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Recombinant Mouse IL-33 Protein

3626-ML 100 Citations 8 Reviews Datasheet / COA / SDS

Carrier Free

Catalog # Availability Size / Price Qty
3626-ML-010/CF

With Carrier

Catalog # Availability Size / Price Qty
3626-ML-010
R&D Systems Recombinant Proteins and Enzymes
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Product Details
Citations (100)
FAQs
Reviews (8)
Summary Product Datasheets Carrier Free Data Images Reconstitution Calculator Background Related Research Areas

Recombinant Mouse IL-33 Protein Summary

Product Specifications

Purity
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Level
<0.01 EU per 1 μg of the protein by the LAL method.
Activity
Measured in a cell proliferation assay using D10.G4.1 mouse helper T cells. The ED50 for this effect is 0.0125-0.05 ng/mL.
Source
E. coli-derived mouse IL-33 protein
Ser109-Ile266
Accession #
Q8BVZ5
N-terminal Sequence
Analysis
Ser109
Predicted Molecular Mass
18 kDa
SDS-PAGE
20 kDa, reducing conditions

Product Datasheets

3626-ML (with carrier)

Product Datasheet
COA
SDS

3626-ML/CF (carrier free)

Product Datasheet
COA
SDS

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

3626-ML

Formulation Lyophilized from a 0.2 μm filtered solution in PBS, EDTA and DTT with BSA as a carrier protein.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, ≤ -20 °C under sterile conditions after reconstitution.

3626-ML/CF

Formulation Lyophilized from a 0.2 μm filtered solution in PBS, EDTA and DTT.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: IL-33

IL-33, also known as NF-HEV and DVS 27, is a 30 kDa proinflammatory protein that may also regulate gene transcription (1‑3). DVS 27 was identifed as a gene that is up‑regulated in vasospastic cerebral arteries (1). NF-HEV was described as a nuclear factor that is preferentially expressed in the endothelial cells of high endothelial venules relative to endothelial cells from other tissues (2). IL-33 was identified based on sequence and structural homology with IL-1 family cytokines (3). DVS 27, NF-HEV, and IL-33 share 100% amino acid sequence identity. IL-33 is constitutively expressed in smooth muscle and airway epithelia. It is up‑regulated in arterial smooth muscle, dermal fibroblasts, and keratinocytes following IL-1 alpha or IL‑1 beta stimulation (1, 3). Similar to IL-1, IL-33 can be cleaved in vitro by caspase‑1, generating an N‑terminal fragment that is slightly shorter than the C‑terminal fragment (3, 4). The N‑terminal portion of full length IL-33 contains a predicted bipartite nuclear localization sequence and a homeodomain-like helix-turn-helix DNA binding domain. By immunofluorescence, full length IL-33 localizes to the nucleus in HUVECs and transfectants (2). The C‑terminal fragment, corresponding to mature IL-33, binds and triggers signaling through mast cell IL‑1 R4/ST2L, a longtime orphan receptor involved in the augmentation of Th2 cell responses (3, 5‑7). A ternary signaling complex is formed by the subsequent association of IL-33 and ST2L with IL‑1 RAcP (8). Stimulation of Th2 polarized lymphocytes with mature IL-33 in vitro induces IL-5 and IL-13 secretion (3). In vivo administration of mature IL-33 promotes increased production of IL-5, IL-13, IgE, and IgA, as well as splenomegaly and inflammatory infiltration of mucosal tissues (3). Full length and mature mouse IL-33 share approximately 55% and 90% aa sequence identity with human and rat IL-33, respectively. Mouse IL-33 shares less than 25% aa sequence identity with other IL-1 family proteins.

References
  1. Onda, H. et al. (1999) J. Cereb. Blood Flow Metab. 19:1279.
  2. Baekkevold, E.S. et al. (2003) Am. J. Pathol. 163:69.
  3. Schmitz, J. et al. (2005) Immunity 23:479.
  4. Black, R.A. et al. (1989) J. Biol. Chem. 264:5323.
  5. Xu, D. et al. (1998) J. Exp. Med. 187:787.
  6. Lohning, M. et al. (1998) Proc. Natl. Acad. Sci. 95:6930.
  7. Dinarello, C.A. (2005) Immunity 23:461.
  8. Chackerian, A.A. et al. (2007) J. Immunol. 179:2551.
Long Name
Interleukin 33
Entrez Gene IDs
90865 (Human); 77125 (Mouse)
Alternate Names
C9orf26; C9orf26chromosome 9 open reading frame 26 (NF-HEV); DKFZp586H0523; DVS27; DVS27-related protein; IL1F11; IL-1F11; IL33; IL-33; interleukin 33; Interleukin-1 family member 11; interleukin-33; NFHEV; NF-HEV; NF-HEVNFEHEV; Nuclear factor from high endothelial venules; RP11-575C20.2

