(S)-3,5-DHPG

Tocris Bioscience | Catalog # 0805

Selective group I mGlu agonist; active enantiomer of 3,5-DHPG (Cat. No. 0342)
Tocris Bioscience

Key Product Details

Description

Selective group I mGlu agonist; active enantiomer of 3,5-DHPG (Cat. No. 0342)
View all Group I mGluR Agonists »

Product Description

(S)-3,5-DHPG is a selective group I mGlu receptor agonist. (S)-3,5-DHPG regulates the expression of microRNAs in mouse cerebral cortex in vivo. (S)-3,5-DHPG induces a profound depression of synaptic dopamine release in mouse cortico-striatal cells in vitro, and anxiety-like behavior in vivo in mice.

Racemate also available.

Product Specifications for (S)-3,5-DHPG

Molecular Weight

183.16

Formula

C8H9NO4

Storage

Desiccate at -20°C

Purity

≥98% (HPLC)

Chemical Name

(S)-3,5-Dihydroxyphenylglycine

CAS Number

162870-29-3

PubChem ID

443586

InChI Key

HOOWCUZPEFNHDT-ZETCQYMHSA-N

SMILES

OC1=CC([C@]([H])(N)C(O)=O)=CC(O)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 9.16 50

Preparing Stock Solutions for (S)-3,5-DHPG

The following data is based on the product molecular weight 183.16.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 10.92 mL 54.60 mL 109.19 mL
2.5 mM 2.18 mL 10.92 mL 21.84 mL
5 mM 1.09 mL 5.46 mL 10.92 mL
25 mM 0.22 mL 1.09 mL 2.18 mL

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Background References

References are publications that support the biological activity of the product. See our Citations tab to view 94 publications citing the usage of this product.

Product Documents for (S)-3,5-DHPG

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for (S)-3,5-DHPG

For research use only

Customer Reviews for (S)-3,5-DHPG (2)

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  • Used in inhibitor cocktail
    Name: Anonymous
    Species: Rat
    Assay Type: In Vitro
    Cell Line/Tissue: Retinal rod bipolar cells
    Verified Customer | Posted 12/03/2019
    Retinal dissections were performed in HEPES-buffered extracellular solution containing glutamate inhibitor cocktail 100 umol/L
    (S)-3,5-DHPG 0805
  • No issues
    Name: Talia James
    Species: Mouse
    Assay Type: Ex Vivo
    Cell Line/Tissue: C57BL/6
    Verified Customer | Posted 01/08/2018
    Pay close attention to enantiomer. Some report that R,S-DHPG is not as effective at inducing LTD as S-DHPG alone, which is something I will anecdotally corroborate.
    Used this compound to induce Group I mGluR-dependent LTD in acute brain slices from the mouse hippocampus at a concentration of 50μM. Reliably induces LTD to 50-80% of baseline.
    (S)-3,5-DHPG 0805

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