Home / TRANCE/TNFSF11/RANK L / Recombinant Mouse TRANCE/RANK L/TNFSF11 (E. coli-expressed)

Recombinant Mouse TRANCE/RANK L/TNFSF11 (E. coli-expressed)

Catalog #: 462-TEC
75 Citations Datasheet / COA / SDS

Carrier Free

Catalog # Availability Size / Price Qty
462-TEC-010/CF

With Carrier

Catalog # Availability Size / Price Qty
462-TEC-010
Recombinant Mouse TRANCE/RANK L/TNFSF11 (E. coli-expressed) Bioactivity
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Citations (75)
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Summary Product Datasheets Carrier Free Data Images Reconstitution Calculator Background Related Research Areas

Recombinant Mouse TRANCE/RANK L/TNFSF11 (E. coli-expressed) Summary

Product Specifications

Purity
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Level
<0.01 EU per 1 μg of the protein by the LAL method.
Activity
Measured by its ability to induce osteoclast differentiation of RAW 264.7 mouse monocyte/macrophage cells. The ED50 for this effect is 0.5‑2 ng/mL.
Source
E. coli-derived mouse TRANCE/TNFSF11/RANK L protein
Lys158-Asp316, with an N-terminal Met
Accession #
Q3TWY5
N-terminal Sequence
Analysis
Met
Predicted Molecular Mass
19 kDa

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462-TEC (with carrier)

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462-TEC/CF (carrier free)

Product Datasheet
COA
SDS

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

462-TEC

Formulation Lyophilized from a 0.2 μm filtered solution in NaH2PO4, NaCl and EDTA with BSA as a carrier protein.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

462-TEC/CF

Formulation Lyophilized from a 0.2 μm filtered solution in NaH2PO4, NaCl and EDTA.
Reconstitution Reconstitute at 100 μg/mL in sterile PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

Scientific Data

Bioactivity Recombinant Mouse TRANCE/RANK L/TNFSF11 (E. coli-expressed) Bioactivity View Larger

Recombinant Mouse TRANCE/TNFSF11/RANK L (Catalog # 462-TEC) induces osteoclast differentiation of the RAW 264.7 mouse monocyte/macrophage cell line. The ED50 for this effect is 0.5-2 ng/mL.

SDS-PAGE Recombinant Mouse TRANCE/RANK L/TNFSF11 (E. coli-expressed) SDS-PAGE View Larger

1 μg/lane of Recombinant Mouse TRANCE/TNFSF11/RANK L was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 19 kDa.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: TRANCE/TNFSF11/RANK L

TRANCE (receptor activator of NF-kappa B ligand [RANK L], also called TNF-related activation-induced cytokine [TRANCE], osteoprotegrin ligand [OPGL], and osteoclast differentiation factor [ODF]), is a member of the tumor necrosis factor (TNF) family. TRANCE was originally identified as an immediate early gene up-regulated by T cell receptor stimulation. The mouse TRANCE cDNA encodes a type II transmembrane protein of 316 amino acids with a predicted cytoplasmic domain of 48 amino acids and an extracellular domain of 247 amino acids. The extracellular domain contains two potential N-linked glycosylation sites. Mouse and human TRANCE share 85% amino acid identity. TRANCE is primarily expressed in T cells and T cell rich organs, such as thymus and lymph nodes. The multi-functions of TRANCE include induction of activation of the c-jun N-terminal kinase, enhancement of T cell growth and dendritic cell function, induction of osteoclastogenesis, and lymph node organogenesis. RANK is the cell surface signaling receptor of TRANCE. RANK has been shown to undergo receptor clustering during signal transduction. Osteoprotegrin, a soluble member of the TNF receptor family which binds TRANCE, is a naturally occurring decoy receptor that counterbalances the effects of TRANCE.

References
  1. Wong, B.R. et al. (1997) J. Biol. Chem. 272:25190.
  2. Anderson, D.M. et al. (1997) Nature 390:175.
  3. Nakagawa, N. et al. (1998) Biochem. Biophys. Res. Commun. 245:382.
  4. Kong, Y-Y. et al. (1999) Nature 397:315.
Long Name
TNF-related Activation-induced Cytokine
Entrez Gene IDs
8600 (Human); 21943 (Mouse); 117516 (Rat); 102137946 (Cynomolgus Monkey)
Alternate Names
CD254 antigen; CD254; ODF; OPGL; OPGLOPTB2; Osteoclast differentiation factor; Osteoprotegerin ligand; RANK L; RANKL; RANKLreceptor activator of nuclear factor kappa B ligand; Receptor activator of nuclear factor kappa-B ligand; sOdf; TNF-related activation-induced cytokine; TNFSF11; TRANCE; TRANCEODFhRANKL2; tumor necrosis factor (ligand) superfamily, member 11; tumor necrosis factor ligand superfamily member 11

Citations for Recombinant Mouse TRANCE/RANK L/TNFSF11 (E. coli-expressed)

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

75 Citations: Showing 1 - 10
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  1. Evaluation of culture conditions for osteoclastogenesis in RAW264.7 cells
    Authors: Y Cheng, H Liu, J Li, Y Ma, C Song, Y Wang, P Li, Y Chen, Z Zhang
    PLoS ONE, 2022;17(11):e0277871.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  2. Npp1 prevents external tooth root resorption by regulation of cervical cementum integrity
    Authors: H Choi, L Yang, Y Liu, JK Jeong, ES Cho
    Scientific Reports, 2022;12(1):21158.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  3. Network Pharmacology Deciphers the Action of Bioactive Polypeptide in Attenuating Inflammatory Osteolysis via the Suppression of Oxidative Stress and Restoration of Bone Remodeling Balance
    Authors: Z Cui, C Feng, J Chen, Y Wang, Q Meng, S Zhao, Y Zhang, D Feng, Z Li, S Sun
    Oxidative Medicine and Cellular Longevity, 2022;2022(0):4913534.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  4. BHLHE40 promotes osteoclastogenesis and abnormal bone resorption via c-Fos/NFATc1
    Authors: Y Zhang, M Yang, S Zhang, Z Yang, Y Zhu, Y Wang, Z Chen, X Lv, Z Huang, Y Xie, L Cai
    Cell & bioscience, 2022;12(1):70.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  5. Carnosol inhibits osteoclastogenesis in�vivo and in�vitro by blocking the RANKL?induced NF?kappaB signaling pathway
    Authors: P Cai, S Yan, Y Lu, X Zhou, X Wang, M Wang, Z Yin
    Molecular Medicine Reports, 2022;26(1):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  6. Regulation of sclerostin by the SIRT1 stabilization pathway in osteocytes
    Authors: JM Kim, YS Yang, J Xie, O Lee, J Kim, J Hong, B Boldyreff, O Filhol, H Chun, MB Greenblatt, G Gao, JH Shim
    Cell Death and Differentiation, 2022;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  7. P2X7 receptor knockdown suppresses osteoclast differentiation by inhibiting autophagy and Ca2+/calcineurin signaling
    Authors: Y Ma, R Di, H Zhao, R Song, H Zou, Z Liu
    Molecular Medicine Reports, 2022;25(5):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  8. TET2 regulates osteoclastogenesis by modulating autophagy in OVX-induced bone loss
    Authors: C Yang, H Tao, H Zhang, Y Xia, J Bai, G Ge, W Li, W Zhang, L Xiao, Y Xu, Z Wang, Y Gu, H Yang, Y Liu, D Geng
    Autophagy, 2022;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  9. STAT3 is critical for skeletal development and bone homeostasis by regulating osteogenesis
    Authors: S Zhou, Q Dai, X Huang, A Jin, Y Yang, X Gong, H Xu, X Gao, L Jiang
    Nature Communications, 2021;12(1):6891.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  10. Deficiency of optineurin enhances osteoclast differentiation by attenuating the NRF2-mediated antioxidant response
    Authors: P Xue, X Hu, E Chang, L Wang, M Chen, TH Wu, DJ Lee, BL Foster, HC Tseng, CC Ko
    Experimental & Molecular Medicine, 2021;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  11. STING suppresses bone cancer pain via immune and neuronal modulation
    Authors: K Wang, CR Donnelly, C Jiang, Y Liao, X Luo, X Tao, S Bang, A McGinnis, M Lee, MJ Hilton, RR Ji
    Nature Communications, 2021;12(1):4558.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  12. Plastrum testudinis extract suppresses osteoclast differentiation via the NF-&kappaB signaling pathway and ameliorates senile osteoporosis
    Authors: H Chen, G Shen, Q Shang, P Zhang, D Yu, X Yu, Z Zhang, W Zhao, Z Wu, F Tang, Liang, X Jiang, H Ren
    Journal of ethnopharmacology, 2021;276(0):114195.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  13. Diterbutyl phthalate attenuates osteoarthritis in ACLT mice via suppressing ERK/c-fos/NFATc1 pathway, and subsequently inhibiting subchondral osteoclast fusion
    Authors: C Fang, JW Guo, YJ Wang, XQ Li, H Zhang, J Cui, Y Hu, YY Jing, X Chen, JC Su
    Acta pharmacologica Sinica, 2021;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  14. Galectin-3 Contributes to the Inhibitory Effect of lalpha,25-(OH)2D3 on Osteoclastogenesis
    Authors: J Gu, X Zhang, C Zhang, Y Li, J Bian, X Liu, Y Yuan, H Zou, X Tong, Z Liu
    International Journal of Molecular Sciences, 2021;22(24):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  15. RSPO3 is important for trabecular bone and fracture risk in mice and humans
    Authors: KH Nilsson, P Henning, ME Shahawy, M Nethander, TL Andersen, C Ejersted, J Wu, KL Gustafsson, A Koskela, J Tuukkanen, PPC Souza, J Tuckermann, M Lorentzon, LE Ruud, T Lehtimäki, JH Tobias, S Zhou, UH Lerner, JB Richards, S Movérare-S, C Ohlsson
    Nature Communications, 2021;12(1):4923.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  16. CNC-bZIP protein NFE2L1 regulates osteoclast differentiation in antioxidant-dependent and independent manners
    Authors: Z Liu, H Wang, Y Hou, Y Yang, J Jia, J Wu, Z Zuo, T Gao, S Ren, Y Bian, S Liu, J Fu, Y Sun, J Li, M Yamamoto, Q Zhang, Y Xu, J Pi
    Redox Biology, 2021;48(0):102180.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  17. Inhibitory Effects of Astaxanthin on CML-HSA-Induced Inflammatory and RANKL-Induced Osteoclastogenic Gene Expression in RAW 264.7 Cells
    Authors: ANM Mamun-Or-R, TT Lucy, M Yagi, Y Yonei
    Biomedicines, 2021;10(1):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  18. ULK1 Suppresses Osteoclast Differentiation and Bone Resorption via Inhibiting Syk-JNK through DOK3
    Authors: Y Zhang, S Zhang, Y Wang, Z Yang, Z Chen, N Wen, M Yang, Z Huang, Y Xie, L Cai
    Oxidative Medicine and Cellular Longevity, 2021;2021(0):2896674.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  19. Effects of N-methyl-D-aspartate receptor antagonist MK-801 (dizocilpine) on bone homeostasis in mice
    Authors: S Kiyohara, N Sakai, K Handa, T Yamakawa, K Ishikawa, M Chatani, A Karakawa, Y Azetsu, M Munakata, M Ozeki, T Negishi-Ko, M Takami
    J Oral Biosci, 2020;0(0):.
    Species: Mouse
    Sample Types: bone marrow cells
    Applications: Cell Culture
  20. Environmental arginine controls multinuclear giant cell metabolism and formation
    Authors: JS Brunner, L Vulliard, M Hofmann, M Kieler, A Lercher, A Vogel, M Russier, JB Brüggenthi, M Kerndl, V Saferding, B Niederreit, A Junza, A Frauenstei, C Scholtysek, Y Mikami, K Klavins, G Krönke, A Bergthaler, JJ O'Shea, T Weichhart, F Meissner, JS Smolen, P Cheng, O Yanes, J Menche, PJ Murray, O Sharif, S Blüml, G Schabbauer
    Nat Commun, 2020;11(1):431.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  21. Neural regulation of energy and bone homeostasis by the synaptic adhesion molecule Calsyntenin-3
    Authors: SJ Kim, YT Jeong, SR Jeong, M Park, HS Go, MY Kim, JK Seong, KW Kim, JT Seo, CH Kim, JH Lee, SJ Moon
    Exp. Mol. Med., 2020;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  22. PD-1 blockade inhibits osteoclast formation and murine bone cancer pain
    Authors: K Wang, Y Gu, Y Liao, S Bang, CR Donnelly, O Chen, X Tao, AJ Mirando, MJ Hilton, RR Ji
    J. Clin. Invest., 2020;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  23. A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation
    Authors: JM Kim, YS Yang, KH Park, X Ge, R Xu, N Li, M Song, H Chun, S Bok, JF Charles, O Filhol-Coc, B Boldyreff, T Dinter, PB Yu, N Kon, W Gu, T Takarada, MB Greenblatt, JH Shim
    Nat Commun, 2020;11(1):2289.
    Species: Mouse
    Sample Types: Whole Cell
    Applications: Bioassay
  24. QKI deficiency leads to osteoporosis by promoting RANKL-induced osteoclastogenesis and disrupting bone metabolism
    Authors: T Du, Z Yan, S Zhu, G Chen, L Wang, Z Ye, W Wang, Q Zhu, Z Lu, X Cao
    Cell Death Dis, 2020;11(5):330.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  25. Opposing roles of hematopoietic-specific small GTPase Rac2 and the guanine nucleotide exchange factor Vav1 in osteoclast differentiation
    Authors: IS Kang, JS Jang, C Kim
    Sci Rep, 2020;10(1):7024.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  26. The IAP Antagonist SM-164 Eliminates Triple-Negative Breast Cancer Metastasis to Bone and Lung in Mice
    Authors: W Lei, R Duan, J Li, X Liu, A Huston, BF Boyce, Z Yao
    Sci Rep, 2020;10(1):7004.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  27. Dendritic cells-derived interferon-lambda1 ameliorated inflammatory bone destruction through inhibiting osteoclastogenesis
    Authors: Y Chen, Y Wang, R Tang, J Yang, C Dou, Y Dong, D Sun, C Zhang, L Zhang, Y Tang, Q Dai, F Luo, J Xu, S Dong
    Cell Death Dis, 2020;11(6):414.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  28. SENP3 Suppresses Osteoclastogenesis by De-conjugating SUMO2/3 from IRF8 in Bone Marrow-Derived Monocytes
    Authors: Y Zhang, K Yang, J Yang, Y Lao, L Deng, G Deng, J Yi, X Sun, Q Wang
    Cell Rep, 2020;30(6):1951-1963.e4.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  29. Identification of Fibroblast Activation Protein as an Osteogenic Suppressor and Anti-osteoporosis Drug Target
    Authors: H Wei, Y Xu, Y Wang, L Xu, C Mo, L Li, B Shen, Y Sun, P Cheng, L Yang, Y Pang, A Qin, Y Cao, SJ Morrison, R Yue
    Cell Rep, 2020;33(2):108252.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  30. A Novel Sulforaphane-Regulated Gene Network in Suppression of Breast Cancer-Induced Osteolytic Bone Resorption
    Authors: SK Pore, ER Hahm, SH Kim, KB Singh, L Nyiranshut, JD Latoche, CJ Anderson, J Adamik, DL Galson, KR Weiss, RJ Watters, B Lee, PN Kumta, SV Singh
    Mol. Cancer Ther., 2019;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  31. Egg White Ovotransferrin Attenuates RANKL-Induced Osteoclastogenesis and Bone Resorption
    Authors: N Shang, J Wu
    Nutrients, 2019;11(9):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  32. EGR1 regulates angiogenic and osteoclastogenic factors in prostate cancer and promotes metastasis
    Authors: L Li, AH Ameri, S Wang, KH Jansson, OM Casey, Q Yang, ML Beshiri, L Fang, RG Lake, S Agarwal, AN Alilin, W Xu, J Yin, K Kelly
    Oncogene, 2019;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Cell Culture
  33. Skeletal phenotype of the neuropeptide Y knockout mouse
    Authors: NKY Wee, BP Sinder, S Novak, X Wang, C Stoddard, BG Matthews, I Kalajzic
    Neuropeptides, 2019;73(0):78-88.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  34. Sensory Neuropeptides and their Receptors Participate in Mechano-Regulation of Murine Macrophages
    Authors: D Muschter, AS Beiderbeck, T Späth, C Kirschneck, A Schröder, S Grässel
    Int J Mol Sci, 2019;20(3):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  35. Trabectedin Reduces Skeletal Prostate Cancer Tumor Size in Association with Effects on M2 Macrophages and Efferocytosis
    Authors: JD Jones, BP Sinder, D Paige, FN Soki, AJ Koh, S Thiele, Y Shiozawa, LC Hofbauer, S Daignault, H Roca, LK McCauley
    Neoplasia, 2019;21(2):172-184.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  36. Regulation of cytoskeleton and adhesion signaling in osteoclasts by tetraspanin CD82
    Authors: A Bergsma, SS Ganguly, ME Wiegand, D Dick, BO Williams, CK Miranti
    Bone Rep, 2019;10(0):100196.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  37. Global deletion of Optineurin results in altered type I IFN signaling and abnormal bone remodeling in a model of Paget's disease
    Authors: SW Wong, BW Huang, X Hu, E Ho Kim, JP Kolb, RJ Padilla, P Xue, L Wang, TH Oguin, PA Miguez, HC Tseng, CC Ko, J Martinez
    Cell Death Differ., 2019;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  38. Adenosine Areceptor (A2AR) stimulation modulates expression of semaphorins 4D and 3A, regulators of bone homeostasis
    Authors: A Mediero, T Wilder, L Shah, BN Cronstein
    FASEB J., 2018;0(0):fj201700217R.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Differentiation
  39. Monomeric C-Reactive Protein Binds and Neutralizes Receptor Activator of NF-?B Ligand-Induced Osteoclast Differentiation
    Authors: ZK Jia, HY Li, YL Liang, LA Potempa, SR Ji, Y Wu
    Front Immunol, 2018;9(0):234.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  40. Targeted disruption of adenosine kinase in myeloid monocyte cells increases osteoclastogenesis and bone resorption in mice
    Authors: Q Ye, G Li, S Liu, Y Guan, Y Li, J Li, H Jia, X Li, Q Li, R Huang, H Wang, Y Zhang
    Int. J. Mol. Med., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  41. The Long Pentraxin 3 Plays a Role in Bone Turnover and Repair
    Authors: D Gr?evi?, M Sironi, S Valentino, L Deban, H Cvija, A Inforzato, N Kova?i?, V Katavi?, T Kelava, I Kalajzi?, A Mantovani, B Bottazzi
    Front Immunol, 2018;9(0):417.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  42. Modulating bone marrow hematopoietic lineage potential to prevent bone metastasis in breast cancer
    Authors: JM Ubellacker, N Baryawno, N Severe, MJ DeCristo, J Sceneay, JN Hutchinson, MT Haider, CS Rhee, Y Qin, WM Gregory, AC Garrido-Ca, I Holen, JE Brown, RE Coleman, DT Scadden, SS McAllister
    Cancer Res., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  43. The Effects of Kaempferol-Inhibited Autophagy on Osteoclast Formation
    Authors: CJ Kim, SH Shin, BJ Kim, CH Kim, JH Kim, HM Kang, BS Park, IR Kim
    Int J Mol Sci, 2018;19(1):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  44. Microbiota Reconstitution Does Not Cause Bone Loss in Germ-Free Mice
    Authors: D Quach, F Collins, N Parameswar, L McCabe, RA Britton
    mSphere, 2018;3(1):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  45. OC-STAMP promotes osteoclast fusion for pathogenic bone resorption in periodontitis via up-regulation of permissive fusogen CD9
    Authors: T Ishii, M Ruiz-Torru, A Ikeda, S Shindo, A Movila, H Mawardi, A Albassam, RA Kayal, AA Al-Dharrab, K Egashira, W Wisitrasam, K Yamamoto, AI Mira, K Sueishi, X Han, MA Taubman, T Miyamoto, T Kawai
    FASEB J., 2018;0(0):fj201701424R.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  46. Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing-bisphosphonates
    Authors: Z Yu, LE Surface, CY Park, MA Horlbeck, GA Wyant, M Abu-Remail, TR Peterson, DM Sabatini, JS Weissman, EK O'Shea
    Elife, 2018;7(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  47. Substance P modulates bone remodeling properties of murine osteoblasts and osteoclasts
    Authors: T Niedermair, S Schirner, R Seebröker, RH Straub, S Grässel
    Sci Rep, 2018;8(1):9199.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  48. C5aR1 interacts with TLR2 in osteoblasts and stimulates the osteoclast-inducing chemokine CXCL10
    Authors: Y Mödinger, A Rapp, J Pazmandi, A Vikman, K Holzmann, M Haffner-Lu, M Huber-Lang, A Ignatius