Citations for Recombinant Mouse IL-33 Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

100 Citations: Showing 1 - 10
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  1. Exogenous oxidative stress suppresses IL-33 -driven proliferation programming in group 2 innate lymphoid cells
    Authors: C Zheng, Z Lu, H Wu, L Cui, J Bi, X Wan
    International immunopharmacology, 2021;95(0):107541.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Bioassay
  2. A role for IL-33-activated ILC2s in eosinophilic vasculitis
    Authors: ME Kotas, J Dion, S Van Dyken, RR Ricardo-Go, CJ Danel, C Taillé, L Mouthon, RM Locksley, B Terrier
    JCI Insight, 2021;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Bioassay
  3. Serum free culture for the expansion and study of type 2 innate lymphoid cells
    Authors: P de Lucía F, C Sherwood, I Saranchova, W Xia, L Munro, CG Pfeifer, JM Piret, WA Jefferies
    Scientific Reports, 2021;11(1):12233.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  4. A gene-environment-induced epigenetic program initiates tumorigenesis
    Authors: D Alonso-Cur, YJ Ho, C Burdziak, JLV Maag, JP Morris, R Chandwani, HA Chen, KM Tsanov, FM Barriga, W Luan, N Tasdemir, G Livshits, E Azizi, J Chun, JE Wilkinson, L Mazutis, SD Leach, R Koche, D Pe'er, SW Lowe
    Nature, 2021;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Bioassay
  5. Myeloid-IL4Ralpha is an indispensable link in IL-33-ILCs-IL-13-IL4Ralpha axis of eosinophil recruitment in murine lungs
    Authors: S Patial, BW Lewis, T Vo, I Choudhary, K Paudel, Y Mao, D Singamsett, F Brombacher, Y Saini
    Scientific Reports, 2021;11(1):15465.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  6. Fasting impairs type 2 helper T cell infiltration in the lung of an eosinophilic asthma mouse model
    Authors: Y Suzuki, T Hayashi, R Yokoyama, F Nakagawa, J Inoue, T Higashi, R Onodera, K Motoyama
    FEBS Open Bio, 2021;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Bioassay
  7. Interleukin-33 and thymic stromal lymphopoietin, but not interleukin-25, are crucial for development of airway eosinophilia induced by chitin
    Authors: K Arae, M Ikutani, K Horiguchi, S Yamaguchi, Y Okada, H Sugiyama, K Orimo, H Morita, H Suto, K Okumura, H Taguchi, K Matsumoto, H Saito, K Sudo, S Nakae
    Scientific Reports, 2021;11(1):5913.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  8. Neuro-mesenchymal units control ILC2 and obesity via a brain-adipose circuit
    Authors: F Cardoso, RGJ Klein Wolt, C Godinho-Si, RG Domingues, H Ribeiro, JA da Silva, I Mahú, AI Domingos, H Veiga-Fern
    Nature, 2021;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Bioassay
  9. Loss of IL-33 enhances elastase-induced and cigarette smoke extract-induced emphysema in mice
    Authors: D Morichika, A Taniguchi, N Oda, U Fujii, S Senoo, J Itano, A Kanehiro, Y Kitaguchi, M Yasuo, M Hanaoka, T Satoh, S Akira, K Kiura, Y Maeda, N Miyahara
    Respiratory Research, 2021;22(1):150.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Bioassay
  10. AMPK induces regulatory innate lymphoid cells after traumatic brain injury
    Authors: B Baban, M Braun, H Khodadadi, A Ward, K Alverson, A Malik, K Nguyen, S Nazarian, DC Hess, S Forseen, AF Post, FL Vale, JR Vender, MN Hoda, O Akbari, K Vaibhav, KM Dhandapani
    JCI Insight, 2021;6(1):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  11. The Prostaglandin D2 Receptor CRTH2 Promotes IL-33-Induced ILC2 Accumulation in the Lung
    Authors: OO Oyesola, C Duque, LC Huang, EM Larson, SP Früh, LM Webb, SA Peng, ED Tait Wojno
    J. Immunol., 2020;204(4):1001-1011.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  12. Hippocampal interleukin-33 mediates neuroinflammation-induced cognitive impairments
    Authors: F Reverchon, V de Concini, V Larrigaldi, S Benmerzoug, S Briault, D Togbé, B Ryffel, VFJ Quesniaux, A Menuet
    J Neuroinflammation, 2020;17(1):268.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Bioassay
  13. Nuocytes from mesenteric lymph node promote allergic responses in a mouse model
    Authors: L Lin, X Tang, Z Chen, J Wei, F Dai, G Sun
    Braz J Otorhinolaryngol, 2020;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  14. ILC2s amplify PD-1 blockade by activating tissue-specific cancer immunity
    Authors: JA Moral, J Leung, LA Rojas, J Ruan, J Zhao, Z Sethna, A Ramnarain, B Gasmi, M Gururajan, D Redmond, G Askan, U Bhanot, E Elyada, Y Park, DA Tuveson, M Gönen, SD Leach, JD Wolchok, RP DeMatteo, T Merghoub, VP Balachandr
    Nature, 2020;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  15. Basophils prime group 2 innate lymphoid cells for neuropeptide-mediated inhibition
    Authors: JM Inclan-Ric, JJ Ponessa, N Valero-Pac, CM Hernandez, CB Sy, AD Lemenze, AM Beaulieu, MC Siracusa
