Recombinant Mouse IL-33 Protein

Carrier Free

Catalog # Availability Size / Price Qty
3626-ML-010/CF

With Carrier

Catalog # Availability Size / Price Qty
3626-ML-010

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Citations (115)
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Recombinant Mouse IL-33 Protein Summary

Product Specifications

Purity
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Level
<0.01 EU per 1 μg of the protein by the LAL method.
Activity
Measured in a cell proliferation assay using D10.G4.1 mouse helper T cells. The ED50 for this effect is 0.0125-0.05 ng/mL.
Source
E. coli-derived mouse IL-33 protein
Ser109-Ile266
Accession #
N-terminal Sequence
Analysis
Ser109
Predicted Molecular Mass
18 kDa
SDS-PAGE
20 kDa, reducing conditions

Product Datasheets

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3626-ML (with carrier)

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3626-ML/CF (carrier free)

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

3626-ML

Formulation Lyophilized from a 0.2 μm filtered solution in PBS, EDTA and DTT with BSA as a carrier protein.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, ≤ -20 °C under sterile conditions after reconstitution.

3626-ML/CF

Formulation Lyophilized from a 0.2 μm filtered solution in PBS, EDTA and DTT.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
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Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: IL-33

IL-33, also known as NF-HEV and DVS 27, is a 30 kDa proinflammatory protein that may also regulate gene transcription (1‑3). DVS 27 was identifed as a gene that is up‑regulated in vasospastic cerebral arteries (1). NF-HEV was described as a nuclear factor that is preferentially expressed in the endothelial cells of high endothelial venules relative to endothelial cells from other tissues (2). IL-33 was identified based on sequence and structural homology with IL-1 family cytokines (3). DVS 27, NF-HEV, and IL-33 share 100% amino acid sequence identity. IL-33 is constitutively expressed in smooth muscle and airway epithelia. It is up‑regulated in arterial smooth muscle, dermal fibroblasts, and keratinocytes following IL-1 alpha or IL‑1 beta stimulation (1, 3). Similar to IL-1, IL-33 can be cleaved in vitro by caspase‑1, generating an N‑terminal fragment that is slightly shorter than the C‑terminal fragment (3, 4). The N‑terminal portion of full length IL-33 contains a predicted bipartite nuclear localization sequence and a homeodomain-like helix-turn-helix DNA binding domain. By immunofluorescence, full length IL-33 localizes to the nucleus in HUVECs and transfectants (2). The C‑terminal fragment, corresponding to mature IL-33, binds and triggers signaling through mast cell IL‑1 R4/ST2L, a longtime orphan receptor involved in the augmentation of Th2 cell responses (3, 5‑7). A ternary signaling complex is formed by the subsequent association of IL-33 and ST2L with IL‑1 RAcP (8). Stimulation of Th2 polarized lymphocytes with mature IL-33 in vitro induces IL-5 and IL-13 secretion (3). In vivo administration of mature IL-33 promotes increased production of IL-5, IL-13, IgE, and IgA, as well as splenomegaly and inflammatory infiltration of mucosal tissues (3). Full length and mature mouse IL-33 share approximately 55% and 90% aa sequence identity with human and rat IL-33, respectively. Mouse IL-33 shares less than 25% aa sequence identity with other IL-1 family proteins.

References
  1. Onda, H. et al. (1999) J. Cereb. Blood Flow Metab. 19:1279.
  2. Baekkevold, E.S. et al. (2003) Am. J. Pathol. 163:69.
  3. Schmitz, J. et al. (2005) Immunity 23:479.
  4. Black, R.A. et al. (1989) J. Biol. Chem. 264:5323.
  5. Xu, D. et al. (1998) J. Exp. Med. 187:787.
  6. Lohning, M. et al. (1998) Proc. Natl. Acad. Sci. 95:6930.
  7. Dinarello, C.A. (2005) Immunity 23:461.
  8. Chackerian, A.A. et al. (2007) J. Immunol. 179:2551.
Long Name
Interleukin 33
Entrez Gene IDs
90865 (Human); 77125 (Mouse)
Alternate Names
C9orf26; C9orf26chromosome 9 open reading frame 26 (NF-HEV); DKFZp586H0523; DVS27; DVS27-related protein; IL1F11; IL-1F11; IL33; IL-33; interleukin 33; Interleukin-1 family member 11; interleukin-33; NFHEV; NF-HEV; NF-HEVNFEHEV; Nuclear factor from high endothelial venules; RP11-575C20.2

Citations for Recombinant Mouse IL-33 Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

