MSK/RSK family kinase inhibitor. Exhibits selectivity for RSK2 over NEK2 and PLK1 (IC50
s are 12, 530 and 2200 nM, respectively). Inhibits MSK1, MSK2, RSK2 and RSK3 in cellular assays. Reduces CREB phosphorylation in HeLa cells.
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All Tocris products are intended for laboratory research use only.
Electrophilic fragment-based design of reversible covalent kinase inhibitors.
Miller et al.