Recombinant Mouse IL-33 Protein
Recombinant Mouse IL-33 Protein Summary
Ser109-Ile266
Analysis
Product Datasheets
Carrier Free
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
3626-ML
Formulation | Lyophilized from a 0.2 μm filtered solution in PBS, EDTA and DTT with BSA as a carrier protein. |
Reconstitution | Reconstitute at 10 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin. |
Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
Stability & Storage: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
3626-ML/CF
Formulation | Lyophilized from a 0.2 μm filtered solution in PBS, EDTA and DTT. |
Reconstitution | Reconstitute at 100 μg/mL in sterile PBS. |
Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. |
Stability & Storage: | Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
Reconstitution Calculator
Background: IL-33
IL-33, also known as NF-HEV and DVS 27, is a 30 kDa proinflammatory protein that may also regulate gene transcription (1‑3). DVS 27 was identifed as a gene that is up‑regulated in vasospastic cerebral arteries (1). NF-HEV was described as a nuclear factor that is preferentially expressed in the endothelial cells of high endothelial venules relative to endothelial cells from other tissues (2). IL-33 was identified based on sequence and structural homology with IL-1 family cytokines (3). DVS 27, NF-HEV, and IL-33 share 100% amino acid sequence identity. IL-33 is constitutively expressed in smooth muscle and airway epithelia. It is up‑regulated in arterial smooth muscle, dermal fibroblasts, and keratinocytes following IL-1 alpha or IL‑1 beta stimulation (1, 3). Similar to IL-1, IL-33 can be cleaved in vitro by caspase‑1, generating an N‑terminal fragment that is slightly shorter than the C‑terminal fragment (3, 4). The N‑terminal portion of full length IL-33 contains a predicted bipartite nuclear localization sequence and a homeodomain-like helix-turn-helix DNA binding domain. By immunofluorescence, full length IL-33 localizes to the nucleus in HUVECs and transfectants (2). The C‑terminal fragment, corresponding to mature IL-33, binds and triggers signaling through mast cell IL‑1 R4/ST2L, a longtime orphan receptor involved in the augmentation of Th2 cell responses (3, 5‑7). A ternary signaling complex is formed by the subsequent association of IL-33 and ST2L with IL‑1 RAcP (8). Stimulation of Th2 polarized lymphocytes with mature IL-33 in vitro induces IL-5 and IL-13 secretion (3). In vivo administration of mature IL-33 promotes increased production of IL-5, IL-13, IgE, and IgA, as well as splenomegaly and inflammatory infiltration of mucosal tissues (3). Full length and mature mouse IL-33 share approximately 55% and 90% aa sequence identity with human and rat IL-33, respectively. Mouse IL-33 shares less than 25% aa sequence identity with other IL-1 family proteins.
- Onda, H. et al. (1999) J. Cereb. Blood Flow Metab. 19:1279.
- Baekkevold, E.S. et al. (2003) Am. J. Pathol. 163:69.
- Schmitz, J. et al. (2005) Immunity 23:479.
- Black, R.A. et al. (1989) J. Biol. Chem. 264:5323.
- Xu, D. et al. (1998) J. Exp. Med. 187:787.
- Lohning, M. et al. (1998) Proc. Natl. Acad. Sci. 95:6930.
- Dinarello, C.A. (2005) Immunity 23:461.
- Chackerian, A.A. et al. (2007) J. Immunol. 179:2551.
Citations for Recombinant Mouse IL-33 Protein
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Cancer cell-derived interleukin-33 decoy receptor sST2 enhances orthotopic tumor growth in a murine pancreatic cancer model
Authors: K Takenaga, M Akimoto, N Koshikawa, H Nagase
PLoS ONE, 2020;15(4):e0232230.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
Allergic inflammation is initiated by IL-33-dependent crosstalk between mast cells and basophils
Authors: CL Hsu, KD Chhiba, R Krier-Burr, S Hosakoppal, S Berdnikovs, ML Miller, PJ Bryce
PLoS ONE, 2020;15(1):e0226701.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
IL-33 induction and signaling are controlled by glutaredoxin-1 in mouse macrophages
Authors: EO Weinberg, B Ferran, Y Tsukahara, MMS Hatch, J Han, CE Murdoch, R Matsui
PLoS ONE, 2019;14(1):e0210827.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
IL-1 and TNF? Contribute to the Inflammatory Niche to Enhance Alveolar Regeneration
Authors: H Katsura, Y Kobayashi, PR Tata, BLM Hogan
Stem Cell Reports, 2019;0(0):.