    Nat. Immunol., 2020;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  16. Cancer cell-derived interleukin-33 decoy receptor sST2 enhances orthotopic tumor growth in a murine pancreatic cancer model
    Authors: K Takenaga, M Akimoto, N Koshikawa, H Nagase
    PLoS ONE, 2020;15(4):e0232230.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  17. Allergic inflammation is initiated by IL-33-dependent crosstalk between mast cells and basophils
    Authors: CL Hsu, KD Chhiba, R Krier-Burr, S Hosakoppal, S Berdnikovs, ML Miller, PJ Bryce
    PLoS ONE, 2020;15(1):e0226701.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  18. Hyperactivity of Innate Immunity Triggers Pain via TLR2-IL-33-Mediated Neuroimmune Crosstalk
    Authors: J Huang, MA Gandini, L Chen, S M'Dahoma, PL Stemkowski, H Chung, DA Muruve, GW Zamponi
    Cell Rep, 2020;33(1):108233.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Bioassay
  19. Sex-specific adipose tissue imprinting of regulatory T cells
    Authors: A Vasanthaku, D Chisanga, J Blume, R Gloury, K Britt, DC Henstridge, Y Zhan, SV Torres, S Liene, N Collins, E Cao, T Sidwell, C Li, RG Spallanzan, Y Liao, PA Beavis, T Gebhardt, N Trevaskis, SL Nutt, JD Zajac, RA Davey, MA Febbraio, D Mathis, W Shi, A Kallies
    Nature, 2020;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  20. Tumor-Derived Lactic Acid Contributes to the Paucity of Intratumoral ILC2s
    Authors: M Wagner, KN Ealey, H Tetsu, T Kiniwa, Y Motomura, K Moro, S Koyasu
    Cell Rep, 2020;30(8):2743-2757.e5.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  21. Costimulation Induces CD4�T Cell Antitumor Immunity via an Innate-like Mechanism
    Authors: C Morales De, JR Maxwell, MM Xu, A Menoret, P Mittal, N Tsurutani, AJ Adler, AT Vella
    Cell Rep, 2019;27(5):1434-1445.e3.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  22. Innate Sensing through Mesenchymal TLR4/MyD88 Signals Promotes Spontaneous Intestinal Tumorigenesis
    Authors: V Koliaraki, N Chalkidi, A Henriques, C Tzaferis, A Polykratis, A Waisman, W Muller, DJ Hackam, M Pasparakis, G Kollias
    Cell Rep, 2019;26(3):536-545.e4.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  23. IL-1 and TNF? Contribute to the Inflammatory Niche to Enhance Alveolar Regeneration
    Authors: H Katsura, Y Kobayashi, PR Tata, BLM Hogan
    Stem Cell Reports, 2019;0(0):.
    Species: Mouse
    Sample Types: Organoids
    Applications: Bioassay
  24. Interleukin-33 delays recovery of mucosal inflammation via downregulation of homeostatic ABCG5/8 in the colon
    Authors: Y Mishima, H Sonoyama, S Ishihara, N Oshima, I Moriyama, K Kawashima, Y Kinoshita
    Lab. Invest., 2019;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  25. ILC2 transfers to apolipoprotein E deficient mice reduce the lipid content of atherosclerotic lesions
    Authors: PT Mantani, P Dunér, I Ljungcrant, J Nilsson, H Björkbacka, GN Fredrikson
    BMC Immunol., 2019;20(1):47.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  26. The Putatively Specific Synthetic REV-ERB Agonist SR9009 Inhibits IgE- and IL-33-Mediated Mast Cell Activation Independently of the Circadian Clock
    Authors: K Ishimaru, S Nakajima, G Yu, Y Nakamura, A Nakao
    Int J Mol Sci, 2019;20(24):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  27. Sex differences in IL-17 contribute to chronicity in male versus female urinary tract infection
    Authors: A Zychlinsky, M Rousseau, L Lacerda Ma, T Canton, CR Consiglio, ML Albert, M Fontes, D Duffy, MA Ingersoll
    JCI Insight, 2019;5(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  28. Innate Lymphoid Cells in the Induction of Obesity
    Authors: T Sasaki, K Moro, T Kubota, N Kubota, T Kato, H Ohno, S Nakae, H Saito, S Koyasu
    Cell Rep, 2019;28(1):202-217.e7.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  29. The Tec kinase ITK is essential for ILC2 survival and epithelial integrity in the intestine
    Authors: HS Cho, A Reboldi, JA Hall, LJ Berg
    Nat Commun, 2019;10(1):784.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  30. IL-33 induction and signaling are controlled by glutaredoxin-1 in mouse macrophages
    Authors: EO Weinberg, B Ferran, Y Tsukahara, MMS Hatch, J Han, CE Murdoch, R Matsui
    PLoS ONE, 2019;14(1):e0210827.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  31. Th2 cell-derived IL-4/IL-13 promote ILC2 accumulation in the lung by ILC2-intrinsic STAT6 signaling in mice
    Authors: C Symowski, D Voehringer
    Eur. J. Immunol., 2019;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  32. Intestinal helminth infection promotes IL-5- and CD4+ T cell-dependent immunity in the lung against migrating parasites
    Authors: KJ Filbey, M Camberis, J Chandler, R Turner, AJ Kettle, RM Eichenberg, P Giacomin, G Le Gros
