Catalog # Availability Size / Price Qty
Ryanodine | CAS No. 15662-33-6 | Ryanodine Receptor Inhibitors
1 Image
Description: Ca2+ release inhibitor

Chemical Name: 1H-Pyrrole-2-carboxylic acid, (3S,4R,4aR,6S,7S,8R,8aS,8bR,9S,9aS)-dodecahydro-4,6,7,8a,8b,9a-hexahydroxy-3,6a,9-trimethyl-7-(1-methylethyl)-6,9-methanobenzo[1,2]pentaleno[1,6-bc]furan-8-yl ester

Purity: ≥98%

Product Details
Citations (34)

Biological Activity

Ryanodine is a potent inhibitor of Ca2+ release from sarcoplasmic reticulum (IC50 values are 10 and 2.8 nM in skeletal and cardiac muscle respectively).

Technical Data

Soluble to 10 mM in ethanol and to 25 mM in DMSO
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Or select another batch:
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Molarity Calculator


*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for Ryanodine

The citations listed below are publications that use Tocris products. Selected citations for Ryanodine include:

34 Citations: Showing 1 - 10

  1. Purinergic signaling in cochlear supporting cells reduces hair cell excitability by increasing the extracellular space.
    Authors: Babola Et al.
    ELife  2020;9:e52160
  2. Dual action of L-Lactate on the activity of NR2B-containing NMDA receptors: from potentiation to neuroprotection.
    Authors: Jourdain Et al.
    Sci Rep  2018;8(1):13472
  3. Calcium-regulatory proteins as modulators of chemotherapy in human neuroblastoma.
    Authors: Florea Et al.
    Oncotarget  2017;8:22876
  4. Metaplasticity mechanisms restore plasticity and associativity in an animal model of Alzheimer's disease.
    Authors: Li
    Proc Natl Acad Sci U.S.A.  2017;114(21):5527
  5. Signaling mechanism for modulation by ATP of glycine receptors on rat retinal ganglion cells.
    Authors: Zhang Et al.
    Sci Rep  2016;6:28938
  6. Calcium handling precedes cardiac differentiation to initiate the first heartbeat.
    Authors: Tyser Et al.
    Elife  2016;5
  7. Cardiac sodium/calcium exchanger preconditioning promotes anti-arrhythmic and cardioprotective effects through mitochondrial calcium-activated potassium channel.
    Authors: Zhang Et al.
    Pflugers Arch  2015;8:10239
  8. Intracellular Ca(2+) release from endoplasmic reticulum regulates slow wave currents and pacemaker activity of interstitial cells of Cajal.
    Authors: Zhu Et al.
    Am J Physiol Cell Physiol  2015;308:C608
  9. Caffeine Modulates Vesicle Release and Recovery at Cerebellar Parallel Fibre Terminals, Independently of Calcium and Cyclic AMP Signalling.
    Authors: Dobson Et al.
    J Neurosci Res  2015;10:e0125974
  10. Modified cytoplasmic Ca2+ sequestration contributes to spinal cord injury-induced augmentation of nerve-evoked contractions in the rat tail artery.
    Authors: Dera Et al.
    PLoS One  2014;9:e111804
  11. Microtubule dynamics at the growth cone are mediated by α7 nicotinic receptor activation of a Gαq and IP3 receptor pathway.
    Authors: Nordman and Kabbani
    J Neurosci  2014;28:2995
  12. Acute SimV. inhibits K ATP channels of porcine coronary artery myocytes.
    Authors: Seto Et al.
    Am J Physiol Cell Physiol  2013;8:e66404
  13. Characterization of functional TRPV1 channels in the sarcoplasmic reticulum of mouse skeletal muscle.
    Authors: Lotteau Et al.
    PLoS One  2013;8:e58673
  14. Mechanisms underlying activation of transient BK current in rabbit urethral smooth muscle cells and its modulation by IP3-generating agonists.
    Authors: Kyle Et al.
    Korean J Physiol Pharmacol  2013;305:C609
  15. Non-Hebbian plasticity at C-fiber synapses in rat spinal cord lamina I neurons.
