( 28 citations )    
Product Datasheet
Catalog Number:1329
Chemical Name:1H-Pyrrole-2-carboxylic acid, (3S,4R,4aR,6S,7S,8R,8aS,8bR,9S,9aS)-dodecahydro-4,6,7,8a,8b,9a-hexahydroxy-3,6a,9-trimethyl-7-(1-methylethyl)-6,9-methanobenzo[1,2]pentaleno[1,6-bc]furan-8-yl ester
Product Details
Citations (28)
Biological Activity
Potent inhibitor of Ca2+ release from sarcoplasmic reticulum (IC50 values are 10 and 2.8 nM in skeletal and cardiac muscle respectively).
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 10 mM in ethanol and to 25 mM in DMSO
  • Purity:
  • Storage:
    Desiccate at -20°C
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Product Datasheets
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The citations listed below are publications that use Tocris products. Selected citations for Ryanodine include:

28 Citations: Showing 1 - 10
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  1. Metaplasticity mechanisms restore plasticity and associativity in an animal model of Alzheimer's disease.
    Authors: Li
    Proc Natl Acad Sci U.S.A.  2017;114(21):5527
  2. Calcium handling precedes cardiac differentiation to initiate the first heartbeat.
    Authors: Tyser Et al.
    Elife  2016;5
  3. Cardiac sodium/calcium exchanger preconditioning promotes anti-arrhythmic and cardioprotective effects through mitochondrial calcium-activated potassium channel.
    Authors: Zhang Et al.
    Pflugers Arch  2015;8:10239
  4. Caffeine Modulates Vesicle Release and Recovery at Cerebellar Parallel Fibre Terminals, Independently of Calcium and Cyclic AMP Signalling.
    Authors: Dobson Et al.
    J Neurosci Res  2015;10:e0125974
  5. Modified cytoplasmic Ca2+ sequestration contributes to spinal cord injury-induced augmentation of nerve-evoked contractions in the rat tail artery.
    Authors: Dera Et al.
    PLoS One  2014;9:e111804
  6. Microtubule dynamics at the growth cone are mediated by α7 nicotinic receptor activation of a Gαq and IP3 receptor pathway.
    Authors: Nordman and Kabbani
    J Neurosci  2014;28:2995
  7. Acute simvastatin inhibits K ATP channels of porcine coronary artery myocytes.
    Authors: Seto Et al.
    Am J Physiol Cell Physiol  2013;8:e66404
  8. Characterization of functional TRPV1 channels in the sarcoplasmic reticulum of mouse skeletal muscle.
    Authors: Lotteau Et al.
    PLoS One  2013;8:e58673
  9. Mechanisms underlying activation of transient BK current in rabbit urethral smooth muscle cells and its modulation by IP3-generating agonists.
    Authors: Kyle Et al.
    Korean J Physiol Pharmacol  2013;305:C609
  10. Non-Hebbian plasticity at C-fiber synapses in rat spinal cord lamina I neurons.
    Authors: Naka Et al.
    Pain  2013;154:1333
  11. Netrin-1 stimulates developing GnRH neurons to extend neurites to the median eminence in a calcium- dependent manner.
    Authors: Low Et al.
    PLoS One  2012;7:e46999
  12. Ethanol alters opioid regulation of Ca(2+) influx through L-type Ca(2+) channels in PC12 cells.
    Authors: Gruol Et al.
    Alcohol Clin Exp Res  2012;36:443
  13. DHA inhibits ER Ca2+ release and ER stress in astrocytes following in vitro ischemia.
    Authors: Begum Et al.
    J Neurochem  2012;120:622
  14. Local small airway epithelial injury induces global smooth muscle contraction and airway constriction.
    Authors: Zhou Et al.
    J Appl Physiol (1985)  2012;112:627
  15. Asynchronous Ca2+ current conducted by voltage-gated Ca2+ (CaV)-2.1 and CaV2.2 channels and its implications for asynchronous neurotransmitter release.
    Authors: Few Et al.
    Proc Natl Acad Sci U S A  2012;109:E452
  16. RyRCa2+ leak limits cardiac Ca2+ window current overcoming the tonic effect of calmodulinin mice.
    Authors: Fernández-Velasco Et al.
    PLoS One  2011;6:e20863
  17. The human immunodeficiency virus coat protein gp120 promotes forward trafficking and surface clustering of NMDA receptors in membrane microdomains.
    Authors: Xu Et al.
    PLoS One  2011;31:17074
  18. Associative, bidirectional changes in neural signaling utilizing NMDA receptor- and endocannabinoid-dependent mechanisms.
    Authors: Li and Burrell
    Learn Mem  2011;18:545
  19. Alteration of Ryanodine-receptors in Cultured Rat Aortic Smooth Muscle Cells.
    Authors: Kim Et al.
    PLoS One  2011;15:431
  20. Cholesterol efflux to apoA-I in ABCA1-expressing cells is regulated by Ca2+-dependent calcineurin signaling.
    Authors: Karwatsky Et al.
    J Lipid Res  2010;51:1144
  21. Activation of muscarinic acetylcholine receptors induces a nitric oxide-dependent long-term depression in rat medial prefrontal cortex.
    Authors: Huang and Hsu
    Cereb Cortex  2010;20:982
  22. Non-cardiomyocytes influence the electrophysiological maturation of human embryonic stem cell-derived cardiomyocytes during differentiation.
    Authors: Kim Et al.
    Int J Clin Exp Pathol  2010;19:783
  23. Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death.
    Authors: Luciani Et al.
    Diabetes  2009;58:422
  24. H(2)O(2)-mediated modulation of cytosolic signaling and organelle function in rat hippocampus.
    Authors: Gerich Et al.
    FASEB J  2009;458:937
  25. Glucose and endoplasmic reticulum calcium channels regulate HIF-1beta via presenilin in pancreatic beta-cells.
    Authors: Dror Et al.
    J Biol Chem  2008;283:9909
  26. Effects of anoxia and aglycemia on cytosolic calcium regulation in rat sensory neurons.
    Authors: Henrich and Buckler
    J Neurophysiol  2008;100:456
  27. Apelin increases contractility in failing cardiac muscle.
    Authors: Dai Et al.
    Eur J Pharmacol  2006;553:222
  28. Ca2+ dynamics in salivary acinar cells: distinct morphology of the acinar lumen underlies near-synchronous global Ca2+ responses.
    Authors: Larina and Thorn
    J Cell Sci  2005;118:4131
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