharmacol, 2018;9(0):572.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  76. Integrative proteomic and transcriptomic analysis provides evidence for TrkB (NTRK2) as a therapeutic target in combination with tyrosine kinase inhibitors for non-small cell lung cancer
    Authors: DR Gomez, LA Byers, M Nilsson, L Diao, J Wang, L Li, P Tong, M Hofstad, B Saigal, I Wistuba, N Kalhor, S Swisher, Y Fan, WK Hong, M Suraokar, C Behrens, C Moran, JV Heymach
    Oncotarget, 2018;9(18):14268-14284.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  77. Alternative NHEJ pathway proteins as components of MYCN oncogenic activity in human neural crest stem cell differentiation: implications for neuroblastoma initiation
    Authors: EA Newman, S Chukkapall, D Bashllari, TT Thomas, RA Van Noord, ER Lawlor, MJ Hoenerhoff, AW Opipari, VP Opipari
    Cell Death Dis, 2017;8(12):3208.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  78. A hypomorphic PIGA gene mutation causes severe defects in neuron development and susceptibility to complement-mediated toxicity in a human iPSC model
    Authors: X Yuan, Z Li, AC Baines, E Gavriilaki, Z Ye, Z Wen, EM Braunstein, LG Biesecker, L Cheng, X Dong, RA Brodsky
    PLoS ONE, 2017;12(4):e0174074.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  79. Novel combinatorial screening identifies neurotrophic factors for selective classes of motor neurons
    Authors: S Schaller, D Buttigieg, A Alory, A Jacquier, M Barad, M Merchant, D Gentien, P de la Gran, G Haase
    Proc. Natl. Acad. Sci. U.S.A, 2017;114(12):E2486-E2493.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  80. MANF Promotes Differentiation and Migration of Neural Progenitor Cells with Potential Neural Regenerative Effects in Stroke
    Authors: KY Tseng, JE Anttila, K Khodosevic, RK Tuominen, M Lindahl, A Domanskyi, M Airavaara
    Mol. Ther., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  81. Molecular analyses of neurogenic defects in a human pluripotent stem cell model of fragile X syndrome
    Authors: MJ Boland, KL Nazor, HT Tran, A Szücs, CL Lynch, R Paredes, F Tassone, PP Sanna, RJ Hagerman, JF Loring
    Brain, 2017;140(3):582-598.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  82. EndophilinAs regulate endosomal sorting of BDNF-TrkB to mediate survival signaling in hippocampal neurons
    Authors: K Burk, JD Murdoch, S Freytag, M Koenig, V Bharat, R Markworth, S Burkhardt, A Fischer, C Dean
    Sci Rep, 2017;7(1):2149.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  83. Three-tier regulation of cell number plasticity by neurotrophins and Tolls in Drosophila
    Authors: I Foldi, N Anthoney, N Harrison, M Gangloff, B Verstak, MP Nallasivan, S AlAhmed, B Zhu, M Phizacklea, M Losada-Per, M Moreira, NJ Gay, A Hidalgo
    J. Cell Biol., 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  84. Effects of neuroactive agents on axonal growth and pathfinding of retinal ganglion cells generated from human stem cells
    Authors: T Yokoi, T Tanaka, E Matsuzaka, F Tamalu, SI Watanabe, S Nishina, N Azuma
    Sci Rep, 2017;7(1):16757.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  85. Altered Differentiation Potential of Gaucher's Disease iPSC Neuronal Progenitors due to Wnt/?-Catenin Downregulation
    Authors: O Awad, LM Panicker, RM Deranieh, MP Srikanth, RA Brown, A Voit, T Peesay, TS Park, ET Zambidis, RA Feldman
    Stem Cell Reports, 2017;9(6):1853-1867.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  86. Whole genome microarray analysis of neural progenitor C17.2 cells during differentiation and validation of 30 neural mRNA biomarkers for estimation of developmental neurotoxicity
    Authors: K Attoff, A Gliga, J Lundqvist, U Norinder, A Forsby
    PLoS ONE, 2017;12(12):e0190066.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  87. Combined small-molecule inhibition accelerates the derivation of functional cortical neurons from human pluripotent stem cells
    Authors: Y Qi, XJ Zhang, N Renier, Z Wu, T Atkin, Z Sun, MZ Ozair, J Tchieu, B Zimmer, F Fattahi, Y Ganat, R Azevedo, N Zeltner, AH Brivanlou, M Karayiorgo, J Gogos, M Tomishima, M Tessier-La, SH Shi, L Studer
    Nat. Biotechnol, 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  88. Axonal Type III Nrg1 Controls Glutamate Synapse Formation and GluA2 Trafficking in Hippocampal-Accumbens Connections
    Authors: C Zhong, W Akmentin, C Du, LW Role, DA Talmage
    eNeuro, 2017;4(1):.
