Biological ActivityRETF-4NA is a chymase substrate peptide that is cleaved more avidly by α2-macroglobulin-bound chymase than the free, unbound form. Displays selectivity over cathepsin G and chymotrypsin.
(Modifications: Arg-1 = N-terminal Ac, Phe-4 = 4-Nitroanilide)
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Tocris products are intended for laboratory research use only, unless stated otherwise.
α2-macroglobulin capture allows detection of mast cell chymase in serum and creates a reservoir of angiotensin II-generated activity.
Raymond et al.
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