S-Isopropylisothiourea hydrobromide
Description: iNOS inhibitor, acts at arginine binding site
Biological Activity
S-Isopropylisothiourea hydrobromide is a potent inhibitor of NO synthase, with selectivity for the inducible form.Technical Data
M.Wt:
199.11
Formula:
C4H10N2S.HBr
Solubility:
Soluble to 100 mM in DMSO
Storage:
Store at RT
CAS No:
4269-97-0
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Potent and selective inhibition of human nitric oxide synthases.
Garvey et al.
J.Biol.Chem., 1994;269:26669 -
Selective inhibitors of neuronal nitric oxide synthase - is no NOS really good NOS for the nervous system?
Moore and Handy
TiPS, 1997;18:204 -
Effect of S-methylisothiourea on neuronal nitric oxide synthase, nociception and blood pressure in the mouse.
Handy et al.
Br.J.Pharmacol., 1995;115:68P
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