Chemical Name: 1H-Pyrrole-2-carboxylic acid, (3S,4R,4aR,6S,7S,8R,8aS,8bR,9S,9aS)-dodecahydro-4,6,7,8a,8b,9a-hexahydroxy-3,6a,9-trimethyl-7-(1-methylethyl)-6,9-methanobenzo[1,2]pentaleno[1,6-bc]furan-8-yl ester
Biological ActivityPotent inhibitor of Ca2+ release from sarcoplasmic reticulum (IC50 values are 10 and 2.8 nM in skeletal and cardiac muscle respectively).
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Conformation state of the ryanodine receptor and functional effects of ryanodine on skeletal muscle.
Ryanodine: a modifier of sarcoplasmic reticulum calcium release in striated muscle.
Sutko et al.
The pharmacology of ryanodine and related compounds.
Sutko et al.
Citations for Ryanodine
The citations listed below are publications that use Tocris products. Selected citations for Ryanodine include:
34 Citations: Showing 1 - 10
Purinergic signaling in cochlear supporting cells reduces hair cell excitability by increasing the extracellular space.
Authors: Babola Et al.
Dual action of L-Lactate on the activity of NR2B-containing NMDA receptors: from potentiation to neuroprotection.
Authors: Jourdain Et al.
Sci Rep 2018;8(1):13472
Calcium-regulatory proteins as modulators of chemotherapy in human neuroblastoma.
Authors: Florea Et al.
Metaplasticity mechanisms restore plasticity and associativity in an animal model of Alzheimer's disease.
Proc Natl Acad Sci U.S.A. 2017;114(21):5527
Signaling mechanism for modulation by ATP of glycine receptors on rat retinal ganglion cells.
Authors: Zhang Et al.
Sci Rep 2016;6:28938
Calcium handling precedes cardiac differentiation to initiate the first heartbeat.
Authors: Tyser Et al.
Cardiac sodium/calcium exchanger preconditioning promotes anti-arrhythmic and cardioprotective effects through mitochondrial calcium-activated potassium channel.
Authors: Zhang Et al.
Pflugers Arch 2015;8:10239
Intracellular Ca(2+) release from endoplasmic reticulum regulates slow wave currents and pacemaker activity of interstitial cells of Cajal.
Authors: Zhu Et al.
Am J Physiol Cell Physiol 2015;308:C608
Caffeine Modulates Vesicle Release and Recovery at Cerebellar Parallel Fibre Terminals, Independently of Calcium and Cyclic AMP Signalling.
Authors: Dobson Et al.
J Neurosci Res 2015;10:e0125974
Modified cytoplasmic Ca2+ sequestration contributes to spinal cord injury-induced augmentation of nerve-evoked contractions in the rat tail artery.
Authors: Dera Et al.
PLoS One 2014;9:e111804
Microtubule dynamics at the growth cone are mediated by α7 nicotinic receptor activation of a Gαq and IP3 receptor pathway.
Authors: Nordman and Kabbani
J Neurosci 2014;28:2995
Acute SimV. inhibits K ATP channels of porcine coronary artery myocytes.
Authors: Seto Et al.
Am J Physiol Cell Physiol 2013;8:e66404
Characterization of functional TRPV1 channels in the sarcoplasmic reticulum of mouse skeletal muscle.
Authors: Lotteau Et al.
PLoS One 2013;8:e58673
Mechanisms underlying activation of transient BK current in rabbit urethral smooth muscle cells and its modulation by IP3-generating agonists.
Authors: Kyle Et al.
Korean J Physiol Pharmacol 2013;305:C609
Non-Hebbian plasticity at C-fiber synapses in rat spinal cord lamina I neurons.
Authors: Naka Et al.
Netrin-1 stimulates developing GnRH neurons to extend neurites to the median eminence in a calcium- dependent manner.
Authors: Low Et al.
PLoS One 2012;7:e46999
Ethanol alters opioid regulation of Ca(2+) influx through L-type Ca(2+) channels in PC12 cells.
Authors: Gruol Et al.
Alcohol Clin Exp Res 2012;36:443
DHA inhibits ER Ca2+ release and ER stress in astrocytes following in vitro ischemia.
Authors: Begum Et al.
J Neurochem 2012;120:622
Local small airway epithelial injury induces global smooth muscle contraction and airway constriction.
Authors: Zhou Et al.
J Appl Physiol (1985) 2012;112:627
Asynchronous Ca2+ current conducted by voltage-gated Ca2+ (CaV)-2.1 and CaV2.2 channels and its implications for asynchronous neurotransmitter release.
Authors: Few Et al.
Proc Natl Acad Sci U S A 2012;109:E452
RyRCa2+ leak limits cardiac Ca2+ window current overcoming the tonic effect of calmodulinin mice.
Authors: Fernández-Velasco Et al.
PLoS One 2011;6:e20863
The human immunodeficiency virus coat protein gp120 promotes forward trafficking and surface clustering of NMDA receptors in membrane microdomains.
Authors: Xu Et al.
PLoS One 2011;31:17074
Associative, bidirectional changes in neural signaling utilizing NMDA receptor- and endocannabinoid-dependent mechanisms.
Authors: Li and Burrell
Learn Mem 2011;18:545
Alteration of Ryanodine-receptors in Cultured Rat Aortic Smooth Muscle Cells.
Authors: Kim Et al.
PLoS One 2011;15:431
Cholesterol efflux to apoA-I in ABCA1-expressing cells is regulated by Ca2+-dependent calcineurin signaling.
Authors: Karwatsky Et al.
J Lipid Res 2010;51:1144
Activation of muscarinic acetylcholine receptors induces a nitric oxide-dependent long-term depression in rat medial prefrontal cortex.
Authors: Huang and Hsu
Cereb Cortex 2010;20:982
Non-cardiomyocytes influence the electrophysiological maturation of human embryonic stem cell-derived cardiomyocytes during differentiation.
Authors: Kim Et al.
Int J Clin Exp Pathol 2010;19:783
Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death.
Authors: Luciani Et al.
H(2)O(2)-mediated modulation of cytosolic signaling and organelle function in rat hippocampus.
Authors: Gerich Et al.
FASEB J 2009;458:937
Glucose and endoplasmic reticulum calcium channels regulate HIF-1beta via presenilin in pancreatic beta-cells.
Authors: Dror Et al.
J Biol Chem 2008;283:9909
Effects of anoxia and aglycemia on cytosolic calcium regulation in rat sensory neurons.
Authors: Henrich and Buckler
J Neurophysiol 2008;100:456
Apelin increases contractility in failing cardiac muscle.
Authors: Dai Et al.
Eur J Pharmacol 2006;553:222
GABA regulates dendritic growth by stabilizing lamellipodia in newly generated interneurons of the olfactory bulb.
Authors: Gascon Et al.
J Neurosci 2006;26:12956
Ca2+ dynamics in salivary acinar cells: distinct morphology of the acinar lumen underlies near-synchronous global Ca2+ responses.
Authors: Larina and Thorn
J Cell Sci 2005;118:4131
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