    Species: Mouse
    Sample Types: Complex Sample Type
    Applications: Bioassay
  89. Neurotoxic reactive astrocytes are induced by activated microglia
    Authors: SA Liddelow, KA Guttenplan, LE Clarke, FC Bennett, CJ Bohlen, L Schirmer, ML Bennett, AE Mnch, WS Chung, TC Peterson, DK Wilton, A Frouin, BA Napier, N Panicker, M Kumar, MS Buckwalter, DH Rowitch, VL Dawson, TM Dawson, B Stevens, BA Barres
    Nature, 2017;541(7638):481-487.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  90. Overexpression of matrix metalloproteinase-9 (MMP-9) rescues insulin-mediated impairment in the 5XFAD model of Alzheimer's disease
    Authors: A Kaminari, N Giannakas, A Tzinia, EC Tsilibary
    Sci Rep, 2017;7(1):683.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  91. Differentiation of nestin?negative human hair follicle outer root sheath cells into neurons in�vitro
    Authors: W Wu, XL Wu, YQ Ji, Z Gao
    Mol Med Rep, 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  92. Presynaptic morphology and vesicular composition determine vesicle dynamics in mouse central synapses
    Authors: L Guillaud, D Dimitrov, T Takahashi
    Elife, 2017;6(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  93. Derivation of mouse embryonic stem cell lines from tyrosine hydroxylase reporter mice crossed with a human SNCA transgenic mouse model of Parkinson's disease
    Authors: M Chumarina, C Azevedo, J Bigarreau, C Vignon, KS Kim, JY Li, L Roybon
    Stem Cell Res, 2017;19(0):17-20.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  94. Common genetic variation drives molecular heterogeneity in human iPSCs
    Authors: H Kilpinen, A Goncalves, A Leha, V Afzal, K Alasoo, S Ashford, S Bala, D Bensaddek, FP Casale, OJ Culley, P Danecek, A Faulconbri, PW Harrison, A Kathuria, D McCarthy, SA McCarthy, R Meleckyte, Y Memari, N Moens, F Soares, A Mann, I Streeter, CA Agu, A Alderton, R Nelson, S Harper, M Patel, A White, SR Patel, L Clarke, R Halai, CM Kirton, A Kolb-Kokoc, P Beales, E Birney, D Danovi, AI Lamond, WH Ouwehand, L Vallier, FM Watt, R Durbin, O Stegle, DJ Gaffney
    Nature, 2017;546(7658):370-375.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  95. Differential gene expression profiles in neurons generated from lymphoblastoid B-cell line-derived iPS cells from monozygotic twin cases with treatment-resistant schizophrenia and discordant responses to clozapine
    Authors: T Nakazawa, M Kikuchi, M Ishikawa, H Yamamori, K Nagayasu, T Matsumoto, M Fujimoto, Y Yasuda, M Fujiwara, S Okada, K Matsumura, A Kasai, A Hayata-Tak, N Shintani, S Numata, K Takuma, W Akamatsu, H Okano, A Nakaya, H Hashimoto, R Hashimoto
    Schizophr. Res., 2017;181(0):75-82.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  96. Embryonic Stem Cell-Derived Neurons Grown on Multi-Electrode Arrays as a Novel In vitro Bioassay for the Detection of Clostridium botulinum Neurotoxins
    Authors: SP Jenkinson, D Grandgirar, M Heidemann, A Tscherter, MA Avondet, SL Leib
    Front Pharmacol, 2017;8(0):73.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  97. Microfabric Vessels for Embryoid Body Formation and Rapid Differentiation of Pluripotent Stem Cells
    Sci Rep, 2016;6(0):31063.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  98. Sustained synchronized neuronal network activity in a human astrocyte co-culture system
    Sci Rep, 2016;6(0):36529.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  99. Dopamine Receptor Antagonists Enhance Proliferation and Neurogenesis of Midbrain Lmx1a-expressing Progenitors
    Authors: Eva Hedlund
    Sci Rep, 2016;6(0):26448.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  100. Isolation, expansion and neural differentiation of stem cells from human plucked hair: a further step towards autologous nerve recovery
    Authors: Margriet A Huisman
