RMM 46

Discontinued Product

5909 has been discontinued.
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RMM 46 | CAS No. 1307896-46-3 | RSK Inhibitors
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Description: MSK/RSK family kinase inhibitor

Chemical Name: 2-Cyano-N-(2-hydroxy-1,1-dimethylethyl)-3-[3-(3,4,5-trimethoxyphenyl)-1H-indazol-5-yl]-2-propenamide

Purity: ≥98%

Product Details
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Biological Activity

RMM 46 is a MSK/RSK family kinase inhibitor. Exhibits selectivity for RSK2 over NEK2 and PLK1 (IC50s are 12, 530 and 2200 nM, respectively). Inhibits MSK1, MSK2, RSK2 and RSK3 in cellular assays. Reduces CREB phosphorylation in HeLa cells.

Technical Data

M.Wt:
450.5
Formula:
C24H26N4O5
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1307896-46-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Electrophilic fragment-based design of reversible covalent kinase inhibitors.
    Miller et al.
    J.Am.Chem.Soc., 2013;135:5298

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