Recombinant Mouse Wnt-3a Protein

Formulations:
Catalog # Availability Size / Price Qty
1324-WN-002
1324-WN-010
Product Details
Citations (130)
FAQs
Reviews (5)

Recombinant Mouse Wnt-3a Protein Summary

Purity
>75%, by SDS-PAGE under reducing conditions and visualized by silver stain
Endotoxin Level
<1.0 EU per 1 μg of the protein by the LAL method.
Activity
Measured by its ability to induce alkaline phosphatase production by MC3T3‑E1 mouse preosteoblast cells. Fischer, L. et al. (2002) J. Biol. Chem. 277:30870. The ED50 for this effect is ≤5 ng/mL. Measured by its ability to induce Topflash reporter activity in HEK293T human embryonic kidney cells.

Protein concentrations should be titrated based on cell type and if appropriate, passage number of the cell line.
Optimal concentrations should be determined by each laboratory for each application.

Source
Chinese Hamster Ovary cell line, CHO-derived mouse Wnt-3a protein
Ser19-Lys352
Accession #
N-terminal Sequence
Analysis
Ser19
Predicted Molecular Mass
37 kDa
SDS-PAGE
41 kDa, reducing conditions

Product Datasheets

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

1324-WN

Formulation Lyophilized from a 0.2 μm filtered solution in PBS, EDTA and CHAPS with BSA as a carrier protein.
Reconstitution Reconstitute at 40 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

1324-WN/CF

Formulation Lyophilized from a 0.2 μm filtered solution in PBS, EDTA and CHAPS.
Reconstitution Reconstitute at 40 µg/mL in sterile PBS.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: Wnt-3a

Wnt-3a is one of 19 vertebrate members of the Wingless-type MMTV integration site (Wnt) family of highly conserved cysteine-rich secreted glycoproteins important for normal developmental processes (1). Wnts bind to the cell surface Frizzled family receptors in conjunction with low-density lipoprotein receptor-related protein family receptors (LRP5 or 6) resulting in the stabilization of intracellular beta -catenin levels (2). As intracellular beta -catenin levels rise, beta -catenin binds to TCF/LEF transcription factors leading to expression of Wnt target genes (3). Endo-IWR 1 (Catalog # 3532, # PSM1324) is a cell-permeant small molecule inhibitor of Axin turnover that suppresses Wnt signal transduction by stabilizing the beta -catenin destruction complex (4). Wnt-3a is a 44 kDa secreted hydrophobic glycoprotein containing a conserved pattern of 24 cysteine residues (5). Wnt-3a has two N-linked glycosylation sites (Asn 87, Asn 298), and Ser 209 is modified with palmitoleic acid (6). Glycosylation and acylation are essential for efficient Wnt secretion and biological activity, respectively (6, 7). Mouse Wnt-3a shares 96% amino acid (aa) identity with human Wnt-3a, and 97% with bovine and canine Wnt-3a. The rat Wnt-3a precursor shares 100% aa identity with mouse Wnt-3a aa 63-352 (8), and also shares 87% aa identity with Wnt3. During embryonic development, Wnt-3a is necessary for proper development of the hippocampus, anterior-posterior patterning, somite development, and tailbud formation (9-12). Wnt-3a also promotes self-renewal of hematopoietic stem cells, neural stem cells, and embryonic stem cells (13-15).

References
  1. Willert, K. and Nusse, R. (2012) Cold Spring Harb. Perspect. Biol. 4:a007864.
  2. MacDonald, B.T. and X. He (2012) Cold Spring Harb. Perspect. Biol. 4:a007880.
  3. Korinek, V. et al. (1997) Science 275:1784.
  4. Chen, B. et al. (2009) Nat. Chem. Biol. 5:100.
  5. Smolich, B.D. et al. (1993) Mol. Biol. Cell 4:1267.
  6. Takada, R. et al. (2006) Dev. Cell 11:791.
  7. Komekado, H. (2007) Genes Cells 12:521.
  8. Entrez Accession # NP_001100475.
  9. Dunty Jr. W. C. et al. (2008) Development 135:85.
  10. Ikeya, M. and S. Takada (2001) Mech. Dev. 103:27.
  11. Lee, S. M. et al. (2000) Development 127:457.
  12. Takada, S. et al. (1994) Genes Dev. 8:174.
  13. Willert, K. et al. (2003) Nature 423:6938.
  14. Kalani, M.Y. et al. (2008) Proc. Natl. Acad. Sci. USA 105:16970.
  15. Ten Berge, D. et al. (2011) Nat. Cell Biol. 13:1070.
Long Name
Wingless-type MMTV Integration Site Family, Member 3a
Entrez Gene IDs
89780 (Human); 22416 (Mouse)
Alternate Names
MGC119418; MGC119419; MGC119420; protein Wnt-3a; wingless-type MMTV integration site family, member 3A; Wnt3a; Wnt-3a

Citations for Recombinant Mouse Wnt-3a Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