    Cytotechnology, 2016;68(5):1849-58.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  101. A robust vitronectin-derived peptide for the scalable long-term expansion and neuronal differentiation of human pluripotent stem cell (hPSC)-derived neural progenitor cells (hNPCs)
    Authors: Divya Varun
    Acta Biomater, 2016;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  102. MicroRNA-302 switch to identify and eliminate undifferentiated human pluripotent stem cells
    Sci Rep, 2016;6(0):32532.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  103. Effects of Feeder Cells on Dopaminergic Differentiation of Human Embryonic Stem Cells
    Authors: Z Zhao, Y Ma, Z Chen, Q Liu, Q Li, D Kong, K Yuan, L Hu, T Wang, X Chen, Y Peng, W Jiang, Y Yu, X Liu
    Front Cell Neurosci, 2016;10(0):291.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  104. Time-Course Statistical Evaluation of Intercellular Adhesion Maturation by Femtosecond Laser Impulse
    Authors: Yoichiroh Hosokawa
    Biophys. J., 2016;111(10):2255-2262.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  105. Increased susceptibility to a? toxicity in neuronal cultures derived from familial Azheimer's disease (PSEN1-A246E) induced pluripotent stem cells
    Authors: Enrique Armijo
    Neurosci. Lett, 2016;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  106. BDNF Effects on Functional Recovery across Motor Behaviors after Cervical Spinal Cord Injury
    Authors: Gary C Sieck
    J. Neurophysiol., 2016;0(0):jn.00654.2016.
    Species: Rat
    Sample Types: In Vivo
    Applications: In Vivo
  107. Capturing the biology of disease severity in a PSC-based model of familial dysautonomia
    Authors: N Zeltner, F Fattahi, NC Dubois, N Saurat, F Lafaille, L Shang, B Zimmer, J Tchieu, MA Soliman, G Lee, JL Casanova, L Studer
    Nat. Med., 2016;22(12):1421-1427.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  108. Induced pluripotent stem cells (iPSC) created from skin fibroblasts of patients with Prader-Willi syndrome (PWS) retain the molecular signature of PWS
    Stem Cell Res, 2016;17(3):526-530.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  109. Hypomorphism of Fto and Rpgrip1l causes obesity in mice
    Authors: G Stratigopo, LC Burnett, R Rausch, R Gill, DB Penn, AA Skowronski, CA LeDuc, AJ Lanzano, P Zhang, DR Storm, D Egli, RL Leibel
    J Clin Invest, 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  110. Neurotrophin-3 Regulates Synapse Development by Modulating TrkC-PTP? Synaptic Adhesion and Intracellular Signaling Pathways
    J Neurosci, 2016;36(17):4816-31.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  111. Noggin Over-Expressing Mouse Embryonic Fibroblasts and MS5 Stromal Cells Enhance Directed Differentiation of Dopaminergic Neurons from Human Embryonic Stem Cells.
    Authors: Lim M, Shin M, Lee S, Minn Y, Hoh J, Cho Y, Kim D, Lee S, Kim C, Park C
    PLoS ONE, 2015;10(9):e0138460.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  112. Neuroprotective effects of oligodendrocyte progenitor cell transplantation in premature rat brain following hypoxic-ischemic injury.
    Authors: Chen, Long-Xia, Ma, Si-Min, Zhang, Peng, Fan, Zi-Chuan, Xiong, Man, Cheng, Guo-Qian, Yang, Yi, Qiu, Zi-Long, Zhou, Wen-Hao, Li, Jin
    PLoS ONE, 2015;10(3):e0115997.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  113. Generation of retinal ganglion cells with functional axons from human induced pluripotent stem cells.
    Authors: Tanaka, Taku, Yokoi, Tadashi, Tamalu, Fuminobu, Watanabe, Shu-Ichi, Nishina, Sachiko, Azuma, Noriyuki
    Sci Rep, 2015;5(0):8344.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  114. Role of Hypoxia-Induced Brain Derived Neurotrophic Factor in Human Pulmonary Artery Smooth Muscle.
    Authors: Hartman W, Helan M, Smelter D, Sathish V, Thompson M, Pabelick C, Johnson B, Prakash Y
    PLoS ONE, 2015;10(7):e0129489.
