Recombinant Human CCL14a/HCC-1 (aa 28-93) Protein
Recombinant Human CCL14a/HCC-1 (aa 28-93) Protein Summary
Accession # Q16627
1578-HC/CF (carrier free)
|Formulation||Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.|
|Reconstitution||Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.|
|Shipping||The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.|
|Stability & Storage:||Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
HCC-1 (Hemofiltrate CC Chemokine-1) was originally isolated from the hemofiltrate of human patients with chronic renal failure (1). It belongs to the CC chemokine superfamily and has been designated CCL14a. HCC-1/CCL14a cDNA encodes a 93 amino acid (aa) residue precursor with a 19 aa signal peptide that is cleaved to form the 74 aa mature secreted proprotein. By alternative splicing, a second longer isoform named HCC-3/CCL14b, which includes sequences from exon 3, also exists (2). HCC-1/CCL14a is expressed constitutively in various normal tissues including spleen, liver, muscle, gut and bone marrow. It circulates at nanomolar concentrations in human plasma. Different post-translationally modified HCC-1/CCL14a, including O-glycosylated and N-terminally truncated variants of HCC-1/CCL14a, have been identified (3, 4). Whereas the 74 aa mature propeptide is a weak CCR1 agonist, the proteolytically processed truncated HCC-1/CCL14a (aa 28 - 93) is a highly potent agonist of CCR1, CCR5 and to a lesser extent, CCR3. HCC-1/CCL14a (aa 28 - 93) promotes chemotaxis of T lymphocytes, monocytes and eosinophils, and inhibits infection of M-tropic human immunodeficiency virus type 1. Activation of the HCC-1/CCL14a propeptide to active peptide is mediated by the urokinase type plasminogen activator or plasmin (5).
- Schulz-Knappe, P. et al. (1996) J. Exp. Med. 183:295.
- Forssmanns, U. et al. (2001) J. Leukocyte Biology 70:357.
- Richter, R. et al. (2000) Biochemistry 39:10799.
- Munch, J. et al. (2002) Antimicrob. Agents Chemother. 46:982.
- Vakili, J. et al. (2001) J. Immunol. 167:3406.
Citation for Recombinant Human CCL14a/HCC-1 (aa 28-93) Protein
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1 Citation: Showing 1 - 1
Possible Roles of CC- and CXC-Chemokines in Regulating Bovine Endometrial Function during Early Pregnancy
Authors: R Sakumoto, KG Hayashi, S Fujii, H Kanahara, M Hosoe, T Furusawa, K Kizaki
Int J Mol Sci, 2017-03-31;18(4):.
Sample Types: Whole Tissue
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