Species: Mouse
Sample Types: Organoids
Applications: Bioassay -
Innate Sensing through Mesenchymal TLR4/MyD88 Signals Promotes Spontaneous Intestinal Tumorigenesis
Authors: V Koliaraki, N Chalkidi, A Henriques, C Tzaferis, A Polykratis, A Waisman, W Muller, DJ Hackam, M Pasparakis, G Kollias
Cell Rep, 2019;26(3):536-545.e4.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Costimulation Induces CD4�T Cell Antitumor Immunity via an Innate-like Mechanism
Authors: C Morales De, JR Maxwell, MM Xu, A Menoret, P Mittal, N Tsurutani, AJ Adler, AT Vella
Cell Rep, 2019;27(5):1434-1445.e3.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The Tec kinase ITK is essential for ILC2 survival and epithelial integrity in the intestine
Authors: HS Cho, A Reboldi, JA Hall, LJ Berg
Nat Commun, 2019;10(1):784.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
ILC2 transfers to apolipoprotein E deficient mice reduce the lipid content of atherosclerotic lesions
Authors: PT Mantani, P Dunér, I Ljungcrant, J Nilsson, H Björkbacka, GN Fredrikson
BMC Immunol., 2019;20(1):47.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Interleukin-33 delays recovery of mucosal inflammation via downregulation of homeostatic ABCG5/8 in the colon
Authors: Y Mishima, H Sonoyama, S Ishihara, N Oshima, I Moriyama, K Kawashima, Y Kinoshita
Lab. Invest., 2019;0(0):.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
The Putatively Specific Synthetic REV-ERB Agonist SR9009 Inhibits IgE- and IL-33-Mediated Mast Cell Activation Independently of the Circadian Clock
Authors: K Ishimaru, S Nakajima, G Yu, Y Nakamura, A Nakao
Int J Mol Sci, 2019;20(24):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Modulation of the IL-33/IL-13 Axis in Obesity by IL-13R?2
Authors: J Duffen, M Zhang, K Masek-Hamm, A Nunez, A Brennan, JEC Jones, J Morin, K Nocka, M Kasaian
J. Immunol., 2018;0(0):.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
IL-33 drives the antitumor effects of dendritic cells via the induction of Tc9 cells
Authors: N Liu, Y Jiang, J Chen, H Nan, Y Zhao, X Chu, A Wang, D Wang, T Qin, S Gao, Q Yi, Y Yue, S Wang
Cell. Mol. Immunol., 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Role of IL-18 induced Amphiregulin expression on virus induced ocular lesions
Authors: SK Varanasi, NK Rajasagi, U Jaggi, BT Rouse
Mucosal Immunol, 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
L-type calcium channel-mediated Zinc wave is involved in the regulation of IL-6 by stimulating non-IgE with LPS and IL-33 in mast cells and dendritic cells
Authors: R Uchida, H Xiang, H Arai, H Kitamura, K Nishida
Biol. Pharm. Bull., 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Macrophages regulate lung ILC2 activation via Pla2g5-dependent mechanisms
Authors: M Yamaguchi, SK Samuchiwal, O Quehenberg, JA Boyce, B Balestrier
Mucosal Immunol, 2018;11(3):615-626.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
IL-33/ST2 plays a critical role in endothelial cell activation and microglia-mediated neuroinflammation modulation
Authors: K Cao, X Liao, J Lu, S Yao, F Wu, X Zhu, D Shi, S Wen, L Liu, H Zhou
J Neuroinflammation, 2018;15(1):136.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Tissue signals imprint ILC2 identity with anticipatory function
Authors: RR Ricardo-Go, SJ Van Dyken, C Schneider, J Lee, JC Nussbaum, HE Liang, D Vaka, WL Eckalbar, AB Molofsky, DJ Erle, RM Locksley
Nat. Immunol., 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Intestinal helminth infection promotes IL-5- and CD4+ T cell-dependent immunity in the lung against migrating parasites
Authors: KJ Filbey, M Camberis, J Chandler, R Turner, AJ Kettle, RM Eichenberg, P Giacomin, G Le Gros
Mucosal Immunol, 2018;0(0):.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Interleukin-18 Amplifies Macrophage Polarization and Morphological Alteration, Leading to Excessive Angiogenesis
Authors: T Kobori, S Hamasaki, A Kitaura, Y Yamazaki, T Nishinaka, A Niwa, S Nakao, H Wake, S Mori, T Yoshino, M Nishibori, H Takahashi
Front Immunol, 2018;9(0):334.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Characterization and allergic role of IL-33-induced neutrophil polarization
Authors: B Sun, L Zhu, Y Tao, HX Sun, Y Li, P Wang, Y Hou, Y Zhao, X Zhang, L Zhang, N Na, Y Zhao
