Reversan

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3722/10
3722/50
Reversan | CAS No. 313397-13-6 | Multidrug Transporter Inhibitors
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Description: Selective MRP1 and P-gp inhibitor

Chemical Name: N-[3-(4-Morpholinyl)propyl]-5,7-diphenylpyrazolo[1,5-a]pyrimidine-3-carboxamide

Purity: ≥99%

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Biological Activity

Selective inhibitor of multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (P-gp). Increases the sensitivity of MRP1-overexpressing tumor cells (MCF7/VP) to doxorubicin (Cat. No. 2252), vincristine (Cat. No. 1257) and etoposide (Cat. No. 1226) by 3.8-, 14.6- and 11.6-fold respectively. Increases the efficacy of vincristine and etoposide in murine models of neuroblastoma in vivo. Does not sensitize MRP2, MRP3, MRP4 or MRP5 transporters to known substrates.

Technical Data

M.Wt:
441.52
Formula:
C26H27N5O2
Solubility:
Soluble to 25 mM in DMSO
Purity:
≥99%
Storage:
Store at RT
CAS No:
313397-13-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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