Recombinant Human PTPRD Fc Chimera Protein, CF

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Recombinant Human PTPRD Fc Chimera Protein Binding Activity
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Product Details

Recombinant Human PTPRD Fc Chimera Protein, CF Summary

Product Specifications

>80%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Level
<0.10 EU per 1 μg of the protein by the LAL method.
Measured by its binding ability in a functional ELISA. When Recombinant Human PTPRD Fc Chimer is immobilized at 1 μg/mL, 100 μL/well, Recombinant Human IL-1 RAPL1/IL-1 R8 Fc Chimera (Catalog # 9949-ML) binds with an ED50 of 1.5-9 ng/mL. 
Human embryonic kidney cell, HEK293-derived human PTPRD protein
Accession # P23468
Accession #
N-terminal Sequence
Structure / Form
Disulfide-linked homodimer
Predicted Molecular Mass
154 kDa
137-151 kDa, reducing conditions

Product Datasheets

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Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.


Formulation Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose.
Reconstitution Reconstitute at 400 μg/mL in PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage:
  • 12 months from date of receipt, ≤ -20 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, ≤ -20 °C under sterile conditions after reconstitution.

Scientific Data

Binding Activity Recombinant Human PTPRD Fc Chimera Protein Binding Activity View Larger

When Recombinant Human PTPRD Fc Chimera is immobilized at 1 µg/mL, 100 µL/well, Recombinant Human IL-1 RAPL1/IL-1 R8 Fc Chimera (Catalog # 9949-ML) binds with an ED50 of 1.5-9 ng/mL.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Background: PTPRD

Human protein-tyrosine phosphatase delta (PTPRD) is a type I membrane protein. It contains a 1245 amino acid (aa) long extracellular domain (ECD), a 25 amino acid long transmembrane domain, and a 622 amino acid cytoplasmic domain. A cleavage during post-translational modification separates the extracellular domain from the transmembrane segment through a process called "ectodomain shedding" (1). The extracellular regions are comprised of three Ig-like C2 domains followed immediately by eight fibronectin type-III like domains (1). The human PTPRD extracellular domain shares 98% and 62% aa identity with mouse and rat PTPRD, respectively. Protein-tyrosine phosphatases (PTPs) constitute a structurally diverse family of tightly regulated enzymes with important regulatory roles (1-6). PTPRD is a member of the PTPs and is detected in brain and other tissues including colon and breast (1). It has been demonstrated that phosphorylated STAT3 (p-STAT3) is a direct substrate of PTPRD and that cancer-specific mutations in PTPRD abrogate its ability to dephosphorylate STAT3 (5). PTPRD interacts with NGL-3 (Netrin-G ligand-3) via its first two FNIII repeats to promote synapse formation (3). PTPRD can also bind to IL1RAPL1 and its paralog IL1RAPL2; the IL1RAPL1/PTPRD complex recruits RhoGAP2 at excitatory synapses to induce dendritic spine formation (4). Recent studies have indicated SALM5 forms heterotetramer with PTPRD to induce synaptic differentiation (6).

  1. Pulido, R. et al. (1995) Proc. Natl. Acad. Sci. USA 92:11686.
  2. Östman, A. et al. (2006) Nature Reviews Cancer 6:307.
  3. Kwon, SK. et al. (2010) J. Biol. Chem. 285:13966.
  4. Valnegri, P. et al. (2011) Hum. Mol. Genet. 20:4797.
  5. Ortiz, B. et al. (2014) Proc. Natl. Acad. Sci. USA. 111:8149.
  6. Lin, Z. et al. (2018) Nat, Commun. 9:268.
Long Name
Protein Tyrosine Phosphatase Receptor-type delta
Entrez Gene IDs
5789 (Human); 19266 (Mouse); 313278 (Rat)
Alternate Names
HPTPDELTA; HPTPMGC119752; MGC119750; MGC119751; protein tyrosine phosphatase, receptor type, D; Protein-tyrosine phosphatase delta; PTP delta; PTPD; PTPdelta; PTP-delta; PTPDMGC119753; PTPRD; receptor type, delta polypeptide; receptor-type tyrosine-protein phosphatase delta; R-PTP-Delta; RPTP-Delta


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