Ro 32-3555

  ( 2 citations )    
Product Datasheet
Catalog Number:2916
Chemical Name:(αR,βR)-β-(Cyclopentylmethyl)-N-hydroxy-γ-oxo-α-[(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)methyl]-1-piperidinebutanamide
Product Details
Citations (2)
Reviews
Biological Activity
Potent, collagenase-selective MMP inhibitor (Ki values are 3.0, 3.4, 4.4, 59, 154 and 527 nM for MMP-1, MMP-13, MMP-8, MMP-9, MMP-2 and MMP-3 respectively). Inhibits cartilage breakdown in vitro and in vivo and displays antiarthritic activity. Orally active.
Technical Data
  • M.Wt:
    436.55
  • Formula:
    C22H36N4O5
  • Solubility:
    Soluble to 100 mM in DMSO and to 100 mM in ethanol
  • Purity:
    >97
  • Storage:
    Store at -20°C
  • CAS No:
    190648-49-8
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Ro 32-3555 include:

2 Citations: Showing 1 - 2
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  1. Matrix metalloproteinase-9 activity and a downregulated Hedgehog pathway impair blood-brain barrier function in an in vitro model of CNS tuberculosis.
    Authors: Brilha
    Sci Rep  2017;7(1):16031
  2. Matrix remodeling maintains embryonic stem cell self-renewal by activating Stat3.
    Authors: Przybyla Et al.
    Stem Cells  2013;31:1097

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