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Resiniferatoxin

Catalog #: 1137
5 Citations Datasheet / COA / SDS

Discontinued Product

1137 has been discontinued.
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Resiniferatoxin | CAS No. 57444-62-9 | TRPV Agonists
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Description: Potent vanilloid receptor agonist

Chemical Name: 4-Hydroxy-3-methoxy-[(2S,3aR,3bS,6aR,9aR,9bR,10R,11aR)-3a,3b,6,6a,9a,10,11,11a-octahydro-6a-hydroxy-8,10-dimethyl-11a-(1-methylethenyl)-7-oxo-2-(phenylmethyl)-7H-2,9b-epoxyazuleno[5,4-e]-1,3-benzodioxol-5-yl]benzeneacetate

Purity: ≥98%

Product Details
Citations (5)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Potent analog of capsaicin that is an agonist at vanilloid receptors (Ki = 43 pM). Like capsaicin, it acts as a selective modulator of primary afferent neurons.

Technical Data

M.Wt:
628.72
Formula:
C37H40O9
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Desiccate at -20°C
CAS No:
57444-62-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Resiniferatoxin

The citations listed below are publications that use Tocris products. Selected citations for Resiniferatoxin include:

5 Citations: Showing 1 - 5

  1. Capsaicin protects cortical neurons against ischemia/reperfusion injury via down-regulating NMDA receptors.
    Authors: Huang Et al.
    Exp Neurol  2017;295:66
  2. Epidermal keratinocyte polarity and motility require Ca2+ influx through TRPV1.
    Authors: Graham Et al.
    J Cell Sci  2013;126:4602
  3. Transient inflammation-induced ongoing pain is driven by TRPV1 sensitive afferents.
    Authors: Okun Et al.
    J Pharmacol Exp Ther  2011;7:4
  4. A putative 'pre-nervous' endocannabinoid system in early echinoderm development.
    Authors: Buznikov Et al.
    Dev Neurosci  2010;32:1
  5. Endocannabinoid-dependent LTD in a nociceptive synapse requires activation of a presynaptic TRPV-like receptor.
    Authors: Yuan and Burrell
    J Neurophysiol  2010;104:2766

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