    Species: Human
    Sample Types: Whole Tissue
    Applications: Bioassay
  115. Generation of Dopamine Neurons from Rodent Fibroblasts through the Expandable Neural Precursor Cell Stage.
    Authors: Lim M, Chang M, Kim S, Yi S, Suh-Kim H, Jung S, Kim M, Kim J, Lee Y, Lee S, Kim D, Lee S, Park C
    J Biol Chem, 2015;290(28):17401-14.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  116. Human iPSC-derived motoneurons harbouring TARDBP or C9ORF72 ALS mutations are dysfunctional despite maintaining viability.
    Authors: Devlin, Anna-Cla, Burr, Karen, Borooah, Shyamang, Foster, Joshua D, Cleary, Elaine M, Geti, Imbisaat, Vallier, Ludovic, Shaw, Christop, Chandran, Siddhart, Miles, Gareth B
    Nat Commun, 2015;6(0):5999.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  117. Dopaminergic control of autophagic-lysosomal function implicates Lmx1b in Parkinson's disease.
    Authors: Laguna A, Schintu N, Nobre A, Alvarsson A, Volakakis N, Jacobsen J, Gomez-Galan M, Sopova E, Joodmardi E, Yoshitake T, Deng Q, Kehr J, Ericson J, Svenningsson P, Shupliakov O, Perlmann T
    Nat Neurosci, 2015;18(6):826-35.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  118. Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts.
    Authors: Wainger B, Buttermore E, Oliveira J, Mellin C, Lee S, Saber W, Wang A, Ichida J, Chiu I, Barrett L, Huebner E, Bilgin C, Tsujimoto N, Brenneis C, Kapur K, Rubin L, Eggan K, Woolf C
    Nat Neurosci, 2015;18(1):17-24.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  119. Modeling the Early Phenotype at the Neuromuscular Junction of Spinal Muscular Atrophy Using Patient-Derived iPSCs.
    Authors: Yoshida M, Kitaoka S, Egawa N, Yamane M, Ikeda R, Tsukita K, Amano N, Watanabe A, Morimoto M, Takahashi J, Hosoi H, Nakahata T, Inoue H, Saito M
    Stem Cell Reports, 2015;4(4):561-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  120. Generation of neuropeptidergic hypothalamic neurons from human pluripotent stem cells.
    Authors: Merkle F, Maroof A, Wataya T, Sasai Y, Studer L, Eggan K, Schier A
    Development, 2015;142(4):633-43.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  121. Neuropeptide Y receptor Y5 as an inducible pro-survival factor in neuroblastoma: implications for tumor chemoresistance.
    Authors: Czarnecka M, Trinh E, Lu C, Kuan-Celarier A, Galli S, Hong S, Tilan J, Talisman N, Izycka-Swieszewska E, Tsuei J, Yang C, Martin S, Horton M, Christian D, Everhart L, Maheswaran I, Kitlinska J
    Oncogene, 2015;34(24):3131-43.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  122. Light-inducible receptor tyrosine kinases that regulate neurotrophin signalling.
    Authors: Chang, Ki-Young, Woo, Doyeon, Jung, Hyunjin, Lee, Sangkyu, Kim, Sungsoo, Won, Joungha, Kyung, Taeyoon, Park, Hyerim, Kim, Nury, Yang, Hee Won, Park, Jae-Yong, Hwang, Eun Mi, Kim, Daesoo, Heo, Won Do
    Nat Commun, 2014;5(0):4057.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  123. Constitutively active TrkB confers an aggressive transformed phenotype to a neural crest-derived cell line.
    Authors: Dewitt J, Ochoa V, Urschitz J, Elston M, Moisyadi S, Nishi R
    Oncogene, 2014;33(8):977-85.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  124. Bicaudal-D1 regulates the intracellular sorting and signalling of neurotrophin receptors.
    Authors: Terenzio M, Golding M, Russell M, Wicher K, Rosewell I, Spencer-Dene B, Ish-Horowicz D, Schiavo G
    EMBO J, 2014;33(14):1582-98.
    Species: N/A
    Sample Types: Protein
    Applications: Western Blot
  125. Infralimbic BDNF/TrkB enhancement of GluN2B currents facilitates extinction of a cocaine-conditioned place preference.
    Authors: Otis J, Fitzgerald M, Mueller D
    J Neurosci, 2014;34(17):6057-64.
    Species: Rat
    Sample Types: In Vivo
    Applications: In Vivo
  126. Hybrid multiphoton volumetric functional imaging of large-scale bioengineered neuronal networks.
    Authors: Dana, Hod, Marom, Anat, Paluch, Shir, Dvorkin, Roman, Brosh, Inbar, Shoham, Shy
    Nat Commun, 2014;5(0):3997.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  127. A time course analysis of the electrophysiological properties of neurons differentiated from human induced pluripotent stem cells (iPSCs).