130 Citations: Showing 1 - 10
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  1. Exosomal Wnt-induced dedifferentiation of colorectal cancer cells contributes to chemotherapy resistance
    Authors: YB Hu, C Yan, L Mu, YL Mi, H Zhao, H Hu, XL Li, DD Tao, YQ Wu, JP Gong, JC Qin
    Oncogene, 2018;0(0):.
    Species: Human
    Sample Types: Whole Cell
    Applications: Bioassay
  2. Composite regulation of ERK activity dynamics underlying tumour-specific traits in the intestine
    Authors: Y Muta, Y Fujita, K Sumiyama, A Sakurai, MM Taketo, T Chiba, H Seno, K Aoki, M Matsuda, M Imajo
    Nat Commun, 2018;9(1):2174.
    Species: Mouse
    Sample Types: Whole Tissue
  3. The Esophageal Organoid System Reveals Functional Interplay Between Notch and Cytokines in Reactive Epithelial�Changes
    Authors: Y Kasagi, PM Chandramou, KA Whelan, K Tanaka, V Giroux, M Sharma, J Wang, AJ Benitez, M DeMarshall, JW Tobias, KE Hamilton, GW Falk, JM Spergel, AJ Klein-Szan, AK Rustgi, AB Muir, H Nakagawa
    Cell Mol Gastroenterol Hepatol, 2018;5(3):333-352.
    Species: Mouse
    Sample Types: organoid
    Applications: Organoid Culture
  4. Manic Fringe deficiency imposes Jagged1 addiction to intestinal tumor cells
    Authors: E López-Arri, V Rodilla, C Colomer, A Vert, A Shelton, JH Cheng, B Yan, A Gonzalez-P, MR Junttila, M Iglesias, F Torres, J Albanell, A Villanueva, A Bigas, CW Siebel, L Espinosa
    Nat Commun, 2018;9(1):2992.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  5. Reduced production of laminin by hepatic stellate cells contributes to impairment in oval cell response to liver injury in aged mice
    Authors: L Qian, H Zhang, Y Gu, D Li, S He, H Wang, Y Cheng, W Yang, H Yu, X Zhao, W Cai, L Meng, M Jin, Y Wang, Y Zhang
    Aging (Albany NY), 2018;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  6. Integrin-Rac signalling for mammary epithelial stem cell self-renewal
    Authors: S Olabi, A Ucar, K Brennan, CH Streuli
    Breast Cancer Res., 2018;20(1):128.
    Species: Mouse
    Sample Types: organoid
    Applications: Bioassay
  7. Decoding the dynamic DNA methylation and hydroxymethylation landscapes in endodermal lineage intermediates during pancreatic differentiation of hESC
    Authors: J Li, X Wu, Y Zhou, M Lee, L Guo, W Han, W Mo, WM Cao, D Sun, R Xie, Y Huang
    Nucleic Acids Res., 2018;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  8. Klotho expression is a prerequisite for proper muscle stem cell function and regeneration of skeletal muscle
    Authors: HE Ahrens, J Huettemeis, M Schmidt, C Kaether, J von Maltza
    Skelet Muscle, 2018;8(1):20.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  9. Long-term organoid culture reveals enrichment of organoid-forming epithelial cells in the fimbrial portion of mouse fallopian tube
    Authors: Y Xie, ES Park, D Xiang, Z Li
    Stem Cell Res, 2018;32(0):51-60.
    Species: Mouse
    Sample Types: organoid
    Applications: Bioassay
  10. Precardiac organoids form two heart fields via Bmp/Wnt signaling
    Authors: P Andersen, E Tampakakis, DV Jimenez, S Kannan, M Miyamoto, HK Shin, A Saberi, S Murphy, E Sulistio, SP Chelko, C Kwon
    Nat Commun, 2018;9(1):3140.
    Species: Mouse
    Sample Types:
  11. Glycoprotein 2 is a specific cell surface marker of human pancreatic progenitors
    Authors: KF Cogger, A Sinha, F Sarangi, EC McGaugh, D Saunders, C Dorrell, S Mejia-Guer, Y Aghazadeh, JL Rourke, RA Screaton, M Grompe, PR Streeter, AC Powers, M Brissova, T Kislinger, MC Nostro
    Nat Commun, 2017;8(1):331.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  12. Activation of Wnt3?/?-catenin signal pathway attenuates apoptosis of the cerebral microvascular endothelial cells induced by oxygen-glucose deprivation
    Authors: J Zhang, J Zhang, C Qi, P Yang, X Chen, Y Liu
    Biochem. Biophys. Res. Commun, 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  13. Stepwise reprogramming of liver cells to a pancreas progenitor state by the transcriptional regulator Tgif2
    Authors: N Cerdá-Este, H Naumann, S Ruzittu, N Mah, IM Pongrac, C Cozzitorto, A Hommel, MA Andrade-Na, E Bonifacio, FM Spagnoli
    Nat Commun, 2017;8(0):14127.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  14. Ganoderma lucidum (Reishi) suppresses proliferation and migration of breast cancer cells via inhibiting Wnt/?-catenin signaling
    Authors: Y Zhang
    Biochem. Biophys. Res. Commun., 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  15. Postnatal Calvarial Skeletal Stem Cells Expressing PRX1 Reside Exclusively in the Calvarial Sutures and Are Required for Bone Regeneration
    Authors: K Wilk, SA Yeh, LJ Mortensen, S Ghaffariga, CM Lombardo, SH Bassir, ZA Aldawood, CP Lin, G Intini
    Stem Cell Reports, 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  16. Proof-of-Concept Gene Editing for the Murine Model of Inducible Arginase-1 Deficiency
    Authors: YY Sin, PR Price, LL Ballantyne, CD Funk
    Sci Rep, 2017;7(1):2585.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  17. Kinesin superfamily protein Kif26b links Wnt5a-Ror signaling to the control of cell and tissue behaviors in vertebrates
    Authors: MW Susman, EP Karuna, RC Kunz, TS Gujral, AV Cantú, SS Choi, BY Jong, K Okada, MK Scales, J Hum, LS Hu, MW Kirschner, R Nishinakam, S Yamada, DJ Laird, LE Jao, SP Gygi, ME Greenberg, HH Ho
    Elife, 2017;6(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  18. N-terminal part of Dishevelled DEP domain is required for Wnt/?-catenin signaling in mammalian cells
    Authors: P Paclíková, O Bernatík, TW Radaszkiew, V Bryja