Cell. Mol. Immunol., 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The effects of IL-33 on airways collagen deposition and matrix metalloproteinase expression in a murine surrogate of asthma
Authors: G An, X Zhang, W Wang, Q Huang, Y Li, S Shan, CJ Corrigan, W Wang, S Ying
Immunology, 2018;0(0):.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Airway inflammation after epicutaneous sensitization of mice requires protease activity of low-dose allergen inhalation
Authors: I Nishioka, T Takai, N Maruyama, S Kamijo, P Suchiva, M Suzuki, S Kunimine, H Ochi, S Shimura, K Sudo, H Ogawa, K Okumura, S Ikeda
J. Allergy Clin. Immunol., 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Cell Culture -
E3 Ligase VHL Promotes Group 2 Innate Lymphoid Cell Maturation and Function via Glycolysis Inhibition and Induction of Interleukin-33 Receptor
Authors: Q Li, D Li, X Zhang, Q Wan, W Zhang, M Zheng, L Zou, C Elly, JH Lee, YC Liu
Immunity, 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Notch Inhibition Enhances Cardiac Reprogramming by Increasing MEF2C Transcriptional Activity
Authors: M Abad, H Hashimoto, H Zhou, MG Morales, B Chen, R Bassel-Dub, EN Olson
Stem Cell Reports, 2017;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Disruption of the TWEAK/Fn14 pathway prevents 5-fluorouracil-induced diarrhea in mice
Authors: T Sezaki, Y Hirata, T Hagiwara, YI Kawamura, T Okamura, R Takanashi, K Nakano, M Tamura-Nak, LC Burkly, T Dohi
World J. Gastroenterol., 2017;23(13):2294-2307.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
IL-33 receptor ST2 regulates the cognitive impairments associated with experimental cerebral malaria
Authors: F Reverchon, S Mortaud, M Sivoyon, I Maillet, A Laugeray, J Palomo, C Montécot, A Herzine, S Meme, W Meme, F Erard, B Ryffel, A Menuet, VFJ Quesniaux
PLoS Pathog., 2017;13(4):e1006322.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Prolonged activation of IL-5-producing ILC2 causes pulmonary arterial hypertrophy
Authors: M Ikutani, K Tsuneyama, M Kawaguchi, J Fukuoka, F Kudo, S Nakae, M Arita, Y Nagai, S Takaki, K Takatsu
JCI Insight, 2017;2(7):e90721.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Interleukin-33 drives hepatic fibrosis through activation of hepatic stellate cells
Authors: Z Tan, Q Liu, R Jiang, L Lv, SS Shoto, I Maillet, V Quesniaux, J Tang, W Zhang, B Sun, B Ryffel
Cell. Mol. Immunol, 2017;0(0):.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Neuronal regulation of type 2 innate lymphoid cells via neuromedin U
Authors: V Cardoso, J Chesné, H Ribeiro, B García-Cas, T Carvalho, T Bouchery, K Shah, NL Barbosa-Mo, N Harris, H Veiga-Fern
Nature, 2017;549(7671):277-281.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
IL-33 Signaling Regulates Innate IL-17A and IL-22 Production via Suppression of Prostaglandin E2 during Lung Fungal Infection
Authors: JM Garth, KM Reeder, MS Godwin, JJ Mackel, CW Dunaway, JP Blackburn, C Steele
J. Immunol., 2017;199(6):2140-2148.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
PD-1 regulates KLRG1(+) group 2 innate lymphoid cells
Authors: S Taylor, Y Huang, G Mallett, C Stathopoul, TC Felizardo, MA Sun, EL Martin, N Zhu, EL Woodward, MS Elias, J Scott, NJ Reynolds, WE Paul, DH Fowler, S Amarnath
J. Exp. Med., 2017;0(0):.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
NK Cells Alleviate Lung Inflammation by Negatively Regulating Group 2 Innate Lymphoid Cells
Authors: J Bi, L Cui, G Yu, X Yang, Y Chen, X Wan
J. Immunol, 2017;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
The Innate Cytokines IL-25, IL-33, and TSLP Cooperate in the Induction of Type 2 Innate Lymphoid Cell Expansion and Mucous Metaplasia in Rhinovirus-Infected Immature Mice
Authors: M Han, C Rajput, JY Hong, J Lei, JL Hinde, Q Wu, JK Bentley, MB Hershenson
J. Immunol., 2017;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
In Vivo Expansion of Activated Foxp3+ Regulatory T Cells and Establishment of a Type 2 Immune Response upon IL-33 Treatment Protect against Experimental Arthritis
J Immunol, 2016;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Basophils promote tumor rejection via chemotaxis and infiltration of CD8+ T cells
Cancer Res., 2016;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Interleukin-33 and RANK-L Interplay in the Alveolar Bone Loss Associated to Periodontitis
PLoS ONE, 2016;11(12):e0168080.