115 Citations: Showing 1 - 10
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  1. Acrylamide, an Air Pollutant, Enhances Allergen-Induced Eosinophilic Lung Inflammation via Group 2 Innate Lymphoid Cells
    Authors: Su, HH;Cheng, CM;Yang, YN;Chang, YW;Li, CY;Wu, ST;Lin, CC;Wu, HE;Suen, JL;
    Mucosal immunology
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  2. A tissue-intrinsic IL-33/EGF circuit promotes epithelial regeneration after intestinal injury
    Authors: Calafiore, M;Fu, YY;Vinci, P;Arnhold, V;Chang, WY;Jansen, SA;Egorova, A;Takashima, S;Kuttiyara, J;Ito, T;Serody, J;Nakae, S;Turnquist, H;van Es, J;Clevers, H;Lindemans, CA;Blazar, BR;Hanash, AM;
    Nature communications
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  3. Heat-Labile Enterotoxin Decreases Macrophage Phagocytosis of Enterotoxigenic Escherichia coli
    Authors: Hollifield, IE;Motyka, NI;Fernando, KA;Bitoun, JP;
    Microorganisms
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  4. Differential and cooperative effects of IL-25 and IL-33 on T helper cells contribute to cryptococcal virulence and brain infection
    Authors: Hansakon, A;Jeerawattanawart, S;Angkasekwinai, P;
    Scientific reports
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  5. Steady-state memory-phenotype conventional CD4+ T cells exacerbate autoimmune neuroinflammation in a bystander manner via the Bhlhe40/GM-CSF axis
    Authors: Cho, MJ;Lee, HG;Yoon, JW;Kim, GR;Koo, JH;Taneja, R;Edelson, BT;Lee, YJ;Choi, JM;
    Experimental & molecular medicine
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  6. Maternal gammadelta T�cells shape offspring pulmonary type 2 immunity in a microbiota-dependent manner
    Authors: PH Papotto, B Yilmaz, G Pimenta, S Mensurado, C Cunha, GJ Fiala, D Gomes da C, N Gonçalves-, BHK Chan, B Blankenhau, RG Domingues, T Carvalho, MR Hepworth, AJ Macpherson, JE Allen, B Silva-Sant
    Cell Reports, 2023-02-07;0(0):112074.
    Species: Mouse
    Sample Types: In Vivo, Whole Cells
    Applications: Bioassay, In Vivo
  7. Crosstalk between ILC2s and Th2 cells varies among mouse models
    Authors: RK Gurram, D Wei, Q Yu, MJ Butcher, X Chen, K Cui, G Hu, M Zheng, X Zhu, J Oh, B Sun, JF Urban, K Zhao, WJ Leonard, J Zhu
    Cell Reports, 2023-02-02;42(2):112073.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  8. IL-33 Deficiency Attenuates Lung Inflammation by Inducing Th17 Response and Impacting the Th17/Treg Balance in LPS-Induced ARDS Mice via Dendritic Cells
    Authors: L Cheng, Y Jiao, W Jiang, X Zhang, L Zhang, G Jia
    Journal of Immunology Research, 2022-12-16;2022(0):9543083.
    Species: Mouse, Transgenic Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  9. Maturation and specialization of group 2 innate lymphoid cells through the lung-gut axis
    Authors: M Zhao, F Shao, D Yu, J Zhang, Z Liu, J Ma, P Xia, S Wang
    Nature Communications, 2022-12-09;13(1):7600.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  10. Physiological microbial exposure transiently inhibits mouse lung ILC2 responses to allergens
    Authors: KE Block, K Iijima, MJ Pierson, DA Walsh, R Tei, TA Kucaba, J Xu, MH Khan, C Staley, TS Griffith, HJ McSorley, H Kita, SC Jameson
    Nature Immunology, 2022-11-21;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  11. RNA-binding protein RBM3 intrinsically suppresses lung innate lymphoid cell activation and inflammation partially through CysLT1R
    Authors: JH Badrani, AN Strohm, L Lacasa, B Civello, K Cavagnero, YA Haung, M Amadeo, LH Naji, SJ Lund, A Leng, H Kim, RE Baum, N Khorram, M Mondal, G Seumois, J Pilotte, PW Vanderklis, HM McGee, TA Doherty
    Nature Communications, 2022-07-30;13(1):4435.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  12. IL-23 plays a significant role in the augmentation of particulate matter-mediated allergic airway inflammation
    Authors: HS Lee, HW Park
    Journal of Cellular and Molecular Medicine, 2022-07-08;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  13. IL-7 induces type 2 cytokine response in lung ILC2s and regulates GATA3 and CD25 expression
    Authors: A Sheikh, J Lu, E Melese, JH Seo, N Abraham
    Journal of leukocyte biology, 2022-05-23;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Stimulation
  14. Single-cell analysis identifies the interaction of altered renal tubules with basophils orchestrating kidney fibrosis
    Authors: T Doke, A Abedini, DL Aldridge, YW Yang, J Park, CM Hernandez, MS Balzer, R Shrestra, G Coppock, JMI Rico, SY Han, J Kim, S Xin, AM Piliponsky, M Angelozzi, V Lefebvre, MC Siracusa, CA Hunter, K Susztak
    Nature Immunology, 2022-05-12;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  15. Fasting impairs type 2 helper T cell infiltration in the lung of an eosinophilic asthma mouse model
    Authors: Y Suzuki, T Hayashi, R Yokoyama, F Nakagawa, J Inoue, T Higashi, R Onodera, K Motoyama
    FEBS Open Bio, 2021-08-20;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Bioassay
  16. Neuro-mesenchymal units control ILC2 and obesity via a brain-adipose circuit
    Authors: F Cardoso, RGJ Klein Wolt, C Godinho-Si, RG Domingues, H Ribeiro, JA da Silva, I Mahú, AI Domingos, H Veiga-Fern
    Nature, 2021-08-18;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Bioassay
  17. Myeloid-IL4Ralpha is an indispensable link in IL-33-ILCs-IL-13-IL4Ralpha axis of eosinophil recruitment in murine lungs
    Authors: S Patial, BW Lewis, T Vo, I Choudhary, K Paudel, Y Mao, D Singamsett, F Brombacher, Y Saini
    Scientific Reports, 2021-07-29;11(1):15465.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  18. A role for IL-33-activated ILC2s in eosinophilic vasculitis
    Authors: ME Kotas, J Dion, S Van Dyken, RR Ricardo-Go, CJ Danel, C Taillé, L Mouthon, RM Locksley, B Terrier