    Mucosal Immunol, 2018;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  33. IL-33/ST2 plays a critical role in endothelial cell activation and microglia-mediated neuroinflammation modulation
    Authors: K Cao, X Liao, J Lu, S Yao, F Wu, X Zhu, D Shi, S Wen, L Liu, H Zhou
    J Neuroinflammation, 2018;15(1):136.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  34. L-type calcium channel-mediated Zinc wave is involved in the regulation of IL-6 by stimulating non-IgE with LPS and IL-33 in mast cells and dendritic cells
    Authors: R Uchida, H Xiang, H Arai, H Kitamura, K Nishida
    Biol. Pharm. Bull., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  35. Role of IL-18 induced Amphiregulin expression on virus induced ocular lesions
    Authors: SK Varanasi, NK Rajasagi, U Jaggi, BT Rouse
    Mucosal Immunol, 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  36. IL-33 drives the antitumor effects of dendritic cells via the induction of Tc9 cells
    Authors: N Liu, Y Jiang, J Chen, H Nan, Y Zhao, X Chu, A Wang, D Wang, T Qin, S Gao, Q Yi, Y Yue, S Wang
    Cell. Mol. Immunol., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  37. Macrophages regulate lung ILC2 activation via Pla2g5-dependent mechanisms
    Authors: M Yamaguchi, SK Samuchiwal, O Quehenberg, JA Boyce, B Balestrier
    Mucosal Immunol, 2018;11(3):615-626.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  38. Interleukin-18 Amplifies Macrophage Polarization and Morphological Alteration, Leading to Excessive Angiogenesis
    Authors: T Kobori, S Hamasaki, A Kitaura, Y Yamazaki, T Nishinaka, A Niwa, S Nakao, H Wake, S Mori, T Yoshino, M Nishibori, H Takahashi
    Front Immunol, 2018;9(0):334.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  39. The effects of IL-33 on airways collagen deposition and matrix metalloproteinase expression in a murine surrogate of asthma
    Authors: G An, X Zhang, W Wang, Q Huang, Y Li, S Shan, CJ Corrigan, W Wang, S Ying
    Immunology, 2018;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  40. Modulation of the IL-33/IL-13 Axis in Obesity by IL-13R?2
    Authors: J Duffen, M Zhang, K Masek-Hamm, A Nunez, A Brennan, JEC Jones, J Morin, K Nocka, M Kasaian
    J. Immunol., 2018;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  41. Airway inflammation after epicutaneous sensitization of mice requires protease activity of low-dose allergen inhalation
    Authors: I Nishioka, T Takai, N Maruyama, S Kamijo, P Suchiva, M Suzuki, S Kunimine, H Ochi, S Shimura, K Sudo, H Ogawa, K Okumura, S Ikeda
    J. Allergy Clin. Immunol., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  42. Characterization and allergic role of IL-33-induced neutrophil polarization
    Authors: B Sun, L Zhu, Y Tao, HX Sun, Y Li, P Wang, Y Hou, Y Zhao, X Zhang, L Zhang, N Na, Y Zhao
    Cell. Mol. Immunol., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  43. Tissue signals imprint ILC2 identity with anticipatory function
    Authors: RR Ricardo-Go, SJ Van Dyken, C Schneider, J Lee, JC Nussbaum, HE Liang, D Vaka, WL Eckalbar, AB Molofsky, DJ Erle, RM Locksley
    Nat. Immunol., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  44. E3 Ligase VHL Promotes Group 2 Innate Lymphoid Cell Maturation and Function via Glycolysis Inhibition and Induction of Interleukin-33 Receptor
    Authors: Q Li, D Li, X Zhang, Q Wan, W Zhang, M Zheng, L Zou, C Elly, JH Lee, YC Liu
    Immunity, 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  45. Disruption of the TWEAK/Fn14 pathway prevents 5-fluorouracil-induced diarrhea in mice
    Authors: T Sezaki, Y Hirata, T Hagiwara, YI Kawamura, T Okamura, R Takanashi, K Nakano, M Tamura-Nak, LC Burkly, T Dohi
    World J. Gastroenterol., 2017;23(13):2294-2307.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  46. Neuronal regulation of type 2 innate lymphoid cells via neuromedin U
    Authors: V Cardoso, J Chesné, H Ribeiro, B García-Cas, T Carvalho, T Bouchery, K Shah, NL Barbosa-Mo, N Harris, H Veiga-Fern
    Nature, 2017;549(7671):277-281.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  47. PD-1 regulates KLRG1(+) group 2 innate lymphoid cells
    Authors: S Taylor, Y Huang, G Mallett, C Stathopoul, TC Felizardo, MA Sun, EL Martin, N Zhu, EL Woodward, MS Elias, J Scott, NJ Reynolds, WE Paul, DH Fowler, S Amarnath
    J. Exp. Med., 2017;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  48. NK Cells Alleviate Lung Inflammation by Negatively Regulating Group 2 Innate Lymphoid Cells
    Authors: J Bi, L Cui, G Yu, X Yang, Y Chen, X Wan
    J. Immunol, 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  49. The Innate Cytokines IL-25, IL-33, and TSLP Cooperate in the Induction of Type 2 Innate Lymphoid Cell Expansion and Mucous Metaplasia in Rhinovirus-Infected Immature Mice
