Pregnane X receptor (PXR) agonist; antibiotic. Reduces number of colon tumors and suppresses expression of TNFα
induced in a colon cancer, PXR-humanized mouse model. Increases apoptosis and decreased proliferation in HT-29 cells. Exhibits low gastrointestinal absorption while retaining its antibacterial activity. Active against gram-positive and gram-negative bacteria.
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All Tocris products are intended for laboratory research use only.
Rifaximin: in vitro and in vivo antibacterial activity-a review.
Jiang et al.
Structural elucidation of the Rifaximin Ph. Eur. Impurity H.
Stradi et al.
Activation of intestinal human pregnane X receptor protects against azoxymethane/dextran sulfate sodium-induced colon cancer.
Cheng et al.