    JCI Insight, 2021-06-22;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Bioassay
  19. Serum free culture for the expansion and study of type 2 innate lymphoid cells
    Authors: P de Lucía F, C Sherwood, I Saranchova, W Xia, L Munro, CG Pfeifer, JM Piret, WA Jefferies
    Scientific Reports, 2021-06-10;11(1):12233.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  20. Loss of IL-33 enhances elastase-induced and cigarette smoke extract-induced emphysema in mice
    Authors: D Morichika, A Taniguchi, N Oda, U Fujii, S Senoo, J Itano, A Kanehiro, Y Kitaguchi, M Yasuo, M Hanaoka, T Satoh, S Akira, K Kiura, Y Maeda, N Miyahara
    Respiratory Research, 2021-05-15;22(1):150.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Bioassay
  21. Exogenous oxidative stress suppresses IL-33 -driven proliferation programming in group 2 innate lymphoid cells
    Authors: C Zheng, Z Lu, H Wu, L Cui, J Bi, X Wan
    International immunopharmacology, 2021-03-20;95(0):107541.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Bioassay
  22. Interleukin-33 and thymic stromal lymphopoietin, but not interleukin-25, are crucial for development of airway eosinophilia induced by chitin
    Authors: K Arae, M Ikutani, K Horiguchi, S Yamaguchi, Y Okada, H Sugiyama, K Orimo, H Morita, H Suto, K Okumura, H Taguchi, K Matsumoto, H Saito, K Sudo, S Nakae
    Scientific Reports, 2021-03-15;11(1):5913.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  23. A gene-environment-induced epigenetic program initiates tumorigenesis
    Authors: D Alonso-Cur, YJ Ho, C Burdziak, JLV Maag, JP Morris, R Chandwani, HA Chen, KM Tsanov, FM Barriga, W Luan, N Tasdemir, G Livshits, E Azizi, J Chun, JE Wilkinson, L Mazutis, SD Leach, R Koche, D Pe'er, SW Lowe
    Nature, 2021-02-03;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Bioassay
  24. AMPK induces regulatory innate lymphoid cells after traumatic brain injury
    Authors: B Baban, M Braun, H Khodadadi, A Ward, K Alverson, A Malik, K Nguyen, S Nazarian, DC Hess, S Forseen, AF Post, FL Vale, JR Vender, MN Hoda, O Akbari, K Vaibhav, KM Dhandapani
    JCI Insight, 2021-01-11;6(1):.
    Species: Mouse, Transgenic Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  25. Hyperactivity of Innate Immunity Triggers Pain via TLR2-IL-33-Mediated Neuroimmune Crosstalk
    Authors: J Huang, MA Gandini, L Chen, S M'Dahoma, PL Stemkowski, H Chung, DA Muruve, GW Zamponi
    Cell Rep, 2020-10-06;33(1):108233.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Bioassay
  26. Hippocampal interleukin-33 mediates neuroinflammation-induced cognitive impairments
    Authors: F Reverchon, V de Concini, V Larrigaldi, S Benmerzoug, S Briault, D Togbé, B Ryffel, VFJ Quesniaux, A Menuet
    J Neuroinflammation, 2020-09-11;17(1):268.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Bioassay
  27. Basophils prime group 2 innate lymphoid cells for neuropeptide-mediated inhibition
    Authors: JM Inclan-Ric, JJ Ponessa, N Valero-Pac, CM Hernandez, CB Sy, AD Lemenze, AM Beaulieu, MC Siracusa
    Nat. Immunol., 2020-08-17;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  28. Inflammatory Type 2 cDCs Acquire Features of cDC1s and Macrophages to Orchestrate Immunity to Respiratory Virus Infection.
    Authors: Bosteels C, Neyt K, Vanheerswynghels M, van Helden M, Sichien D, Debeuf N, De Prijck S, Bosteels V, Vandamme N, Martens L, Saeys Y, Louagie E, Lesage M, Williams D, Tang S, Mayer J, Ronchese F, Scott C, Hammad H, Guilliams M, Lambrecht B
    Immunity, 2020-05-08;0(0):.
    Species: Mouse
    Sample Types: Primary Cells
  29. Cancer cell-derived interleukin-33 decoy receptor sST2 enhances orthotopic tumor growth in a murine pancreatic cancer model
    Authors: K Takenaga, M Akimoto, N Koshikawa, H Nagase
    PLoS ONE, 2020-04-27;15(4):e0232230.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  30. Sex-specific adipose tissue imprinting of regulatory T cells
    Authors: A Vasanthaku, D Chisanga, J Blume, R Gloury, K Britt, DC Henstridge, Y Zhan, SV Torres, S Liene, N Collins, E Cao, T Sidwell, C Li, RG Spallanzan, Y Liao, PA Beavis, T Gebhardt, N Trevaskis, SL Nutt, JD Zajac, RA Davey, MA Febbraio, D Mathis, W Shi, A Kallies
    Nature, 2020-02-26;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  31. Tumor-Derived Lactic Acid Contributes to the Paucity of Intratumoral ILC2s
    Authors: M Wagner, KN Ealey, H Tetsu, T Kiniwa, Y Motomura, K Moro, S Koyasu
    Cell Rep, 2020-02-25;30(8):2743-2757.e5.
    Species: Mouse
    Sample Types: In Vivo, Whole Cells
    Applications: Bioassay, In Vivo
  32. ILC2s amplify PD-1 blockade by activating tissue-specific cancer immunity
    Authors: JA Moral, J Leung, LA Rojas, J Ruan, J Zhao, Z Sethna, A Ramnarain, B Gasmi, M Gururajan, D Redmond, G Askan, U Bhanot, E Elyada, Y Park, DA Tuveson, M Gönen, SD Leach, JD Wolchok, RP DeMatteo, T Merghoub, VP Balachandr
    Nature, 2020-02-19;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  33. Nuocytes from mesenteric lymph node promote allergic responses in a mouse model
    Authors: L Lin, X Tang, Z Chen, J Wei, F Dai, G Sun
    Braz J Otorhinolaryngol, 2020-02-12;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  34. Allergic inflammation is initiated by IL-33-dependent crosstalk between mast cells and basophils
    Authors: CL Hsu, KD Chhiba, R Krier-Burr, S Hosakoppal, S Berdnikovs, ML Miller, PJ Bryce
    PLoS ONE, 2020-01-15;15(1):e0226701.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  35. The Prostaglandin D2 Receptor CRTH2 Promotes IL-33-Induced ILC2 Accumulation in the Lung
    Authors: OO Oyesola, C Duque, LC Huang, EM Larson, SP Früh, LM Webb, SA Peng, ED Tait Wojno
