RS 67506 hydrochloride
Chemical Name: 1-(4-Amino-5-chloro-2-methoxyphenyl)-3-[1-2-methylsulphonylamino)ethyl-4-piperidinyl]-1-propanone hydrochloride
Biological ActivityRS 67506 hydrochloride is a potent and selective 5-HT4 partial agonist, with a pKi of 8.8 at 5-HT4 sites in guinea pig striatum, but < 6.0 at several other receptors including 5-HT1A, 1D, 2A, 2C, D1, D2 and M1-3. It is active in vivo and has an intrinsic activity compared to 5-HT of 0.6.
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Central 5-HT4 receptors.
Eglen et al.
Pharmacological characterization of two novel and potent 5-HT4 receptor agonists, RS 67333 and RS 67506, in vitro and in vivo.
Eglen et al.
The effects of novel, selective 5-hydroxytryptamine (5HT)4 ligands in rat spatial navigation.
Fontana et al.
Citation for RS 67506 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for RS 67506 hydrochloride include:
1 Citation: Showing 1 - 1
Adaptation of NS cells growth and differentiation to high-throughput screening-compatible plates.
Authors: Garavaglia Et al.
BMC Neurosci 2010;11:7
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