RS 67506 hydrochloride

Name: RS 67506 hydrochloride
Brand: Tocris Bioscience
SKU: 0990

Catalog #: 0990
1 Citation Datasheet / COA / SDS

Discontinued Product

0990 has been discontinued.

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RS 67506 hydrochloride | CAS No. 168986-61-6 | 5-HT4 Receptor Agonists

1 Image

Description: 5-HT4 partial agonist

Chemical Name: 1-(4-Amino-5-chloro-2-methoxyphenyl)-3-[1-2-methylsulphonylamino)ethyl-4-piperidinyl]-1-propanone hydrochloride

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Product Details

Citations (1)

Reviews

Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

RS 67506 hydrochloride is a potent and selective 5-HT₄ partial agonist, with a pK_i of 8.8 at 5-HT₄ sites in guinea pig striatum, but < 6.0 at several other receptors including 5-HT_{1A, 1D, 2A, 2C}, D₁, D₂ and M_1-3. It is active in vivo and has an intrinsic activity compared to 5-HT of 0.6.

Technical Data

M.Wt:

454.41

Formula:

C₁₈H₂₈ClN₃O₄S.HCl

Solubility:

Soluble to 80 mM in water

Storage:

Store at RT

CAS No:

168986-61-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:

Sold with the permission of Roche Bioscience

Background References

High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
Central 5-HT₄ receptors.
Eglen et al.
TiPS, 1995;16:391
Pharmacological characterization of two novel and potent 5-HT₄ receptor agonists, RS 67333 and RS 67506, in vitro and in vivo.
Eglen et al.
Br.J.Pharmacol., 1995;115:1387
The effects of novel, selective 5-hydroxytryptamine (5HT)₄ ligands in rat spatial navigation.
Fontana et al.
Neuropharmacology, 1997;36:689

Product Datasheets

Certificate of Analysis is currently unavailable on-line. Please contact Customer Service

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Mass

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M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citation for RS 67506 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for RS 67506 hydrochloride include:

1 Citation: Showing 1 - 1

Adaptation of NS cells growth and differentiation to high-throughput screening-compatible plates.
Authors: Garavaglia Et al.
BMC Neurosci 2010;11:7

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