    J. Immunol., 2020-01-03;204(4):1001-1011.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  36. Allergin-1 Immunoreceptor Suppresses House Dust Mite-Induced Allergic Airway Inflammation
    Authors: H Miki, S Tahara-Han, MS Almeida, K Hitomi, S Shibagaki, K Kanemaru, YH Lin, K Iwata, S Miyake, S Shibayama, T Sumida, K Shibuya, A Shibuya
    J. Immunol., 2020-01-03;204(4):753-762.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  37. The Putatively Specific Synthetic REV-ERB Agonist SR9009 Inhibits IgE- and IL-33-Mediated Mast Cell Activation Independently of the Circadian Clock
    Authors: K Ishimaru, S Nakajima, G Yu, Y Nakamura, A Nakao
    Int J Mol Sci, 2019-12-14;20(24):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  38. ILC2 transfers to apolipoprotein E deficient mice reduce the lipid content of atherosclerotic lesions
    Authors: PT Mantani, P Dunér, I Ljungcrant, J Nilsson, H Björkbacka, GN Fredrikson
    BMC Immunol., 2019-12-10;20(1):47.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  39. Interleukin-33 delays recovery of mucosal inflammation via downregulation of homeostatic ABCG5/8 in the colon
    Authors: Y Mishima, H Sonoyama, S Ishihara, N Oshima, I Moriyama, K Kawashima, Y Kinoshita
    Lab. Invest., 2019-10-22;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  40. Innate Lymphoid Cells in the Induction of Obesity
    Authors: T Sasaki, K Moro, T Kubota, N Kubota, T Kato, H Ohno, S Nakae, H Saito, S Koyasu
    Cell Rep, 2019-07-02;28(1):202-217.e7.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  41. Th2 cell-derived IL-4/IL-13 promote ILC2 accumulation in the lung by ILC2-intrinsic STAT6 signaling in mice
    Authors: C Symowski, D Voehringer
    Eur. J. Immunol., 2019-06-05;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  42. Sex differences in IL-17 contribute to chronicity in male versus female urinary tract infection
    Authors: A Zychlinsky, M Rousseau, L Lacerda Ma, T Canton, CR Consiglio, ML Albert, M Fontes, D Duffy, MA Ingersoll
    JCI Insight, 2019-05-30;5(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  43. Costimulation Induces CD4�T Cell Antitumor Immunity via an Innate-like Mechanism
    Authors: C Morales De, JR Maxwell, MM Xu, A Menoret, P Mittal, N Tsurutani, AJ Adler, AT Vella
    Cell Rep, 2019-04-30;27(5):1434-1445.e3.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  44. IL-1 and TNF? Contribute to the Inflammatory Niche to Enhance Alveolar Regeneration
    Authors: H Katsura, Y Kobayashi, PR Tata, BLM Hogan
    Stem Cell Reports, 2019-03-28;0(0):.
    Species: Mouse
    Sample Types: Organoids
    Applications: Bioassay
  45. The Tec kinase ITK is essential for ILC2 survival and epithelial integrity in the intestine
    Authors: HS Cho, A Reboldi, JA Hall, LJ Berg
    Nat Commun, 2019-02-15;10(1):784.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  46. IL-33 induction and signaling are controlled by glutaredoxin-1 in mouse macrophages
    Authors: EO Weinberg, B Ferran, Y Tsukahara, MMS Hatch, J Han, CE Murdoch, R Matsui
    PLoS ONE, 2019-01-25;14(1):e0210827.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  47. Innate Sensing through Mesenchymal TLR4/MyD88 Signals Promotes Spontaneous Intestinal Tumorigenesis
    Authors: V Koliaraki, N Chalkidi, A Henriques, C Tzaferis, A Polykratis, A Waisman, W Muller, DJ Hackam, M Pasparakis, G Kollias
    Cell Rep, 2019-01-15;26(3):536-545.e4.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  48. L-type calcium channel-mediated Zinc wave is involved in the regulation of IL-6 by stimulating non-IgE with LPS and IL-33 in mast cells and dendritic cells
    Authors: R Uchida, H Xiang, H Arai, H Kitamura, K Nishida
    Biol. Pharm. Bull., 2018-11-10;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  49. Intestinal helminth infection promotes IL-5- and CD4+ T cell-dependent immunity in the lung against migrating parasites
    Authors: KJ Filbey, M Camberis, J Chandler, R Turner, AJ Kettle, RM Eichenberg, P Giacomin, G Le Gros
    Mucosal Immunol, 2018-11-06;0(0):.
    Species: Mouse
    Sample Types: In Vivo, Whole Cells
    Applications: Bioassay, In Vivo
  50. IL-33 drives the antitumor effects of dendritic cells via the induction of Tc9 cells
    Authors: N Liu, Y Jiang, J Chen, H Nan, Y Zhao, X Chu, A Wang, D Wang, T Qin, S Gao, Q Yi, Y Yue, S Wang
    Cell. Mol. Immunol., 2018-10-01;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  51. Tissue signals imprint ILC2 identity with anticipatory function
    Authors: RR Ricardo-Go, SJ Van Dyken, C Schneider, J Lee, JC Nussbaum, HE Liang, D Vaka, WL Eckalbar, AB Molofsky, DJ Erle, RM Locksley
    Nat. Immunol., 2018-09-10;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  52. Role of IL-18 induced Amphiregulin expression on virus induced ocular lesions
    Authors: SK Varanasi, NK Rajasagi, U Jaggi, BT Rouse
    Mucosal Immunol, 2018-08-07;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  53. IL-33/ST2 plays a critical role in endothelial cell activation and microglia-mediated neuroinflammation modulation
    Authors: K Cao, X Liao, J Lu, S Yao, F Wu, X Zhu, D Shi, S Wen, L Liu, H Zhou
    J Neuroinflammation, 2018-05-04;15(1):136.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  54. Interleukin-18 Amplifies Macrophage Polarization and Morphological Alteration, Leading to Excessive Angiogenesis
    Authors: T Kobori, S Hamasaki, A Kitaura, Y Yamazaki, T Nishinaka, A Niwa, S Nakao, H Wake, S Mori, T Yoshino, M Nishibori, H Takahashi
    Front Immunol, 2018-03-06;9(0):334.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  55. Characterization and allergic role of IL-33-induced neutrophil polarization
    Authors: B Sun, L Zhu, Y Tao, HX Sun, Y Li, P Wang, Y Hou, Y Zhao, X Zhang, L Zhang, N Na, Y Zhao