    Mol. Cell. Biol., 2017;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  19. Adult Mouse Liver Contains Two Distinct Populations of Cholangiocytes
    Authors: B Li, C Dorrell, PS Canaday, C Pelz, A Haft, M Finegold, M Grompe
    Stem Cell Reports, 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  20. Interplay between metabolic identities in the intestinal crypt supports stem cell function
    Authors: MJ Rodríguez-, M Schewe, M Meerlo, E Stigter, J Gerrits, M Pras-Raves, A Sacchetti, M Hornsveld, KC Oost, HJ Snippert, N Verhoeven-, R Fodde, BM Burgering
    Nature, 2017;543(7645):424-427.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  21. Acceleration of bone regeneration by activating Wnt/?-catenin signalling pathway via lithium released from lithium chloride/calcium phosphate cement in osteoporosis
    Authors: L Li, X Peng, Y Qin, R Wang, J Tang, X Cui, T Wang, W Liu, H Pan, B Li
    Sci Rep, 2017;7(0):45204.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  22. Efficient Derivation of Functional Human Airway Epithelium from Pluripotent Stem Cells via Temporal Regulation of Wnt Signaling
    Authors: KB McCauley, F Hawkins, M Serra, DC Thomas, A Jacob, DN Kotton
    Cell Stem Cell, 2017;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  23. Point mutations in murine Nkx2-5 phenocopy human congenital heart disease and induce pathogenic Wnt signaling
    Authors: MB Furtado, JC Wilmanns, A Chandran, J Perera, O Hon, C Biben, TJ Willow, HT Nim, G Kaur, S Simonds, Q Wu, D Willians, E Salimova, N Plachta, JM Denegre, SA Murray, D Fatkin, M Cowley, JT Pearson, D Kaye, M Ramialison, RP Harvey, NA Rosenthal, MW Costa
    JCI Insight, 2017;2(6):e88271.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Bioassay
  24. A Wnt-producing niche drives proliferative potential and progression in lung adenocarcinoma
    Authors: T Tammela, FJ Sanchez-Ri, NM Cetinbas, K Wu, NS Joshi, K Helenius, Y Park, R Azimi, NR Kerper, RA Wesselhoef, X Gu, L Schmidt, M Cornwall-B, ÖH Yilmaz, W Xue, P Katajisto, A Bhutkar, T Jacks
    Nature, 2017;545(7654):355-359.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  25. Generation of iPSC-derived limb progenitor-like cells for stimulating phalange regeneration in the adult mouse
    Authors: Y Chen, H Xu, G Lin
    Cell Discov, 2017;3(0):17046.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  26. R-spondin1 Controls Muscle Cell Fusion through Dual Regulation of Antagonistic Wnt Signaling Pathways
    Authors: F Lacour, E Vezin, CF Bentzinger, MC Sincennes, L Giordani, A Ferry, R Mitchell, K Patel, MA Rudnicki, MC Chaboissie, AA Chassot, F Le Grand
    Cell Rep, 2017;18(10):2320-2330.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  27. Constructing cellular niche properties by localized presentation of Wnt proteins on synthetic surfaces
    Authors: M Lowndes, S Junyent, SJ Habib
    Nat Protoc, 2017;12(7):1498-1512.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  28. In Vitro Polarization of Colonoids to Create an Intestinal Stem Cell Compartment
    Authors: PJ Attayek, AA Ahmad, Y Wang, I Williamson, CE Sims, ST Magness, NL Allbritton
    PLoS ONE, 2016;11(4):e0153795.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  29. The p53 Family Coordinates Wnt and Nodal Inputs in Mesendodermal Differentiation of Embryonic Stem Cells
    Authors: Joan Massagué
    Cell Stem Cell, 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  30. Diverse Functions of Retinoic Acid in Brain Vascular Development
    J Neurosci, 2016;36(29):7786-801.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  31. Pigment Epithelium-derived Factor (PEDF) Blocks Wnt3a-induced Autophagy in Pancreatic Intraepithelial Neoplasms
    J Biol Chem, 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  32. Retinol Promotes In Vitro Growth of Proximal Colon Organoids through a Retinoic Acid-Independent Mechanism
    PLoS ONE, 2016;11(8):e0162049.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  33. Wnt Protein Signaling Reduces Nuclear Acetyl-CoA Levels to Suppress Gene Expression during Osteoblast Differentiation
    Authors: CM Karner, E Esen, J Chen, FF Hsu, J Turk, F Long
    J. Biol. Chem., 2016;291(25):13028-39.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  34. Trop2 marks transient gastric fetal epithelium and adult regenerating cells after epithelial damage
    Authors: Marie-Isabelle Garcia
    Development, 2016;143(9):1452-63.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  35. WNT/?-catenin signaling promotes VSMCs to osteogenic transdifferentiation and calcification through directly modulating Runx2 gene expression
    Authors: Ting Cai
    Exp Cell Res, 2016;0(0):.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  36. Noncanonical WNT-5A signaling impairs endogenous lung repair in COPD
    Authors: Hoeke A Baarsma
    J. Exp. Med, 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  37. Tissue-Specific Stem Cells Obtained by Reprogramming of Non-Obese Diabetic (NOD) Mouse-Derived Pancreatic Cells Confer Insulin Production in Response to Glucose
    PLoS ONE, 2016;11(9):e0163580.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  38. Dickkopf-1 promotes hematopoietic regeneration via direct and niche-mediated mechanisms
    Nat. Med, 2016;0(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  39. Partial maintenance and long-term expansion of murine skin epithelial stem cells by Wnt-3a in vitro.
    Authors: Ouji Y, Ishizaka S, Nakamura-Uchiyama F, Okuzaki D, Yoshikawa M
    J Invest Dermatol, 2015;135(6):1598-608.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  40. Convergence of cMyc and beta-catenin on Tcf7l1 enables endoderm specification.