    Authors: Naka Et al.
    Pain  2013;154:1333
  16. Netrin-1 stimulates developing GnRH neurons to extend neurites to the median eminence in a calcium- dependent manner.
    Authors: Low Et al.
    PLoS One  2012;7:e46999
  17. Ethanol alters opioid regulation of Ca(2+) influx through L-type Ca(2+) channels in PC12 cells.
    Authors: Gruol Et al.
    Alcohol Clin Exp Res  2012;36:443
  18. DHA inhibits ER Ca2+ release and ER stress in astrocytes following in vitro ischemia.
    Authors: Begum Et al.
    J Neurochem  2012;120:622
  19. Local small airway epithelial injury induces global smooth muscle contraction and airway constriction.
    Authors: Zhou Et al.
    J Appl Physiol (1985)  2012;112:627
  20. Asynchronous Ca2+ current conducted by voltage-gated Ca2+ (CaV)-2.1 and CaV2.2 channels and its implications for asynchronous neurotransmitter release.
    Authors: Few Et al.
    Proc Natl Acad Sci U S A  2012;109:E452
  21. RyRCa2+ leak limits cardiac Ca2+ window current overcoming the tonic effect of calmodulinin mice.
    Authors: Fernández-Velasco Et al.
    PLoS One  2011;6:e20863
  22. The human immunodeficiency virus coat protein gp120 promotes forward trafficking and surface clustering of NMDA receptors in membrane microdomains.
    Authors: Xu Et al.
    PLoS One  2011;31:17074
  23. Associative, bidirectional changes in neural signaling utilizing NMDA receptor- and endocannabinoid-dependent mechanisms.
    Authors: Li and Burrell
    Learn Mem  2011;18:545
  24. Alteration of Ryanodine-receptors in Cultured Rat Aortic Smooth Muscle Cells.
    Authors: Kim Et al.
    PLoS One  2011;15:431
  25. Cholesterol efflux to apoA-I in ABCA1-expressing cells is regulated by Ca2+-dependent calcineurin signaling.
    Authors: Karwatsky Et al.
    J Lipid Res  2010;51:1144
  26. Activation of muscarinic acetylcholine receptors induces a nitric oxide-dependent long-term depression in rat medial prefrontal cortex.
    Authors: Huang and Hsu
    Cereb Cortex  2010;20:982
  27. Non-cardiomyocytes influence the electrophysiological maturation of human embryonic stem cell-derived cardiomyocytes during differentiation.
    Authors: Kim Et al.
    Int J Clin Exp Pathol  2010;19:783
  28. Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death.
    Authors: Luciani Et al.
    Diabetes  2009;58:422
  29. H(2)O(2)-mediated modulation of cytosolic signaling and organelle function in rat hippocampus.
    Authors: Gerich Et al.
    FASEB J  2009;458:937
  30. Glucose and endoplasmic reticulum calcium channels regulate HIF-1beta via presenilin in pancreatic beta-cells.
    Authors: Dror Et al.
    J Biol Chem  2008;283:9909
  31. Effects of anoxia and aglycemia on cytosolic calcium regulation in rat sensory neurons.
    Authors: Henrich and Buckler
    J Neurophysiol  2008;100:456
  32. Apelin increases contractility in failing cardiac muscle.
    Authors: Dai Et al.
    Eur J Pharmacol  2006;553:222
  33. GABA regulates dendritic growth by stabilizing lamellipodia in newly generated interneurons of the olfactory bulb.
    Authors: Gascon Et al.
    J Neurosci  2006;26:12956
  34. Ca2+ dynamics in salivary acinar cells: distinct morphology of the acinar lumen underlies near-synchronous global Ca2+ responses.
    Authors: Larina and Thorn
    J Cell Sci  2005;118:4131


No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for Ryanodine

There are currently no reviews for this product. Be the first to review Ryanodine and earn rewards!

Have you used Ryanodine?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.