    Cell. Mol. Immunol., 2018-03-05;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  56. The effects of IL-33 on airways collagen deposition and matrix metalloproteinase expression in a murine surrogate of asthma
    Authors: G An, X Zhang, W Wang, Q Huang, Y Li, S Shan, CJ Corrigan, W Wang, S Ying
    Immunology, 2018-02-18;0(0):.
    Species: Mouse
    Sample Types: In Vivo, Whole Cells
    Applications: Bioassay, In Vivo
  57. E3 Ligase VHL Promotes Group 2 Innate Lymphoid Cell Maturation and Function via Glycolysis Inhibition and Induction of Interleukin-33 Receptor
    Authors: Q Li, D Li, X Zhang, Q Wan, W Zhang, M Zheng, L Zou, C Elly, JH Lee, YC Liu
    Immunity, 2018-02-13;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  58. Airway inflammation after epicutaneous sensitization of mice requires protease activity of low-dose allergen inhalation
    Authors: I Nishioka, T Takai, N Maruyama, S Kamijo, P Suchiva, M Suzuki, S Kunimine, H Ochi, S Shimura, K Sudo, H Ogawa, K Okumura, S Ikeda
    J. Allergy Clin. Immunol., 2018-02-06;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  59. Modulation of the IL-33/IL-13 Axis in Obesity by IL-13R?2
    Authors: J Duffen, M Zhang, K Masek-Hamm, A Nunez, A Brennan, JEC Jones, J Morin, K Nocka, M Kasaian
    J. Immunol., 2018-01-05;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  60. Macrophages regulate lung ILC2 activation via Pla2g5-dependent mechanisms
    Authors: M Yamaguchi, SK Samuchiwal, O Quehenberg, JA Boyce, B Balestrier
    Mucosal Immunol, 2017-12-20;11(3):615-626.
    Species: Mouse
    Sample Types: In Vivo, Whole Cells
    Applications: Bioassay, In Vivo
  61. Neuronal regulation of type 2 innate lymphoid cells via neuromedin U
    Authors: V Cardoso, J Chesné, H Ribeiro, B García-Cas, T Carvalho, T Bouchery, K Shah, NL Barbosa-Mo, N Harris, H Veiga-Fern
    Nature, 2017-09-06;549(7671):277-281.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  62. IL-33 Signaling Regulates Innate IL-17A and IL-22 Production via Suppression of Prostaglandin E2 during Lung Fungal Infection
    Authors: JM Garth, KM Reeder, MS Godwin, JJ Mackel, CW Dunaway, JP Blackburn, C Steele
    J. Immunol., 2017-08-07;199(6):2140-2148.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  63. The Innate Cytokines IL-25, IL-33, and TSLP Cooperate in the Induction of Type 2 Innate Lymphoid Cell Expansion and Mucous Metaplasia in Rhinovirus-Infected Immature Mice
    Authors: M Han, C Rajput, JY Hong, J Lei, JL Hinde, Q Wu, JK Bentley, MB Hershenson
    J. Immunol., 2017-07-12;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  64. PD-1 regulates KLRG1(+) group 2 innate lymphoid cells
    Authors: S Taylor, Y Huang, G Mallett, C Stathopoul, TC Felizardo, MA Sun, EL Martin, N Zhu, EL Woodward, MS Elias, J Scott, NJ Reynolds, WE Paul, DH Fowler, S Amarnath
    J. Exp. Med., 2017-05-10;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  65. IL-33 receptor ST2 regulates the cognitive impairments associated with experimental cerebral malaria
    Authors: F Reverchon, S Mortaud, M Sivoyon, I Maillet, A Laugeray, J Palomo, C Montécot, A Herzine, S Meme, W Meme, F Erard, B Ryffel, A Menuet, VFJ Quesniaux
    PLoS Pathog., 2017-04-27;13(4):e1006322.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  66. Disruption of the TWEAK/Fn14 pathway prevents 5-fluorouracil-induced diarrhea in mice
    Authors: T Sezaki, Y Hirata, T Hagiwara, YI Kawamura, T Okamura, R Takanashi, K Nakano, M Tamura-Nak, LC Burkly, T Dohi
    World J. Gastroenterol., 2017-04-07;23(13):2294-2307.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  67. Prolonged activation of IL-5-producing ILC2 causes pulmonary arterial hypertrophy
    Authors: M Ikutani, K Tsuneyama, M Kawaguchi, J Fukuoka, F Kudo, S Nakae, M Arita, Y Nagai, S Takaki, K Takatsu
    JCI Insight, 2017-04-06;2(7):e90721.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  68. NK Cells Alleviate Lung Inflammation by Negatively Regulating Group 2 Innate Lymphoid Cells
    Authors: J Bi, L Cui, G Yu, X Yang, Y Chen, X Wan
    J. Immunol, 2017-03-08;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  69. Notch Inhibition Enhances Cardiac Reprogramming by Increasing MEF2C Transcriptional Activity
    Authors: M Abad, H Hashimoto, H Zhou, MG Morales, B Chen, R Bassel-Dub, EN Olson
    Stem Cell Reports, 2017-03-02;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  70. Interleukin-33 drives hepatic fibrosis through activation of hepatic stellate cells
    Authors: Z Tan, Q Liu, R Jiang, L Lv, SS Shoto, I Maillet, V Quesniaux, J Tang, W Zhang, B Sun, B Ryffel
    Cell. Mol. Immunol, 2017-02-13;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  71. Leukotrienes provide an NFAT-dependent signal that synergizes with IL-33 to activate ILC2s
    Authors: Jakob von Moltke
    J. Exp. Med, 2016-12-23;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  72. Interleukin-33 and RANK-L Interplay in the Alveolar Bone Loss Associated to Periodontitis
    PLoS ONE, 2016-12-19;11(12):e0168080.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  73. Basophils promote tumor rejection via chemotaxis and infiltration of CD8+ T cells
    Cancer Res., 2016-11-22;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  74. A Proinflammatory Role of Type 2 Innate Lymphoid Cells in Murine Immune-Mediated Hepatitis
    Authors: Gisa Tiegs
    J. Immunol., 2016-11-21;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  75. IL-33/ST2 signaling excites sensory neurons and mediates itch response in a mouse model of poison ivy contact allergy
    Proc. Natl. Acad. Sci. U.S.A., 2016-11-07;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  76. In Vivo Expansion of Activated Foxp3+ Regulatory T Cells and Establishment of a Type 2 Immune Response upon IL-33 Treatment Protect against Experimental Arthritis
