Biological Activity[Sar9,Met(O2)11]-Substance P is a potent selective NK1 tachykinin receptor agonist.
(Modifications: X = Sar, Met-11 = Met(O2) & C-terminal amide)
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Tocris products are intended for laboratory research use only, unless stated otherwise.
Characterisation of central and peripheral effects of septide with the use of five tachykinin NK1 receptor antagonists in the rat.
Cellier et al.
Profile of neuronal excitation following selective activation of the neurokinin-1 receptor in rat deep dorsal horn in vitro.
King et al.
Brain Res., 1997;767:55
Small sensory neurons in the rat dorsal root ganglia express functional NK-1 tachykinin receptor.
Li and Zhao
125I-BH[Sar9,Met(O2)11]-SP, a new selective ligand for the NK-1 receptor in the central nervous system.
Tousignant et al.
Brain Res., 1990;524:263
Citations for [Sar9,Met(O2)11]-Substance P
The citations listed below are publications that use Tocris products. Selected citations for [Sar9,Met(O2)11]-Substance P include:
2 Citations: Showing 1 - 2
Hyperalgesia and sensitization of dorsal horn neurons following activation of NK-1 receptors in the rostral ventromedial medulla.
Authors: Khasabov Et al.
J Neurophysiol 2017;118:2727
Divergent β-arrestin-dependent signaling events are dependent upon sequences within G-protein-coupled receptor C termini.
Authors: Pal Et al.
J Biol Chem 2013;288:3265
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