Pure antiestrogen that downregulates estrogen receptor expression (IC50
= 0.04 nM). Displays potent antiproliferative activity in vitro
= 0.035 - 0.09 nM in MCF-7 cells) and causes long term regression of tamoxifen-resistant MCF-7 xenografts in vivo
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Partial antagonism between steroidal and nonsteroidal antiestrogens in human breast cancer cell lines.
Muller et al.
Cancer Res., 1998;58:263
RU 58668: Further in vitro and in vivo pharmacological data related to its antitumoral activity.
Van de Velde et al.
J.Steroid Molec.Biol., 1996;59:449