    J Immunol, 2016-07-29;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  77. IL-33 Contributes to Schistosoma japonicum-induced Hepatic Pathology through Induction of M2 Macrophages
    Sci Rep, 2016-07-21;6(0):29844.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  78. Glial-cell-derived neuroregulators control type 3 innate lymphoid cells and gut defence
    Nature, 2016-07-13;535(7612):440-3.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  79. Dopaminergic Toxin 1-Methyl-4-Phenylpyridinium, Proteins alpha-Synuclein and Glia Maturation Factor Activate Mast Cells and Release Inflammatory Mediators.
    Authors: Kempuraj D, Thangavel R, Yang E, Pattani S, Zaheer S, Santillan D, Santillan M, Zaheer A
    PLoS ONE, 2015-08-14;10(8):e0135776.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  80. IL-33 promotes an innate immune pathway of intestinal tissue protection dependent on amphiregulin-EGFR interactions.
    Authors: Monticelli L, Osborne L, Noti M, Tran S, Zaiss D, Artis D
    Proc Natl Acad Sci U S A, 2015-08-04;112(34):10762-7.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  81. Group 2 innate lymphoid cells utilize the IRF4-IL-9 module to coordinate epithelial cell maintenance of lung homeostasis.
    Authors: Mohapatra A, Van Dyken S, Schneider C, Nussbaum J, Liang H, Locksley R
    Mucosal Immunol, 2015-07-01;9(1):275-86.
    Species: Mouse
    Sample Types: In Vivo, Tissue Homogenates
    Applications: In Vivo, Western Blot
  82. IL-33 receptor ST2 amplifies the expansion of NK cells and enhances host defense during mouse cytomegalovirus infection.
    Authors: Nabekura T, Girard J, Lanier L
    J Immunol, 2015-04-29;194(12):5948-52.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  83. Eosinophil-associated ribonuclease 11 is a macrophage chemoattractant.
    Authors: Yamada K, Barker T, Dyer K, Rice T, Percopo C, Garcia-Crespo K, Cho S, Lee J, Druey K, Rosenberg H
    J Biol Chem, 2015-02-20;290(14):8863-75.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  84. Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity.
    Authors: Brestoff, Jonathan, Kim, Brian S, Saenz, Steven A, Stine, Rachel R, Monticelli, Laurel A, Sonnenberg, Gregory, Thome, Joseph J, Farber, Donna L, Lutfy, Kabirull, Seale, Patrick, Artis, David
    Nature, 2014-12-22;519(7542):242-6.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  85. Platelet-derived growth factor primes cancer-associated fibroblasts for apoptosis.
    Authors: Rizvi S, Mertens J, Bronk S, Hirsova P, Dai H, Roberts L, Kaufmann S, Gores G
    J Biol Chem, 2014-06-27;289(33):22835-49.
    Species: Mouse
    Sample Types: Whole Organism
    Applications: In Vivo
  86. Airway uric acid is a sensor of inhaled protease allergens and initiates type 2 immune responses in respiratory mucosa.
    Authors: Hara K, Iijima K, Elias M, Seno S, Tojima I, Kobayashi T, Kephart G, Kurabayashi M, Kita H
    J Immunol, 2014-03-24;192(9):4032-42.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  87. Blockade of IL-33 release and suppression of type 2 innate lymphoid cell responses by helminth secreted products in airway allergy.
    Authors: McSorley H, Blair N, Smith K, McKenzie A, Maizels R
    Mucosal Immunol, 2014-02-05;7(5):1068-78.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  88. TNF superfamily member TL1A elicits type 2 innate lymphoid cells at mucosal barriers.
    Authors: Yu, X, Pappu, R, Ramirez-Carrozzi, V, Ota, N, Caplazi, P, Zhang, J, Yan, D, Xu, M, Lee, W P, Grogan, J L
    Mucosal Immunol, 2013-11-13;7(3):730-40.
    Species: Mouse
    Sample Types: In Vivo, Whole Cells
    Applications: Bioassay, In Vivo
  89. Bee venom phospholipase A2 induces a primary type 2 response that is dependent on the receptor ST2 and confers protective immunity.
    Authors: Palm N, Rosenstein R, Yu S, Schenten D, Florsheim E, Medzhitov R
    Immunity, 2013-10-24;39(5):976-85.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  90. Interleukin-33/ST2 axis promotes breast cancer growth and metastases by facilitating intratumoral accumulation of immunosuppressive and innate lymphoid cells.
    Authors: Jovanovic I, Pejnovic N, Radosavljevic G, Pantic J, Milovanovic M, Arsenijevic N, Lukic M
    Int J Cancer, 2013-10-10;134(7):1669-82.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  91. Control of T helper 2 responses by transcription factor IRF4-dependent dendritic cells.
    Authors: Gao Y, Nish S, Jiang R, Hou L, Licona-Limon P, Weinstein J, Zhao H, Medzhitov R
    Immunity, 2013-09-26;39(4):722-32.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  92. Murine mast cells secrete and respond to interleukin-33.
    Authors: Tung, Hui-Ying, Plunkett, Beverly, Huang, Shau-Ku, Zhou, Yufeng
    J Interferon Cytokine Res, 2013-09-12;34(3):141-7.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  93. Interleukin-33 and alveolar macrophages contribute to the mechanisms underlying the exacerbation of IgE-mediated airway inflammation and remodelling in mice.
    Authors: Mizutani N, Nabe T, Yoshino S
    Immunology, 2013-06-01;139(2):205-18.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  94. Macrophages as IL-25/IL-33-responsive cells play an important role in the induction of type 2 immunity.
    Authors: Yang Z, Grinchuk V, Urban J, Bohl J, Sun R, Notari L, Yan S, Ramalingam T, Keegan A, Wynn T, Shea-Donohue T, Zhao A
    2013-03-25;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  95. IL-33 causes selective mast cell tolerance to bacterial cell wall products by inducing IRAK1 degradation.
    Authors: Sandig H, Jobbings C, Roldan N, Whittingham-Dowd J, Orinska Z, Takeuchi O, Akira S, Bulfone-Paus S
    Eur J Immunol, 2013-03-06;43(4):979-88.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  96. Interleukin-33 primes mast cells for activation by IgG immune complexes.
