Catalog Number: 5650
Chemical Name: 5-Chloro-N-[6-[5-methyl-4-(1-oxobutyl)-1H-pyrazol-1-yl]-3-pyridazinyl]-1-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-1H-indole-3-carboxamide hydrochloride
Biological Activity
Potent P2Y12 antagonist (IC50 = 17 nM). Displays antiplatelet and antithrombotic activity in vivo. Orally available.
Technical Data
  • M.Wt:
    599.51
  • Formula:
    C28H31ClN8O3.HCl
  • Solubility:
    Soluble to 20 mM in DMSO with gentle warming
  • Purity:
    >98%
  • Storage:
    Store at -20°C
  • CAS No:
    1279829-64-9
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. N-[6-(4-butanoyl-5-methyl-1H-pyrazol-1-yl)pyridazin-3-yl]-5-chloro-1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide (SAR216471), a novel intravenous and oral, reversible, and directly acting P2Y12 antagonist.
    Boldron et al.
    J.Med.Chem., 2014;57:7293
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