    Authors: M Han, C Rajput, JY Hong, J Lei, JL Hinde, Q Wu, JK Bentley, MB Hershenson
    J. Immunol., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  50. IL-33 Signaling Regulates Innate IL-17A and IL-22 Production via Suppression of Prostaglandin E2 during Lung Fungal Infection
    Authors: JM Garth, KM Reeder, MS Godwin, JJ Mackel, CW Dunaway, JP Blackburn, C Steele
    J. Immunol., 2017;199(6):2140-2148.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  51. Prolonged activation of IL-5-producing ILC2 causes pulmonary arterial hypertrophy
    Authors: M Ikutani, K Tsuneyama, M Kawaguchi, J Fukuoka, F Kudo, S Nakae, M Arita, Y Nagai, S Takaki, K Takatsu
    JCI Insight, 2017;2(7):e90721.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  52. Interleukin-33 drives hepatic fibrosis through activation of hepatic stellate cells
    Authors: Z Tan, Q Liu, R Jiang, L Lv, SS Shoto, I Maillet, V Quesniaux, J Tang, W Zhang, B Sun, B Ryffel
    Cell. Mol. Immunol, 2017;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  53. Notch Inhibition Enhances Cardiac Reprogramming by Increasing MEF2C Transcriptional Activity
    Authors: M Abad, H Hashimoto, H Zhou, MG Morales, B Chen, R Bassel-Dub, EN Olson
    Stem Cell Reports, 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  54. IL-33 receptor ST2 regulates the cognitive impairments associated with experimental cerebral malaria
    Authors: F Reverchon, S Mortaud, M Sivoyon, I Maillet, A Laugeray, J Palomo, C Montécot, A Herzine, S Meme, W Meme, F Erard, B Ryffel, A Menuet, VFJ Quesniaux
    PLoS Pathog., 2017;13(4):e1006322.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  55. Interleukin-33 and RANK-L Interplay in the Alveolar Bone Loss Associated to Periodontitis
    PLoS ONE, 2016;11(12):e0168080.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  56. Glial-cell-derived neuroregulators control type 3 innate lymphoid cells and gut defence
    Nature, 2016;535(7612):440-3.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  57. IL-33/ST2 signaling excites sensory neurons and mediates itch response in a mouse model of poison ivy contact allergy
    Proc. Natl. Acad. Sci. U.S.A., 2016;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  58. In Vivo Expansion of Activated Foxp3+ Regulatory T Cells and Establishment of a Type 2 Immune Response upon IL-33 Treatment Protect against Experimental Arthritis
    J Immunol, 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  59. Basophils promote tumor rejection via chemotaxis and infiltration of CD8+ T cells
    Cancer Res., 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  60. Leukotrienes provide an NFAT-dependent signal that synergizes with IL-33 to activate ILC2s
    Authors: Jakob von Moltke
    J. Exp. Med, 2016;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  61. A Proinflammatory Role of Type 2 Innate Lymphoid Cells in Murine Immune-Mediated Hepatitis
    Authors: Gisa Tiegs
    J. Immunol., 2016;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  62. IL-33 Contributes to Schistosoma japonicum-induced Hepatic Pathology through Induction of M2 Macrophages
    Sci Rep, 2016;6(0):29844.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  63. IL-33 receptor ST2 amplifies the expansion of NK cells and enhances host defense during mouse cytomegalovirus infection.
    Authors: Nabekura T, Girard J, Lanier L
    J Immunol, 2015;194(12):5948-52.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  64. IL-33 promotes an innate immune pathway of intestinal tissue protection dependent on amphiregulin-EGFR interactions.
    Authors: Monticelli L, Osborne L, Noti M, Tran S, Zaiss D, Artis D
    Proc Natl Acad Sci U S A, 2015;112(34):10762-7.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  65. Dopaminergic Toxin 1-Methyl-4-Phenylpyridinium, Proteins alpha-Synuclein and Glia Maturation Factor Activate Mast Cells and Release Inflammatory Mediators.
    Authors: Kempuraj D, Thangavel R, Yang E, Pattani S, Zaheer S, Santillan D, Santillan M, Zaheer A
    PLoS ONE, 2015;10(8):e0135776.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  66. Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity.
    Authors: Brestoff, Jonathan, Kim, Brian S, Saenz, Steven A, Stine, Rachel R, Monticelli, Laurel A, Sonnenberg, Gregory, Thome, Joseph J, Farber, Donna L, Lutfy, Kabirull, Seale, Patrick, Artis, David
    Nature, 2015;519(7542):242-6.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  67. Eosinophil-associated ribonuclease 11 is a macrophage chemoattractant.
    Authors: Yamada K, Barker T, Dyer K, Rice T, Percopo C, Garcia-Crespo K, Cho S, Lee J, Druey K, Rosenberg H
    J Biol Chem, 2015;290(14):8863-75.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  68. Blockade of IL-33 release and suppression of type 2 innate lymphoid cell responses by helminth secreted products in airway allergy.
