Recombinant Human IL-17RA/IL-17R Fc Chimera Protein, CF
Recombinant Human IL-17RA/IL-17R Fc Chimera Protein, CF Summary
|Human IL-17 RA/IL-17 R
Accession # Q96F46
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
|Formulation||Lyophilized from a 0.2 μm filtered solution in PBS.|
|Reconstitution||Reconstitute at 100 μg/mL in sterile PBS.|
|Shipping||The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.|
|Stability & Storage:||Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Interleukin 17 (also known as CTLA‑8) is a T cell‑expressed pleotropic cytokine. IL‑17 binds to IL‑17 receptor (IL‑17 R) which shares no homology with any known family of receptors. While the expression of IL‑17 is restricted to activated T cells, the IL‑17 R mRNA exhibits a broad tissue distribution, and has been detected in virtually all cells and tissues tested. The human IL‑17 R gene was localized to chromosome 22. Human IL‑17 R is an 866 amino acid (aa) type I membrane glycoprotein with a 293 aa extracellular domain, a 21 aa carboxy‑proximal transmembrane domain, and a 525 aa cytoplasmic tail. The aa sequence of human IL‑17 R is 69% identical to the mouse IL‑17 R. The signaling events of IL‑17 includes activation of NF‑ kappa B and JNK, and require TNF receptor‑associated factors 6 (TRAF6) in the signaling pathway.
Citations for Recombinant Human IL-17RA/IL-17R Fc Chimera Protein, CF
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
Citations: Showing 1 - 4
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Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site
Authors: ER Goedken, MA Argiriadi, JD Dietrich, AM Petros, N Krishnan, SC Panchal, W Qiu, H Wu, H Zhu, AM Adams, PM Bodelle, L Goguen, PL Richardson, PF Slivka, M Srikumaran, AK Upadhyay, B Wu, RA Judge, A Vasudevan, SM Gopalakris, PB Cox, VS Stoll, C Sun
Scientific Reports, 2022-08-26;12(1):14561.
Sample Types: Recombinant Protein
Diverse Human VH antibody fragments with bio-therapeutic properties from the Crescendo Mouse
Authors: Y Teng, JL Young, B Edwards, P Hayes, L Thompson, C Johnston, C Edwards, Y Sanders, M Writer, D Pinto, Y Zhang, M Roode, P Chovanec, L Matheson, AE Corcoran, A Fernandez, L Montoliu, B Rossi, V Tosato, K Gjuracic, D Nikitin, C Bruschi, B McGuinness, T Sandal, M Romanos
N Biotechnol, 2019-10-07;55(0):65-76.
Sample Types: In Vivo
Applications: In Vivo
Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists
Sci Rep, 2016-08-16;6(0):30859.
Sample Types: Protein
Inhibiting complex IL-17A and IL-17RA interactions with a linear peptide
Sci Rep, 2016-05-17;6(0):26071.
Sample Types: Whole Cells
Applications: Surface Plasmon Resonance
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