Catalog Number: 1329
Chemical Name: 1H-Pyrrole-2-carboxylic acid, (3S,4R,4aR,6S,7S,8R,8aS,8bR,9S,9aS)-dodecahydro-4,6,7,8a,8b,9a-hexahydroxy-3,6a,9-trimethyl-7-(1-methylethyl)-6,9-methanobenzo[1,2]pentaleno[1,6-bc]furan-8-yl ester
Biological Activity
Potent inhibitor of Ca2+ release from sarcoplasmic reticulum (IC50 values are 10 and 2.8 nM in skeletal and cardiac muscle respectively).
Technical Data
  • M.Wt:
    493.55
  • Formula:
    C25H35NO9
  • Solubility:
    Soluble to 10 mM in ethanol and to 25 mM in DMSO
  • Purity:
    >98%
  • Storage:
    Desiccate at -20°C
  • CAS No:
    15662-33-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Conformation state of the ryanodine receptor and functional effects of ryanodine on skeletal muscle.
    Bianchi
    Biochem.Pharmacol., 1997;53:909
  2. Ryanodine: a modifier of sarcoplasmic reticulum calcium release in striated muscle.
    Sutko et al.
    Fed.Proc., 1985;44:2984
  3. The pharmacology of ryanodine and related compounds.
    Sutko et al.
    Pharmacol.Rev., 1997;49:53
Citations:

The citations listed below are publications that use Tocris products. Selected citations for Ryanodine include:

20 Citations: Showing 1 - 10
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  1. Metaplasticity mechanisms restore plasticity and associativity in an animal model of Alzheimer's disease.
    Authors: Li
    Proc Natl Acad Sci U.S.A. 2017;114(21):5527
  2. Cardiac sodium/calcium exchanger preconditioning promotes anti-arrhythmic and cardioprotective effects through mitochondrial calcium-activated potassium channel.
    Authors: Zhang Et al.
    Pflugers Arch 2015;8:10239
  3. Caffeine Modulates Vesicle Release and Recovery at Cerebellar Parallel Fibre Terminals, Independently of Calcium and Cyclic AMP Signalling.
    Authors: Dobson Et al.
    J Neurosci Res 2015;10:e0125974
  4. Microtubule dynamics at the growth cone are mediated by α7 nicotinic receptor activation of a Gαq and IP3 receptor pathway.
    Authors: Nordman and Kabbani
    J Neurosci 2014;28:2995
  5. Acute simvastatin inhibits K ATP channels of porcine coronary artery myocytes.
    Authors: Seto Et al.
    Am J Physiol Cell Physiol 2013;8:e66404
  6. Characterization of functional TRPV1 channels in the sarcoplasmic reticulum of mouse skeletal muscle.
    Authors: Lotteau Et al.
    PLoS One 2013;8:e58673
  7. Mechanisms underlying activation of transient BK current in rabbit urethral smooth muscle cells and its modulation by IP3-generating agonists.
    Authors: Kyle Et al.
    Korean J Physiol Pharmacol 2013;305:C609
  8. Netrin-1 stimulates developing GnRH neurons to extend neurites to the median eminence in a calcium- dependent manner.
    Authors: Low Et al.
    PLoS One 2012;7:e46999
  9. DHA inhibits ER Ca2+ release and ER stress in astrocytes following in vitro ischemia.
    Authors: Begum Et al.
    J Neurochem 2012;120:622
  10. Local small airway epithelial injury induces global smooth muscle contraction and airway constriction.
    Authors: Zhou Et al.
    J Appl Physiol (1985) 2012;112:627
  11. Asynchronous Ca2+ current conducted by voltage-gated Ca2+ (CaV)-2.1 and CaV2.2 channels and its implications for asynchronous neurotransmitter release.
    Authors: Few Et al.
    Proc Natl Acad Sci U S A 2012;109:E452
  12. RyRCa2+ leak limits cardiac Ca2+ window current overcoming the tonic effect of calmodulinin mice.
    Authors: Fernández-Velasco Et al.
    PLoS One 2011;6:e20863
  13. The human immunodeficiency virus coat protein gp120 promotes forward trafficking and surface clustering of NMDA receptors in membrane microdomains.
    Authors: Xu Et al.
    PLoS One 2011;31:17074
  14. Associative, bidirectional changes in neural signaling utilizing NMDA receptor- and endocannabinoid-dependent mechanisms.
    Authors: Li and Burrell
    Learn Mem 2011;18:545
  15. Alteration of Ryanodine-receptors in Cultured Rat Aortic Smooth Muscle Cells.
    Authors: Kim Et al.
    PLoS One 2011;15:431
  16. Cholesterol efflux to apoA-I in ABCA1-expressing cells is regulated by Ca2+-dependent calcineurin signaling.
    Authors: Karwatsky Et al.
    J Lipid Res 2010;51:1144
  17. Non-cardiomyocytes influence the electrophysiological maturation of human embryonic stem cell-derived cardiomyocytes during differentiation.
    Authors: Kim Et al.
    Int J Clin Exp Pathol 2010;19:783
  18. H(2)O(2)-mediated modulation of cytosolic signaling and organelle function in rat hippocampus.
    Authors: Gerich Et al.
    FASEB J 2009;458:937
  19. Glucose and endoplasmic reticulum calcium channels regulate HIF-1beta via presenilin in pancreatic beta-cells.
    Authors: Dror Et al.
    J Biol Chem 2008;283:9909
  20. Ca2+ dynamics in salivary acinar cells: distinct morphology of the acinar lumen underlies near-synchronous global Ca2+ responses.
    Authors: Larina and Thorn
    J Cell Sci 2005;118:4131
Expand to show all 20 Citations

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