    Authors: McSorley H, Blair N, Smith K, McKenzie A, Maizels R
    Mucosal Immunol, 2014;7(5):1068-78.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  69. Airway uric acid is a sensor of inhaled protease allergens and initiates type 2 immune responses in respiratory mucosa.
    Authors: Hara K, Iijima K, Elias M, Seno S, Tojima I, Kobayashi T, Kephart G, Kurabayashi M, Kita H
    J Immunol, 2014;192(9):4032-42.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  70. TNF superfamily member TL1A elicits type 2 innate lymphoid cells at mucosal barriers.
    Authors: Yu, X, Pappu, R, Ramirez-Carrozzi, V, Ota, N, Caplazi, P, Zhang, J, Yan, D, Xu, M, Lee, W P, Grogan, J L
    Mucosal Immunol, 2014;7(3):730-40.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  71. Platelet-derived growth factor primes cancer-associated fibroblasts for apoptosis.
    Authors: Rizvi S, Mertens J, Bronk S, Hirsova P, Dai H, Roberts L, Kaufmann S, Gores G
    J Biol Chem, 2014;289(33):22835-49.
    Species: Mouse
    Sample Types: Whole Organism
    Applications: In Vivo
  72. Murine mast cells secrete and respond to interleukin-33.
    Authors: Tung, Hui-Ying, Plunkett, Beverly, Huang, Shau-Ku, Zhou, Yufeng
    J Interferon Cytokine Res, 2014;34(3):141-7.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  73. Interleukin-33/ST2 axis promotes breast cancer growth and metastases by facilitating intratumoral accumulation of immunosuppressive and innate lymphoid cells.
    Authors: Jovanovic I, Pejnovic N, Radosavljevic G, Pantic J, Milovanovic M, Arsenijevic N, Lukic M
    Int J Cancer, 2014;134(7):1669-82.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  74. Interleukin-33 and alveolar macrophages contribute to the mechanisms underlying the exacerbation of IgE-mediated airway inflammation and remodelling in mice.
    Authors: Mizutani N, Nabe T, Yoshino S
    Immunology, 2013;139(2):205-18.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  75. Macrophages as IL-25/IL-33-responsive cells play an important role in the induction of type 2 immunity.
    Authors: Yang Z, Grinchuk V, Urban J, Bohl J, Sun R, Notari L, Yan S, Ramalingam T, Keegan A, Wynn T, Shea-Donohue T, Zhao A
    , 2013;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  76. Control of T helper 2 responses by transcription factor IRF4-dependent dendritic cells.
    Authors: Gao Y, Nish S, Jiang R, Hou L, Licona-Limon P, Weinstein J, Zhao H, Medzhitov R
    Immunity, 2013;39(4):722-32.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  77. IL-33 causes selective mast cell tolerance to bacterial cell wall products by inducing IRAK1 degradation.
    Authors: Sandig H, Jobbings C, Roldan N, Whittingham-Dowd J, Orinska Z, Takeuchi O, Akira S, Bulfone-Paus S
    Eur J Immunol, 2013;43(4):979-88.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  78. Bee venom phospholipase A2 induces a primary type 2 response that is dependent on the receptor ST2 and confers protective immunity.
    Authors: Palm N, Rosenstein R, Yu S, Schenten D, Florsheim E, Medzhitov R
    Immunity, 2013;39(5):976-85.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  79. Interleukin-33 primes mast cells for activation by IgG immune complexes.
    Authors: Kaieda S, Wang J, Shnayder R, Fishgal N, Hei H, Lee R, Stevens R, Nigrovic P
    PLoS ONE, 2012;7(10):e47252.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  80. Regulation of innate CD8+ T-cell activation mediated by cytokines.
    Proc Natl Acad Sci U S A, 2012;109(25):9971-6.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  81. Interleukin-1alpha controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33.
    J. Exp. Med., 2012;209(8):1505-17.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  82. Antigen-independent differentiation and maintenance of effector-like resident memory T cells in tissues.
    Authors: Casey KA, Fraser KA, Schenkel JM, Moran A, Abt MC, Beura LK, Lucas PJ, Artis D, Wherry EJ, Hogquist K, Vezys V, Masopust D
    J. Immunol., 2012;188(10):4866-75.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  83. Pulmonary innate lymphoid cells are major producers of IL-5 and IL-13 in murine models of allergic asthma.
    Authors: Wolterink RG, KleinJan A, van Nimwegen M, Bergen I, de Bruijn M, Levani Y, Hendriks RW
    Eur. J. Immunol., 2012;42(5):1106-16.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  84. Intravenous gammaglobulin suppresses inflammation through a novel Th2 pathway.
    Authors: Anthony RM, Kobayashi T, Wermeling F, Ravetch JV
    Nature, 2011;475(7354):110-3.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  85. Production and functions of IL-33 in the central nervous system.
