Recombinant Human SUMO Protein Set (1, 2, 3)

100 ug each of rhSUMO1, rhSUMO2, and rhSUMO3
Catalog # Availability Size / Price Qty
K-700
Product Details
FAQs
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Reviews (2)

Recombinant Human SUMO Protein Set (1, 2, 3) Summary

Small Ubiquitin-like Modifiers (SUMOs) are a family of small, related proteins that can be enzymatically attached to a target protein by a post-translational modification process termed SUMOylation. There are four known SUMOs (SUMO1-4). All SUMO proteins share a conserved Ubiquitin domain and a C-terminal diglycine cleavage/attachment site. Following cleavage of a C-terminal prosegment, the C-terminal glycine residue of SUMO is enzymatically attached to a lysine residue on a target protein. In humans, SUMO is conjugated to a variety of molecules in the presence of the SAE1/UBA2 SUMO-activating (E1) enzyme and the UBE2I/Ubc9 SUMO-conjugating (E2) enzyme. In yeast, the SUMO-activating (E1) enzyme is Aos1/Uba2p. SUMOylation can occur without the requirement of a specific SUMO ligase (E3), where SUMO is transferred directly from UBE2I/Ubc9 to specific substrates. Unlike SUMO1, which is usually conjugated to proteins as a monomer, SUMO2 and SUMO3 are known to form high molecular weight polymers on proteins. SUMO precursor processing and deconjugation are catalyzed by a family of cysteine proteases known as SUMO-specific proteases (SENPs) and DeSUMOylating Isopeptidase 1.

Specifications

Shipping Conditions
The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Species
Human

Product Datasheets

Background: SUMO1/2/3

Long Name
Small Ubiquitin-like Modifier 1, 2, & 3
Alternate Names
SUMO1/2/3

Reagents Provided

FAQs

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Reviews for Recombinant Human SUMO Protein Set (1, 2, 3)

Average Rating: 4.5 (Based on 2 Reviews)

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Recombinant Human SUMO Protein Set (1, 2, 3)
By Anonymous on 12/11/2019
Application:

We purchased this SUMO proteins and it turns out they are quiet clean. We ran them on the gel and the protein concentration looks correct. Shipment was great.


Recombinant Human SUMO Protein Set (1, 2, 3)
By Anonymous on 05/09/2018
Application: