RS 67333 hydrochloride

  ( 5 citations )    
Product Datasheet
Catalog Number:0989
Chemical Name:1-(4-Amino-5-chloro-2-methoxyphenyl)-3-[1-butyl-4-piperidinyl]-1-propanone hydrochloride
Product Details
Citations (5)
Supplemental Products
Reviews
Biological Activity
A potent and highly selective 5-HT4 partial agonist, with pKi values of 8.7 at 5-HT4 sites in guinea pig striatum and > 6 at various other receptors, including 5-HT1A, 1D, 2A, 2C, D1, D2 and M1-3. Active in vivo, with an intrinsic activity relative to 5-HT of 0.5.
Technical Data
  • M.Wt:
    389.36
  • Formula:
    C19H29ClN2O2.HCl
  • Solubility:
    Soluble to 25 mM in water with gentle warming
  • Purity:
    >99
  • Storage:
    Store at RT
  • CAS No:
    168986-60-5
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of Roche Bioscience
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for RS 67333 hydrochloride include:

5 Citations: Showing 1 - 5
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  1. Bidirectional regulation of emotional memory by 5-HT1B receptors involves hippocampal p11.
    Authors: Eriksson Et al.
    Learn Mem  2013;18:1096
  2. 5-hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of dendritic cells in vitro and in vivo.
    Authors: Müller Et al.
    PLoS One  2009;4:e6453
  3. Role of p11 in cellular and behavioral effects of 5-HT4 receptor stimulation.
    Authors: Warner-Schmidt Et al.
    J Neurosci  2009;29:1937
  4. 5-Hydroxytryptamine induces a protein kinase A/mitogen-activated protein kinase-mediated and macromolecular synthesis-dependent late phase of long-term potentiation in the amygdala.
    Authors: Huang and Kandel
    Obesity (Silver Spring)  2007;27:3111
  5. Low-frequency stimulation induces a pathway-specific late phase of LTP in the amygdala that is mediated by PKA and dependent on protein synthesis.
    Authors: Huang and Kandel
    J Neurosci  2007;14:497

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