Recombinant Human MMR/CD206 Protein

Carrier Free

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With Carrier

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R&D Systems Recombinant Proteins and Enzymes
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Citations (11)
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Recombinant Human MMR/CD206 Protein Summary

Product Specifications

>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Level
<0.01 EU per 1 μg of the protein by the LAL method.
Measured by its binding ability in a functional ELISA. When Mannan is coated at 0.2 μg/mL (100 μL/well), the concentration of Recombinant Human MMR/CD206 that produces 50% of the optimal binding response is approximately 0.200-1.20 μg/mL.
Mouse myeloma cell line, NS0-derived human MMR/CD206 protein
Leu19-Lys1383 (Thr399Ala) & (Leu407Phe), with a C-terminal 6-His tag
Accession #
N-terminal Sequence
Predicted Molecular Mass
157 kDa
160 kDa, under reducing conditions.

Product Datasheets

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2534-MR (with carrier)

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2534-MR/CF (carrier free)

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.


Formulation Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.


Formulation Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Background: MMR/CD206

The MMR (macrophage mannose receptor) is also called MR due to its presence on cells other than macrophages, and is designated CD206, Mrc1 (mannose receptor C type 1), or CLEC13D (C‑type lectin domain family 13, member D) (1‑4). CD206 is a 175‑190 kDa endocytic receptor that is expressed on M2 alternatively activated tissue macrophages including tumor‑associated macrophages (TAMs), inflammatory dendritic cells in selected lymphoid organs, and liver, splenic, lymphatic, and dermal microvascular endothelial cells (1, 2, 5‑8). The 1456 amino acid (aa) human CD206 precursor contains a signal sequence (18 aa), an extracellular domain (ECD) containing an N‑terminal cysteine‑rich domain, a fibronectin type II repeat, eight C‑type lectin domains (CTLDs), and several N‑glycosylation sites (1371 aa), a transmembrane segment and a short (46 aa) cytoplasmic domain (2‑4). Metalloproteinases can mediate the shedding of the soluble ECD (2). The human CD206 ECD shares 83%, 84%, 89%, 89% and 90% aa sequence identity with mouse, rat, equine, porcine and canine CD206, respectively. The cysteine‑rich domain recognizes some pituitary hormones such as LH (luteinizing hormone/lutropin) and TSH (thyroid stimulating hormone/thyrotropin), chondroitin sulfates, and sulfated N‑acetylgalactosamines including sulfo‑Lewisa and ‑Lewisx (1, 7, 9). The FNII domain mediates Ca2+‑independent binding of collagens (2, 10). The CTLDs participate in Ca2+‑dependent recognition of branched sugars with terminal mannose, fucose or N‑acetylglucosamine that occur on many pathogenic microorganisms (7, 11). CD206 internalizes ligands in clathrin‑coated vesicles, sorts them to phagosomes or early endosomes, and recycles to the cell surface (1, 6, 7). CD206 also promotes clearance of glycoproteins that promote allergy or ongoing inflammation, such as lysosomal hydrolases and myeloperoxidases (1, 2, 5‑7). It is involved in T cell polarization and production of pro‑ and anti‑inflammatory cytokines (1, 2). It facilitates peptide presentation on MHC II, and cross‑presentation on MHC I which is important for tumor immunogenicity (1, 2, 12). This function may be blocked by engagement of CD206 on TAMs by tumor mucins (8).

  1. Gazi, U. and L. Martinez-Pomares (2009) Immunobiology 214:554.
  2. Martinez-Pomares, L. (2012) J. Leukoc. Biol. 92:1177.
  3. Harris, N. et al. (1992) Blood 80:2363.
  4. Taylor, M.E. et al. (1990) J. Biol. Chem. 265:12156.
  5. Chieppa, M. et al. (2003) J. Immunol. 171:4552.
  6. Figdor, C. et al. (2002) Nat. Rev. Immunol. 2:77.
  7. Taylor, P.R. et al. (2005) Trends Immunol. 26:104.
  8. Allavena, P. et al. (2010) Clin. Dev. Immunol. 2010:547179.
  9. Leteux, C. et al. (2000) J. Exp. Med. 191:1117.
  10. Martinez-Pomares, L. et al. (2006) Eur. J. Immunol. 36:1074.
  11. Taylor, M.E. et al. (1992) J. Biol. Chem. 267:1719.
  12. Singh S.K. et al. (2011) Eur. J. Immunol. 41:916.
Long Name
Macrophage Mannose Receptor
Entrez Gene IDs
4360 (Human); 17533 (Mouse); 291327 (Rat)
Alternate Names
CD206; CLEC13D; CLEC13Dmacrophage mannose receptor 1; C-type lectin domain family 13 member D; mannose receptor, C type 1; MMR; MMRCD206 antigen; MRC1

Citations for Recombinant Human MMR/CD206 Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