    Authors: Morrison G, Scognamiglio R, Trumpp A, Smith A
    EMBO J, 2015;35(3):356-68.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  41. Differential expression of claudin family members during osteoblast and osteoclast differentiation: Cldn-1 is a novel positive regulator of osteoblastogenesis.
    Authors: Alshbool F, Mohan S
    PLoS ONE, 2015;9(12):e114357.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  42. Canonical wnt signaling in dendritic cells regulates Th1/Th17 responses and suppresses autoimmune neuroinflammation.
    Authors: Suryawanshi A, Manoharan I, Hong Y, Swafford D, Majumdar T, Taketo M, Manicassamy B, Koni P, Thangaraju M, Sun Z, Mellor A, Munn D, Manicassamy S
    J Immunol, 2015;194(7):3295-304.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  43. Induction of tissue-specific stem cells by reprogramming factors, and tissue-specific selection.
    Authors: Noguchi, H, Saitoh, I, Tsugata, T, Kataoka, H, Watanabe, M, Noguchi, Y
    Cell Death Differ, 2015;22(1):145-55.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  44. Wnt activity and basal niche position sensitize intestinal stem and progenitor cells to DNA damage.
    Authors: Tao S, Tang D, Morita Y, Sperka T, Omrani O, Lechel A, Sakk V, Kraus J, Kestler H, Kuhl M, Rudolph K
    EMBO J, 2015;34(5):624-40.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  45. SOX2 primes the epigenetic landscape in neural precursors enabling proper gene activation during hippocampal neurogenesis.
    Authors: Amador-Arjona, Alejandr, Cimadamore, Flavio, Huang, Chun-Ten, Wright, Rebecca, Lewis, Susan, Gage, Fred H, Terskikh, Alexey V
    Proc Natl Acad Sci U S A, 2015;112(15):E1936-45.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  46. Heavy Metal Ion Regulation of Gene Expression: MECHANISMS BY WHICH LEAD INHIBITS OSTEOBLASTIC BONE-FORMING ACTIVITY THROUGH MODULATION OF THE Wnt/beta-CATENIN SIGNALING PATHWAY.
    Authors: Beier E, Sheu T, Dang D, Holz J, Ubayawardena R, Babij P, Puzas J
    J Biol Chem, 2015;290(29):18216-26.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  47. Hepatic progenitor cells of biliary origin with liver repopulation capacity.
    Authors: Lu W, Bird T, Boulter L, Tsuchiya A, Cole A, Hay T, Guest R, Wojtacha D, Man T, Mackinnon A, Ridgway R, Kendall T, Williams M, Jamieson T, Raven A, Hay D, Iredale J, Clarke A, Sansom O, Forbes S
    Nat Cell Biol, 2015;17(8):971-83.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  48. Inhibited Wnt signaling causes age-dependent abnormalities in the bone matrix mineralization in the Apert syndrome FGFR2(S252W/+) mice.
    Authors: Zhang L, Chen P, Chen L, Weng T, Zhang S, Zhou X, Zhang B, Liu L
    PLoS ONE, 2015;10(2):e112716.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  49. Epsin is required for Dishevelled stability and Wnt signalling activation in colon cancer development.
    Authors: Chang B, Tessneer K, McManus J, Liu X, Hahn S, Pasula S, Wu H, Song H, Chen Y, Cai X, Dong Y, Brophy M, Rahman R, Ma J, Xia L, Chen H
    Nat Commun, 2015;6(0):6380.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  50. In vitro generation of neuromesodermal progenitors reveals distinct roles for wnt signalling in the specification of spinal cord and paraxial mesoderm identity.
    Authors: Gouti, Mina, Tsakiridis, Anestis, Wymeersch, Filip J, Huang, Yali, Kleinjung, Jens, Wilson, Valerie, Briscoe, James
    PLoS Biol, 2014;12(8):e1001937.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  51. Drugging a stem cell compartment using Wnt3a protein as a therapeutic.
    Authors: Dhamdhere, Girija R, Fang, Mark Y, Jiang, Jie, Lee, Katherin, Cheng, Du, Olveda, Rebecca, Liu, Bo, Mulligan, Kimberle, Carlson, Jeffery, Ransom, Ryan C, Weis, William, Helms, Jill A
    PLoS ONE, 2014;9(1):e83650.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  52. Recombinant Wnt3a and Wnt5a elicit macrophage cytokine production and tolerization to microbial stimulation via Toll-like receptor 4.
    Authors: Yu C, Nguyen T, Irvine K, Sweet M, Frazer I, Blumenthal A
    Eur J Immunol, 2014;44(5):1480-90.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  53. Epigenome-guided analysis of the transcriptome of plaque macrophages during atherosclerosis regression reveals activation of the Wnt signaling pathway.
    Authors: Ramsey S, Vengrenyuk Y, Menon P, Podolsky I, Feig J, Aderem A, Fisher E, Gold E
    PLoS Genet, 2014;10(12):e1004828.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  54. Beta-catenin is vital for the integrity of mouse embryonic stem cells.
    Authors: Raggioli A, Junghans D, Rudloff S, Kemler R
    PLoS ONE, 2014;9(1):e86691.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  55. Manipulating gene expression and signaling activity in cultured mouse limb bud cells.
    Authors: Lewandowski J, Pursell T, Rabinowitz A, Vokes S
    Dev Dyn, 2014;243(7):928-36.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  56. Pannexin 3 inhibits proliferation of osteoprogenitor cells by regulating Wnt and p21 signaling.
    Authors: Ishikawa M, Iwamoto T, Fukumoto S, Yamada Y
    J Biol Chem, 2014;289(5):2839-51.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  57. Canonical WNT signaling inhibits follicle stimulating hormone mediated steroidogenesis in primary cultures of rat granulosa cells.
    Authors: Stapp A, Gomez B, Gifford C, Hallford D, Hernandez Gifford J
    PLoS ONE, 2014;9(1):e86432.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Bioassay
  58. Intestinal subepithelial myofibroblasts support the growth of intestinal epithelial stem cells.
