(S)-3,5-DHPG

  ( 28 citations ) ( 1 Review )    
Product Datasheet
Catalog Number:0805
Chemical Name:(S)-3,5-Dihydroxyphenylglycine
Product Details
Citations (28)
Supplemental Products
Reviews
Biological Activity
Selective group I mGlu receptor agonist.

Available as part of the Group I mGlu Receptor Tocriset™ and Mixed mGlu Receptor Tocriset™. Racemate also available.

Technical Data
  • M.Wt:
    183.16
  • Formula:
    C8H9NO4
  • Solubility:
    Soluble to 50 mM in water
  • Purity:
    >98
  • Storage:
    Desiccate at -20°C
  • CAS No:
    162870-29-3
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
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Citations:

The citations listed below are publications that use Tocris products. Selected citations for (S)-3,5-DHPG include:

28 Citations: Showing 1 - 10
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  1. A novel crosstalk within the endocannabinoid system controls GABA transmission in the striatum.
    Authors: Musella
    Sci Rep  2017;7(1):7363
  2. Single-Molecule Imaging of PSD-95 mRNA Translation in Dendrites and Its Dysregulation in a Mouse Model of Fragile X Syndrome.
    Authors: Ifrim Et al.
    PLoS One  2015;35:7116
  3. Homer protein-metabotropic glutamate receptor binding regulates endocannabinoid signaling and affects hyperexcitability in a mouse model of fragile X syndrome.
    Authors: Tang and Alger
    J Neurosci  2015;35:3938
  4. Stimulation-evoked Ca2+ signals in astrocytic processes at hippocampal CA3-CA1 synapses of adult mice are modulated by glutamate and ATP.
    Authors: Tang Et al.
    J Neurosci  2015;35:3016
  5. Inhibition of Group I Metabotropic Glutamate Receptors Reverses Autistic-Like Phenotypes Caused by Deficiency of the Translation Repressor eIF4E Binding Protein 2.
    Authors: Aguilar-Valles Et al.
    Neuropharmacology  2015;35:11125
  6. A Low Affinity GCaMP3 Variant (GCaMPer) for Imaging the Endoplasmic Reticulum Calcium Store.
    Authors: Henderson Et al.
    J Neurosci  2015;10:e0139273
  7. Modulation of neuronal microcircuit activities within the medial prefrontal cortex by mGluR5 positive allosteric modulator.
    Authors: Pollard Et al.
    J Psychopharmacol  2014;28:935
  8. Group I metabotropic glutamate receptor mediated dynamic immune dysfunction in children with fragile X syndrome.
    Authors: Careaga Et al.
    J Neuroinflammation  2014;11:110
  9. The role of metabotropic glutamate receptor 5 on the stromal cell-derived factor-1/CXCR4 system in oral cancer.
    Authors: Kuribayashi Et al.
    J Biol Chem  2013;8:e80773
  10. Hippocampal Gαq/11 but not Gαo-coupled receptors are altered in aging.
    Authors: McQuail Et al.
    PLoS One  2013;70:63
  11. Haploinsufficiency of Cyfip1 produces fragile X-like phenotypes in mice.
    Authors: Bozdagi Et al.
    J Neurosci  2012;7:e42422
  12. Endocannabinoid-mediated long-term depression of afferent excitatory synapses in hippocampal pyramidal cells and GABAergic interneurons.
    Authors: Peterfi Et al.
    J Neurosci  2012;32:14448
  13. Characterization of a truncated metabotropic glutamate receptor in a primitive metazoan, the parasitic flatworm Schistosoma mansoni.
    Authors: Taman and Ribeiro
    PLoS One  2011;6:e27119
  14. Dual regulation of fragile X mental retardation protein by group I metabotropic glutamate receptors controls translation-dependent epileptogenesis in the hippocampus.
    Authors: Zhao Et al.
    J Neurosci  2011;31:725
  15. Ictal activity induced by group I metabotropic glutamate receptor activation and loss of afterhyperpolarizations.
    Authors: Pan Et al.
    Neuropharmacology  2010;59:86
  16. The scaffold protein NHERF2 determines the coupling of P2Y1 nucleotide and mGluR5 glutamate receptor to different ion channels in neurons.
    Authors: Filippov Et al.
    Mol Pharmacol  2010;30:11068
  17. Kisspeptin directly excites anorexigenic proopiomelanocortin neurons but inhibits orexigenic neuropeptide Y cells by an indirect synaptic mechanism.
    Authors: Fu and Pol
    J Neurosci  2010;30:10205
  18. FMRP mediates mGluR5-dependent translation of amyloid precursor protein.
    Authors: Westmark and Malter
    PLoS Biol  2007;5:e52
  19. Calpain-mediated mGluR1alpha truncation: a key step in excitotoxicity.
    Authors: Xu Et al.
    Neuron  2007;53:399
  20. Potent and specific action of the mGlu1 antagonists YM-298198 and JNJ16259685 on synaptic transmission in rat cerebellar slices.
    Authors: Fukunaga Et al.
    Br J Pharmacol  2007;151:870
  21. Fragile X mental retardation protein deficiency leads to excessive mGluR5-dependent internalization of AMPA receptors.
    Authors: Nakamoto Et al.
    Proc Natl Acad Sci U S A  2007;104:15537
  22. High sensitivity to neuromodulator-activated signaling pathways at physiological [K+] of confocally imaged respiratory center neurons in on-line-calibrated newborn rat brainstem slices.
    Authors: Ruangkittisakul Et al.
    J Neurosci  2006;26:11870
  23. Blockade of mGluR1 receptor results in analgesia and disruption of motor and cognitive performances: effects of A-841720, a novel non-competitive mGluR1 receptor antagonist.
    Authors: El-Kouhen Et al.
    Br J Pharmacol  2006;149:761
  24. Ancestral reconstruction of the ligand-binding pocket of Family C G protein-coupled receptors.
    Authors: Kuang Et al.
    J Neurosci  2006;103:14050
  25. Stimulation of endocannabinoid formation in brain slice cultures through activation of group I metabotropic glutamate receptors.
    Authors: Jung Et al.
    Proc Natl Acad Sci U S A  2005;68:1196
  26. Signaling microdomains regulate inositol 1,4,5-trisphosphate-mediated intracellular calcium transients in cultured neurons.
    Authors: Jacob Et al.
    Proc Natl Acad Sci U S A  2005;25:2853
  27. Activity-dependent expression of inositol 1,4,5-trisphosphate receptor type 1 in hippocampal neurons.
    Authors: Cai Et al.
    PLoS One  2004;279:23691
  28. Dopamine controls the firing pattern of dopamine neurons via a network feedback mechanism.
    Authors: Paladini Et al.
    Sci Rep  2003;100:2866
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Average Rating: 5 (Based on 1 review)

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  Mouse Talia James 01/08/2018
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Summary

Species Mouse

Other Experimental Details

Other Experimental Details Pay close attention to enantiomer. Some report that R,S-DHPG is not as effective at inducing LTD as S-DHPG alone, which is something I will anecdotally corroborate.

Please scroll the above reviews for more
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