11 Citations: Showing 1 - 10
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  1. Mapping of Recognition Sites of Monoclonal Antibodies Responsible for the Inhibition of Pneumolysin Functional Activity
    Authors: I Kucinskait, M Simanavici, J Dapkunas, M Pleckaityt, A Zvirbliene
    Biomolecules, 2020;10(7):.
    Species: Human
    Sample Types: Cell Culture Supernates
    Applications: ELISA (detection)
  2. Ozone-derived oxysterols impair lung macrophage phagocytosis via adduction of some phagocytosis receptors
    Authors: PF Duffney, HH Kim, NA Porter, I Jaspers
    J. Biol. Chem., 2020;0(0):.
    Species: Human
    Sample Types: Protein
    Applications: ELISA Development
  3. Transcriptional and functional insights into the host immune response against the emerging fungal pathogen Candida auris
    Authors: M Bruno, S Kersten, JM Bain, M Jaeger, D Rosati, MD Kruppa, DW Lowman, PJ Rice, B Graves, Z Ma, YN Jiao, A Chowdhary, G Renieris, FL van de Vee, BJ Kullberg, EJ Giamarello, A Hoischen, NAR Gow, AJP Brown, JF Meis, DL Williams, MG Netea
    Nat Microbiol, 2020;0(0):.
    Species: Human
    Sample Types: Protein
    Applications: Bioassay
  4. N-Oxy lipid-based click chemistry for orthogonal coupling of mannan onto nanoliposomes prepared by microfluidic mixing: Synthesis of lipids, characterisation of mannan-coated nanoliposomes and in vitro stimulation of dendritic cells
    Authors: E Bartheldyo, P Turánek Kn, K Zachová, J Mašek, P Kulich, R Effenberg, D Zyka, F Hubatka, J Kotou?ek, H ?elechovsk, R Héžová, A Tome?ková, E Mašková, M Fojtíková, S Macaulay, P Bystrický, L Paulovi?ov, E Paulovi?ov, L Drož, M Ledvina, M Raška, J Turánek
    Carbohydr Polym, 2019;207(0):521-532.
    Applications: Binding Assay
  5. Lectin nanoparticle assays for detecting breast cancer-associated glycovariants of cancer antigen 15-3 (CA15-3) in human plasma
    Authors: J Terävä, L Tiainen, U Lamminmäki, PL Kellokumpu, K Pettersson, K Gidwani
    PLoS ONE, 2019;14(7):e0219480.
    Species: Human
    Sample Types: Natural Protein
    Applications: Bioassay
  6. A glucose-responsive insulin therapy protects animals against hypoglycemia
    Authors: R Yang, M Wu, S Lin, RP Nargund, X Li, T Kelly, L Yan, G Dai, Y Qian, Q Dallas-Yan, PA Fischer, Y Cui, X Shen, P Huo, DD Feng, MD Erion, DE Kelley, J Mu
    JCI Insight, 2018;3(1):.
    Applications: Bioassay
  7. Pneumolysin binds to the mannose receptor C type 1 (MRC-1) leading to anti-inflammatory responses and enhanced pneumococcal survival
    Authors: K Subramania, DR Neill, HA Malak, L Spelmink, S Khandaker, G Dalla Libe, E Dearing, A Kirby, M Yang, A Achour, J Nilvebrant, PÅ Nygren, L Plant, A Kadioglu, B Henriques-
    Nat Microbiol, 2018;0(0):.
    Applications: Surface Plasmon Resonance
  8. Bee Venom Phospholipase A2, a Novel Foxp3+ Regulatory T Cell Inducer, Protects Dopaminergic Neurons by Modulating Neuroinflammatory Responses in a Mouse Model of Parkinson's Disease.
    Authors: Chung E, Lee G, Lee C, Ye M, Chung H, Kim H, Bae S, Hwang D, Bae H
    J Immunol, 2015;195(10):4853-60.
    Species: Human
    Sample Types: Whole Cells
    Applications: Surface Plasmon Resonance
  9. Correction: A chitin-like component on sclerotic cells of fonsecaea pedrosoi inhibits dectin-1-mediated murine Th17 development by masking beta-glucans.
    PLoS ONE, 2015;10(3):e0119244.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  10. O-mannosylation of the Mycobacterium tuberculosis adhesin Apa is crucial for T cell antigenicity during infection but is expendable for protection.
    Authors: Nandakumar, Subhadra, Kannanganat, Sunil, Dobos, Karen M, Lucas, Megan, Spencer, John S, Fang, Sunan, McDonald, Melissa, Pohl, Jan, Birkness, Kristin, Chamcha, Venkates, Ramirez, Melissa, Plikaytis, Bonnie B, Posey, James E, Amara, Rama Rao, Sable, Suraj B
    PLoS Pathog, 2013;9(10):e1003705.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  11. Pichia pastoris-produced mucin-type fusion proteins with multivalent O-glycan substitution as targeting molecules for mannose-specific receptors of the immune system.
    Authors: Gustafsson A, Sjoblom M, Strindelius L, Johansson T, Fleckenstein T, Chatzissavidou N, Lindberg L, Angstrom J, Rova U, Holgersson J
    Glycobiology, 2011;21(8):1071-86.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Surface Plasmon Resonance


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Recombinant Human MMR/CD206 Protein
By Anonymous on 09/23/2019
Application: Immunoassay Standard

I used this protein as a standard for developing an ELISA in combination with pAb (cat.AF2534) and mAb (cat.MAB25341). This combination gives good standard curve but unfortunately did not detect any MMR in our samples.