Catalog Number: 1418
Chemical Name: 5-[(1E)-2-(4-Hydroxyphenyl)ethenyl]-1,3,benzenediol
Biological Activity
A phytoestrogen with antitumor, antioxidant, antiplatelet, anti-inflammatory and antifungal effects. Inhibits cytochrome P450 1A1 (IC50 = 23 μM) and displays mixed agonist/antagonist actions at ERα and ERβ estrogen receptors. Converted into the anticancer agent piceatannol (Cat. No. 1554) by cytochrome P450 1B1.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in ethanol and to 100 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at +4°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Therapeutic potential of resveratrol: the in vivo evidence.
    Baur and Sinclair
    Nat.Rev.Drug Discov., 2006;5:493
  2. Resveratrol acts as a mixed agonist/antagonist for estrogen receptors α and β.
    Bowers et al.
    Endocrinology, 2000;141:3657
  3. Resveratrol is a selective human cytochrome P450 1A1 inhibitor.
    Chun et al.
    Biochem.Biophys.Res.Commun., 1999;262:20
  4. Effects of stilbenes on arachidonate metabolism in leukocytes.
    Kimura et al.
    Biochim.Biophys.Acta, 1985;834:275
  5. Biological effects of resveratrol.
    Life Sci., 2000;66:663
  6. Regulation of histone H2A.Z exprsesion is mediated by sirtuin 1 in prostate cancer.
    Baptista et al.
    Oncotarget, 2013;4:1673
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