Ryanodine

Name: Ryanodine
Brand: Tocris Bioscience
SKU: 1329
Price: 286 USD
Availability: InStock

Tocris Bioscience | Catalog # 1329

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Citations (244)

Product Documents

Ca2+ release inhibitor

Product Description
Product Specifications
Solubility
Preparing Stock Solutions
Calculators
Background References
Product Documents
Specific Notices
Research Areas

Key Product Details

Description

Ca2+ release inhibitor

View all Ryanodine Receptor Inhibitors »

Product Description

Ryanodine is a potent inhibitor of Ca²⁺ release from sarcoplasmic reticulum (IC₅₀ values are 10 and 2.8 nM in skeletal and cardiac muscle respectively).

Product Specifications for Ryanodine

Molecular Weight

493.55

Formula

C₂₅H₃₅NO₉

Storage

Store at -20°C

Purity

≥98% (HPLC)

Chemical Name

1H-Pyrrole-2-carboxylic acid, (3S,4R,4aR,6S,7S,8R,8aS,8bR,9S,9aS)-dodecahydro-4,6,7,8a,8b,9a-hexahydroxy-3,6a,9-trimethyl-7-(1-methylethyl)-6,9-methanobenzo[1,2]pentaleno[1,6-bc]furan-8-yl ester

CAS Number

15662-33-6

PubChem ID

11317883

InChI Key

JJSYXNQGLHBRRK-SFEDZAPPSA-N

SMILES

O=C(C6=CC=CN6)O[C@@H]1[C@@]([C@@H](C)C)(O)[C@]4(C)[C@@]3(O)[C@@](O)1[C@]5(C)[C@@]2(O)CC[C@H](C)[C@@H](O)[C@@]23O[C@](O)4C5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	12.34	25
	Ethanol	4.94	10

Preparing Stock Solutions for Ryanodine

The following data is based on the product molecular weight 493.55.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.25 mM	8.10 mL	40.52 mL	81.05 mL
1.25 mM	1.62 mL	8.10 mL	16.21 mL
2.5 mM	0.81 mL	4.05 mL	8.10 mL
12.5 mM	0.16 mL	0.81 mL	1.62 mL

Calculators

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 244 publications citing the usage of this product.

Sutko Ryanodine: a modifier of sarcoplasmic reticulum calcium release in striated muscle. Fed.Proc. 1985 PMID: 2415406
Sutko The pharmacology of ryanodine and related compounds. Pharmacol.Rev. 1997 PMID: 9085309
Bianchi Conformation state of the ryanodine receptor and functional effects of ryanodine on skeletal muscle. Biochem.Pharmacol. 1997 PMID: 9174102

Product Documents for Ryanodine

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Download SDS

Product Specific Notices for Ryanodine

For research use only

Related Research Areas

Ion Channels and Regulators

Citations for Ryanodine

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