    Authors: Kaieda S, Wang J, Shnayder R, Fishgal N, Hei H, Lee R, Stevens R, Nigrovic P
    PLoS ONE, 2012-10-11;7(10):e47252.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  97. Interleukin-1alpha controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33.
    J. Exp. Med., 2012-07-16;209(8):1505-17.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  98. Regulation of innate CD8+ T-cell activation mediated by cytokines.
    Proc Natl Acad Sci U S A, 2012-06-04;109(25):9971-6.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  99. Pulmonary innate lymphoid cells are major producers of IL-5 and IL-13 in murine models of allergic asthma.
    Authors: Wolterink RG, KleinJan A, van Nimwegen M, Bergen I, de Bruijn M, Levani Y, Hendriks RW
    Eur. J. Immunol., 2012-05-01;42(5):1106-16.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  100. Antigen-independent differentiation and maintenance of effector-like resident memory T cells in tissues.
    Authors: Casey KA, Fraser KA, Schenkel JM, Moran A, Abt MC, Beura LK, Lucas PJ, Artis D, Wherry EJ, Hogquist K, Vezys V, Masopust D
    J. Immunol., 2012-04-13;188(10):4866-75.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  101. IL-33-responsive lineage- CD25+ CD44(hi) lymphoid cells mediate innate type 2 immunity and allergic inflammation in the lungs.
    Authors: Bartemes KR, Iijima K, Kobayashi T, Kephart GM, McKenzie AN, Kita H
    J. Immunol., 2011-12-23;188(3):1503-13.
    Species: Mouse
    Sample Types: In Vivo, Whole Cells
    Applications: Bioassay, In Vivo
  102. Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus.
    Authors: Monticelli LA, Sonnenberg GF, Abt MC
    Nat. Immunol., 2011-11-01;12(11):1045-54.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  103. Intravenous gammaglobulin suppresses inflammation through a novel Th2 pathway.
    Authors: Anthony RM, Kobayashi T, Wermeling F, Ravetch JV
    Nature, 2011-06-19;475(7354):110-3.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  104. IL-33-activated dendritic cells are critical for allergic airway inflammation.
    Authors: Besnard AG, Togbe D, Guillou N, Erard F, Quesniaux V, Ryffel B
    Eur. J. Immunol., 2011-05-25;41(6):1675-86.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  105. Endogenous IL-33 enhances Th2 cytokine production and T-cell responses during allergic airway inflammation.
    Authors: Louten J, Rankin AL, Li Y
    Int. Immunol., 2011-03-21;23(5):307-15.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  106. Production and functions of IL-33 in the central nervous system.
    Authors: Yasuoka S, Kawanokuchi J, Parajuli B, Jin S, Doi Y, Noda M, Sonobe Y, Takeuchi H, Mizuno T, Suzumura A
    Brain Res., 2011-02-22;1385(0):8-17.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  107. A natural protective function of invariant NKT cells in a mouse model of innate-cell-driven lung inflammation.
    Authors: Bourgeois EA, Levescot A, Diem S, Chauvineau A, Berges H, Milpied P, Lehuen A, Damotte D, Gombert JM, Schneider E, Girard JP, Gourdy P, Herbelin A
    Eur. J. Immunol., 2011-01-11;41(2):299-305.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  108. Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus.
    Authors: Kayamuro H, Yoshioka Y, Abe Y, Arita S, Katayama K, Nomura T, Yoshikawa T, Kubota-Koketsu R, Ikuta K, Okamoto S, Mori Y, Kunisawa J, Kiyono H, Itoh N, Nagano K, Kamada H, Tsutsumi Y, Tsunoda S
    J. Virol., 2010-09-29;84(24):12703-12.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  109. Systemically dispersed innate IL-13-expressing cells in type 2 immunity.
    Authors: Price AE, Liang HE, Sullivan BM
    Proc. Natl. Acad. Sci. U.S.A., 2010-06-07;107(25):11489-94.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  110. Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity.
    Authors: Neill DR, Wong SH, Bellosi A, Flynn RJ, Daly M, Langford TK, Bucks C, Kane CM, Fallon PG, Pannell R, Jolin HE, McKenzie AN
    Nature, 2010-03-03;464(7293):1367-70.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  111. Caspase-1, caspase-8, and calpain are dispensable for IL-33 release by macrophages.
    Authors: Ohno T, Oboki K, Kajiwara N, Morii E, Aozasa K, Flavell RA, Okumura K, Saito H, Nakae S
    J. Immunol., 2009-12-15;183(12):7890-7.
    Species: Mouse
    Sample Types: N/A, Whole Cells
    Applications: Bioassay, ELISA (Standard)
  112. MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent immunity.
    Authors: Perrigoue JG, Saenz SA, Siracusa MC, Allenspach EJ, Taylor BC, Giacomin PR, Nair MG, Du Y, Zaph C, Van Rooijen N, Comeau MR, Pearce EJ, Laufer TM, Artis D
    Nat. Immunol., 2009-05-24;10(7):697-705.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  113. The pro-Th2 cytokine IL-33 directly interacts with invariant NKT and NK cells to induce IFN-gamma production.
    Authors: Bourgeois E, Van LP, Samson M, Diem S, Barra A, Roga S, Gombert JM, Schneider E, Dy M, Gourdy P, Girard JP, Herbelin A
    Eur. J. Immunol., 2009-04-01;39(4):1046-55.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  114. Inhibition of interleukin-33 signaling attenuates the severity of experimental arthritis.
    Authors: Palmer G, Talabot-Ayer D, Lamacchia C, Toy D, Seemayer CA, Viatte S, Finckh A, Smith DE, Gabay C
    Arthritis Rheum., 2009-03-01;60(3):738-49.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  115. Induction of IL-33 expression and activity in central nervous system glia.
    Authors: Hudson CA, Christophi GP, Gruber RC, Wilmore JR, Lawrence DA, Massa PT
    J. Leukoc. Biol., 2008-06-13;84(3):631-43.
    Species: Mouse
    Sample Types: N/A, Whole Cells
    Applications: Bioassay, ELISA (Standard)