    Authors: Lei N, Jabaji Z, Wang J, Joshi V, Brinkley G, Khalil H, Wang F, Jaroszewicz A, Pellegrini M, Li L, Lewis M, Stelzner M, Dunn J, Martin M
    PLoS ONE, 2014;9(1):e84651.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  59. BMP4 is required for the initial expression of MITF in melanocyte precursor differentiation from embryonic stem cells.
    Authors: Yang J, Wang J, Pan L, Li H, Rao C, Zhang X, Niu G, Qu J, Hou L
    Exp Cell Res, 2014;320(1):54-61.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  60. Hepatocyte growth factor (Hgf) stimulates low density lipoprotein receptor-related protein (Lrp) 5/6 phosphorylation and promotes canonical Wnt signaling.
    Authors: Koraishy F, Silva C, Mason S, Wu D, Cantley L
    J Biol Chem, 2014;289(20):14341-50.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  61. Distinct Wnt-driven primitive streak-like populations reflect in vivo lineage precursors.
    Authors: Tsakiridis, Anestis, Huang, Yali, Blin, Guillaum, Skylaki, Stavroul, Wymeersch, Filip, Osorno, Rodrigo, Economou, Costas, Karagianni, Eleni, Zhao, Suling, Lowell, Sally, Wilson, Valerie
    Development, 2014;141(6):1209-21.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  62. Noncanonical Wnt5a enhances Wnt/beta-catenin signaling during osteoblastogenesis.
    Authors: Okamoto M, Udagawa N, Uehara S, Maeda K, Yamashita T, Nakamichi Y, Kato H, Saito N, Minami Y, Takahashi N, Kobayashi Y
    Sci Rep, 2014;4(0):4493.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  63. WNT7B promotes bone formation in part through mTORC1.
    Authors: Chen J, Tu X, Esen E, Joeng K, Lin C, Arbeit J, Ruegg M, Hall M, Ma L, Long F
    PLoS Genet, 2014;10(1):e1004145.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  64. Generation of organized germ layers from a single mouse embryonic stem cell.
    Authors: Poh Y, Chen J, Hong Y, Yi H, Zhang S, Chen J, Wu D, Wang L, Jia Q, Singh R, Yao W, Tan Y, Tajik A, Tanaka T, Wang N
    Nat Commun, 2014;5(0):4000.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  65. Hhex and Cer1 mediate the Sox17 pathway for cardiac mesoderm formation in embryonic stem cells.
    Authors: Liu Y, Kaneda R, Leja T, Subkhankulova T, Tolmachov O, Minchiotti G, Schwartz R, Barahona M, Schneider M
    Stem Cells, 2014;32(6):1515-26.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  66. Wnt7a stimulates myogenic stem cell motility and engraftment resulting in improved muscle strength.
    Authors: Bentzinger C, von Maltzahn J, Dumont N, Stark D, Wang Y, Nhan K, Frenette J, Cornelison D, Rudnicki M
    J Cell Biol, 2014;205(1):97-111.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  67. Dose-dependent effect of estrogen suppresses the osteo-adipogenic transdifferentiation of osteoblasts via canonical Wnt signaling pathway.
    Authors: Gao B, Huang Q, Lin Y, Wei B, Guo Y, Sun Z, Wang L, Fan J, Zhang H, Han Y, Li X, Shi J, Liu J, Yang L, Luo Z
    PLoS ONE, 2014;9(6):e99137.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  68. Nkx2-5 regulates cardiac growth through modulation of Wnt signaling by R-spondin3.
    Authors: Cambier L, Plate M, Sucov H, Pashmforoush M
    Development, 2014;141(15):2959-71.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  69. Secreted Frizzled-related protein potentiation versus inhibition of Wnt3a/beta-catenin signaling.
    Authors: Xavier C, Melikova M, Chuman Y, Uren A, Baljinnyam B, Rubin J
    Cell Signal, 2014;26(1):94-101.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  70. Transport activity and presence of ClC-7/Ostm1 complex account for different cellular functions.
    Authors: Weinert S, Jabs S, Hohensee S, Chan W, Kornak U, Jentsch T
    EMBO Rep, 2014;15(7):784-91.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  71. Phosphatase WIP1 regulates adult neurogenesis and WNT signaling during aging.
    Authors: Zhu, Yunhua, Demidov, Oleg N, Goh, Amanda M, Virshup, David M, Lane, David P, Bulavin, Dmitry V
    J Clin Invest, 2014;124(7):3263-73.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  72. Custos controls beta-catenin to regulate head development during vertebrate embryogenesis.
    Authors: Komiya Y, Mandrekar N, Sato A, Dawid I, Habas R
    Proc Natl Acad Sci U S A, 2014;111(36):13099-104.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  73. The combined hyperlipidemia caused by impaired Wnt-LRP6 signaling is reversed by Wnt3a rescue.
    Authors: Go G, Srivastava R, Hernandez-Ono A, Gang G, Smith S, Booth C, Ginsberg H, Mani A
    Cell Metab, 2014;19(2):209-20.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  74. The transcription factor Pou3f1 promotes neural fate commitment via activation of neural lineage genes and inhibition of external signaling pathways.
    Authors: Zhu Q, Song L, Peng G, Sun N, Chen J, Zhang T, Sheng N, Tang W, Qian C, Qiao Y, Tang K, Han J, Li J, Jing N
    Elife, 2014;3(0):.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  75. Pertussis toxin-sensitive heterotrimeric G(alphai/o) proteins mediate WNT/beta-catenin and WNT/ERK1/2 signaling in mouse primary microglia stimulated with purified WNT-3A.
    Authors: Halleskog C, Schulte G
    Cell Signal, 2013;25(4):822-8.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  76. A network of heterochronic genes including Imp1 regulates temporal changes in stem cell properties.
    Authors: Nishino, Jinsuke, Kim, Sunjung, Zhu, Yuan, Zhu, Hao, Morrison, Sean J
    Elife, 2013;2(0):e00924.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  77. Osteoblast CFTR inactivation reduces differentiation and osteoprotegerin expression in a mouse model of cystic fibrosis-related bone disease.