    Authors: Pre D, Nestor M, Sproul A, Jacob S, Koppensteiner P, Chinchalongporn V, Zimmer M, Yamamoto A, Noggle S, Arancio O
    PLoS ONE, 2014;9(7):e103418.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  128. Local translation and retrograde axonal transport of CREB regulates IL-6-induced nociceptive plasticity.
    Authors: Melemedjian O, Tillu D, Moy J, Asiedu M, Mandell E, Ghosh S, Dussor G, Price T
    Mol Pain, 2014;10(0):45.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  129. Selective lentiviral gene delivery to CD133-expressing human glioblastoma stem cells.
    Authors: Bayin, N Sumru, Modrek, Aram S, Dietrich, August, Lebowitz, Jonathan, Abel, Tobias, Song, Hae-Ri, Schober, Markus, Zagzag, David, Buchholz, Christia, Chao, Moses V, Placantonakis, Dimitris
    PLoS ONE, 2014;9(12):e116114.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  130. Highly efficient generation of induced neurons from human fibroblasts that survive transplantation into the adult rat brain.
    Authors: Pereira, Maria, Pfisterer, Ulrich, Rylander, Daniella, Torper, Olof, Lau, Shong, Lundblad, Martin, Grealish, Shane, Parmar, Malin
    Sci Rep, 2014;4(0):6330.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  131. Reprogramming non-human primate somatic cells into functional neuronal cells by defined factors.
    Authors: Zhou, Zhi, Kohda, Kazuhisa, Ibata, Keiji, Kohyama, Jun, Akamatsu, Wado, Yuzaki, Michisuk, Okano, Hirotaka, Sasaki, Erika, Okano, Hideyuki
    Mol Brain, 2014;7(0):24.
    Species: Primate - Callitrix jacchus (Common Marmoset)
    Sample Types: Whole Cells
    Applications: Bioassay
  132. Long-term culture of rat hippocampal neurons at low density in serum-free medium: combination of the sandwich culture technique with the three-dimensional nanofibrous hydrogel PuraMatrix.
    Authors: Kaneko A, Sankai Y
    PLoS ONE, 2014;9(7):e102703.
    Species: Rat
    Sample Types: Whole Tissue
    Applications: Bioassay
  133. Enrichment and characterization of human dermal stem/progenitor cells by intracellular granularity.
    Authors: Shim, Joong Hy, Lee, Tae Ryon, Shin, Dong Woo
    Stem Cells Dev, 2013;22(8):1264-74.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  134. A small molecule screen in stem-cell-derived motor neurons identifies a kinase inhibitor as a candidate therapeutic for ALS.
    Authors: Yang Y, Gupta S, Kim K, Powers B, Cerqueira A, Wainger B, Ngo H, Rosowski K, Schein P, Ackeifi C, Arvanites A, Davidow L, Woolf C, Rubin L
    Cell Stem Cell, 2013;12(6):713-26.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  135. Protein tyrosine phosphatase receptor type O inhibits trigeminal axon growth and branching by repressing TrkB and Ret signaling.
    Authors: Gatto G, Dudanova I, Suetterlin P, Davies A, Drescher U, Bixby J, Klein R
    J Neurosci, 2013;33(12):5399-410.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  136. Medial ganglionic eminence-like cells derived from human embryonic stem cells correct learning and memory deficits.
    Authors: Liu Y, Weick J, Liu H, Krencik R, Zhang X, Ma L, Zhou G, Ayala M, Zhang S
    Nat Biotechnol, 2013;31(5):440-7.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  137. MicroRNA-based promotion of human neuronal differentiation and subtype specification.
    Authors: Stappert L, Borghese L, Roese-Koerner B, Weinhold S, Koch P, Terstegge S, Uhrberg M, Wernet P, Brustle O
    PLoS ONE, 2013;8(3):e59011.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  138. ProNGF promotes neurite growth from a subset of NGF-dependent neurons by a p75NTR-dependent mechanism.
    Authors: Howard, Laura, Wyatt, Sean, Nagappan, Guhan, Davies, Alun M
    Development, 2013;140(10):2108-17.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  139. mTOR-dependent proliferation defect in human ES-derived neural stem cells affected by myotonic dystrophy type 1.
