Catalog Number: 1418
Chemical Name: 5-[(1E)-2-(4-Hydroxyphenyl)ethenyl]-1,3,benzenediol
Biological Activity
A phytoestrogen with antitumor, antioxidant, antiplatelet, anti-inflammatory and antifungal effects. Inhibits cytochrome P450 1A1 (IC50 = 23 μM) and displays mixed agonist/antagonist actions at ERα and ERβ estrogen receptors. Converted into the anticancer agent piceatannol (Cat. No. 1554) by cytochrome P450 1B1. Activates autophagy.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in ethanol and to 100 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Therapeutic potential of resveratrol: the in vivo evidence.
    Baur and Sinclair
    Nat.Rev.Drug Discov., 2006;5:493
  2. Resveratrol acts as a mixed agonist/antagonist for estrogen receptors α and β.
    Bowers et al.
    Endocrinology, 2000;141:3657
  3. Resveratrol is a selective human cytochrome P450 1A1 inhibitor.
    Chun et al.
    Biochem.Biophys.Res.Commun., 1999;262:20
  4. Effects of stilbenes on arachidonate metabolism in leukocytes.
    Kimura et al.
    Biochim.Biophys.Acta, 1985;834:275
  5. Biological effects of resveratrol.
    Life Sci., 2000;66:663
  6. Regulation of histone H2A.Z exprsesion is mediated by sirtuin 1 in prostate cancer.
    Baptista et al.
    Oncotarget, 2013;4:1673
  7. Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles.
    Galluzzi et al.
    Nat.Rev.Drug.Discov., 2017;

The citations listed below are publications that use Tocris products. Selected citations for Resveratrol include:

7 Citations: Showing 1 - 7
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  1. Suppressive Effects of Resveratrol Treatment on The Intrinsic Evoked Excitability of CA1 Pyramidal Neurons.
    Authors: Meftahi Et al.
    Evid Based Complement Alternat Med 2015;17:532
  2. Astrocytes expressing mutant SOD1 and TDP43 trigger motoneuron death that is mediated via sodium channels and nitroxidative stress.
    Authors: Rojas Et al.
    Front Cell Neurosci 2014;8:24
  3. Regulation of neurons in the dorsal motor nucleus of the vagus by SIRT1.
    Authors: Jiang and Zsombok
    Front Neurosci 2014;7:270
  4. A critical role for interferon regulatory factor 9 in cerebral ischemic stroke.
    Authors: Chen Et al.
    J Neurosci 2014;34:11897
  5. Active Constituents from Liriope platyphylla Root against Cancer Growth In Vitro.
    Authors: Wang Et al.
    Cancer Res 2013;2013:857929
  6. SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1.
    Authors: Pacholec Et al.
    J Biol Chem 2010;285:8340
  7. Identifying the estrogen receptor coactivator PELP1 in autophagosomes.
    Authors: Ohshiro Et al.
    Br J Pharmacol 2007;67:8164

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