    J. Cell. Mol. Med., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  49. Bevacizumab or fibronectin gene editing inhibits the osteoclastogenic effects of fibroblasts derived from human radicular cysts
    Authors: HC Wang, P Wang, YW Chen, Y Zhang
    Acta Pharmacol. Sin., 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  50. Inhibition of STAT5A promotes osteogenesis by DLX5 regulation
    Authors: KM Lee, KH Park, JS Hwang, M Lee, DS Yoon, HA Ryu, HS Jung, KW Park, J Kim, SW Park, SH Kim, YM Chun, WJ Choi, JW Lee
    Cell Death Dis, 2018;9(11):1136.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  51. Artemisinin-Daumone Hybrid Inhibits Cancer Cell-Mediated Osteolysis by Targeting Cancer Cells and Osteoclasts
    Authors: GT Ma, SK Lee, KK Park, J Park, SH Son, M Jung, WY Chung
    Cell. Physiol. Biochem., 2018;49(4):1460-1475.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  52. Inhibition of lipopolysaccharide-induced osteoclast formation and bone resorption in vitro and in vivo by cysteine proteinase inhibitors
    Authors: F Strålberg, A Kassem, F Kasprzykow, M Abrahamson, A Grubb, C Lindholm, UH Lerner
    J. Leukoc. Biol, 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  53. Effects of Osteogenic-Conditioned Medium from Human Periosteum-Derived Cells on Osteoclast Differentiation
    Authors: HC Park, YB Son, SL Lee, GJ Rho, YH Kang, BW Park, SH Byun, SC Hwang, IA Cho, YC Cho, IY Sung, DK Woo, JH Byun
    Int J Med Sci, 2017;14(13):1389-1401.
    Species: Human
    Sample Types: Cell Culture Supernates
  54. Small leucine rich proteoglycans, a novel link to osteoclastogenesis
    Authors: V Kram, TM Kilts, N Bhattachar, L Li, MF Young
    Sci Rep, 2017;7(1):12627.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  55. SNX10 gene mutation leading to osteopetrosis with dysfunctional osteoclasts
    Authors: EL Stattin, P Henning, J Klar, E McDermott, C Stecksen-B, PE Sandström, TG Kellgren, P Rydén, G Hallmans, T Lönnerholm, A Ameur, MH Helfrich, FP Coxon, N Dahl, J Wikström, UH Lerner
    Sci Rep, 2017;7(1):3012.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  56. Adipokine Chemerin Bridges Metabolic Dyslipidemia and Alveolar Bone Loss in Mice
    Authors: Erivan S Ramos-Juni
    J. Bone Miner. Res, 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  57. Dynamics of the sealing zone in cultured osteoclasts
    Authors: Sarit Batsir
    Cytoskeleton (Hoboken), 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  58. Tumor Cell-Derived Exosomes from the Prostate Cancer Cell Line TRAMP-C1 Impair Osteoclast Formation and Differentiation
    PLoS ONE, 2016;11(11):e0166284.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  59. Prader-Willi Critical Region, a Non-Translated, Imprinted Central Regulator of Bone Mass: Possible Role in Skeletal Abnormalities in Prader-Willi Syndrome.
    Authors: Khor E, Fanshawe B, Qi Y, Zolotukhin S, Kulkarni R, Enriquez R, Purtell L, Lee N, Wee N, Croucher P, Campbell L, Herzog H, Baldock P
    PLoS ONE, 2016;11(1):e0148155.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  60. Activin A inhibits RANKL-mediated osteoclast formation, movement and function in murine bone marrow macrophage cultures.
    Authors: Fowler T, Kamalakar A, Akel N, Kurten R, Suva L, Gaddy D
    J Cell Sci, 2015;128(4):683-94.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  61. Heavy Metal Ion Regulation of Gene Expression: MECHANISMS BY WHICH LEAD INHIBITS OSTEOBLASTIC BONE-FORMING ACTIVITY THROUGH MODULATION OF THE Wnt/beta-CATENIN SIGNALING PATHWAY.
    Authors: Beier E, Sheu T, Dang D, Holz J, Ubayawardena R, Babij P, Puzas J
    J Biol Chem, 2015;290(29):18216-26.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  62. Netrin-1 is a critical autocrine/paracrine factor for osteoclast differentiation.
    Authors: Mediero A, Ramkhelawon B, Perez-Aso M, Moore K, Cronstein B
