Catalog Number: 1178
Biological Activity
Potent selective NK1 tachykinin receptor agonist.
Technical Data
  • M.Wt:
    1393
  • Formula:
    C64H100N18O15S
  • Sequence:
    RPKPQQFFXLM

    (Modifications: X = Sar, Met-11 = Met(O2), Met-11 = C-terminal amide)

  • Solubility:
    Soluble to 1 mg/ml in water
  • Storage:
    Desiccate at -20°C
  • CAS No:
    110880-55-2
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Characterisation of central and peripheral effects of septide with the use of five tachykinin NK1 receptor antagonists in the rat.
    Cellier et al.
    Br.J.Pharmacol., 1999;127:717
  2. Profile of neuronal excitation following selective activation of the neurokinin-1 receptor in rat deep dorsal horn in vitro.
    King et al.
    Brain Res., 1997;767:55
  3. Small sensory neurons in the rat dorsal root ganglia express functional NK-1 tachykinin receptor.
    Li and Zhao
    Eur.J.Neurosci., 1998;10:1292
  4. 125I-BH[Sar9,Met(O2)11]-SP, a new selective ligand for the NK-1 receptor in the central nervous system.
    Tousignant et al.
    Brain Res., 1990;524:263
Citations:

The citations listed below are publications that use Tocris products. Selected citations for [Sar9,Met(O2)11]-Substance P include:

1 Citations: Showing 1 - 1

  1. Divergent β-arrestin-dependent signaling events are dependent upon sequences within G-protein-coupled receptor C termini.
    Authors: Pal Et al.
    J Biol Chem 2013;288:3265

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