Catalog Number: 1137
Chemical Name: 4-Hydroxy-3-methoxy-[(2S,3aR,3bS,6aR,9aR,9bR,10R,11aR) -3a,3b,6,6a,9a,10,11,11a-octahydro-6a-hydroxy-8,10-dimethyl-11a-(1-methylethenyl)-7-oxo-2-(phenylmethyl)-7H-2,9b-epoxyazuleno[5,4-e]-1,3-benzodioxol-5-yl]benzeneacetate
Biological Activity
Potent analog of capsaicin that is an agonist at vanilloid receptors (Ki = 43 pM). Like capsaicin, it acts as a selective modulator of primary afferent neurons. Also available as part of the Vanilloid TRPV1 Receptor Tocriset™.
Technical Data
  • M.Wt:
    628.72
  • Formula:
    C37H40O9
  • Solubility:
    Soluble to 100 mM in DMSO and to 50 mM in ethanol
  • Purity:
    >98%
  • Storage:
    Desiccate at -20°C
  • CAS No:
    57444-62-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Distinct structure-activity relations for stimulation of 45Ca uptake and for high affinity binding in cultured rat dorsal root ganglion neurons and dorsal root ganglion membranes.
    Acs et al.
    Brain Res.Mol.Brain Res., 1996;35:173
  2. Cellular mechanism of action of resiniferatoxin: a potent sensory neuron excitotoxin.
    Winter et al.
    Brain Res., 1990;520:131
  3. Resiniferatoxin: an ultrapotent selective modulator of capsaicin-sensitive primary afferent neurons.
    Szolcsanyi et al.
    J.Pharmacol.Exp.Ther., 1990;255:923
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Resiniferatoxin include:

4 Citations: Showing 1 - 4
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  1. Epidermal keratinocyte polarity and motility require Ca2+ influx through TRPV1.
    Authors: Graham Et al.
    J Cell Sci 2013;126:4602
  2. Transient inflammation-induced ongoing pain is driven by TRPV1 sensitive afferents.
    Authors: Okun Et al.
    J Pharmacol Exp Ther 2011;7:4
  3. A putative 'pre-nervous' endocannabinoid system in early echinoderm development.
    Authors: Buznikov Et al.
    Dev Neurosci 2010;32:1
  4. Endocannabinoid-dependent LTD in a nociceptive synapse requires activation of a presynaptic TRPV-like receptor.
    Authors: Yuan and Burrell
    J Neurophysiol 2010;104:2766

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