Recombinant Mouse HABP1/C1QBP Protein, CF

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Recombinant Mouse HABP1/C1QBP Protein, CF Summary

Product Specifications

>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Level
<0.10 EU per 1 μg of the protein by the LAL method.
Measured by its ability to bind human C1q in a functional ELISA.
E. coli-derived mouse HABP1/C1QBP protein
Met-Met Mouse HABP1
Accession # NP_031599
6-His tag
N-terminus C-terminus
Accession #
N-terminal Sequence
Predicted Molecular Mass
24.8 kDa

Product Datasheets

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Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.


Formulation Lyophilized from a 0.2 μm filtered solution in MOPS and NaCl with Trehalose.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS.
Shipping The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
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Background: HABP1/C1QBP

Hyaluronan binding protein 1 (HABP1), also known as C1qBP/C1qR and p32, is a ubiquitous acidic glycoprotein that functions in spermatogenesis and as a receptor for proinflammatory molecules (1, 2). HABP1 is synthesized with a 71 amino acid (aa) N-terminal preproprotein and a 208 aa mature region (3). The 32 kDa mature mouse HABP1, which contains a MAM33-like sequence, shares 90% and 99% aa sequence identity with human and rat HABP1, respectively. HABP1 assembles into a doughnut shaped trimer, with negatively charged residues asymmetrically distributed on one face lining the channel of the complex (4). HABP1 can be cleaved by cell surface MMP-14/MT1-MMP, a protease important in angiogenesis and tumor metastasis (5). Cell surface HABP1 binds a wide range of extracellular molecules, including hyaluronan, vitronectin, complement component C1q, HMW kininogen, and bacterial and viral proteins (2, 6 - 9). Within the cell, HABP1 binds to molecules containing the C1q globular domain, multiple isoforms of PKC, mitochondrial Hrk, the cytoplasmic tails of adrenergic and GABA-A receptors, the mRNA splicing factor ASF/SF2, and the CBF transcription factor (10 - 16). Apoptosis and direct phosphorylation by Erk1/2 induces HABP1 translocation to the nucleus (17).

  1. Thakur, S.C. et al. (2006) J. Androl. 27:604.
  2. Peerschke, E.I.B. and B. Ghebrehiwet (2007) Immunobiology 212:333.
  3. Lynch, N.J. et al. (1997) FEBS Lett. 418:111.
  4. Jiang, J. et al. (1999) Proc. Natl. Acad. Sci. 96:3572. 
  5. Rozanov, D.V. et al. (2002) J. Biol. Chem. 277:9318. 
  6. Deb, T.B. and K. Datta (1996) J. Biol. Chem. 271:2206. 
  7. Lim, B.L. et al. (1996) J. Biol. Chem. 271:26739. 
  8. Grebrehiwet, B. et al. (1994) J. Exp. Med. 179:1809. 
  9. Waggoner, S.N. et al. (2007) J. Leukoc. Biol. 82 epub. 291:829.
  10. Innamorati, G. et al. (2006) Cell. Signal. 18:761.
  11. Robles-Flores, M. et al. (2002) J. Biol. Chem. 277:5247.
  12. Sunayama, J. et al. (1994) Cell Death Differ. 11:771.
  13. Pupo, A.S. and K.P. Minneman (2003) J. Recept. Signal Transduct. Res. 23:185.
  14. Schaerer, M.T. et al. (2001) J. Biol. Chem. 276:26597.
  15. Peterson-Mahrt, S.K. et al. (1999) EMBO J. 18:1014.
  16. Chattopadhyay, C. et al. (2004) Nucleic Acids Res. 32:3632.
  17. Majumdar, M. et al. (2002) Biochem. Biophys. Res. Commun. 291:829.
Long Name
Hyaluronic Acid-binding Protein
Entrez Gene IDs
708 (Human); 12261 (Mouse)
Alternate Names
C1q globular domain-binding protein; C1QBP; complement component 1 Q subcomponent-binding protein, mitochondrial; complement component 1, q subcomponent binding protein; gC1qBP; GC1q-R protein; gC1qR; gC1Q-R; Glycoprotein gC1qBP; HABP1; HABP1p33; Hyaluronan-binding protein 1; Mitochondrial matrix protein p32; p32; SF2p32; splicing factor SF2-associated protein


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