Chemical Name: 5-[(1E)-2-(4-Hydroxyphenyl)ethenyl]-1,3,benzenediol
Biological ActivityResveratrol is a phytoestrogen with antitumor, antioxidant, antiplatelet, anti-inflammatory and antifungal effects. Inhibits cytochrome P450 1A1 (IC50 = 23 μM) and displays mixed agonist/antagonist actions at ERα and ERβ estrogen receptors. Converted into the anticancer agent piceatannol (Cat. No. 1554) by cytochrome P450 1B1. Activates autophagy. Also activates TRPA1 in prostate cancer-associated fibroblasts. Also SIRT1 activator.
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Regulation of histone H2A.Z exprsesion is mediated by sirtuin 1 in prostate cancer.
Baptista et al.
Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles.
Galluzzi et al.
Activation of mutated TRPA1 ion channel by resveratrol in human prostate cancer associated fibroblasts (CAF).
Vancauwenberghe et al.
Resveratrol is a selective human cytochrome P450 1A1 inhibitor.
Chun et al.
Therapeutic potential of resveratrol: the in vivo evidence.
Baur and Sinclair
Nat.Rev.Drug Discov., 2006;5:493
Biological effects of resveratrol.
Life Sci., 2000;66:663
Resveratrol acts as a mixed agonist/antagonist for estrogen receptors α and β.
Bowers et al.
Effects of stilbenes on arachidonate metabolism in leukocytes.
Kimura et al.
Citations for Resveratrol
The citations listed below are publications that use Tocris products. Selected citations for Resveratrol include:
7 Citations: Showing 1 - 7
Suppressive Effects of Resveratrol Treatment on The Intrinsic Evoked Excitability of CA1 Pyramidal Neurons.
Authors: Meftahi Et al.
Evid Based Complement Alternat Med 2015;17:532
Astrocytes expressing mutant SOD1 and TDP43 trigger motoneuron death that is mediated via sodium channels and nitroxidative stress.
Authors: Rojas Et al.
Front Cell Neurosci 2014;8:24
Regulation of neurons in the dorsal motor nucleus of the vagus by SIRT1.
Authors: Jiang and Zsombok
Front Neurosci 2014;7:270
A critical role for IF. regulatory factor 9 in cerebral ischemic stroke.
Authors: Chen Et al.
J Neurosci 2014;34:11897
Active Constituents from Liriope platyphylla Root against Cancer Growth In Vitro.
Authors: Wang Et al.
Cancer Res 2013;2013:857929
SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1.
Authors: Pacholec Et al.
J Biol Chem 2010;285:8340
Identifying the estrogen receptor coactivator PELP1 in autophagosomes.
Authors: Ohshiro Et al.
Br J Pharmacol 2007;67:8164
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