    J Bone Miner Res, 2015;30(5):837-54.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  63. Notch pathway inhibition controls myeloma bone disease in the murine MOPC315.BM model.
    Authors: Schwarzer R, Nickel N, Godau J, Willie B, Duda G, Schwarzer R, Cirovic B, Leutz A, Manz R, Bogen B, Dorken B, Jundt F
    Blood Cancer J, 2014;4(0):e217.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  64. Chloroquine reduces osteoclastogenesis in murine osteoporosis by preventing TRAF3 degradation.
    Authors: Xiu Y, Xu H, Zhao C, Li J, Morita Y, Yao Z, Xing L, Boyce B
    J Clin Invest, 2014;124(1):297-310.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  65. NOTCH inhibits osteoblast formation in inflammatory arthritis via noncanonical NF-kappaB.
    Authors: Zhang H, Hilton M, Anolik J, Welle S, Zhao C, Yao Z, Li X, Wang Z, Boyce B, Xing L
    J Clin Invest, 2014;124(7):3200-14.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  66. A nonapoptotic role for CASP2/caspase 2: modulation of autophagy.
    Authors: Tiwari, Meenaksh, Sharma, Lokendra, Vanegas, Difernan, Callaway, Danielle, Bai, Yidong, Lechleiter, James D, Herman, Brian
    Autophagy, 2014;10(6):1054-70.
  67. TBK1 mediates critical effects of measles virus nucleocapsid protein (MVNP) on pagetic osteoclast formation.
    Authors: Sun Q, Sammut B, Wang F, Kurihara N, Windle J, Roodman G, Galson D
    J Bone Miner Res, 2014;29(1):90-102.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  68. Osteoblast CFTR inactivation reduces differentiation and osteoprotegerin expression in a mouse model of cystic fibrosis-related bone disease.
    Authors: Stalvey M, Clines K, Havasi V, McKibbin C, Dunn L, Chung W, Clines G
    PLoS ONE, 2013;8(11):e80098.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  69. Chemerin neutralization blocks hematopoietic stem cell osteoclastogenesis.
    Authors: Muruganandan S, Dranse H, Rourke J, McMullen N, Sinal C
    Stem Cells, 2013;31(10):2172-82.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  70. Macrophage infiltration predicts a poor prognosis for human ewing sarcoma.
    Authors: Fujiwara T, Fukushi J, Yamamoto S, Matsumoto Y, Setsu N, Oda Y, Yamada H, Okada S, Watari K, Ono M, Kuwano M, Kamura S, Iida K, Okada Y, Koga M, Iwamoto Y
    Am. J. Pathol., 2011;179(3):1157-70.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  71. Inhibition of osteoclastogenesis by mechanically loaded osteocytes: involvement of MEPE.
    Authors: Kulkarni RN, Bakker AD, Everts V, Klein-Nulend J
    Calcif. Tissue Int., 2010;87(5):461-8.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  72. Estrogen-dependent and C-C chemokine receptor-2-dependent pathways determine osteoclast behavior in osteoporosis.
    Authors: Binder NB, Niederreiter B, Hoffmann O, Stange R, Pap T, Stulnig TM, Mack M, Erben RG, Smolen JS, Redlich K
    Nat. Med., 2009;15(4):417-24.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  73. Hematopoietic stem cell-targeted neonatal gene therapy reverses lethally progressive osteopetrosis in oc/oc mice.
    Authors: Johansson MK, de Vries TJ, Schoenmaker T, Ehinger M, Brun AC, Fasth A, Karlsson S, Everts V, Richter J
    Blood, 2007;109(12):5178-85.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  74. Gingival fibroblasts are better at inhibiting osteoclast formation than periodontal ligament fibroblasts.
    Authors: de Vries TJ, Schoenmaker T, Wattanaroonwong N, van den Hoonaard M, Nieuwenhuijse A, Beertsen W, Everts V
    J. Cell. Biochem., 2006;98(2):370-82.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  75. Recruitment of osteoclast precursors by stromal cell derived factor-1 (SDF-1) in giant cell tumor of bone.
    Authors: Liao TS, Yurgelun MB, Chang SS, Zhang HZ, Murakami K, Blaine TA, Parisien MV, Kim W, Winchester RJ, Lee FY
    J. Orthop. Res., 2005;23(1):203-9.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay

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