    Authors: Denis J, Gauthier M, Rachdi L, Aubert S, Giraud-Triboult K, Poydenot P, Benchoua A, Champon B, Maury Y, Baldeschi C, Scharfmann R, Pietu G, Peschanski M, Martinat C
    J Cell Sci, 2013;126(0):1763-72.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  140. Transcription factor-mediated reprogramming of fibroblasts to expandable, myelinogenic oligodendrocyte progenitor cells.
    Authors: Najm, Fadi J, Lager, Angela M, Zaremba, Anita, Wyatt, Krysta, Caprariello, Andrew V, Factor, Daniel C, Karl, Robert T, Maeda, Tadao, Miller, Robert H, Tesar, Paul J
    Nat Biotechnol, 2013;31(5):426-33.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  141. Sodium phenylbutyrate enhances astrocytic neurotrophin synthesis via protein kinase C (PKC)-mediated activation of cAMP-response element-binding protein (CREB): implications for Alzheimer disease therapy.
    Authors: Corbett, Grant T, Roy, Avik, Pahan, Kalipada
    J Biol Chem, 2013;288(12):8299-312.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  142. NeuroD1 regulates survival and migration of neuroendocrine lung carcinomas via signaling molecules TrkB and NCAM.
    Authors: Osborne, Jihan K, Larsen, Jill E, Shields, Misty D, Gonzales, Joshua X, Shames, David S, Sato, Mitsuo, Kulkarni, Ashwinik, Wistuba, Ignacio, Girard, Luc, Minna, John D, Cobb, Melanie
    Proc Natl Acad Sci U S A, 2013;110(16):6524-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  143. Inhibition of PIKfyve by YM-201636 dysregulates autophagy and leads to apoptosis-independent neuronal cell death.
    Authors: Martin, Sally, Harper, Callista, May, Linda M, Coulson, Elizabet, Meunier, Frederic, Osborne, Shona L
    PLoS ONE, 2013;8(3):e60152.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  144. Self-assembling peptide nanofiber scaffolds enhance dopaminergic differentiation of mouse pluripotent stem cells in 3-dimensional culture.
    Authors: Ni, Na, Hu, Yaohua, Ren, Huixia, Luo, Chuanmin, Li, Peng, Wan, Jian-Bo, Su, Huanxing
    PLoS ONE, 2013;8(12):e84504.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  145. Nicotine elicits prolonged calcium signaling along ventral hippocampal axons.
    Authors: Zhong C, Talmage D, Role L
    PLoS ONE, 2013;8(12):e82719.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  146. Neuregulin and BDNF induce a switch to NMDA receptor-dependent myelination by oligodendrocytes.
    Authors: Lundgaard I, Luzhynskaya A, Stockley J, Wang Z, Evans K, Swire M, Volbracht K, Gautier H, Franklin R, Attwell D, Karadottir R
    PLoS Biol, 2013;11(12):e1001743.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Cell Culture
  147. Directed differentiation and functional maturation of cortical interneurons from human embryonic stem cells.
    Authors: Maroof A, Keros S, Tyson J, Ying S, Ganat Y, Merkle F, Liu B, Goulburn A, Stanley E, Elefanty A, Widmer H, Eggan K, Goldstein P, Anderson S, Studer L
    Cell Stem Cell, 2013;12(5):559-72.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  148. BDNF regulates atypical PKC at spinal synapses to initiate and maintain a centralized chronic pain state.
    Authors: Melemedjian O, Tillu D, Asiedu M, Mandell E, Moy J, Blute V, Taylor C, Ghosh S, Price T
    Mol Pain, 2013;9(0):12.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  149. A human Dravet syndrome model from patient induced pluripotent stem cells.
    Authors: Higurashi N, Uchida T, Lossin C, Misumi Y, Okada Y, Akamatsu W, Imaizumi Y, Zhang B, Nabeshima K, Mori M, Katsurabayashi S, Shirasaka Y, Okano H, Hirose S
    Mol Brain, 2013;6(0):19.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  150. E-cadherin-expressing feeder cells promote neural lineage restriction of human embryonic stem cells.
    Authors: Moore RN, Cherry JF, Mathur V
    Stem Cells Dev., 2012;21(1):30-41.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  151. Inhibition of uterine sarcoma cell growth through suppression of endogenous tyrosine kinase B signaling.