    Authors: Yasuoka S, Kawanokuchi J, Parajuli B, Jin S, Doi Y, Noda M, Sonobe Y, Takeuchi H, Mizuno T, Suzumura A
    Brain Res., 2011;1385(0):8-17.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  86. Endogenous IL-33 enhances Th2 cytokine production and T-cell responses during allergic airway inflammation.
    Authors: Louten J, Rankin AL, Li Y
    Int. Immunol., 2011;23(5):307-15.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  87. IL-33-responsive lineage- CD25+ CD44(hi) lymphoid cells mediate innate type 2 immunity and allergic inflammation in the lungs.
    Authors: Bartemes KR, Iijima K, Kobayashi T, Kephart GM, McKenzie AN, Kita H
    J. Immunol., 2011;188(3):1503-13.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  88. A natural protective function of invariant NKT cells in a mouse model of innate-cell-driven lung inflammation.
    Authors: Bourgeois EA, Levescot A, Diem S, Chauvineau A, Berges H, Milpied P, Lehuen A, Damotte D, Gombert JM, Schneider E, Girard JP, Gourdy P, Herbelin A
    Eur. J. Immunol., 2011;41(2):299-305.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  89. Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus.
    Authors: Monticelli LA, Sonnenberg GF, Abt MC
    Nat. Immunol., 2011;12(11):1045-54.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  90. IL-33-activated dendritic cells are critical for allergic airway inflammation.
    Authors: Besnard AG, Togbe D, Guillou N, Erard F, Quesniaux V, Ryffel B
    Eur. J. Immunol., 2011;41(6):1675-86.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  91. Interleukin-1 family cytokines as mucosal vaccine adjuvants for induction of protective immunity against influenza virus.
    Authors: Kayamuro H, Yoshioka Y, Abe Y, Arita S, Katayama K, Nomura T, Yoshikawa T, Kubota-Koketsu R, Ikuta K, Okamoto S, Mori Y, Kunisawa J, Kiyono H, Itoh N, Nagano K, Kamada H, Tsutsumi Y, Tsunoda S
    J. Virol., 2010;84(24):12703-12.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  92. Systemically dispersed innate IL-13-expressing cells in type 2 immunity.
    Authors: Price AE, Liang HE, Sullivan BM
    Proc. Natl. Acad. Sci. U.S.A., 2010;107(25):11489-94.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  93. Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity.
    Authors: Neill DR, Wong SH, Bellosi A, Flynn RJ, Daly M, Langford TK, Bucks C, Kane CM, Fallon PG, Pannell R, Jolin HE, McKenzie AN
    Nature, 2010;464(7293):1367-70.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  94. The pro-Th2 cytokine IL-33 directly interacts with invariant NKT and NK cells to induce IFN-gamma production.
    Authors: Bourgeois E, Van LP, Samson M, Diem S, Barra A, Roga S, Gombert JM, Schneider E, Dy M, Gourdy P, Girard JP, Herbelin A
    Eur. J. Immunol., 2009;39(4):1046-55.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  95. MHC class II-dependent basophil-CD4+ T cell interactions promote T(H)2 cytokine-dependent immunity.
    Authors: Perrigoue JG, Saenz SA, Siracusa MC, Allenspach EJ, Taylor BC, Giacomin PR, Nair MG, Du Y, Zaph C, Van Rooijen N, Comeau MR, Pearce EJ, Laufer TM, Artis D
    Nat. Immunol., 2009;10(7):697-705.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  96. Caspase-1, caspase-8, and calpain are dispensable for IL-33 release by macrophages.
    Authors: Ohno T, Oboki K, Kajiwara N, Morii E, Aozasa K, Flavell RA, Okumura K, Saito H, Nakae S
    J. Immunol., 2009;183(12):7890-7.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  97. Inhibition of interleukin-33 signaling attenuates the severity of experimental arthritis.
    Authors: Palmer G, Talabot-Ayer D, Lamacchia C, Toy D, Seemayer CA, Viatte S, Finckh A, Smith DE, Gabay C
    Arthritis Rheum., 2009;60(3):738-49.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  98. Induction of IL-33 expression and activity in central nervous system glia.
    Authors: Hudson CA, Christophi GP, Gruber RC, Wilmore JR, Lawrence DA, Massa PT
    J. Leukoc. Biol., 2008;84(3):631-43.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  99. Group 2 innate lymphoid cells utilize the IRF4-IL-9 module to coordinate epithelial cell maintenance of lung homeostasis.
    Authors: Mohapatra A, Van Dyken S, Schneider C, Nussbaum J, Liang H, Locksley R
    Mucosal Immunol, 0;9(1):275-86.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  100. Inflammatory Type 2 cDCs Acquire Features of cDC1s and Macrophages to Orchestrate Immunity to Respiratory Virus Infection.
    Authors: Bosteels C, Neyt K, Vanheerswynghels M, van Helden M, Sichien D, Debeuf N, De Prijck S, Bosteels V, Vandamme N, Martens L, Saeys Y, Louagie E, Lesage M, Williams D, Tang S, Mayer J, Ronchese F, Scott C, Hammad H, Guilliams M, Lambrecht B
    Immunity, 0;0(0):.
    Species: Mouse
    Sample Types: Primary Cells