Species: Mouse
Sample Types: Whole Tissue
Applications: Bioassay -
IL-33 Contributes to Schistosoma japonicum-induced Hepatic Pathology through Induction of M2 Macrophages
Sci Rep, 2016;6(0):29844.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
IL-33/ST2 signaling excites sensory neurons and mediates itch response in a mouse model of poison ivy contact allergy
Proc. Natl. Acad. Sci. U.S.A., 2016;0(0):.
Species: Mouse
Sample Types: In Vivo
Applications: Neutralization -
Glial-cell-derived neuroregulators control type 3 innate lymphoid cells and gut defence
Nature, 2016;535(7612):440-3.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
A Proinflammatory Role of Type 2 Innate Lymphoid Cells in Murine Immune-Mediated Hepatitis
Authors: Gisa Tiegs
J. Immunol., 2016;0(0):.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Leukotrienes provide an NFAT-dependent signal that synergizes with IL-33 to activate ILC2s
Authors: Jakob von Moltke
J. Exp. Med, 2016;0(0):.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
IL-33 promotes an innate immune pathway of intestinal tissue protection dependent on amphiregulin-EGFR interactions.
Authors: Monticelli L, Osborne L, Noti M, Tran S, Zaiss D, Artis D
Proc Natl Acad Sci U S A, 2015;112(34):10762-7.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity.
Authors: Brestoff, Jonathan, Kim, Brian S, Saenz, Steven A, Stine, Rachel R, Monticelli, Laurel A, Sonnenberg, Gregory, Thome, Joseph J, Farber, Donna L, Lutfy, Kabirull, Seale, Patrick, Artis, David
Nature, 2015;519(7542):242-6.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
IL-33 receptor ST2 amplifies the expansion of NK cells and enhances host defense during mouse cytomegalovirus infection.
Authors: Nabekura T, Girard J, Lanier L
J Immunol, 2015;194(12):5948-52.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Dopaminergic Toxin 1-Methyl-4-Phenylpyridinium, Proteins alpha-Synuclein and Glia Maturation Factor Activate Mast Cells and Release Inflammatory Mediators.
Authors: Kempuraj D, Thangavel R, Yang E, Pattani S, Zaheer S, Santillan D, Santillan M, Zaheer A
PLoS ONE, 2015;10(8):e0135776.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Eosinophil-associated ribonuclease 11 is a macrophage chemoattractant.
Authors: Yamada K, Barker T, Dyer K, Rice T, Percopo C, Garcia-Crespo K, Cho S, Lee J, Druey K, Rosenberg H
J Biol Chem, 2015;290(14):8863-75.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Airway uric acid is a sensor of inhaled protease allergens and initiates type 2 immune responses in respiratory mucosa.
Authors: Hara K, Iijima K, Elias M, Seno S, Tojima I, Kobayashi T, Kephart G, Kurabayashi M, Kita H
J Immunol, 2014;192(9):4032-42.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Interleukin-33/ST2 axis promotes breast cancer growth and metastases by facilitating intratumoral accumulation of immunosuppressive and innate lymphoid cells.
Authors: Jovanovic I, Pejnovic N, Radosavljevic G, Pantic J, Milovanovic M, Arsenijevic N, Lukic M
Int J Cancer, 2014;134(7):1669-82.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
TNF superfamily member TL1A elicits type 2 innate lymphoid cells at mucosal barriers.
Authors: Yu, X, Pappu, R, Ramirez-Carrozzi, V, Ota, N, Caplazi, P, Zhang, J, Yan, D, Xu, M, Lee, W P, Grogan, J L
Mucosal Immunol, 2014;7(3):730-40.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Murine mast cells secrete and respond to interleukin-33.
