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Ro 32-3555

Catalog #: 2916
2 Citations Datasheet / COA / SDS

Discontinued Product

2916 has been discontinued.
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Ro 32-3555 | CAS No. 190648-49-8 | Synthetic Metalloprotease Inhibitors
1 Image
Description: Potent, collagenase-selective MMP inhibitor

Chemical Name: (αR,βR)-β-(Cyclopentylmethyl)-N-hydroxy-γ-oxo-α-[(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)methyl]-1-piperidinebutanamide

Purity: ≥97%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Potent, collagenase-selective MMP inhibitor (Ki values are 3.0, 3.4, 4.4, 59, 154 and 527 nM for MMP-1, MMP-13, MMP-8, MMP-9, MMP-2 and MMP-3 respectively). Inhibits cartilage breakdown in vitro and in vivo and displays antiarthritic activity. Orally active.

Technical Data

M.Wt:
436.55
Formula:
C22H36N4O5
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
190648-49-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Ro 32-3555, an orally active Col. inhibitor, prevents cartilage breakdown in vitro and in vivo.
    Lewis et al.
    Br.J.Pharmacol., 1997;121:540
  2. Design and synthesis of the cartilage protective agent (CPA, Ro32-3555).
    Broadhurst et al.
    Bioorg.Med.Chem.Letts., 1997;7:2299
  3. Ro 32-3555, an orally active Col. selective inhibitor, prevents structural damage in the SRT/ORT mouse model of osteoarthritis.
    Brewster et al.
    Arthrit.Rheumat., 1998;41:1639

Product Datasheets

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Citations for Ro 32-3555

The citations listed below are publications that use Tocris products. Selected citations for Ro 32-3555 include:

2 Citations: Showing 1 - 2

  1. Matrix metalloproteinase-9 activity and a downregulated Hedgehog pathway impair blood-brain barrier function in an in vitro model of CNS tuberculosis.
    Authors: Brilha
    Sci Rep  2017;7(1):16031
  2. Matrix remodeling maintains embryonic stem cell self-renewal by activating Stat3.
    Authors: Przybyla Et al.
    Stem Cells  2013;31:1097

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