Recombinant Human Cbl-B Protein, CF
Please inquire regarding future lot manufacture; Will be discontinued when existing inventory is gone.
Recombinant Human Cbl-B Protein, CF Summary
Met1 - Leu982
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
|Formulation||Supplied as a solution in HEPES, NaCl, Glycerol and DTT.|
|Shipping||The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.|
|Stability & Storage:||Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Cbl-B (Casitas B-lineage lymphoma protooncogene b, aka RNF56) is a member of the Cbl family of RING-type E3 Ubiquitin ligases, and has been implicated in the regulation of pathways associated with cell differentiation, tissue development, skeletal muscle atrophy and adaptive immunity. Along with its RING-type zinc finger domain, Cbl-B contains an N-terminal tyrosine kinase binding (TKB) domain and a C-terminal UBA (Ubiquitin Associated) domain. This E3 ligase preferentially interacts with phosphotyrosine-modifed intracellular signaling molecules, targeting them for ubiquitination. Reported substrates for Cbl-B include VAV1, PIKR1, SYK, SRC, EGFR, AXL and others. Downregulation of Cbl-B has been shown to remove the requirement for CD28 co-stimulation during T-cell activation, suggesting Cbl-B inhibitors may be useful in various cancer immunotherapies.
- Kobashigawa, Y. et al. (2011) Proc. Nat. Acad. Sci. 108: 20579.
- Rorsman, C. et al. (2016) J. Biol. Chem. 291: 11608.
- Sitaram, P. et al. (2019) Int. J. Mol. Sci. 20: 5821.
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