Home / Additional Estrogen and Related Receptor Compounds / RU 58668

RU 58668

Catalog #: 3224
2 Citations Datasheet / COA / SDS

Discontinued Product

3224 has been discontinued.
View all Additional Estrogen and Related Receptor Compounds products.
RU 58668 | CAS No. 151555-47-4 | Additional Estrogen and Related Receptor Compounds
1 Image
Description: Pure antiestrogen

Chemical Name: (11β,17β)-11-[4-[[5-[(4,4,5,5,5-Pentafluoropentyl)sulfonyl]pentyl]oxy]phenylestra-1,3,5,(10)-triene-3,17-diol

Purity: ≥95%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Pure antiestrogen that downregulates estrogen receptor expression (IC50 = 0.04 nM). Displays potent antiproliferative activity in vitro (IC50 = 0.035 - 0.09 nM in MCF-7 cells) and causes long term regression of tamoxifen-resistant MCF-7 xenografts in vivo.

Technical Data

M.Wt:
658.76
Formula:
C34H43F5O5S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥95%
Storage:
Store at +4°C
CAS No:
151555-47-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Partial antagonism between steroidal and nonsteroidal antiestrogens in human breast cancer cell lines.
    Muller et al.
    Cancer Res., 1998;58:263
  2. RU 58668: Further in vitro and in vivo pharmacological data related to its antitumoral activity.
    Van de Velde et al.
    J.Steroid Molec.Biol., 1996;59:449
  3. Drug delivery systems for oestrogenic hormones and antagonists: the need for selective targeting in OE-dependent cancers.
    Ameller et al.
    J.Steroid Molec.Biol., 2004;92:1

Product Datasheets

Reconstitution Calculator
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Reconstitution Calculator

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Citations for RU 58668

The citations listed below are publications that use Tocris products. Selected citations for RU 58668 include:

2 Citations: Showing 1 - 2

  1. Activating ESR1 Mutations Differentially Affect the Efficacy of ER Antagonists.
    Authors: Toy Et al.
    Cancer Discov  2017;7:277
  2. Oestrogen Receptor-α binds the FOXP3 promoter and modulates regulatory T-cell function in human cervical cancer.
    Authors: Adurthi Et al.
    Sci Rep  2017;7:17289

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