    Authors: Makino, Kenichi, Kawamura, Kazuhiro, Sato, Wataru, Kawamura, Nanami, Fujimoto, Toshio, Terada, Yukihiro
    PLoS ONE, 2012;7(7):e41049.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  152. The suppressive effect of an intra-prefrontal cortical infusion of BDNF on cocaine-seeking is Trk receptor and extracellular signal-regulated protein kinase mitogen-activated protein kinase dependent.
    Authors: Whitfield TW, Shi X, Sun WL
    J. Neurosci., 2011;31(3):834-42.
    Species: Rat
    Sample Types: In Vivo
    Applications: In Vivo
  153. Soluble Endoglin Specifically Binds Bone Morphogenetic Proteins 9 and 10 via Its Orphan Domain, Inhibits Blood Vessel Formation, and Suppresses Tumor Growth.
    Authors: Castonguay R, Werner ED, Matthews RG, Presman E, Mulivor AW, Solban N, Sako D, Pearsall RS, Underwood KW, Seehra J, Kumar R, Grinberg AV
    J. Biol. Chem., 2011;286(34):30034-46.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Surface Plasmon Resonance
  154. EGF and bFGF pre-treatment enhances neural specification and the response to neuronal commitment of MIAMI cells.
    Authors: Delcroix GJ, Curtis KM, Schiller PC, Montero-Menei CN
    Differentiation, 2010;80(4):213-27.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  155. Matrix-binding vascular endothelial growth factor (VEGF) isoforms guide granule cell migration in the cerebellum via VEGF receptor Flk1.
    Authors: Ruiz de Almodovar C, Coulon C, Salin PA, Knevels E, Chounlamountri N, Poesen K, Hermans K, Lambrechts D, Van Geyte K, Dhondt J, Dresselaers T, Renaud J, Aragones J, Zacchigna S, Geudens I, Gall D, Stroobants S, Mutin M, Dassonville K, Storkebaum E, Jordan BF, Eriksson U, Moons L, D'Hooge R, Haigh JJ, Belin MF, Schiffmann S, Van Hecke P, Gallez B, Vinckier S, Chedotal A, Honnorat J, Thomasset N, Carmeliet P, Meissirel C
    J. Neurosci., 2010;30(45):15052-66.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  156. A single intra-PFC infusion of BDNF prevents cocaine-induced alterations in extracellular glutamate within the nucleus accumbens.
    Authors: Berglind WJ, Whitfield TW, LaLumiere RT, Kalivas PW, McGinty JF
    J. Neurosci., 2009;29(12):3715-9.
    Species: Rat
    Sample Types: In Vivo
    Applications: In Vivo
  157. Long-term tripotent differentiation capacity of human neural stem (NS) cells in adherent culture.
    Authors: Sun Y, Pollard S, Conti L, Toselli M, Biella G, Parkin G, Willatt L, Falk A, Cattaneo E, Smith A
    Mol. Cell. Neurosci., 2008;38(2):245-58.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  158. Brain-derived neurotrophic factor stimulates bone/cementum-related protein gene expression in cementoblasts.
    Authors: Kajiya M, Shiba H, Fujita T, Ouhara K, Takeda K, Mizuno N, Kawaguchi H, Kitagawa M, Takata T, Tsuji K, Kurihara H
    J. Biol. Chem., 2008;283(23):16259-67.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  159. Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage.
    Authors: Elkabetz Y, Panagiotakos G, Al Shamy G, Socci ND, Tabar V, Studer L
    Genes Dev., 2008;22(2):152-65.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  160. Neurotrophins modulate monocyte chemotaxis without affecting macrophage function.
    Authors: Samah B, Porcheray F, Gras G
    Clin. Exp. Immunol., 2008;151(3):476-86.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  161. BDNF plasma levels in acute stroke.
    Authors: Di Lazzaro V, Profice P, Pilato F, Dileone M, Florio L, Tonali PA, Angelucci F
    Neurosci. Lett., 2007;422(2):128-30.
    Species: N/A
    Sample Types: N/A
    Applications: ELISA (Standard)
  162. A highly enriched niche of precursor cells with neuronal and glial potential within the hair follicle dermal papilla of adult skin.
    Authors: Hunt DP, Morris PN, Sterling J, Anderson JA, Joannides A, Jahoda C, Compston A, Chandran S
    Stem Cells, 2007;26(1):163-72.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  163. A BDNF infusion into the medial prefrontal cortex suppresses cocaine seeking in rats.
    Authors: Berglind WJ, See RE, Fuchs RA, Ghee SM, Whitfield TW, Miller SW, McGinty JF
    Eur. J. Neurosci., 2007;26(3):757-66.