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Average Rating: 4.6 (Based on 8 Reviews)

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Recombinant Mouse IL-33 Protein
By Anonymous on 10/19/2021
Application: In vivo study
Recombinant Mouse IL-33 Protein
By Anonymous on 04/17/2020
Application: In vivo study
Reason for Rating: Works as described.
Recombinant Mouse IL-33 Protein
By Anonymous on 09/16/2019
Application: ELISA positive control
Other Recombinant Mouse IL-33 Protein 3626-ML
Recombinant Mouse IL-33 Protein
By Nicole Brown on 01/07/2019

Reason for Rating: Used as a positive control on western blot; able to detect as little as 0.25ug; higher concentrations result in very large, saturated bands

Western blot used to confirm IL-33 knockout in mice; kidney samples from WT, +/-, and -/- IL-33 mice were prepared and blotted

Recombinant Mouse IL-33 Protein 3626-ML
Recombinant Mouse IL-33 Protein
By Anonymous on 05/15/2018
Application: Immunoassay Standard
By Mehdi Alavi on 05/14/2018
Application: Immunoassay Standard
Recombinant Mouse IL-33 Protein
By Anonymous on 02/12/2018
Application: Characterization prior to use.
Reason for Rating: Single peak at correct MW observed.
Other Recombinant Mouse IL-33 Protein 3626-ML
Recombinant Mouse IL-33 Protein
By Anonymous on 05/18/2016
Application: Cell migration/motility