Ryanodine

  ( 28 citations )    
Product Datasheet
Catalog Number:1329
Chemical Name:1H-Pyrrole-2-carboxylic acid, (3S,4R,4aR,6S,7S,8R,8aS,8bR,9S,9aS)-dodecahydro-4,6,7,8a,8b,9a-hexahydroxy-3,6a,9-trimethyl-7-(1-methylethyl)-6,9-methanobenzo[1,2]pentaleno[1,6-bc]furan-8-yl ester
Product Details
Citations (28)
Reviews
Biological Activity
Potent inhibitor of Ca2+ release from sarcoplasmic reticulum (IC50 values are 10 and 2.8 nM in skeletal and cardiac muscle respectively).
Technical Data
  • M.Wt:
    493.55
  • Formula:
    C25H35NO9
  • Solubility:
    Soluble to 10 mM in ethanol and to 25 mM in DMSO
  • Purity:
    >98
  • Storage:
    Desiccate at -20°C
  • CAS No:
    15662-33-6
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for Ryanodine include:

28 Citations: Showing 1 - 10
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  1. Metaplasticity mechanisms restore plasticity and associativity in an animal model of Alzheimer's disease.
    Authors: Li
    Proc Natl Acad Sci U.S.A.  2017;114(21):5527
  2. Calcium handling precedes cardiac differentiation to initiate the first heartbeat.
    Authors: Tyser Et al.
    Elife  2016;5
  3. Cardiac sodium/calcium exchanger preconditioning promotes anti-arrhythmic and cardioprotective effects through mitochondrial calcium-activated potassium channel.
    Authors: Zhang Et al.
    Pflugers Arch  2015;8:10239
  4. Caffeine Modulates Vesicle Release and Recovery at Cerebellar Parallel Fibre Terminals, Independently of Calcium and Cyclic AMP Signalling.
    Authors: Dobson Et al.
    J Neurosci Res  2015;10:e0125974
  5. Modified cytoplasmic Ca2+ sequestration contributes to spinal cord injury-induced augmentation of nerve-evoked contractions in the rat tail artery.
    Authors: Dera Et al.
    PLoS One  2014;9:e111804
  6. Microtubule dynamics at the growth cone are mediated by α7 nicotinic receptor activation of a Gαq and IP3 receptor pathway.
    Authors: Nordman and Kabbani
    J Neurosci  2014;28:2995
  7. Acute simvastatin inhibits K ATP channels of porcine coronary artery myocytes.
    Authors: Seto Et al.
    Am J Physiol Cell Physiol  2013;8:e66404
  8. Characterization of functional TRPV1 channels in the sarcoplasmic reticulum of mouse skeletal muscle.
    Authors: Lotteau Et al.
    PLoS One  2013;8:e58673
  9. Mechanisms underlying activation of transient BK current in rabbit urethral smooth muscle cells and its modulation by IP3-generating agonists.
    Authors: Kyle Et al.
    Korean J Physiol Pharmacol  2013;305:C609
  10. Non-Hebbian plasticity at C-fiber synapses in rat spinal cord lamina I neurons.
    Authors: Naka Et al.
    Pain  2013;154:1333
  11. Netrin-1 stimulates developing GnRH neurons to extend neurites to the median eminence in a calcium- dependent manner.
    Authors: Low Et al.
    PLoS One  2012;7:e46999
  12. Ethanol alters opioid regulation of Ca(2+) influx through L-type Ca(2+) channels in PC12 cells.
    Authors: Gruol Et al.
    Alcohol Clin Exp Res  2012;36:443
  13. DHA inhibits ER Ca2+ release and ER stress in astrocytes following in vitro ischemia.
    Authors: Begum Et al.
    J Neurochem  2012;120:622
  14. Local small airway epithelial injury induces global smooth muscle contraction and airway constriction.
    Authors: Zhou Et al.
    J Appl Physiol (1985)  2012;112:627
  15. Asynchronous Ca2+ current conducted by voltage-gated Ca2+ (CaV)-2.1 and CaV2.2 channels and its implications for asynchronous neurotransmitter release.
    Authors: Few Et al.
    Proc Natl Acad Sci U S A  2012;109:E452
  16. RyRCa2+ leak limits cardiac Ca2+ window current overcoming the tonic effect of calmodulinin mice.
    Authors: Fernández-Velasco Et al.
    PLoS One  2011;6:e20863
  17. The human immunodeficiency virus coat protein gp120 promotes forward trafficking and surface clustering of NMDA receptors in membrane microdomains.
    Authors: Xu Et al.
    PLoS One  2011;31:17074
  18. Associative, bidirectional changes in neural signaling utilizing NMDA receptor- and endocannabinoid-dependent mechanisms.
    Authors: Li and Burrell
    Learn Mem  2011;18:545
  19. Alteration of Ryanodine-receptors in Cultured Rat Aortic Smooth Muscle Cells.
    Authors: Kim Et al.
    PLoS One  2011;15:431
  20. Cholesterol efflux to apoA-I in ABCA1-expressing cells is regulated by Ca2+-dependent calcineurin signaling.
    Authors: Karwatsky Et al.
    J Lipid Res  2010;51:1144
  21. Activation of muscarinic acetylcholine receptors induces a nitric oxide-dependent long-term depression in rat medial prefrontal cortex.
    Authors: Huang and Hsu
    Cereb Cortex  2010;20:982
  22. Non-cardiomyocytes influence the electrophysiological maturation of human embryonic stem cell-derived cardiomyocytes during differentiation.
    Authors: Kim Et al.
    Int J Clin Exp Pathol  2010;19:783
  23. Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death.
    Authors: Luciani Et al.
    Diabetes  2009;58:422
  24. H(2)O(2)-mediated modulation of cytosolic signaling and organelle function in rat hippocampus.
    Authors: Gerich Et al.
    FASEB J  2009;458:937
  25. Glucose and endoplasmic reticulum calcium channels regulate HIF-1beta via presenilin in pancreatic beta-cells.
    Authors: Dror Et al.
    J Biol Chem  2008;283:9909
  26. Effects of anoxia and aglycemia on cytosolic calcium regulation in rat sensory neurons.
    Authors: Henrich and Buckler
    J Neurophysiol  2008;100:456
  27. Apelin increases contractility in failing cardiac muscle.
    Authors: Dai Et al.
    Eur J Pharmacol  2006;553:222
  28. Ca2+ dynamics in salivary acinar cells: distinct morphology of the acinar lumen underlies near-synchronous global Ca2+ responses.
    Authors: Larina and Thorn
    J Cell Sci  2005;118:4131
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