Authors: Tung, Hui-Ying, Plunkett, Beverly, Huang, Shau-Ku, Zhou, Yufeng
J Interferon Cytokine Res, 2014;34(3):141-7.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Blockade of IL-33 release and suppression of type 2 innate lymphoid cell responses by helminth secreted products in airway allergy.
Authors: McSorley H, Blair N, Smith K, McKenzie A, Maizels R
Mucosal Immunol, 2014;7(5):1068-78.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Platelet-derived growth factor primes cancer-associated fibroblasts for apoptosis.
Authors: Rizvi S, Mertens J, Bronk S, Hirsova P, Dai H, Roberts L, Kaufmann S, Gores G
J Biol Chem, 2014;289(33):22835-49.
Species: Mouse
Sample Types: Whole Organism
Applications: In Vivo -
Bee venom phospholipase A2 induces a primary type 2 response that is dependent on the receptor ST2 and confers protective immunity.
Authors: Palm N, Rosenstein R, Yu S, Schenten D, Florsheim E, Medzhitov R
Immunity, 2013;39(5):976-85.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Interleukin-33 and alveolar macrophages contribute to the mechanisms underlying the exacerbation of IgE-mediated airway inflammation and remodelling in mice.
Authors: Mizutani N, Nabe T, Yoshino S
Immunology, 2013;139(2):205-18.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
IL-33 causes selective mast cell tolerance to bacterial cell wall products by inducing IRAK1 degradation.
Authors: Sandig H, Jobbings C, Roldan N, Whittingham-Dowd J, Orinska Z, Takeuchi O, Akira S, Bulfone-Paus S
Eur J Immunol, 2013;43(4):979-88.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Control of T helper 2 responses by transcription factor IRF4-dependent dendritic cells.
Authors: Gao Y, Nish S, Jiang R, Hou L, Licona-Limon P, Weinstein J, Zhao H, Medzhitov R
Immunity, 2013;39(4):722-32.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Macrophages as IL-25/IL-33-responsive cells play an important role in the induction of type 2 immunity.
Authors: Yang Z, Grinchuk V, Urban J, Bohl J, Sun R, Notari L, Yan S, Ramalingam T, Keegan A, Wynn T, Shea-Donohue T, Zhao A
, 2013;0(0):.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Antigen-independent differentiation and maintenance of effector-like resident memory T cells in tissues.
Authors: Casey KA, Fraser KA, Schenkel JM, Moran A, Abt MC, Beura LK, Lucas PJ, Artis D, Wherry EJ, Hogquist K, Vezys V, Masopust D
J. Immunol., 2012;188(10):4866-75.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Pulmonary innate lymphoid cells are major producers of IL-5 and IL-13 in murine models of allergic asthma.
Authors: Wolterink RG, KleinJan A, van Nimwegen M, Bergen I, de Bruijn M, Levani Y, Hendriks RW
Eur. J. Immunol., 2012;42(5):1106-16.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Interleukin-1alpha controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33.
J. Exp. Med., 2012;209(8):1505-17.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Interleukin-33 primes mast cells for activation by IgG immune complexes.
Authors: Kaieda S, Wang J, Shnayder R, Fishgal N, Hei H, Lee R, Stevens R, Nigrovic P
PLoS ONE, 2012;7(10):e47252.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Regulation of innate CD8+ T-cell activation mediated by cytokines.
Proc Natl Acad Sci U S A, 2012;109(25):9971-6.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
IL-33-activated dendritic cells are critical for allergic airway inflammation.
Authors: Besnard AG, Togbe D, Guillou N, Erard F, Quesniaux V, Ryffel B
Eur. J. Immunol., 2011;41(6):1675-86.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Intravenous gammaglobulin suppresses inflammation through a novel Th2 pathway.
Authors: Anthony RM, Kobayashi T, Wermeling F, Ravetch JV
Nature, 2011;475(7354):110-3.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Endogenous IL-33 enhances Th2 cytokine production and T-cell responses during allergic airway inflammation.
Authors: Louten J, Rankin AL, Li Y
Int. Immunol., 2011;23(5):307-15.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
IL-33-responsive lineage- CD25+ CD44(hi) lymphoid cells mediate innate type 2 immunity and allergic inflammation in the lungs.
Authors: Bartemes KR, Iijima K, Kobayashi T, Kephart GM, McKenzie AN, Kita H
J. Immunol., 2011;188(3):1503-13.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
A natural protective function of invariant NKT cells in a mouse model of innate-cell-driven lung inflammation.