    Authors: Stalvey M, Clines K, Havasi V, McKibbin C, Dunn L, Chung W, Clines G
    PLoS ONE, 2013;8(11):e80098.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  78. Postnatal ablation of osteoblast Smad4 enhances proliferative responses to canonical Wnt signaling through interactions with beta-catenin.
    Authors: Salazar V, Zarkadis N, Huang L, Watkins M, Kading J, Bonar S, Norris J, Mbalaviele G, Civitelli R
    J Cell Sci, 2013;126(0):5598-609.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  79. Evidence for tankyrases as antineoplastic targets in lung cancer.
    Authors: Busch A, Johnson K, Stan R, Sanglikar A, Ahmed Y, Dmitrovsky E, Freemantle S
    BMC Cancer, 2013;13(0):211.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  80. Induction of intestinal stem cells by R-spondin 1 and Slit2 augments chemoradioprotection.
    Authors: Zhou, Wei-Jie, Geng, Zhen H, Spence, Jason R, Geng, Jian-Guo
    Nature, 2013;501(7465):107-11.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: cell culture
  81. CSF-1 receptor-dependent colon development, homeostasis and inflammatory stress response.
    Authors: Huynh D, Akcora D, Malaterre J, Chan C, Dai X, Bertoncello I, Stanley E, Ramsay R
    PLoS ONE, 2013;8(2):e56951.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  82. Flk1+ and VE-cadherin+ endothelial cells derived from iPSCs recapitulates vascular development during differentiation and display similar angiogenic potential as ESC-derived cells.
    Authors: Kohler, Erin E, Wary, Kishore, Li, Fei, Chatterjee, Ishita, Urao, Norifumi, Toth, Peter T, Ushio-Fukai, Masuko, Rehman, Jalees, Park, Changwon, Malik, Asrar B
    PLoS ONE, 2013;8(12):e85549.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  83. Monitoring and robust induction of nephrogenic intermediate mesoderm from human pluripotent stem cells.
    Authors: Mae, Shin-Ich, Shono, Akemi, Shiota, Fumihiko, Yasuno, Tetsuhik, Kajiwara, Masatosh, Gotoda-Nishimura, Nanaka, Arai, Sayaka, Sato-Otubo, Aiko, Toyoda, Taro, Takahashi, Kazutosh, Nakayama, Naoki, Cowan, Chad A, Aoi, Takashi, Ogawa, Seishi, McMahon, Andrew P, Yamanaka, Shinya, Osafune, Kenji
    Nat Commun, 2013;4(0):1367.
  84. Fluid flow and interlinked feedback loops establish left-right asymmetric decay of Cerl2 mRNA.
    Authors: Nakamura, Tetsuya, Saito, Daisuke, Kawasumi, Aiko, Shinohara, Kyosuke, Asai, Yasuko, Takaoka, Katsuyos, Dong, Fenglan, Takamatsu, Atsuko, Belo, Jose Ant, Mochizuki, Atsushi, Hamada, Hiroshi
    Nat Commun, 2013;3(0):1322.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Bioassay
  85. Mutational analysis of sclerostin shows importance of the flexible loop and the cystine-knot for Wnt-signaling inhibition.
    Authors: Boschert V, van Dinther M, Weidauer S, van Pee K, Muth E, ten Dijke P, Mueller T
    PLoS ONE, 2013;8(11):e81710.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  86. Mesothelial cells give rise to hepatic stellate cells and myofibroblasts via mesothelial-mesenchymal transition in liver injury.
    Proc Natl Acad Sci U S A, 2013;110(6):2324-9.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  87. Both LRP5 and LRP6 receptors are required to respond to physiological Wnt ligands in mammary epithelial cells and fibroblasts.
    Authors: Goel S, Chin EN, Fakhraldeen SA
    J. Biol. Chem., 2012;287(20):16454-66.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  88. Prolactin stimulates precursor cells in the adult mouse hippocampus.
    Authors: Walker, Tara L, Vukovic, Jana, Koudijs, Margaret, Blackmore, Daniel G, Mackay, Eirinn W, Sykes, Alex M, Overall, Rupert W, Hamlin, Adam S, Bartlett, Perry F
    PLoS ONE, 2012;7(9):e44371.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  89. Heparan sulfate 6-O-endosulfatases (Sulfs) coordinate the Wnt signaling pathways to regulate myoblast fusion during skeletal muscle regeneration.
    Authors: Tran, Thanh H, Shi, Xiaofeng, Zaia, Joseph, Ai, Xingbin
    J Biol Chem, 2012;287(39):32651-64.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  90. Reversible modification of adenomatous polyposis coli (APC) with K63-linked polyubiquitin regulates the assembly and activity of the beta-catenin destruction complex.
    Authors: Tran H, Polakis P
    J Biol Chem, 2012;287(34):28552-63.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  91. Cross-talk between insulin and Wnt signaling in preadipocytes: role of Wnt co-receptor low density lipoprotein receptor-related protein-5 (LRP5).
    Authors: Palsgaard J, Emanuelli B, Winnay JN, Sumara G, Karsenty G, Kahn CR
    J. Biol. Chem., 2012;287(15):12016-26.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  92. A molecular signature for purified definitive endoderm guides differentiation and isolation of endoderm from mouse and human embryonic stem cells.
    Authors: Wang P, McKnight K, Wong D, Rodriguez R, Sugiyama T, Gu X, Ghodasara A, Qu K, Chang H, Kim S
    Stem Cells Dev, 2012;21(12):2273-87.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  93. Role of Gadd45a in Wip1-dependent regulation of intestinal tumorigenesis.
    Cell Death Differ., 2012;19(11):1761-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  94. Self-renewal of embryonic-stem-cell-derived progenitors by organ-matched mesenchyme.
    Authors: Sneddon, Julie B, Borowiak, Malgorza, Melton, Douglas
    Nature, 2012;491(7426):765-8.
    Species: Mouse
    Sample Types: Whole Cells
  95. Cell-surface markers for the isolation of pancreatic cell types derived from human embryonic stem cells.
