Catalog Number: 0990
Chemical Name: 1-(4-Amino-5-chloro-2-methoxyphenyl)-3-[1-2-methylsulphonylamino)ethyl-4-piperidinyl]-1-propanone hydrochloride
Biological Activity
A potent and selective 5-HT4 partial agonist, with a pKi of 8.8 at 5-HT4 sites in guinea pig striatum, but < 6.0 at several other receptors including 5-HT1A, 1D, 2A, 2C, D1, D2 and M1-3. It is active in vivo and has an intrinsic activity compared to 5-HT of 0.6.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 80 mM in water
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of Roche Bioscience
Background References
  1. The effects of novel, selective 5-hydroxytryptamine (5HT)4 ligands in rat spatial navigation.
    Fontana et al.
    Neuropharmacology, 1997;36:689
  2. Pharmacological characterization of two novel and potent 5-HT4 receptor agonists, RS 67333 and RS 67506, in vitro and in vivo.
    Eglen et al.
    Br.J.Pharmacol., 1995;115:1387
  3. Central 5-HT4 receptors.
    Eglen et al.
    TiPS, 1995;16:391

The citations listed below are publications that use Tocris products. Selected citations for RS 67506 hydrochloride include:

Showing Results 1 - 1 of 1

  1. Adaptation of NS cells growth and differentiation to high-throughput screening-compatible plates.
    Authors: Garavaglia Et al.
    BMC Neurosci
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