    Species: Rat
    Sample Types: In Vivo
    Applications: In Vivo
  164. SULF1 and SULF2 regulate heparan sulfate-mediated GDNF signaling for esophageal innervation.
    Authors: Ai X, Kitazawa T, Do AT, Kusche-Gullberg M, Labosky PA, Emerson CP
    Development, 2007;134(18):3327-38.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  165. Effects of NGF and BDNF on baseline glutamate and dopamine release in the hippocampal formation of the adult rat.
    Authors: Paredes D, Granholm AC, Bickford PC
    Brain Res., 2007;1141(0):56-64.
  166. Differentiation of ES cells into cerebellar neurons.
    Authors: Salero E, Hatten ME
    Proc. Natl. Acad. Sci. U.S.A., 2007;104(8):2997-3002.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  167. Multipotent adult progenitor cells from swine bone marrow.
    Authors: Zeng L, Rahrmann E, Hu Q, Lund T, Sandquist L, Felten M, O'Brien TD, O'Brien TD, Zhang J, Verfaillie C
    Stem Cells, 2006;24(11):2355-66.
    Species: Porcine
    Sample Types: Whole Cells
    Applications: Bioassay
  168. Platelet-derived growth factor (PDGF-BB) and brain-derived neurotrophic factor (BDNF) induce striatal neurogenesis in adult rats with 6-hydroxydopamine lesions.
    Authors: Mohapel P, Frielingsdorf H, Haggblad J, Zachrisson O, Brundin P
    Neuroscience, 2005;132(3):767-76.
    Species: Rat
    Sample Types: In Vivo
    Applications: In Vivo
  169. Derivation of midbrain dopamine neurons from human embryonic stem cells.
    Authors: Perrier AL, Tabar V, Barberi T, Rubio ME, Bruses J, Topf N, Harrison NL, Studer L
    Proc. Natl. Acad. Sci. U.S.A., 2004;101(34):12543-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  170. Analysis of induced pluripotent stem cells carrying 22q11.2 deletion.
    Authors: T Yoshikawa, Hisano Y, Iwayama Y, Toyota T, Itasaka N, Dean B
    Transl Psychiatry, 0;6(11):e934.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay

FAQs

  1. The vial is supposed to contain lyophilized protein but it appears to be empty. Is there anything in it?

    • Pellets can be dislodged during shipping and become disbursed on the vial wall and in the cap. Centrifuge or tap the vial on the benchtop to return this material to the vial bottom. If this does not reveal a pellet, closely inspect the cone of the vial. Some pellets appear as only a tiny amount of material or as a transparent film due to the original buffer formulation. This is a normal appearance for many proteins. For example, if the product is originally lyophilized from a solvent such as acetonitrile or ethanol, and supplied carrier-free, you may not be able to detect the pellet with the naked eye. This does not mean the vial is empty. Reconstitute the vial as directed. After reconstitution, protein concentration can be tested with a spectrophotometer.

  2. What is the recommended method for reconstitution of a lyophilized protein or antibody?

    • Unless more specific directions are on the Certificate of Analysis provided with the product, we suggest the following procedure to ensure optimal recovery: 1. Allow the vial and reconstitution buffer to equilibrate to room temperature. 2. Briefly centrifuge the vial to ensure that all lyophiliate is collected at the bottom of the vial. 3. Add the amount of buffer required to achieve the concentration recommended on the product insert. 4. Allow the vial to reconstitute for 15-30 minutes at room temperature with gentle agitation, like on a rocker platform or rotating by hand.  Avoid vigorous shaking that can cause foaming and protein denaturation. 5. Aliquot into volumes greater than 20 μL and store as indicated on the product insert. If the vial exhibits flakes or particulates, mix the product for a couple of hours at room temperature and then at 4oC overnight. Contact Technical Service if product does not go into solution.  

       

  3. Are R&D Systems recombinant proteins and antibodies sterile?

    • Although the vials are bottled using aseptic techniques, heat-treated vials, and sterile stock solutions, they are not considered or guaranteed to be sterile. If sterile material is needed for an experiment, the material can be filtered through a 0.2 micron filter designed for use with biological fluids.

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Recombinant Human BDNF Protein
By Anonymous on 01/09/2020
Application: Stem/Immune cell maintenance or differentiation
Reason for Rating: Performed well in differentiating iPS cells into neuronal cells