Catalog Number: 2916
Chemical Name: (αR,βR)-β-(Cyclopentylmethyl)-N-hydroxy-γ-oxo-α-[(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)methyl]-1-piperidinebutanamide
Biological Activity
Potent, collagenase-selective MMP inhibitor (Ki values are 3.0, 3.4, 4.4, 59, 154 and 527 nM for MMP-1, MMP-13, MMP-8, MMP-9, MMP-2 and MMP-3 respectively). Inhibits cartilage breakdown in vitro and in vivo and displays antiarthritic activity. Orally active.
Technical Data
  • M.Wt:
    436.55
  • Formula:
    C22H36N4O5
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >97%
  • Storage:
    Store at -20°C
  • CAS No:
    190648-49-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Ro 32-3555, an orally active collagenase inhibitor, prevents cartilage breakdown in vitro and in vivo.
    Lewis et al.
    Br.J.Pharmacol., 1997;121:540
  2. Design and synthesis of the cartilage protective agent (CPA, Ro32-3555).
    Broadhurst et al.
    Bioorg.Med.Chem.Letts., 1997;7:2299
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Ro 32-3555 include:

1 Citations: Showing 1 - 1

  1. Matrix remodeling maintains embryonic stem cell self-renewal by activating Stat3.
    Authors: Przybyla Et al.
    Stem Cells 2013;31:1097

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