RU 58668

RU 58668 | CAS No. 151555-47-4 | Additional Estrogen and Related Receptor Compounds
1 Image
Description: Pure antiestrogen

Chemical Name: (11β,17β)-11-[4-[[5-[(4,4,5,5,5-Pentafluoropentyl)sulfonyl]pentyl]oxy]phenylestra-1,3,5,(10)-triene-3,17-diol

Purity: ≥95%

Product Details
Citations (2)

Biological Activity

Pure antiestrogen that downregulates estrogen receptor expression (IC50 = 0.04 nM). Displays potent antiproliferative activity in vitro (IC50 = 0.035 - 0.09 nM in MCF-7 cells) and causes long term regression of tamoxifen-resistant MCF-7 xenografts in vivo.

Technical Data

Soluble to 100 mM in DMSO and to 100 mM in ethanol
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Partial antagonism between steroidal and nonsteroidal antiestrogens in human breast cancer cell lines.
    Muller et al.
    Cancer Res., 1998;58:263
  2. RU 58668: Further in vitro and in vivo pharmacological data related to its antitumoral activity.
    Van de Velde et al.
    J.Steroid Molec.Biol., 1996;59:449
  3. Drug delivery systems for oestrogenic hormones and antagonists: the need for selective targeting in OE-dependent cancers.
    Ameller et al.
    J.Steroid Molec.Biol., 2004;92:1

Product Datasheets

Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Molarity Calculator


*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Citations for RU 58668

The citations listed below are publications that use Tocris products. Selected citations for RU 58668 include:

2 Citations: Showing 1 - 2


No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for RU 58668

There are currently no reviews for this product. Be the first to review RU 58668 and earn rewards!

Have you used RU 58668?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.