Authors: Bourgeois EA, Levescot A, Diem S, Chauvineau A, Berges H, Milpied P, Lehuen A, Damotte D, Gombert JM, Schneider E, Girard JP, Gourdy P, Herbelin A
Eur. J. Immunol., 2011;41(2):299-305.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus.
Authors: Monticelli LA, Sonnenberg GF, Abt MC
Nat. Immunol., 2011;12(11):1045-54.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Production and functions of IL-33 in the central nervous system.
Authors: Yasuoka S, Kawanokuchi J, Parajuli B, Jin S, Doi Y, Noda M, Sonobe Y, Takeuchi H, Mizuno T, Suzumura A
Brain Res., 2011;1385(0):8-17.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus.
Authors: Kayamuro H, Yoshioka Y, Abe Y, Arita S, Katayama K, Nomura T, Yoshikawa T, Kubota-Koketsu R, Ikuta K, Okamoto S, Mori Y, Kunisawa J, Kiyono H, Itoh N, Nagano K, Kamada H, Tsutsumi Y, Tsunoda S
J. Virol., 2010;84(24):12703-12.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity.
Authors: Neill DR, Wong SH, Bellosi A, Flynn RJ, Daly M, Langford TK, Bucks C, Kane CM, Fallon PG, Pannell R, Jolin HE, McKenzie AN
Nature, 2010;464(7293):1367-70.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Systemically dispersed innate IL-13-expressing cells in type 2 immunity.
Authors: Price AE, Liang HE, Sullivan BM
Proc. Natl. Acad. Sci. U.S.A., 2010;107(25):11489-94.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
The pro-Th2 cytokine IL-33 directly interacts with invariant NKT and NK cells to induce IFN-gamma production.
Authors: Bourgeois E, Van LP, Samson M, Diem S, Barra A, Roga S, Gombert JM, Schneider E, Dy M, Gourdy P, Girard JP, Herbelin A
Eur. J. Immunol., 2009;39(4):1046-55.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Inhibition of interleukin-33 signaling attenuates the severity of experimental arthritis.
Authors: Palmer G, Talabot-Ayer D, Lamacchia C, Toy D, Seemayer CA, Viatte S, Finckh A, Smith DE, Gabay C
Arthritis Rheum., 2009;60(3):738-49.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent immunity.
Authors: Perrigoue JG, Saenz SA, Siracusa MC, Allenspach EJ, Taylor BC, Giacomin PR, Nair MG, Du Y, Zaph C, Van Rooijen N, Comeau MR, Pearce EJ, Laufer TM, Artis D
Nat. Immunol., 2009;10(7):697-705.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Caspase-1, caspase-8, and calpain are dispensable for IL-33 release by macrophages.
Authors: Ohno T, Oboki K, Kajiwara N, Morii E, Aozasa K, Flavell RA, Okumura K, Saito H, Nakae S
J. Immunol., 2009;183(12):7890-7.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Induction of IL-33 expression and activity in central nervous system glia.
Authors: Hudson CA, Christophi GP, Gruber RC, Wilmore JR, Lawrence DA, Massa PT
J. Leukoc. Biol., 2008;84(3):631-43.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Group 2 innate lymphoid cells utilize the IRF4-IL-9 module to coordinate epithelial cell maintenance of lung homeostasis.
Authors: Mohapatra A, Van Dyken S, Schneider C, Nussbaum J, Liang H, Locksley R
Mucosal Immunol, 0;9(1):275-86.
Species: Mouse
Sample Types: In Vivo
Applications: In Vivo -
Inflammatory Type 2 cDCs Acquire Features of cDC1s and Macrophages to Orchestrate Immunity to Respiratory Virus Infection.
Authors: Bosteels C, Neyt K, Vanheerswynghels M, van Helden M, Sichien D, Debeuf N, De Prijck S, Bosteels V, Vandamme N, Martens L, Saeys Y, Louagie E, Lesage M, Williams D, Tang S, Mayer J, Ronchese F, Scott C, Hammad H, Guilliams M, Lambrecht B
Immunity, 0;0(0):.
Species: Mouse
Sample Types: Primary Cells
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Average Rating: 4.6 (Based on 7 Reviews)
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Reason for Rating: Works as described.
Reason for Rating: Used as a positive control on western blot; able to detect as little as 0.25ug; higher concentrations result in very large, saturated bands
Western blot used to confirm IL-33 knockout in mice; kidney samples from WT, +/-, and -/- IL-33 mice were prepared and blotted
Reason for Rating: Single peak at correct MW observed.