    Authors: Kelly OG, Chan MY, Martinson LA
    Nat. Biotechnol., 2011;29(8):750-6.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  96. Single transcription factor reprogramming of hair follicle dermal papilla cells to induced pluripotent stem cells.
    Authors: Tsai SY, Bouwman BA, Ang YS, Kim SJ, Lee DF, Lemischka IR, Rendl M
    Stem Cells, 2011;29(6):964-71.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  97. Distinct modes of inhibition by sclerostin on bone morphogenetic protein and Wnt signaling pathways.
    Authors: Krause C, Korchynskyi O, de Rooij K, Weidauer SE, de Gorter DJ, van Bezooijen RL, Hatsell S, Economides AN, Mueller TD, Lowik CW, ten Dijke P
    J. Biol. Chem., 2010;285(53):41614-26.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  98. Wnt3a activates dormant c-Kit(-) bone marrow-derived cells with short-term multilineage hematopoietic reconstitution capacity.
    Authors: Trowbridge JJ, Guezguez B, Moon RT
    Stem Cells, 2010;28(8):1379-89.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  99. Activation of canonical wingless-type MMTV integration site family (Wnt) signaling in mature adipocytes increases beta-catenin levels and leads to cell dedifferentiation and insulin resistance.
    Authors: Gustafson B, Smith U
    J. Biol. Chem., 2010;285(18):14031-41.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  100. Human embryonic and rat adult stem cells with primitive endoderm-like phenotype can be fated to definitive endoderm, and finally hepatocyte-like cells.
    Authors: Roelandt P, Pauwelyn KA, Sancho-Bru P
    PLoS ONE, 2010;5(8):e12101.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Expansion/Differentiation
  101. Isolation and propagation of enteric neural crest progenitor cells from mouse embryonic stem cells and embryos.
    Authors: Kawaguchi J, Nichols J, Gierl MS, Faial T, Smith A
    Development, 2010;137(5):693-704.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  102. Wnt isoform-specific interactions with coreceptor specify inhibition or potentiation of signaling by LRP6 antibodies.
    Authors: Gong Y, Bourhis E, Chiu C, Stawicki S, DeAlmeida VI, Liu BY, Phamluong K, Cao TC, Carano RA, Ernst JA, Solloway M, Rubinfeld B, Hannoush RN, Wu Y, Polakis P, Costa M
    PLoS ONE, 2010;5(9):e12682.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Binding Assay
  103. Notch and Wnt signaling mediated rod photoreceptor regeneration by Muller cells in adult mammalian retina.
    Authors: Del Debbio CB, Balasubramanian S, Parameswaran S, Chaudhuri A, Qiu F, Ahmad I
    PLoS ONE, 2010;5(8):e12425.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  104. Canonical Wnt signaling negatively regulates platelet function.
    Authors: Steele BM, Harper MT, Macaulay IC, Morrell CN, Perez-Tamayo A, Foy M, Habas R, Poole AW, Fitzgerald DJ, Maguire PB
    Proc. Natl. Acad. Sci. U.S.A., 2009;106(47):19836-41.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  105. H-Ras is degraded by Wnt/beta-catenin signaling via beta-TrCP-mediated polyubiquitylation.
    Authors: Kim SE, Yoon JY, Jeong WJ, Jeon SH, Park Y, Yoon JB, Park YN, Kim H, Choi KY
    J. Cell. Sci., 2009;122(0):842-8.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  106. Stably overexpressed human Frizzled-2 signals through the beta-catenin pathway and does not activate Ca2+-mobilization in Human Embryonic Kidney 293 cells.
    Authors: Verkaar F, van Rosmalen JW, Smits JF, Blankesteijn WM, Zaman GJ
    Cell. Signal., 2009;21(1):22-33.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  107. Transcriptional regulation of SM22alpha by Wnt3a: convergence with TGFbeta(1)/Smad signaling at a novel regulatory element.
    Authors: Shafer SL, Towler DA
    J. Mol. Cell. Cardiol., 2009;46(5):621-35.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  108. Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells.
    Authors: Borowiak M, Maehr R, Chen S, Chen AE, Tang W, Fox JL, Schreiber SL, Melton DA
    Cell Stem Cell, 2009;4(4):348-58.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  109. Directed induction of anterior and posterior primitive streak by Wnt from embryonic stem cells cultured in a chemically defined serum-free medium.
    Authors: Nakanishi M, Kurisaki A, Hayashi Y, Warashina M, Ishiura S, Kusuda-Furue M, Asashima M
    FASEB J., 2009;23(1):114-22.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  110. Cooperative folding and ligand-binding properties of LRP6 beta-propeller domains.
    Authors: Liu CC, Pearson C, Bu G
    J. Biol. Chem., 2009;284(22):15299-307.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  111. Wnt signaling mediates experience-related regulation of synapse numbers and mossy fiber connectivities in the adult hippocampus.
    Authors: Gogolla N, Galimberti I, Deguchi Y, Caroni P
    Neuron, 2009;62(4):510-25.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  112. A late requirement for Wnt and FGF signaling during activin-induced formation of foregut endoderm from mouse embryonic stem cells.
    Authors: Hansson M, Olesen DR, Peterslund JM, Engberg N, Kahn M, Winzi M, Klein T, Maddox-Hyttel P, Serup P
    Dev. Biol., 2009;330(2):286-304.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  113. Wnt-3a and Dickkopf-1 stimulate neurite outgrowth in Ewing tumor cells via a Frizzled3- and c-Jun N-terminal kinase-dependent mechanism.
    Authors: Endo Y, Beauchamp E, Woods D, Taylor WG, Toretsky JA, Uren A, Rubin JS
    Mol. Cell. Biol., 2008;28(7):2368-79.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  114. The microRNA miR-8 is a conserved negative regulator of Wnt signaling.
