Toll-like receptor 7 (TLR7) agonist; induces immune cell activation and increases cytokine production. Displays antitumor and antiviral activity in various animal models.
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Loxoribine induces chronic lymphocytic leukemia B cells to traverse the cell cycle.
Goodman et al.
The toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily.
Heil et al.
Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of toll-like receptor 7.
Lee et al.