FAQs

  1. Has R&D Systems conducted testing to determine the half life or other details, such as administration or dosing, of this protein in an in vivo setting?

    • We do not perform any in vivo testing, therefore, details relating to half-life, administration, or dosing should be verified within the available literature. Specific references pertaining to this product used in an in vivo setting can be found in the Citations tab on this product page - the results can be filtered by application of interest.

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Reviews for Recombinant Mouse IL-33 Protein

Average Rating: 4.7 (Based on 9 Reviews)

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Recombinant Mouse IL-33 Protein
By Do-Hyun Kim on 09/27/2022
Application: In vivo study

Recombinant Mouse IL-33 Protein
By Anonymous on 10/19/2021
Application: In vivo study

Recombinant Mouse IL-33 Protein
By Anonymous on 04/17/2020
Application: In vivo study
Reason for Rating: Works as described.

Recombinant Mouse IL-33 Protein
By Anonymous on 09/16/2019
Application: ELISA positive control

Recombinant Mouse IL-33 Protein
By Nicole Brown on 01/07/2019

Reason for Rating: Used as a positive control on western blot; able to detect as little as 0.25ug; higher concentrations result in very large, saturated bands

Western blot used to confirm IL-33 knockout in mice; kidney samples from WT, +/-, and -/- IL-33 mice were prepared and blotted


Recombinant Mouse IL-33 Protein
By Anonymous on 05/15/2018
Application: Immunoassay Standard

Recombinant Mouse IL-33 Protein
By Mehdi Alavi on 05/14/2018
Application: Immunoassay Standard

Recombinant Mouse IL-33 Protein
By Anonymous on 02/12/2018
Application: Characterization prior to use.
Reason for Rating: Single peak at correct MW observed.

Recombinant Mouse IL-33 Protein
By Anonymous on 05/18/2016
Application: Cell migration/motility