    Authors: Kennell JA, Gerin I, MacDougald OA, Cadigan KM
    Proc. Natl. Acad. Sci. U.S.A., 2008;105(40):15417-22.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  115. Myogenic growth factors can decrease extraocular muscle force generation: a potential biological approach to the treatment of strabismus.
    Authors: Anderson BC, Christiansen SP, McLoon LK
    Invest. Ophthalmol. Vis. Sci., 2008;49(1):221-9.
    Species: Rabbit
    Sample Types: In Vivo
    Applications: In Vivo
  116. Human ES cell-derived neural rosettes reveal a functionally distinct early neural stem cell stage.
    Authors: Elkabetz Y, Panagiotakos G, Al Shamy G, Socci ND, Tabar V, Studer L
    Genes Dev., 2008;22(2):152-65.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  117. Parathyroid hormone signaling through low-density lipoprotein-related protein 6.
    Authors: Wan M, Yang C, Li J, Wu X, Yuan H, Ma H, He X, Nie S, Chang C, Cao X
    Genes Dev., 2008;22(21):2968-79.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  118. Short-term BMP-4 treatment initiates mesoderm induction in human embryonic stem cells.
    Authors: Zhang P, Li J, Tan Z, Wang C, Liu T, Chen L, Yong J, Jiang W, Sun X, DU L, Ding M, Deng H
    Blood, 2007;111(4):1933-41.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  119. Wnt3a binds to several sFRPs in the nanomolar range.
    Authors: Wawrzak D, Metioui M, Willems E, Hendrickx M, de Genst E, Leyns L
    Biochem. Biophys. Res. Commun., 2007;357(4):1119-23.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  120. Sustained interactive Wnt and FGF signaling is required to maintain isthmic identity.
    Authors: Canning CA, Lee L, Irving C, Mason I, Jones CM
    Dev. Biol., 2007;305(1):276-86.
    Species: Chicken
    Sample Types: Whole Tissue
    Applications: Bioassay
  121. Betacellulin and nicotinamide sustain PDX1 expression and induce pancreatic beta-cell differentiation in human embryonic stem cells.
    Authors: Cho YM, Lim JM, Yoo DH, Kim JH, Chung SS, Park SG, Kim TH, Oh SK, Choi YM, Moon SY, Park KS, Lee HK
    Biochem. Biophys. Res. Commun., 2007;366(1):129-34.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  122. Nephroblastoma overexpressed (Nov) inhibits osteoblastogenesis and causes osteopenia.
    Authors: Rydziel S, Stadmeyer L, Zanotti S, Durant D, Smerdel-Ramoya A, Canalis E
    J. Biol. Chem., 2007;282(27):19762-72.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  123. Canonical Wnt signaling is a positive regulator of mammalian cardiac progenitors.
    Authors: Kwon C, Arnold J, Hsiao EC, Taketo MM, Conklin BR, Srivastava D
    Proc. Natl. Acad. Sci. U.S.A., 2007;104(26):10894-9.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  124. Production of Wnt inhibitors by myeloma cells: potential effects on canonical Wnt pathway in the bone microenvironment.
    Authors: Giuliani N, Morandi F, Tagliaferri S, Lazzaretti M, Donofrio G, Bonomini S, Sala R, Mangoni M, Rizzoli V
    Cancer Res., 2007;67(16):7665-74.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  125. Wnt/beta-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency.
    Authors: Miyabayashi T, Teo JL, Yamamoto M, McMillan M, Nguyen C, Kahn M
    Proc. Natl. Acad. Sci. U.S.A., 2007;104(13):5668-73.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  126. An early role for WNT signaling in specifying neural patterns of Cdx and Hox gene expression and motor neuron subtype identity.
    Authors: Nordstrom U, Maier E, Jessell TM, Edlund T
    PLoS Biol., 2006;4(8):e252.
    Species: Chicken
    Sample Types: Whole Tissue
    Applications: Bioassay
  127. Wnt3a gradient converts radial to bilateral feather symmetry via topological arrangement of epithelia.
    Authors: Yue Z, Jiang TX, Widelitz RB, Chuong CM
    Proc. Natl. Acad. Sci. U.S.A., 2006;103(0):951-5.
    Species: Chicken
    Sample Types: In Vivo
    Applications: In Vivo
  128. Multipotentiality, homing properties, and pyramidal neurogenesis of CNS-derived LeX(ssea-1)+/CXCR4+ stem cells.
    Authors: Corti S, Locatelli F, Papadimitriou D, Donadoni C, Del Bo R, Fortunato F, Strazzer S, Salani S, Bresolin N, Comi GP
    FASEB J., 2005;19(13):1860-2.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  129. Chemokine-Like Receptor 1 Is a Novel Wnt Target Gene that Regulates Mesenchymal Stem Cell Differentiation.
    Authors: Muruganandan S, Govindarajan R, McMullen N, Sinal C
    Stem Cells, 0;35(3):711-724.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  130. Neuroprotective and regenerative roles of intranasal Wnt-3a Administration after focal ischemic stroke in mice.
    Authors: Wei Z, Zhang J, Taylor T, Gu X, Zhao Y, Wei L
    J Cereb Blood Flow Metab, 0;0(0):271678X177026.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo

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Recombinant Mouse Wnt-3a Protein
By Anonymous on 10/25/2017
Application: In vivo study

Recombinant Mouse Wnt-3a Protein
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Application: In vivo study

Recombinant Mouse Wnt-3a Protein
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Application: Stem/Immune cell maintenance or differentiation
Reason for Rating: Consistent and expect bioactive in our cell culture assays. Also expected protein concentration

Use rec Wnt in the growth and differentiation of cultures.


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By Anonymous on 07/21/2016
Application: Stem/Immune cell maintenance or differentiation

Recombinant Mouse Wnt-3a Protein
By Anonymous on 05/17/2016
Application: Cardiac Regeneration
Reason for Rating: reproducible results