hh SB 203186 hydrochloride (CAS 207572-69-8): R&D Systems
Catalog Number: 0785
Chemical Name: 1-Piperidinylethyl-1H-indole-3-carboxylate hydrochloride
Biological Activity
Potent 5-HT4 receptor antagonist with high affinity for human atrial 5-HT4 receptors.
Technical Data
  • M.Wt:
  • Formula:
  • Solubility:
    Soluble to 100 mM in water
  • Purity:
  • Storage:
    Store at RT
  • CAS No:
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Additional Information
Licensing Caveats:
Sold with the permission of GlaxoSmithKline
Background References
  1. 5-HT4 receptor antagonist affinities of SB207710, SB205008 and SB 203186 in the human colon, rat oesophagus and guinea-pig ileum peristaltic reflex.
    McLean and Coupar
    Naunyn Schmiedebergs Arch.Pharmacol., 1995;352:132
  2. Blockade of human and porcine myocardial 5-HT4 receptors by SB 203186.
    Parker et al.
    Naunyn Schmiedebergs Arch.Pharmacol., 1995;353:28
  3. Characterisation of 5-HT4 receptor mediating tachycardia in piglet isolated right atrium.
    Midhurst and Kaumann et al.
    Br.J.Pharmacol., 1993;110:1023

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